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Klas Wiman

Klas Wiman

Professor | Docent
Visiting address: BioClinicum, J6:10, Akademiska stråket 1, 17164 Solna
Postal address: K7 Onkologi-Patologi, K7 Forskning Wiman, 171 77 Stockholm
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About me

  • I am Professor of Molecular Cell and Tumor Biology at ̽»¨¾«Ñ¡ since 1999. My main research interest is cancer and novel cancer therapy. For more than three decades, I have studied the tumor suppressor gene TP53. I was coordinator of an EU Integrated project (Mutp53) with 23 partners and a budget of 8 M Euros 2004-2009, and have co-edited two books on p53 (Springer 2005 and 2012). I have also co-founded the company Aprea Therapeutics with colleagues with the aim of developing novel p53-targeted anti-cancer drugs. More recently, my research has been supported by an ERC Advanced Grant.

Research

  • My laboratory performs research on p53 and the p53 tumor suppressor pathway, the p53 target gene Zmat3 (Wig-1), and therapeutic reactivation of mutant p53. We have identified the molecule APR-246 that can trigger apoptosis in TP53 mutant tumor cells and inhibit tumor growth in vivo in mice. It targets the cellular redox balance as well. APR-246 has been tested in several clinical trials in patients with MDS/AML. We are exploring the use of APR-246 for cancer prevention. We are also working on novel strategies for pharmacological induction of translational readthrough for reactivation of nonsense mutant TP53 in tumors.

Selected publications

  • Article: CELL DEATH AND DISEASE. 2022;13(11):997
    Palomar-Siles M; Heldin A; Zhang M; Strandgren C; Yurevych V; van Dinter JT; Engels SAG; Hofman DA; Ohlin S; Meineke B; Bykov VJN; van Heesch S; Wiman KG
  • Article: EMBO MOLECULAR MEDICINE. 2021;13(2):e10852
    Ceder S; Eriksson SE; Cheteh EH; Dawar S; Corrales Benitez M; Bykov VJN; Fujihara KM; Grandin M; Li X; Ramm S; Behrenbruch C; Simpson KJ; Hollande F; Abrahmsen L; Clemons NJ; Wiman KG
  • Review: NATURE REVIEWS CANCER. 2018;18(2):89-102
    Bykov VJN; Eriksson SE; Bianchi J; Wiman KG
  • Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(29):3633-3639
    Lehmann S; Bykov VJN; Ali D; Andren O; Cherif H; Tidefelt U; Uggla B; Yachnin J; Juliusson G; Moshfegh A; Paul C; Wiman KG; Andersson P-O
  • Article: CANCER CELL. 2009;15(5):376-388
    Lambert JMR; Gorzov P; Veprintsev DB; Soderqvist M; Segerback D; Bergman J; Fersht AR; Hainaut P; Wiman KG; Bykov VJN
  • Review: CANCER CELL. 2007;12(4):303-312
    Soussi T; Wiman KG

Articles

  • Article: RNA BIOLOGY. 2023;20(1):368-383
    Heldin A; Cancer M; Palomar-Siles M; Ohlin S; Zhang M; Sun-Zhang A; Mariani A; Liu J; Bykov VJN; Wiman KGG
  • Article: PLOS ONE. 2023;18(11):e0292468
    Palomar-Siles M; Yurevych V; Bykov VJN; Wiman KG
  • Article: CELL DEATH AND DISEASE. 2022;13(3):214
    Zhang Q; Balourdas D-I; Baron B; Senitzki A; Haran TE; Wiman KG; Soussi T; Joerger AC
  • Article: CELL DEATH AND DISEASE. 2021;12(7):709
    Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
  • Article: CELL DEATH AND DIFFERENTIATION. 2021;28(5):1477-1492
    Doffe F; Carbonnier V; Tissier M; Leroy B; Martins I; Mattsson JSM; Micke P; Pavlova S; Pospisilova S; Smardova J; Joerger AC; Wiman KG; Kroemer G; Soussi T
  • Article: CELL DEATH DISCOVERY. 2020;6(1):42
    Cheteh EH; Sarne V; Ceder S; Bianchi J; Augsten M; Rundqvist H; Egevad L; Ostman A; Wiman KG
  • Article: CLINICAL GENETICS. 2019;96(3):216-225
    Kharaziha P; Ceder S; Axell O; Krall M; Fotouhi O; Bohm S; Lain S; Borg A; Larsson C; Wiman KG; Tham E; Bajalica-Lagercrantz S
  • Article: TRANSLATIONAL ONCOLOGY. 2018;11(6):1343-1349
    Synnott NC; Madden SF; Bykov VJN; Crown J; Wiman KG; Duffy MJ
  • Article: CELL CHEMICAL BIOLOGY. 2018;25(10):1219-1230.e3
    Zhang Q; Bergman J; Wiman KG; Bykov VJN
  • Article: SCIENTIFIC REPORTS. 2018;8(1):12671
    Haffo L; Lu J; Bykov VJN; Martin SS; Ren X; Coppo L; Wiman KG; Holmgren A
  • Article: BLOOD. 2018;131(24):2670-2681
    Ren W; Ye X; Su H; Li W; Liu D; Pirmoradian M; Wang X; Zhang B; Zhang Q; Chen L; Nie M; Liu Y; Meng B; Huang H; Jiang W; Zeng Y; Li W; Wu K; Hou Y; Wiman KG; Li Z; Zhang H; Peng R; Zhu S; Pan-Hammarstrom Q
  • Article: CELL DEATH AND DISEASE. 2018;9(5):439
    Zhang Q; Bykov VJN; Wiman KG; Zawacka-Pankau J
  • Article: CELL DEATH AND DISEASE. 2017;8(6):e2848
    Cheteh EH; Augsten M; Rundqvist H; Bianchi J; Sarne V; Egevad L; Bykov VJN; Ostman A; Wiman KG
  • Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):483-495
    Wiman KG; Zhivotovsky B
  • Article: NATURE COMMUNICATIONS. 2017;8:14844
    Liu DS; Duong CP; Haupt S; Montgomery KG; House CM; Azar WJ; Pearson HB; Fisher OM; Read M; Guerra GR; Haupt Y; Cullinane C; Wiman KG; Abrahmsen L; Phillips WA; Clemons NJ
  • Article: FRONTIERS IN ONCOLOGY. 2017;7:323
    Zhang M; Heldin A; Palomar-Siles M; Ohlin S; Bykov VJN; Wiman KG
  • Article: JOURNAL OF OVARIAN RESEARCH. 2016;9(1):27
    Fransson A; Glaessgen D; Alfredsson J; Wiman KG; Bajalica-Lagercrantz S; Mohell N
  • Article: CELL CYCLE. 2016;15(9):1267-1275
    Madapura HS; Salamon D; Wiman KG; Lain S; Klein E; Nagy N
  • Article: ONCOTARGET. 2016;7(2):1895-1911
    Bersani C; Huss M; Giacomello S; Xu L-D; Bianchi J; Eriksson S; Jerhammar F; Alexeyenko A; Vilborg A; Lundeberg J; Lui W-O; Wiman KG
  • Article: GUT. 2015;64(10):1506-1516
    Liu DSH; Read M; Cullinane C; Azar WJ; Fennell CM; Montgomery KG; Haupt S; Haupt Y; Wiman KG; Duong CP; Clemons NJ; Phillips WA
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All other publications

  • Review: NATURE REVIEWS CLINICAL ONCOLOGY. 2024;21(2):106-120
    Tuval A; Strandgren C; Heldin A; Palomar-Siles M; Wiman KG
  • Corrigendum: ONCOGENE. 2023;42(9):709
    Bersani C; Xu L-D; Vilborg A; Lui W-O; Wiman KG
  • Corrigendum: CELL DEATH AND DISEASE. 2022;13(8):672
    Ceder S; Eriksson SE; Liang YY; Cheteh EH; Zhang SM; Fujihara KM; Bianchi J; Bykov VJN; Abrahmsen L; Clemons NJ; Nordlund P; Rudd SG; Wiman KG
  • Corrigendum: CELL DEATH AND DISEASE. 2019;10(10):769
    Zhang Q; Bykov VJN; Wiman KG; Zawacka-Pankau J
  • Review: JOURNAL OF MOLECULAR CELL BIOLOGY. 2019;11(4):330-341
    Eriksson SE; Ceder S; Bykov VJN; Wiman KG
  • Editorial comment: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):418-421
    Wiman KG; Zhivotovsky B
  • Review: FRONTIERS IN ONCOLOGY. 2016;6:21
    Bykov VJN; Zhang Q; Zhang M; Ceder S; Abrahmsen L; Wiman KG
  • Review: CELL DEATH AND DIFFERENTIATION. 2015;22(8):1239-1249
    Soussi T; Wiman KG
  • Review: FEBS LETTERS. 2014;588(16):2622-2627
    Bykov VJN; Wiman KG
  • Editorial comment: CELL DEATH AND DIFFERENTIATION. 2013;20(11):1438-1439
    Wiman KG
  • Editorial comment: CELL DEATH AND DIFFERENTIATION. 2012;19(1):180-183
    Blandino G; Deppert W; Hainaut P; Levine A; Lozano G; Olivier M; Rotter V; Wiman K; Oren M
  • Review: CELL DEATH AND DIFFERENTIATION. 2011;18(9):1434-1440
    Vilborg A; Bersani C; Wilhelm MT; Wiman KG
  • Review: ONCOGENE. 2010;29(30):4245-4252
    Wiman KG
  • Review: JOURNAL OF MOLECULAR MEDICINE. 2010;88(7):645-652
    Vilborg A; Wilhelm MT; Wiman KG
  • Editorial comment: THE LANCET ONCOLOGY. 2009;10(9):913-919
    Hainaut P; Wiman KG
  • Review: CANCER LETTERS. 2009;276(1):1-7
    Wang X; Zhenchuk A; Wiman KG; Albertioni F
  • Review: ONCOGENE. 2007;26(15):2243-2254
    Selivanova G; Wiman KG
  • Review: ADVANCES IN CANCER RESEARCH. 2007;97:321-338
    Wiman KG
  • Review: MEDICAL ONCOLOGY. 1998;15(4):222-228
    Wiman KG
  • Review: EXPERIMENTAL CELL RESEARCH. 1997;237(1):14-18
    Wiman KG
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Employments

  • Professor, Department of Oncology-Pathology, ̽»¨¾«Ñ¡, 1999-

Degrees and Education

  • Docent, ̽»¨¾«Ñ¡, 1987

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