探花精选

Kristoffer Sahlholm

Kristoffer Sahlholm

Affiliated to Research
Visiting address: Solnav盲gen 9, Biomedicum C4, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa FK Genetisk och farmakologisk epidemiologi, 171 77 Stockholm
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About me

  • My research is focused on G protein-coupled receptors, in particular dopamine
    receptors, and their interactions with natural and synthetic ligands.
    I finished my PhD at the Dept. of Neuroscience, KI, in 2011 (labs of Drs.
    Peter 脜rhem and Kjell Fuxe). My thesis was focused on the regulation of
    dopamine receptors by transmembrane voltage and made use of electrophysiology
    to study receptor signaling. My postdoctoral work included fluorescence-based
    signaling assays and behavioral pharmacology (University of Barcelona, Spain


  • Dr. Francisco Ciruela), autoradiography (Washington University in St. Louis,
    MO, Dr. Robert H. Mach), radioligand binding (University of Pennsylvania, PA,
    Dr. Robert H. Mach), rodent PET imaging (University of Groeningen

  • Netherlands, Drs. Philip Elsinga and Aren van Waarde), and rodent fMRI (ETH,
    Switzerland, Drs. Marcus Rudin and Aileen Schroeter).
    Since 2018, I am a group leader at the Dept. of Medical and Translational Biology 

  • (tenured since 2024
  • see external link, top right), Ume氓 University, while maintaining active affiliations with 

  • the Dept. of Physiology and Pharmacology, KI, as well as with the Dept. of
    Pathology and Experimental Therapeutics, University of Barcelona.

Research

  • Psychotic disorders (e.g., schizophrenia, bipolar disorder with mania, and
    schizoaffective disorder) are believed to affect about 3% of the global
    population and are characterized by delusions and hallucinations. Dopamine
    receptors form the main targets for antipsychotic therapy. However, current
    medication does not adequately address all aspects of schizophrenia
    symptomatology and, in addition, is fraught with troublesome side effects. It
    has been postulated that the time course of drug-receptor interactions, as
    well as the differential engagement of neurotransmitter receptor subtypes,
    may influence both side effect profiles and clinical efficacies of
    antipsychotics.
    Our group investigates the modes of action of current and experimental
    antipsychotic drugs, with the aim to inform the development of novel,
    improved therapeutics. We are also interested in the interplay of different
    neurotransmitter systems at the cellular as well as the whole-animal level.
    We use time-resolved live-cell signaling assays to examine drug-receptor
    interactions, as well as behavioral readouts in rodents to characterize the
    in vivo actions of experimental and clinically used drugs.

Articles

  • Article: NEUROTHERAPEUTICS. 2024;21(2):e00334
    Stan TL; Ronaghi A; Barrientos SA; Halje P; Censoni L; Garro-Martinez E; Nasretdinov A; Malinina E; Hjorth S; Svensson P; Waters S; Sahlholm K; Petersson P
  • Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2023;26(9):599-606
    Agren R; Betari N; Saarinen M; Zeberg H; Svenningsson P; Sahlholm K
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(13):10924
    Agren R; Geerdink N; Brunner HG; Paucar M; Kamsteeg E-J; Sahlholm K
  • Article: MOLECULAR BIOLOGY AND EVOLUTION (MBE). 2023;40(6):msad130
    Agren R; Patil S; Zhou X; FinnGen; Sahlholm K; Paabo S; Zeberg H
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2023;180(7):958-974
    Lopez-Cano M; Font J; Aso E; Sahlholm K; Cabre G; Giraldo J; De Koninck Y; Hernando J; Llebaria A; Fernandez-Duenas V; Ciruela F
  • Article: BIOMEDICINE & PHARMACOTHERAPY. 2023;160:114327
    Valle-Leon M; Casajuana-Martin N; del Torrent CL; Argerich J; Gomez-Acero L; Sahlholm K; Ferre S; Pardo L; Ciruela F
  • Journal article: NEUROSCIENCE APPLIED. 2023;2:103686
    Ciruela F; Valle-Le贸n M; del Torrent CL; 脕lvarez-Montoya P; L贸pez-Cano M; Casajuana-Martin N; Ferr茅 S; Pardo L; Sahlholm K
  • Article: FRONTIERS IN PHARMACOLOGY. 2023;14:1087171
    Burstrom V; agren R; Betari N; Valle-Leon M; Garro-Martinez E; Ciruela F; Sahlholm K
  • Article: NEUROPSYCHOPHARMACOLOGY. 2022;47(13):2319-2329
    Saarinen M; Mantas I; Flais I; Agren R; Sahlholm K; Millan MJ; Svenningsson P
  • Article: BIOMEDICINES. 2021;10(1):22
    agren R; Sahlholm K
  • Article: THE FASEB JOURNAL. 2021;35(11):e22013
    Agren R; Sahlholm K
  • Article: FUTURE MEDICINAL CHEMISTRY. 2021;13(17):1465-1474
    Betari N; Teigen K; Sahlholm K; Haavik J
  • Article: CHEMICAL SCIENCE. 2021;12(33):10990-11003
    Stepniewski TM; Mancini A; Agren R; Torrens-Fontanals M; Semache M; Bouvier M; Sahlholm K; Breton B; Selent J
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(8):4078
    Agren R; Stepniewski TM; Zeberg H; Selent J; Sahlholm K
  • Article: BIOMOLECULES. 2021;11(4):529
    Hsieh C-J; Riad A; Lee JY; Sahlholm K; Xu K; Luedtke RR; Mach RH
  • Article: NEUROPSYCHOPHARMACOLOGY. 2021;46(3):665-672
    Valle-Leon M; Callado LF; Aso E; Cajiao-Manrique MM; Sahlholm K; Lopez-Cano M; Soler C; Altafaj X; Watanabe M; Ferre S; Fernandez-Duenas V; Menchon JM; Ciruela F
  • Article: NEUROLOGY: GENETICS. 2021;7(1):e546
    Paucar M; Agren R; Li T; Lissmats S; Bergendal A; Weinberg J; Nilsson D; Savichetva I; Sahlholm K; Nilsson J; Svenningsson P
  • Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(19):3130-3143
    Agren R; Zeberg H; Stepniewski TM; Free RB; Reilly SW; Luedtke RR; Arhem P; Ciruela F; Sibley DR; Mach RH; Selent J; Nilsson J; Sahlholm K
  • Article: CURRENT BIOLOGY. 2020;30(17):3465-3469.e4
    Zeberg H; Dannemann M; Sahlholm K; Tsuo K; Maricic T; Wiebe V; Hevers W; Robinson HPC; Kelso J; Paeaebo S
  • Article: FUTURE MEDICINAL CHEMISTRY. 2020;12(16):1461-1474
    Betari N; Sahlholm K; Ishizuka Y; Teigen K; Haavik J
  • Show more

All other publications

  • Corrigendum: NEUROPSYCHOPHARMACOLOGY. 2023;48(5):846
    Saarinen M; Mantas I; Flais I; Agren R; Sahlholm K; Millan MJ; Svenningsson P
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2023;48:391
    Saarinen M; Diaz A; Agren R; Betari N; Zeberg H; Sahlholm K; Carlsson J; Svenningsson P
  • Conference publication: NEUROPSYCHOPHARMACOLOGY. 2022;47:391
    Svenningson P; Saarinen M; Mantas I; Flais I; Agren R; Sahlholm K; Millan MJ
  • Corrigendum: NEUROLOGY: GENETICS. 2021;7(2):e567
    Paucar M; Agren R; Li T; Lissmats S; Bergendal A; Weinberg J; Nilsson D; Savichetva I; Sahlholm K; Nilsson J; Svenningsson P
  • Conference publication: MOVEMENT DISORDERS. 2020;35:S21-S22
    Paucar M; Agren R; Li T; Lissmats S; Bergendal A; Savitcheva I; Nilsson D; Sahlholm K; Svenningsson P; Nilsson J
  • Conference publication: BEHAVIOR GENETICS. 2019;49(6):550
    Zeberg H; Sahlholm K
  • Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2019;29:S237-s238
    Sahlholm K; Valle-Leon M; Fernandez-Duenas V; Ciruela F
  • Editorial comment: FUTURE MEDICINAL CHEMISTRY. 2018;10(23):2675-2677
    Sahlholm K; Valle-Leon M; Fernandez-Duenas V; Ciruela F
  • Letter: NATURE COMMUNICATIONS. 2018;9(1):3577
    Zeberg H; Sahlholm K
  • Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2015;42:S20
    Sahlholm K; Sijbesma JWA; Maas B; Kwizera C; Ramakrishnan NK; Dierckx RAJO; Elsinga PH; Van Waarde A
  • Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2014;24:s520
    Sahlholm K; Zeberg H; Marcellino D; Nilsson J; Ogren SO; Fuxe K; Arhem P
  • Conference publication: EPILEPSIA. 2014;55:123-124
    Nilsson J; Sahlholm K; Arhem P
  • Letter: MOLECULAR PSYCHIATRY. 2013;18(1):12-14
    Sahlholm K; Arhem P; Fuxe K; Marcellino D
  • Meeting abstract: BIOPHYSICAL JOURNAL. 2013;104(2):26A
    Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Ogren SO; Arhem P
  • Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:166
    Marcellino D; Sahlholm K; Arhem P; Fuxe K
  • Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:167
    Sahlholm K; Frisk S; Marcellino D; Nilsson J; Fuxe K; Arhem P
  • Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):517A
    Sahlholm K; Frisk S; Nilsson J; Marcellino D; Fuxe K; Arhem P
  • Thesis / dissertation: 2011
    Sahlholm, Kristoffer
  • Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2011;21:S511-S512
    Sahlholm K; Frisk S; Fuxe K; Arhem P
  • Meeting abstract: BIOPHYSICAL JOURNAL. 2010;98(3):213A
    Nilsson J; Madeja M; Sahlholm K; Arhem P
  • Show more

Employments

  • Affiliated to Research, Department of Physiology and Pharmacology, 探花精选, 2023-2026

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of neuroscience, 探花精选, 2011
  • Master Of Medical Science, 探花精选, 2010

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