̽ѡ

Leonie Saft

Leonie Saft

Affiliated to Research | Docent
Visiting address: BioClinicum J6:20, Akademiska stråket 1, 17164 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Rassidakis, 171 77 Stockholm

About me

  • I am a senior consultant in clinical pathology and team leader of the division of Hematopathology and Flow Cytometry at Karolinska University Laboratory (KUL), Solna. I studied medicine in Germany (Philipps University Marburg, 1988/89; J.W. Goethe University, Frankfurt, 1989–1994) and in the USA (University of Texas Medical Branch, UTMB, Galveston, Texas, 1994–95), earning both German and American ̽ѡ degrees. I obtained my doctoral degree in 1996 at J.W. Goethe University in Frankfurt with a dissertation on nosocomial Aspergillus infections. After a period of clinical work in hematology/oncology (Klinikum Darmstadt, Germany), I performed my specialist training in Clinical Pathology (Leipzig, 1997–98; Uppsala, 1999–2001; and since 2001 Karolinska University Hospital) and became specialist in 2003 with subspecializations in neuro-oncopathology and hematopathology.

Research

  • Following my PhD studies at Karolinska Institute, Huddinge (2008-2013) and thesis defence (2013) on Myelodysplastic syndrome (MDS) (supervisor: Prof. Eva Hellström-Lindberg), I participated as a reference pathologist in several clinical trials by the Nordic MDS Group. In addition, I became involved in International Multicenter Studies (European Leuk Net MDS Flow Working Group) to explore the role of flow cytometry in unexplained cytopenias and suspected MDS. I am currently engaged in clinical research projects with other units at Karolinska University Laboratory, focusing on the molecular characterization of lymphoma and  acute pediatric leukemias as part of Genomic Medicine Sweden (GMS). Additionally, I am local PI in a bilateral research project aiming at identifying potential precursor stages of lymphoma in lymphoid tissues. I also lead a research project on the development of AI-based tools in bone marrow diagnostics for implementation in routine diagnostics (Clinical Fellowship 2022–2024, CIMV, Linköping University).

Teaching

  • Since 2001, I have been teaching at both the undergraduate and graduate levels at ̽ѡ. I have served as course leader for specialist training courses and have participated as a teacher in international courses. Since 2024, I am visiting professor at Semmelweis University in Budapest, teaching in the ̽ѡ program.

Articles

  • Article: PRECISION ONCOGENOMICS. 2024;1(1):1-7
    Wessman S; Mogensen N; Ranta S; Saft L; von Bahr Greenwood T; Tesi B; De Ståhl TD; Baecklund F
  • Article: PATHOLOGIE. 2023;44(3):164-175
    Saft L
  • Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2023;104(1):87-97
    Westers TM; Saft L; van der Velden VHJ; te Marvelde JG; Dunlop A; Ireland R; Valent P; Porwit A; Bene MC; van de Loosdrecht AA
  • Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2023;104(1):77-86
    Loosdrecht AA; Kern W; Porwit A; Valent P; Kordasti S; Cremers E; Alhan C; Duetz C; Dunlop A; Hobo W; Preijers F; Wagner-Ballon O; Chapuis N; Fontenay M; Bettelheim P; Eidenschink-Brodersen L; Font P; Johansson U; Loken MR; Marvelde JG; Matarraz S; Ogata K; Oelschlaegel U; Orfao A; Psarra K; Subira D; Wells DA; Bene MC; Della Porta MG; Burbury K; Bellos F; van der Velden VHJ; Westers TM; Saft L; Ireland R
  • Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2023;104(1):15-26
    van der Velden VHJ; Preijers F; Johansson U; Westers TM; Dunlop A; Porwit A; Bene MC; Valent P; te Marvelde J; Wagner-Ballon O; Oelschlaegel U; Saft L; Kordasti S; Ireland R; Cremers E; Alhan C; Duetz C; Hobo W; Chapuis N; Fontenay M; Bettelheim P; Eidenshink-Brodersen L; Font P; Loken MR; Matarraz S; Ogata K; Orfao A; Psarra K; Subira D; Wells DA; Della Porta MG; Burbury K; Bellos F; Weiss E; Kern W; van de Loosdrecht A
  • Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2023;104(1):51-65
    Kern W; Westers TM; Bellos F; Bene MC; Bettelheim P; Brodersen LE; Burbury K; Chu S-C; Cullen M; Della Porta M; Dunlop AS; Johansson U; Matarraz S; Oelschlaegel U; Ogata K; Porwit A; Preijers F; Psarra K; Saft L; Subira D; Weiss E; van der Velden VHJ; van de Loosdrecht A
  • Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(6):925-940
    Jadersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzen S; Bohlin A; Arnroth C; Erkers T; Seashore-Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Ostling P; Schinazi RF; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis GZ; Hoglund M; Henter J-I; Herold N
  • Journal article: HEMASPHERE. 2022;6:442-443
    Jädersten M; Lilienthal I; Tsesmetzis N; Lourda M; Bengtzén S; Bohlin A; Arnroth C; Erkers T; Seashore‐Ludlow B; Giraud G; Barkhordar GS; Tao S; Fogelstrand L; Saft L; Östling P; Schinazi R; Kim B; Schaller T; Juliusson G; Deneberg S; Lehmann S; Rassidakis G; Höglund M; Henter J; Herold N
  • Article: FRONTIERS IN ONCOLOGY. 2022;12:899325
    Arthur C; Rezayee F; Mogensen N; Saft L; Rosenquist R; Nordenskjold M; Harila-Saari A; Tham E; Barbany G
  • Article: FRONTIERS IN PEDIATRICS. 2022;10:1082986
    Krstic A; Rezayee F; Saft L; Hammarsjoe A; Svenberg P; Barbany G
  • Article: JOURNAL OF HEMATOPATHOLOGY. 2020;13(2):79-88
    Saft L; Timar B; Porwit A
  • Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2020;98(3):250-258
    Dinnopoulos K; Hansen OK; Sjo LD; Saft L; Schjodt IM; Hansen JW; Gronbaek K
  • Article: LEUKEMIA & LYMPHOMA. 2020;61(3):604-613
    Ivanov Ofverholm I; Zachariadis V; Taylan F; Marincevic-Zuniga Y; Anh NT; Saft L; Nilsson D; Syvanen A-C; Lonnerholm G; Harila-Saari A; Nordenskjold M; Heyman M; Nordgren A; Nordlund J; Barbany G
  • Article: LEUKEMIA RESEARCH. 2018;71:75-81
    Ogata K; Sei K; Saft L; Kawahara N; Della Porta MG; Chapuis N; Yamamoto Y
  • Article: BRITISH JOURNAL OF HAEMATOLOGY. 2018;180(4):526-533
    Scharenberg C; Jansson M; Saft L; Hellstrom-Lindberg E
  • Article: BLOOD. 2017;130(7):881-890
    Mortera-Blanco T; Dimitriou M; Woll PS; Karimi M; Elvarsdottir E; Conte S; Tobiasson M; Jansson M; Douagi I; Moarii M; Saft L; Papaemmanuil E; Jacobsen SEW; Hellstrom-Lindberg E
  • Article: ANNALS OF HEMATOLOGY. 2017;96(7):1105-1112
    de Swart L; Smith A; MacKenzie M; Symeonidis A; Neukirchen J; Mikulenkova D; Vallespi T; Zini G; Paszkowska-Kowalewska M; Kruger A; Saft L; Fenaux P; Bowen D; Hellstrom-Lindberg E; Cermak J; Stauder R; Tatic A; Holm MS; Malcovati L; Madry K; Droste J; Blijlevens N; de Witte T; Germing U
  • Article: HAEMATOLOGICA. 2017;102(3):498-508
    Scharenberg C; Giai V; Pellagatti A; Saft L; Dimitriou M; Jansson M; Jadersten M; Grandien A; Douagi I; Neuberg DS; LeBlanc K; Boultwood J; Karimi M; Jacobsen SEW; Woll PS; Hellstrom-Lindberg E
  • Article: HAEMATOLOGICA. 2017;102(2):308-319
    Westers TM; Cremers EMP; Oelschlaegel U; Johansson U; Bettelheim P; Matarraz S; Orfao A; Moshaver B; Brodersen LE; Loken MR; Wells DA; Subira D; Cullen M; Marvelde JGT; van der Velden VHJ; Preijers FWMB; Chu S-C; Feuillard J; Guderin E; Psarra K; Porwit A; Saft L; Ireland R; Milne T; Bene MC; Witte BI; Della Porta MG; Kern W; van De Loosdrecht AA
  • Journal article: BLOOD. 2016;128(22):4329
    Scharenberg C; Woll PS; Giai V; Pellagatti A; Saft L; Dimitriou M; Jädersten M; Jansson M; Douagi I; Neuberg DS; Karimi M; Le Blanc K; Boultwood J; Jacobsen SE; Hellstrom-Lindberg E
  • Article: AMERICAN JOURNAL OF HEMATOLOGY. 2016;91(12):1234-1238
    Hansen JW; Westman MK; Sjo LD; Saft L; Kristensen LS; Orskov AD; Treppendahl M; Andersen MK; Gronbaek K
  • Article: ANNALS OF HEMATOLOGY. 2016;95(11):1825-1832
    Dahlstrom J; Liu T; Yuan X; Saft L; Ghaderi M; Wei YB; Lavebratt C; Li P; Zheng C; Bjorkholm M; Xu D
  • Article: PEDIATRIC BLOOD & CANCER. 2015;62(6):951-956
    Ranta S; Nilsson F; Harila-Saari A; Saft L; Tani E; Soderhall S; Porwit A; Hultdin M; Noren-Nystrom U; Heyman M
  • Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;80(6):424-431
    Derolf AR; Laane E; Bjorklund E; Saft L; Bjorkholm M; Porwit A
  • Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2014;93(5):439-445
    Svensson T; Chowdhury O; Garelius H; Lorenz F; Saft L; Jacobsen S-E; Hellstrom-Lindberg E; Cherif H
  • Article: ONCOSCIENCE. 2014;1(8):550-557
    Wasik AM; Nygren L; Almestrand S; Zong F; Flygare J; Wennerholm SB; Saft L; Andersson P; Kimby E; Wahlin BE; Christensson B; Sander B
  • Article: HAEMATOLOGICA. 2014;99(6):1041-1049
    Saft L; Karimi M; Ghaderi M; Matolcsy A; Mufti GJ; Kulasekararaj A; Goehring G; Giagounidis A; Selleslag D; Muus P; Sanz G; Mittelman M; Bowen D; Porwit A; Fu T; Backstrom J; Fenaux P; MacBeth KJ; Hellstrom-Lindberg E
  • Article: BLOOD CANCER JOURNAL. 2014;4(3):e189
    Tobiasson M; Dybedahl I; Holm MS; Karimi M; Brandefors L; Garelius H; Grovdal M; Hogh-Dufva I; Gronbaek K; Jansson M; Marcher C; Nilsson L; Kittang AO; Porwit A; Saft L; Mollgard L; Hellstrom-Lindberg E
  • Article: LEUKEMIA RESEARCH. 2013;37(3):266-273
    Saft L; Bjorklund E; Berg E; Hellstrom-Lindberg E; Porwit A
  • Article: HAEMATOLOGICA. 2012;97(8):1209-1217
    Della Porta MG; Picone C; Pascutto C; Malcovati L; Tamura H; Handa H; Czader M; Freeman S; Vyas P; Porwit A; Saft L; Westers TM; Alhan C; Cali C; van de Loosdrecht AA; Ogata K
  • Journal article: BLOOD. 2011;118(21):3798
    Tobiasson M; Brandefors L; Dybedal I; Garelius H; Grövdal M; Dufva IH; Kjeldsen L; Nilsson L; Kittang AO; Porwit A; Saft L; Holm MS; Möllgård L; Hellström-Lindberg E
  • Journal article: BLOOD. 2011;118(21):790
    Scharenberg C; Giai V; Pellagatti A; Saft L; Karlsson G; Jansson M; Forsblom L; Jadersten M; Karlsson S; Boultwood J; Hellstrom-Lindberg E
  • Article: HAEMATOLOGICA. 2011;96(7):963-971
    Mollgard L; Saft L; Treppendahl MB; Dybedal I; Norgaard JM; Astermark J; Ejerblad E; Garelius H; Dufva IH; Jansson M; Jadersten M; Kjeldsen L; Linder O; Nilsson L; Vestergaard H; Porwit A; Gronbaek K; Lindberg EH
  • Journal article: JOURNAL OF HEMATOPATHOLOGY. 2011;4(2):69-79
    Porwit A; Saft L
  • Article: JOURNAL OF CLINICAL ONCOLOGY. 2011;29(15):1971-1979
    Jaedersten M; Saft L; Smith A; Kulasekararaj A; Pomplun S; Goehring G; Hedlund A; Hast R; Schlegelberger B; Porwit A; Hellstrom-Lindberg E; Mufti GJ
  • Journal article: LEUKEMIA RESEARCH. 2011;35:s52
    Saft L; Björklund E; Hellström-Lindberg E; Porwit A
  • Article: HAEMATOLOGICA. 2009;94(12):1762-1766
    Jadersten M; Saft L; Pellagatti A; Goehring G; Wainscoat JS; Boultwood J; Porwit A; Schlegelberger B; Hellstrom-Lindberg E
  • Journal article: BLOOD. 2008;112(11):5104
    Jädersten M; Saft L; Pellagatti A; Göhring G; Fernández-Santamaria C; Wainscoat JS; Boultwood J; Porwit A; Schlegelberger B; Hellström-Lindberg E
  • Article: ANTICANCER RESEARCH. 2006;26(6C):4895-4899
    Rubio CA; Grimelius L; Lindholm J; Hamberg H; Porwit A; Elmberger G; Hoog A; Kanter L; Eriksson E; Stemme S; Orrego A; Saft L; Petersson F; De la Torre M; Ekstrom C; Astrom K; Rundgren A; Djokic M; Chandanos E; Lenander C; Machado M; Nilsson P; Mattsson L
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All other publications

  • Review: HISTOPATHOLOGY. 2023;83(6):829-849
    Saft L; Kvasnicka HM; Boudova L; Gianelli U; Lazzi S; Rozman M
  • Letter: ACTA ONCOLOGICA. 2023;62(6):560-564
    Smedby KE; Waesterlid T; Tham E; Haider Z; Joelsson J; Thorvaldsdottir B; Krstic A; Wahlin BE; Foroughi-Asl H; Karlsson C; Eloranta S; Saft L; Palma M; Kwiecinska A; Hansson L; Osterborg A; Wirta V; Rassidakis G; Sander B; Sonnevi K; Rosenquist R
  • Review: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2023;104(1):27-50
    Porwit A; Bene MC; Duetz C; Matarraz S; Oelschlaegel U; Westers TM; Wagner-Ballon O; Kordasti S; Valent P; Preijers F; Alhan C; Bellos F; Bettelheim P; Burbury K; Chapuis N; Cremers E; Della Porta MG; Dunlop A; Eidenschink-Brodersen L; Font P; Fontenay M; Hobo W; Ireland R; Johansson U; Loken MR; Ogata K; Orfao A; Psarra K; Saft L; Subira D; te Marvelde J; Wells DA; van der Velden VHJ; Kern W; van de Loosdrecht AA
  • Letter: ACTA ONCOLOGICA. 2022;61(7):824-829
    Abdulla M; Hollander P; Lindskog C; Sundstrom C; Enblad G; Saft L; Amini R-M
  • Letter: LEUKEMIA. 2022;36(5):1436-1439
    Rasmussen B; Gohring G; Bernard E; Nilsson L; Tobiasson M; Jadersten M; Garelius H; Dybedal I; Gronbaek K; Ejerblad E; Lorenz F; Flogegard M; Marcher CW; oster Fernstrom A; Cavelier L; Papaemmanuil E; Ebeling F; Kittang AO; Norgaard JM; Saft L; Mollgard L; Hellstrom-Lindberg E
  • Preprint: RESEARCH SQUARE. 2022
    Arthur C; Rezayee F; Mogensen N; Saft L; Rosenquist R; Nordenskjöld M; Harila-Saari A; Tham E; Barbany G
  • Review: JOURNAL OF HEMATOPATHOLOGY. 2022;15(1):13-19
    Saft L; Perdiki-Grigoriadi M; Rassidakis G
  • Conference publication: BLOOD. 2021;138:3995
    Kern W; Westers TM; Bellos F; Bene MC; Bettelheim P; Brodersen LE; Burbury K; Chu S-C; Cullen M; Della Porta M; Dunlop AS; Johansson U; Matarraz S; Oelschlaegel U; Ogata K; Porwit A; Preijers FWMB; Psarra K; Saft L; Subira D; Weiss E; Van de Loosdrecht AA
  • Review: AMERICAN JOURNAL OF CLINICAL PATHOLOGY. 2021;155(2):179-210
    Kelemen K; Saft L; Craig FE; Orazi A; Nakashima M; Wertheim GB; George TI; Horny H-P; King RL; Quintanilla-Martinez L; Wang SA; Rimsza LM; Reichard KK
  • Published conference paper: PATHOBIOLOGY. 2019;86(1):62-75
    Hebeda KM; Tzankov A; Boudova L; Saft L; Hasserjian RP; de Boer M; Fend F; Orazi A; Leguit R
  • Conference publication: BLOOD. 2018;132:794
    Hansen JW; Johansen MM; Westman MK; Saft L; Sjo LD; Marcher CW; Holm MS; Dimitriou M; Karimi M; Raaschou-Jensen K; Glenthoj AB; Severinsen MT; Hellstrom-Lindberg E; Andersen MK; Gronbaek K
  • Conference publication: BLOOD. 2018;132:3105
    Dimopoulos K; Hansen OK; Hansen JW; Sjo L; Saft L; Gronbaek K
  • Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2018;180(5):744-748
    Kwiecinska A; Tsesmetzis N; Ghaderi M; Kis L; Saft L; Rassidakis GZ
  • Conference publication: HAEMATOLOGICA. 2017;102:183
    Hansen JW; Westman M; Orskov AD; Sjo L; Saft L; Holm MS; Marcher CC; Karimi M; Hellstrom-Lindberg E; Andersen MK; Gronbaek K
  • Conference publication: HAEMATOLOGICA. 2016;101:74-75
    Hansen JW; Westman MK; Sjo LD; Saft L; Kristensen LS; Orskov AD; Treppendahl M; Andersen MK; Gronbaek K
  • Conference publication: BLOOD. 2014;124(21):414
    Saft L; Li JS; Greenberg PL; Sekeres MA; Sanz GF; Dreyfus F; Fenaux P; Swern AS; Sugrue MM; Hellstrom-Lindberg E
  • Conference publication: HAEMATOLOGICA. 2014;99:688
    Wasik A; Nygren L; Almestrand S; Zong F; Flygare J; Wennerholm SB; Saft L; Andersson P; Kimby E; Christensson B; Sander B
  • Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;80(3):237-238
    Wasik AM; Nygren L; Almestrand S; Zong F; Flygare J; Baumgartner-Wennerholm S; Saft L; Andersson P; Kimby E; Christensson B; Sander B
  • Conference publication: HAEMATOLOGICA. 2014;99:695
    Kwiecinska A; Ghaderi M; Xagoraris I; Matolcsy A; Saft L; Otsterborg A; Rassidakis G
  • Conference publication: LEUKEMIA RESEARCH. 2013;37:S66
    Saft L; Karimi M; Ghaderi M; Matolscy A; Fenaux P; Mufti G; Giagounidis A; Selleslag D; Muus P; Sanz G; Mittelman M; Bowen D; Porwit A; Fu T; Backstrom J; MacBeth K; Hellstrom-Lindberg E
  • Doctoral thesis: 2013
    Saft L
  • Conference publication: HAEMATOLOGICA. 2013;98:483
    Saft L; Karimi M; Ghaderi M; Matolscy A; Fenaux P; Mufti G; Giagounidis A; Selleslag D; Muus P; Sanz G; Mittelman M; Bowen D; Porwit A; Fu T; Backstrom J; MacBeth K; Hellstrom-Lindberg E
  • Conference publication: HAEMATOLOGICA. 2013;98:251
    Svensson T; Garelius H; Lorenz F; Saft L; Hellstrom-Lindberg E; Cherif H
  • Conference publication: HAEMATOLOGICA. 2012;97:140-141
    Tobiasson M; Brandefors L; Dybedahl I; Garelius H; Grovdal M; Hogh-Dufva I; Kjeldsen L; Marcher C; Nilsson L; Kittang AO; Porwit A; Saft L; Holm MS; Mollgard L; Hellstrom-Lindberg E
  • Conference publication: BLOOD. 2011;118(21):1622-1623
    Tobiasson M; Brandefors L; Dybedal I; Garelius H; Grovdal M; Dufva IH; Kjeldsen L; Nilsson L; Kittang AO; Porwit A; Saft L; Holm MS; Mollgard L; Hellstrom-Lindberg E
  • Conference publication: BLOOD. 2011;118(21):359
    Scharenberg C; Giai V; Pellagatti A; Saft L; Karlsson G; Jansson M; Forsblom L; Jadersten M; Karlsson S; Boultwood J; Hellstrom-Lindberg E
  • Conference publication: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2011;79A(12):1051-1052
    Picone C; Tenore A; Vanelli L; Malcovati L; Pascutto C; Ogata K; Tamura H; Handa H; Czader M; Freeman S; Vyas P; Porwit A; Saft L; Westers TM; Alhan C; Cali C; van de Loosdrecht AA; Cazzola M; Della Porta MG
  • Conference publication: HAEMATOLOGICA. 2010;95:126
    Jadersten M; Saft L; Smith A; Kulasekararaj A; Pomplun S; Hast R; Porwit A; Hellstrom-Lindberg E; Mufti G
  • Meeting abstract: LEUKEMIA RESEARCH. 2009;33:S39
    Jadersten M; Saft L; Garelius H; Hast R; Nilsson L; Samuelsson J; Porwit A; Hellstrom-Lindberg E
  • Conference publication: HAEMATOLOGICA. 2009;94:102
    Jadersten MS; Saft L; Garelius H; Hast R; Nilsson L; Samuelsson J; Porwit A; Hellstrom-Lindberg E
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Employments

  • Affiliated to Research, Department of Oncology-Pathology, ̽ѡ, 2023-2026
  • Clinical Assistant, Department of Oncology-Pathology, ̽ѡ, 2024-2024

Degrees and Education

  • Docent, Pathology, ̽ѡ, 2025
  • Degree Of Doctor Of Philosophy, Department of Medicine, Huddinge, ̽ѡ, 2013

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