探花精选

Keira Melican

Keira Melican

Principal Researcher | Docent
Telephone: +46852487069
Visiting address: Cmm, L8:02, Karolinska Universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Derm o Ven Eidsmo L, 171 77 Stockholm
Part of:

About me

  • Associate Professor working with Bacterial Pathogenesis.
    Chairman of the Swedish Society for Microbiology
    2004 Bachelor of Science, Monash University, Melbourne, Australia
    2005 Master of Science, Uppsala University, Uppsala, Sweden
    2010 PhD in Medicine, 探花精选, Stockholm, Sweden
    2010-2013 Marie Curie Postdoctoral Fellow, Paris Cardiovascular Research
    Center, Paris, France
    2014 - 2019 Assistant Professor, Swedish Medical Nanoscience Center,
    探花精选, Stockholm, Sweden
    2019 - Senior Researcher, Department of Neuroscience, Karolinska
    Institutet, Stockholm

Research

  • In my team we aim to understand the dynamic interplay which occurs between
    host and pathogen following infection, as a means to find alternative
    treatment options. To do this we use a number of cutting-edge techniques
    including intravital imaging, /in vivo/ modelling, immunological screening
    and nano探花精选 approaches.
    Our current focus is on two different clinically important bacterial
    pathogens, /Staphylococcus aureus/ and uropathogenic /Escherichia coli/.
    In our work with /Staphylococcus/ we are using humanized models of skin
    colonisation to understand how methicillin resistant /S. aureus/ (MRSA)
    colonizes healthy human skin and the inflammatory reaction this triggers.
    Further we are investigating the role of coagulase negative Staphylococci
    (CoNS) in skin colonisation and its interactions with MRSA.
    To study UPEC kidney infection we use a spatially-temporally controlled in
    vivo model to allow single cell resolution of kidney infection. This work has
    led to the description of an infection-mediated protective coagulation
    response to prevent the progression of infection to sepsis. Ongoing work aims
    to understand how different innate immune response activate
    following local bacterial infections.

Teaching

  • I am course responsible for the PhD course in Clinical and Molecular
    Bacteriology as well as free-standing course and workshops focussing on
    interdisiplanary approaches to Infection.
    I lecture in a number of both undergraduate and graduate courses here at KI
    as well as other universities around Sweden.

Articles

  • Article: MICROBIOLOGY-SGM. 2025;171(1)
    Zhang T; Luo R; Ehrstroem M; Melican K
  • Article: BIOMATERIALS ADVANCES. 2025;166:214068
    Gurtler A-L; Lang JC; Czyrski GS; Sirois JP; Melican K; Rades T; Heinz A
  • Article: BIOFILM. 2024;8:100212
    Zhang T; Ray S; Melican K; Richter-Dahlfors A
  • Journal article: RSC PHARMACEUTICS. 2024;1(3):570-580
    G眉rtler A-L; Sirois JP; Lang JC; Melican K; Rades T; Heinz A
  • Article: PLOS PATHOGENS. 2024;20(8):e1012056
    Lang JC; Brutscher A; Ehrstrom M; Melican K
  • Article: NATURE NANOTECHNOLOGY. 2024;19(7):887-888
    Lang JC; Melican K
  • Journal article: SUSTAINABLE MICROBIOLOGY. 2024;1(1):qvae023
    Lang JC; Shahata M; Melican K
  • Article: FEMS MICROBES. 2023;4:xtad007
    Antypas H; Zhang T; Choong FX; Melican K; Richter-Dahlfors A
  • Article: PATHOGENS AND DISEASE. 2022;80(1):fty087
    Schulz A; Chuquimia OD; Antypas H; Steiner SE; Sandoval RM; Tanner GA; Molitoris BA; Richter-Dahlfors A; Melican K
  • Article: BMC INFECTIOUS DISEASES. 2022;22(1):509
    Steiner SE; Edgren G; Melican K; Richter-Dahlfors A; Brauner A
  • Article: BIOFILM. 2021;3:100060
    Choong FX; Huzell S; Rosenberg M; Eckert JA; Nagaraj M; Zhang T; Melican K; Otzen DE; Richter-Dahlfors A
  • Article: NATURE COMMUNICATIONS. 2021;12(1):4547
    Manriquez V; Nivoit P; Urbina T; Echenique-Rivera H; Melican K; Fernandez-Gerlinger M-P; Flamant P; Schmitt T; Bruneval P; Obino D; Dumenil G
  • Article: ADVANCED MATERIALS TECHNOLOGIES. 2021;6(7):2001307
    Ziesmer J; Tajpara P; Hempel N-J; Ehrstrom M; Melican K; Eidsmo L; Sotiriou GA
  • Article: PLOS PATHOGENS. 2021;17(5):e1009553
    Steiner SE; Choong FX; Antypas H; Morado-Urbina CE; Schulz A; Farinotti AB; Bas DB; Svensson CI; Richter-Dahlfors A; Melican K
  • Article: FRONTIERS IN MICROBIOLOGY. 2020;11:26
    Martin-Rodriguez AJ; Rhen M; Melican K; Richter-Dahlfors A
  • Article: CELL REPORTS. 2019;29(5):1074-1081.e5
    Schulz A; Jiang L; de Vor L; Ehrstrom M; Wermeling F; Eidsmo L; Melican K
  • Article: MICROBIOLOGY SPECTRUM. 2019;7(3):10.1128/microbiolspec.bai
    Richter-Dahlfors A; Melican K
  • Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2744
    Sedin J; Giraud A; Steinr SEE; Ahl D; Persson AEG; Melican K; Richter-Dahlfors A; Phillipson M
  • Article: PATHOGENS AND DISEASE. 2018;76(8):fty087
    Schulz A; Chuquimia OD; Antypas H; Steiner SE; Sandoval RM; Tanner GA; Molitoris BA; Richter-Dahlfors A; Melican K
  • Article: NATURE COMMUNICATIONS. 2018;9(1):4450
    Charles-Orszag A; Tsai F-C; Bonazzi D; Manriquez V; Sachse M; Mallet A; Salles A; Melican K; Staneva R; Bertin A; Millien C; Goussard S; Lafaye P; Shorte S; Piel M; Krijnse-Locker J; Brochard-Wyart F; Bassereau P; Dumenil G
  • Show more

All other publications

  • Preprint: BIORXIV. 2024
    Lang JC; Brutscher A; Ehrstr枚m M; Melican K
  • Letter: ALLERGY. 2022;77(12):3680-3683
    Gallais Serezal I; Tajpara P; Schonfeldt T; Ignatov B; Sortebech D; Hoffer E; Zhang T; Rooijackers E; Ehrstrom M; Nylen S; Matura M; Melican K; Eidsmo L
  • Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S186
    Serezal IG; Tajpara P; Schonfeldt T; Ignatov B; Hoffer E; Ehrstrom M; Nylen S; Matura M; Melican K; Eidsmo L
  • Preprint: BIORXIV. 2021
    Manriquez V; Nivoit P; Urbina T; Echenique-Rivera H; Melican K; Flamant P; Schmitt T; Bruneval P; Obino D; Dum茅nil G
  • Book chapter: BACTERIA AND INTRACELLULARITY. 2019;p. 315-324
    Richter鈥怐ahlfors A; Melican K
  • Preprint: BIORXIV. 2018
    Charles-Orszag A; Tsai F-C; Bonazzi D; Manriquez V; Sachse M; Mallet A; Salles A; Melican K; Staneva R; Bertin A; Millien C; Goussard S; Lafaye P; Shorte S; Piel M; Krijnse-Locker J; Brochard-Wyart F; Bassereau P; Dum茅nil G
  • Published conference paper: JOURNAL OF INTERNAL MEDICINE. 2017;282(1):24-36
    Loffler S; Melican K; Nilsson KPR; Richter-Dahlfors A
  • Review: FEBS LETTERS. 2016;590(13):2014-2026
    Stolp B; Melican K
  • Editorial comment: FUTURE MICROBIOLOGY. 2013;8(5):567-569
    Melican K; Dumenil G
  • Review: CURRENT OPINION IN MICROBIOLOGY. 2012;15(1):50-56
    Melican K; Dumenil G
  • Doctoral thesis: 2010
    Melican K
  • Book chapter: BACTERIAL VIRULENCE. 2010;p. 251-277
    Enninga J; Tournebize R; Melican K; Richter鈥怐ahlfors A
  • Review: BIOTECHNOLOGY JOURNAL. 2009;4(6):804-811
    Melican K; Richter-Dahlfors A
  • Review: CURRENT OPINION IN MICROBIOLOGY. 2009;12(1):31-36
    Melican K; Richter-Dahfors A
  • Conference publication: FEBS JOURNAL. 2009;276:51
    Richter-Dahlfors A; Melican K; Boekel J; Mansson L; Sandoval RM; Tanner GA; Kallskog O; Palm F; Molitoris BA
  • Review: CELLULAR MICROBIOLOGY. 2007;9(10):2334-2343
    Mansson LE; Melican K; Molitoris BA; Richter-Dahlfors A

Grants

  • How human epidermal Langerhans cells detect and differentiate commensal and pathogenic Staphylococcus
    Swedish Research Council
    1 January 2025 - 31 December 2027
  • Preventing invasive infections by hijacking bacterial communication
    Novo Nordisk Fonden
    1 April 2023 - 31 December 2026
  • Swedish Research Council
    1 January 2021 - 31 December 2023
  • The phenotypic and genetic mechanisms mediating bacterial microbiota colonization of human skin in vivo.
    探花精选 - KID
    1 June 2020 - 1 June 2024
  • Uropathogenic Escherichia coli Haemolysin toxin: Beyond poking holes
    Swedish Society of Medicine
    1 June 2020 - 30 June 2022
  • Swedish Research Council
    1 January 2020 - 31 December 2023
  • Senior Researcher position
    AIMES, Center for the Advancement of Integrated Medical and Engineering Sciences
    1 September 2019 - 31 March 2025
  • Swedish Research Council
    1 January 2017 - 31 December 2017

Employments

  • Principal Researcher, Department of Medicine, 探花精选, 2025-
  • Principal Researcher, Department of Neuroscience, 探花精选, 2022-2025

Degrees and Education

  • Docent, 探花精选, 2022
  • Degree Of Doctor Of Philosophy, Department of neuroscience, 探花精选, 2010

Supervision

  • Anna-Lena G眉rtler, Electrospun skin patches for the treatment of psoriasis, 2024
  • Mariam Shahata, 2023
  • Andreas Brutscher, Profiling the immune response of healthy human skin to colonization by different Staphylococcus sp., 2022
  • Tianqi Zhang, 2020
  • Julia Lang
  • Anette Schulz

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