探花精选

Karoline Scholzen

Karoline Scholzen

Phd Student
Visiting address: Solnav盲gen 9, 9A, 17177 Stockholm
Postal address: C2 Medicinsk biokemi och biofysik, C2 Biokemi Arn茅r, 171 77 Stockholm

About me

  • I am a PhD student with a strong background in biochemistry and cell biology. In the past years, we developed highly selective fluorescent probes as activity sensor for the activity of Thioredoxin Reductase (TXNRD1) in live cells. TXNRD1 is a selenoprotein, involved in many redox processes in mammalian cells. Due to the increase of oxidative stress in many cancer types, TXNRD1 is considered a possible therapeutc target, making its research highly relevant.

Research

  • My research interests are on the one hand to improve the methodology on redox related research, by developing new assays for intracellular enzyme activity measurements in live cells and on the other hand to increase the resolution of those methods and achieve redox signaling with single cell resolution. We use a number of classic biochemical and cell biological methods, which are combined with single cell RNA sequencing to investigate the effect of enzyme activity on different pathways. The single cell resolution allows us to increase the sensitivity of the methods, and capturing enzyme activity fluctuations, which would be lost due to bulk analysis. 

Teaching

  • I have been involved as a teaching assistant in the biochemistry lab in the bio探花精选 and 探花精选 program.

Articles

  • Article: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. 2025;88:127624
    Scholzen KC; Arner ESJ
  • Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2024;146(8):5204-5214
    Zeisel L; Felber JG; Scholzen KC; Schmitt C; Wiegand AJ; Komissarov L; Arner ESJ; Thorn-Seshold O
  • Article: ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY. 2023;79(Pt 6):545-555
    Mazurkewich S; Scholzen KC; Brusch RH; Poulsen J-CN; Theibich Y; Huttner S; Olsson L; Larsbrink J; Lo Leggio L
  • Article: REDOX BIOLOGY. 2023;62:102703
    Cheff DM; Huang C; Scholzen KC; Gencheva R; Ronzetti MH; Cheng Q; Hall MD; Arner ESJ
  • Article: CHEM. 2022;8(5):1493-1517
    Zeisel L; Felber JG; Scholzen KC; Poczka L; Cheff D; Maier MS; Cheng Q; Shen M; Hall MD; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O
  • Article: NATURE COMMUNICATIONS. 2022;13(1):1754
    Felber JG; Poczka L; Scholzen KC; Zeisel L; Maier MS; Busker S; Theisen U; Brandstaedter C; Becker K; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O
  • Article: CELL HOST & MICROBE. 2021;29(8):1316-1332.e12
    Walch P; Selkrig J; Knodler LA; Rettel M; Stein F; Fernandez K; Vieitez C; Potel CM; Scholzen K; Geyer M; Rottner K; Steele-Mortimer O; Savitski MM; Holden DW; Typas A
  • Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2021;143(23):8791-8803
    Felber JG; Zeisel L; Poczka L; Scholzen K; Busker S; Maier MS; Theisen U; Brandstaedter C; Becker K; Arner ESJ; Thorn-Seshold J; Thorn-Seshold O

Employments

  • Phd Student, Department of Medical Biochemistry and Biophysics, 探花精选, 2022-2026

Degrees and Education

  • Master of Science, Biochemistry, An Evaluation of next Generation Redox Sensing Probes, University of Heidelberg, 2021
  • Bachelor of Science, Biochemistry, University of Heidelberg, 2019

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