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Karine Chemin

Karine Chemin

Senior Research Specialist | Docent
Visiting address: CMM L8:04 Karolinska universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Malmström V, 171 77 Stockholm
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About me

  • Karine Chemin is Associate Professor (docent, Immunology) at the Rheumatology Division at the Karolinska Institute and team leader at the Center for Molecular Medicine (CMM). She is coordinator for the Allergy immunology inflammation (Aii) doctoral school, Karolinska Institute.

    2018-: Senior researcher, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
    2014-2018: Assistant Professor, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
    2011-2014: Postdoc, Rheumatology Division, Karolinska Institute, Stockholm, Sweden.
    2006-2010: Postdoc, Curie Institute, Paris, France. 


  • 2002-2006: PhD student, Hematology, Hôpital Saint Louis Paris, France. 

  • 2001-2002: Master student, Hôpital Saint Louis Paris, France
    2000: Bachelor degree, Cell Biology, University Rennes 1, France
    1999: ERASMUS exchange, Center of Immunology Turku, Finland

Research

  • Tissue-resident memory T cells in rheumatic diseases

    Although the etiology of autoimmune diseases is unknown, a complex interplay between genetics, environment and epigenetics is proposed to be the cause of self-tolerance failure. In my team, we are interested in the function of tissue-resident memory T cells in the pathogenesis of autoimmune diseases such as rheumatoid arthritis (RA) and idiopathic inflammatory myopathies (IIM). In these two inflammatory disorders, the strongest genetic risk factor is the major histocompatibility complex (MHC) locus highlighting the importance of T cells in the pathogenesis. T cells are vital for defending the body against pathogens such as viruses and bacteria whereas, in autoimmune diseases, T cells mistakenly attack our own body. We believe that, by studying T cells at the site of inflammation, we can understand their pathogenic effector function, their antigen specificity and the mechanisms implicated in their migration and retention in the tissue. We also have a specific interest in the subset of cytotoxic CD4+ T cells sharing common effector functions with CD8+ T cells. We use single cell technologies (SmartSeq2 and 10X genomics) in association with conventional cell biology/molecular biology techniques on clinical samples to investigate the diversity of T-cell populations. Our translational research relies on strong collaborations with the Rheumatology Clinic, KS (Prof Ingrid Lundberg´s team) as well as with geneticist/bioinformatics expert (Dr. Lina Diaz-Gallo). Our ambition is to provide a better understanding of the mechanisms driving rheumatic diseases to improve diagnosis and treatment approaches.

    Research Support:
    Vetenskapsrådet (Swedish Research Council)
    Stiftelsen Konung Gustaf V:s 80‑årsfond
    Reumatikerfonden
    Nanna Svartz Fond

Teaching

  • 2013-: Teaching at PhD courses KI: Basic immunology, #2302, Basic inflammation, #2705, Cell signaling #3049, Cytokines in Inflammation #1626, Translational medicine in the Field of Autoimmunity #2760, Clinical and Experimental NeuroImmunology #3200
    2019- : Teaching at the Rheumatology Clinic (̽»¨¾«Ñ¡ students in rotation)
    2021-2022: Teaching at the Medical Research and Innovative Medicine, Uppsala
    2013-2020: Teaching at the Biomedicine Master Programme, KI
    2017 and 2019: Organisation of the PhD course Cytokines in Inflammation, #1626, KI
    2019 and 2020: Organisation of the PhD course Basic Immunology, #5229, KI

Articles

  • Journal article: RMD OPEN. 2024;10(4):e004510
    Turcinov S; Sharma RK; De Vries C; Circiumaru A; Gerstner C; Mathsson-Alm L; Raposo B; Dubnovitsky A; Ronnblom L; Kwok WW; Chemin K; Malmstrom V; Hensvold A
  • Article: RHEUMATOLOGY. 2024;63(5):1466-1473
    Van Gompel E; Demirdal D; Fernandes-Cerqueira C; Horuluoglu B; Galindo-Feria A; Wigren E; Graslund S; De Langhe E; Benveniste O; Notarnicola A; Chemin K; Lundberg IE
  • Article: EMBO MOLECULAR MEDICINE. 2023;15(10):e17240
    Argyriou A; Horuluoglu B; Galindo-Feria AS; Diaz-Boada JS; Sijbranda M; Notarnicola A; Dani L; van Vollenhoven A; Ramskold D; Nennesmo I; Dastmalchi M; Lundberg IE; Diaz-Gallo L-M; Chemin K
  • Article: CLINICAL RHEUMATOLOGY. 2023;42(10):2889-2895
    Zickert A; Jankovic MR; Malmstrom V; Chemin K; Gunnarsson I
  • Article: KIDNEY INTERNATIONAL. 2023;103(5):973-985
    Sharma RK; Yoosuf N; Afonso M; Scheffschick A; Avik A; Bartoletti A; Horuluoglu B; Boada JSD; Boddul SK; Jonasdottir AD; Lovstrom B; Brauner H; Raposo B; Chemin K; Bruchfeld A; Gunnarsson I; Malmstrom V
  • Article: ARTHRITIS & RHEUMATOLOGY. 2023;75(5):673-684
    Turcinov S; af Klint E; Van Schoubroeck B; Kouwenhoven A; Mia S; Chemin K; Wils H; Van Hove C; De Bondt A; Keustermans K; Van Houdt J; Reumers J; Felix N; Rao NL; Peeters P; Stevenaert F; Klareskog L; McKinnon M; Baker D; Suri A; Malmstroem V
  • Article: SCIENTIFIC REPORTS. 2022;12(1):11876
    Hardt U; Carlberg K; af Klint E; Sahlstrom P; Larsson L; van Vollenhoven A; Machado SH; Israelsson L; Amara K; Chemin K; Korotkova M; Hedestam GBK; Catrina AI; Teichmann SA; Stahl PL; Malmstrom V
  • Article: NATURE COMMUNICATIONS. 2022;13(1):4046
    Argyriou A; Wadsworth MH; Lendvai A; Christensen SM; Hensvold AH; Gerstner C; van Vollenhoven A; Kravarik K; Winkler A; Malmstrom V; Chemin K
  • Article: JOURNAL OF AUTOIMMUNITY. 2022;131:102857
    Iyer VS; Boddul SV; Johnsson A-K; Raposo B; Sharma RK; Shen Y; Kasza Z; Lim KW; Chemin K; Nilsson G; Malmstrom V; Phan AT; Wermeling F
  • Article: FRONTIERS IN IMMUNOLOGY. 2022;13:826152
    Faustini F; Sippl N; Stalesen R; Chemin K; Dunn N; Fogdell-Hahn A; Gunnarsson I; Malmstroem V
  • Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2021;205(1):44-52
    Sippl N; Faustini F; Ronnelid J; Turcinov S; Chemin K; Gunnarsson I; Malmstrom V
  • Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(2):194-202
    Ivanchenko M; Thorlacius GE; Hedlund M; Ottosson V; Meneghel L; Bjorkander S; Ossoinak A; Tingstrom J; Bremme K; Sverremark-Ekstrom E; Gemzell-Danielsson K; Sonesson S-E; Chemin K; Wahren-Herlenius M
  • Article: BMC IMMUNOLOGY. 2020;21(1):27
    Gerstner C; Turcinov S; Hensvold AH; Chemin K; Uchtenhagen H; Ramwadhdoebe TH; Dubnovitsky A; Kozhukh G; Ronnblom L; Kwok WW; Achour A; Catrina A; van Baarsen LGM; Malmstrom V
  • Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(10):1454-1462
    Diaz-Gallo L-M; Ramskold D; Shchetynsky K; Folkersen L; Chemin K; Brynedal B; Uebe S; Okada Y; Alfredsson L; Klareskog L; Padyukov L
  • Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):188
    Houtman M; Ekholm L; Hesselberg E; Chemin K; Malmstrom V; Reed AM; Lundberg IE; Padyukov L
  • Article: JOURNAL OF AUTOIMMUNITY. 2018;90:28-38
    Houtman M; Shchetynsky K; Chemin K; Hensvold AH; Ramskold D; Tandre K; Eloranta M-L; Ronnblom L; Uebe S; Catrina AI; Malmstrom V; Padyukov L
  • Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;192(3):259-270
    Aqrawi LA; Ivanchenko M; Bjork A; Sepulveda JIR; Imgenberg-Kreuz J; Kvarnstrom M; Haselmayer P; Jensen JL; Nordmark G; Chemin K; Skarstein K; Wahren-Herlenius M
  • Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2018;48(4):655-669
    Chemin K; Ramskold D; Diaz-Gallo L-M; Herrath J; Houtman M; Tandre K; Ronnblom L; Catrina A; Malmstrom V
  • Article: FRONTIERS IN IMMUNOLOGY. 2018;9:3033
    Lloyd KA; Wigerblad G; Sahlstrom P; Garimella MG; Chemin K; Steen J; Titcombe PJ; Marklein B; Zhou D; Stalesen R; Ossipova E; Lundqvist C; Ekwall O; Ronnelid J; Mueller DL; Karlsson MCI; Kaplan MJ; Skriner K; Klareskog L; Wermeling F; Malmstrom V; Gronwall C
  • Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(5):1124-1135
    Chemin K; Pollastro S; James E; Ge C; Albrecht I; Herrath J; Gerstner C; Tandre K; Rizzi TS; Ronnblom L; Catrina A; Holmdahl R; Klareskog L; de Vries N; Malmstrom V
  • Show more

All other publications

  • Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:292.1-29292
    Galindo-Feria AS; Argyriou A; Horuluoglu B; Diaz-Boada JS; Notarnicola A; Dani L; Van Vollenhoven A; Ramskold D; Nennesmo I; Dastmalchi M; Lundberg IE; Diaz-Gallo LM; Chemin K
  • Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:575.1-57575
    Horuluoglu B; Galindo-Feria AS; Kumar R; Kozhukh G; Diaz-Boada JS; Ramskold D; Chemin K; Malmstrom V; Lundberg IE
  • Editorial comment: NATURE REVIEWS. RHEUMATOLOGY. 2023;19(5):259-260
    Chemin K; Malmstrom V
  • Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):442-443
    Horuluoglu B; Galindo-Feria AS; Kozhukh G; Dubnovitsky A; Chemin K; Malmstrom V; Lundberg IE
  • Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):428
    Argyriou A; Galindo-Feria A; Horuluoglu B; Diaz-Boada JS; Notarnicola A; Dani L; Van Vol-Lenhoven A; Ramskold D; Nennesmo I; Dastmalchi M; Lundberg IE; Diaz-Gallo LM; Chemin K
  • Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):458-459
    Van Gompel E; Demirdal D; Horuluoglu B; Galindo-Feria A; Fernandes-Cerqueira C; Dastmalchi M; Wigren E; Graslund S; Lundberg IE; Notarnicola A; Chemin K
  • Conference publication: ARTHRITIS & RHEUMATOLOGY. 2023;75:3468-3469
    Turcinov S; de Vries C; Sharma RK; Gerstner C; Raposo B; Dubnovitsky A; Kwok W; Chemin K; Malmstrom V; Hensvold A
  • Conference publication: ARTHRITIS & RHEUMATOLOGY. 2023;75:4891-4892
    Van Gompel E; Stalesen R; Gronwall C; van Vollenhoven A; Israelsson L; Lundberg I; Malmstrom V; Chemin K; Joshua V
  • Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:751-752
    Demirdal D; Van Gompel E; Wigren E; Dastmalchi M; Horuluoglu B; Galindo-Feria AS; Graslund S; Chemin K; Lundberg IE; Notarnicola A
  • Preprint: MEDRXIV. 2021
    Hardt U; Carlberg K; Klint EA; Sahlström P; Larsson L; van Vollenhoven A; Machado SH; Israelsson L; Amara K; Chemin K; Korotkova M; Hedestam GBK; Catrina AI; Teichmann SA; Ståhl PL; Malmström V
  • Letter: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2019;195(3):305-309
    Ivanchenko M; Aqrawi LA; Bjork A; Wahren-Herlenius M; Chemin K
  • Review: FRONTIERS IN IMMUNOLOGY. 2019;10:353
    Chemin K; Gerstner C; Malmstrom V
  • Letter: ARTHRITIS & RHEUMATOLOGY. 2016;68(8):2053-2054
    Chemin K; Albrecht I; Pollastro S; de Vries N; Holmdahl R; Malmstrom V
  • Review: CURRENT OPINION IN RHEUMATOLOGY. 2016;28(2):181-188
    Chemin K; Klareskog L; Malmstrom V
  • Review: SEMINARS IN IMMUNOPATHOLOGY. 2010;32(2):107-116
    Fischer A; Picard C; Chemin K; Dogniaux S; Le Deist F; Hivroz C

Employments

  • Senior Research Specialist, Department of Medicine, ̽»¨¾«Ñ¡, 2022-

Degrees and Education

  • Docent, ̽»¨¾«Ñ¡, 2021

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