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Lucia Coppo

Lucia Coppo

Researcher
Visiting address: Solnavägen 9, 9A, 17177 Stockholm
Postal address: C2 Medicinsk biokemi och biofysik, C2 Biokemi Arnér, 171 77 Stockholm
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About me

  • Lucia joined the Biochemistry Division in 2012
    *Researcher* in the Biochemistry Elias Arner's group
    *Postdoc appointments* 2012- 2018 Postdoctoral fellow at the
    Biochemistry division Arne Holmgren's group.
    April 2013-July 2013 King’s College of London, Fellowship
    by CTI-Science biotech Company to test the antioxidant and metal chelator
    properties of a new compound.
    *PhD in Molecular Medicine* 2008-2012 Department of Neuroscience,
    Pharmacology Unit, University of Siena, Italy.
    With the addition of the European label “/Doctor Europaeus/” in
    compliance with the requirements of the European University Association.
    Exchange PhD program: visiting student in Brighton and Sussex Medical School
    Falmer, Brighton
    2021-Awarded of *EMBO short-term fellowship* in the Ivan Gout’s Lab UCL,
    London, UK.
    2020-2021 Awarded of *Fulbright scholarship* in Ed Schmidt’s lab, Montana
    State University, US.
    Serving as a member of a thesis examination committee
    2020 October 27th *Member of the Doctoral Thesis panel.* Candidate: Pablo
    Marti Andres, Department of Physiology Faculty of Pharmacy, Universitat de
    València Spain.
    2020 June 12th *Member of half-time control committee* for the PhD
    student Mattia Russel Pantalone, Söderberg-Naucler’s lab,
    Department of Medicine, Karolinska Institute.
    2019-October 11th *Member of half-time control committee *for the PhD
    student Pierre Sabatier, Zubarev ‘s lab, MBB Department.
    2017 March 24th. *Member of the Doctoral Thesis panel.* Candidate: Cristina
    Álvarez Zaldiernas. Faculty of Medicine and Health Sciences of the
    University of Barcelona, Spain.

Research

  • During my PhD, I investigated how redox signaling and regulation, control
    platelet aggregation and how redox modifications as glutathionylation lead to
    not conventional protein secretion. Moreover, I was also interested in how
    glutathionylation can modulate protein function and the connection between
    redox biology and immunity.
    Following my interest on redox regulation and signaling I applied for a
    postdoctoral position in the group of Prof. Arne Holmgren, redox pioneer,
    widely known for the in-depth studies of Thioredoxins, Thioredoxin Reductases
    and for the discovery and characterization of Glutaredoxins (Grxs).
    I particularly worked in developing highly sensitive assays that allow to
    detected Grx at picomolar levels and glutathione in human plasma. Overall,
    these methods have simplicity and rapidity combined with high sensitivity as
    main advantages
  • therefore, they may be particularly suitable for large-scale
    clinical studies.
    I started to work with transgenic mouse models to study the crosstalk of Trx
    and Grx pathways in Trx, Trx reductase and/or Glutathione Reductase null-mice
    in the hepatocytes.
    Another main focus of my research is to characterize the role of Grx2 using
    a mouse model with Grx2 depletion in mitochondria. The transgenic mice
    developed an unexpected phenotype consisting in increase body weight already
    at early stage of life that suggest an key role of Grx2 in metabolism.

Teaching

  • May 2019: Teaching and Learning in Higher Education
    Involved in Biomedicine Program: Introduction to Biomedicine and Den Friska
    Människan 1

Articles

  • Article: REDOX BIOLOGY. 2023;67:102915
    Blandino G; Fiorani M; Canonico B; De Matteis R; Guidarelli A; Montanari M; Buffi G; Coppo L; Arner ESJ; Cantoni O
  • Article: TOXICS. 2022;10(8):433
    Branco V; Coppo L; Aschner M; Carvalho C
  • Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2022;722:109212
    Li M; Coppo L; Jena BP; Larsson L
  • Article: REDOX BIOLOGY. 2022;51:102277
    Scalcon V; Folda A; Lupo MG; Tonolo F; Pei N; Battisti I; Ferri N; Arrigoni G; Bindoli A; Holmgren A; Coppo L; Rigobello MP
  • Article: SCIENCE ADVANCES. 2022;8(1):eabm1148
    Coppo L; Mishra P; Siefert N; Holmgren A; Paabo S; Zeberg H
  • Article: REDOX BIOLOGY. 2021;43:101975
    Ogata FT; Branco V; Vale FF; Coppo L
  • Article: JOURNAL OF ORGANOMETALLIC CHEMISTRY. 2021;943:121822
    Koh WX; Coppo L; Ganguly R; Holmgren A; Leong WK
  • Article: ANTIOXIDANTS. 2021;10(3):359
    Miller CG; Kundert JA; Prigge JR; Amato JA; Perez AE; Coppo L; Rizzo GN; Kavanaugh MP; Orlicky DJ; Shearn CT; Schmidt EE
  • Article: CHEMISTRYSELECT. 2021;6(8):1845-1851
    Sengupta R; Coppo L; Sircar E; Mishra P; Holmgren A
  • Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2020;33(9):2441-2445
    Koh WX; Coppo L; Holmgren A; Kong JW; Leong WK
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(34):12708-12716
    Sengupta R; Coppo L; Mishra P; Holmgren A
  • Article: FREE RADICAL BIOLOGY AND MEDICINE. 2019;134:350-358
    Ren X; Santhosh SM; Coppo L; Ogata FT; Lu J; Holmgren A
  • Article: ANALYTICAL BIOCHEMISTRY. 2019;568:24-30
    Coppo L; Ogata FT; Santhosh SM; Sventelius T; Holmgren A
  • Article: SCIENTIFIC REPORTS. 2018;8(1):12671
    Haffo L; Lu J; Bykov VJN; Martin SS; Ren X; Coppo L; Wiman KG; Holmgren A
  • Article: REDOX BIOLOGY. 2017;13:278-287
    Branco V; Coppo L; Sola S; Lu J; Rodrigues CMP; Holmgren A; Carvalho C
  • Article: REDOX BIOLOGY. 2017;12:634-647
    Rodriguez-Garcia A; Hevia D; Mayo JC; Gonzalez-Menendez P; Coppo L; Lu J; Holmgren A; Sainz RM
  • Article: CELL REPORTS. 2017;19(13):2771-2781
    Prigge JR; Coppo L; Martin SS; Ogata F; Miller CG; Bruschwein MD; Orlicky DJ; Shearn CT; Kundert JA; Lytchier J; Herr AE; Mattsson A; Taylor MP; Gustafsson TN; Arner ESJ; Holmgren A; Schmidt EE
  • Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1239
    Diotallevi M; Checconi P; Palamara AT; Celestino I; Coppo L; Holmgren A; Abbas K; Peyrot F; Mengozzi M; Ghezzi P
  • Article: AMINO ACIDS. 2016;48(6):1477-1489
    Ulivelli M; Priora R; Di Giuseppe D; Coppo L; Summa D; Margaritis A; Frosali S; Bartalini S; Martini G; Cerase A; Di Simplicio P
  • Article: ANALYTICAL BIOCHEMISTRY. 2016;499:24-33
    Coppo L; Montano SJ; Padilla AC; Holmgren A
  • Show more

All other publications

  • Review: ANTIOXIDANTS AND REDOX SIGNALING. 2023;38(13):920-958
    Coppo L; Scheggi S; DeMontis G; Priora R; Frosali S; Margaritis A; Summa D; Di Giuseppe D; Ulivelli M; Di Simplicio P
  • Review: ANTIOXIDANTS AND REDOX SIGNALING. 2022;36(13):1037-1050
    Ogata FT; Simoes Sato AY; Coppo L; Arai RJ; Stern AI; Pequeno Monteiro H
  • Corrigendum: CHEMISTRYSELECT. 2021;6(12):2893
    Sengupta R; Coppo L; Sircar E; Mishra P; Holmgren A
  • Published conference paper: AMINO ACIDS. 2014;46(2):429-439
    Di Giuseppe D; Priora R; Coppo L; Ulivelli M; Bartalini S; Summa D; Margaritis A; Frosali S; Di Simplicio P
  • Review: METHODS IN ENZYMOLOGY. 2010;473:149-159
    Priora R; Coppo L; Salzano S; Di Simplicio P; Ghezzi P

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