探花精选

Jurga Laurencikiene

Jurga Laurencikiene

Researcher | Docent
Visiting address: Blickag氓ngen 16 (byggnad NEO), 14183 Huddinge
Postal address: H7 Medicin, Huddinge, H7 BioNut Laurencikiene, 171 77 Stockholm
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About me

  • The group focuses on the function of adipose tissue immune cells and their role in obesity-related complications such as insulin resistance and type 2 diabetes. In addition, we are interested in how signals coming from immune cells are influencing healthy vs unhealthy adipose tissue expansion and how sex differences influence these processes.
    The transferability of research results between sexes has been questioned with great differences found both in human and murine metabolic and immune system research. Sex dimorphism is a well-known phenomena in development of obesity-related insulin resistance (IR) and type 2 diabetes (T2D) as well as in general immune response. Men have a higher risk of insulin resistance and metabolic complications compared to pre-menopausal
    women even though obesity is more prevalent in women. Several sex-related differences in white adipose tissue (WAT) function have been defined, for example leptin secretion and adipocyte lipolysis. Therefore, it is apparent that WAT function contributes to metabolic differences observed between sexes. However, most of such studies focused on adipocyte phenotype, while also immune cells have a central role in regulation of metabolism and inflammation in WAT. Furthermore, immune cells also respond to insulin and can develop insulin resistance. Our hypothesis is that WAT immune cells possess sex differences in composition of populations and their functions, which affects WAT expansion and its phenotype.

Research

  • Adipocytes, adipose tissue immune cells, obesity, type 2 diabetes, inflammation, sex differences.

Teaching

  • - Director of studies for the Master鈥檚 programme in Biomedicine,
    - Course director of the elective course in "Circulation, Metabolism and Endocrinology" in a Master's programme in Biomedicine,
    - Co-ordinator of a doctoral program in Metabolism and Endocrinology (MetEndo),
    - Board member of the graduate program in Metabolism and Endocrinology (MetEndo) at KI,
    - Teacher in courses under Master's programme in Biomedicine and doctoral courses at KI.
    - Teacher's representative in the Programme committee for Biomedicine programmes and Programme committee for undergraduate education at MedH.

Articles

  • Article: NATURE COMMUNICATIONS. 2024;15(1):7957
    Hofwimmer K; de Paula Souza J; Subramanian N; Vuji膷i膰 M; Rachid L; M茅reau H; Zhao C; Dror E; Barreby E; Bj枚rkstr枚m NK; Wernstedt Asterholm I; B枚ni-Schnetzler M; Meier DT; Donath MY; Laurencikiene J
  • Article: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. 2024;47(9):2249-2260
    Subramanian N; Wiik A; Rullman E; Melin M; Lundberg TR; Flanagan J; Holmberg M; Dekanski A; Dhejne C; Arver S; Gustafsson T; Laurencikiene J; Andersson DP
  • Article: NATURE BIOTECHNOLOGY. 2024;42(4):587-590
    Sych T; Schlegel J; Barriga HMG; Ojansivu M; Hanke L; Weber F; Bostancioglu RB; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; El Andaloussi S; Fuerth D; Stevens MM; Sezgin E
  • Article: SCIENTIFIC REPORTS. 2023;13(1):10559
    Vavakova M; Hofwimmer K; Laurencikiene J; Goransson O
  • Article: CARDIOVASCULAR DIABETOLOGY. 2023;22(1):84
    Subramanian N; Hofwimmer K; Tavira B; Massier L; Andersson DP; Arner P; Laurencikiene J
  • Article: NATURE COMMUNICATIONS. 2023;14(1):1438
    Massier L; Jalkanen J; Elmastas M; Zhong J; Wang T; Nankam PAN; Frendo-Cumbo S; Backdahl J; Subramanian N; Sekine T; Kerr AG; Tseng BTP; Laurencikiene J; Buggert M; Lourda M; Kublickiene K; Bhalla N; Andersson A; Valsesia A; Astrup A; Blaak EE; Stahl PL; Viguerie N; Langin D; Wolfrum C; Blueher M; Ryden M; Mejhert N
  • Article: GUT. 2022;71(11):2179-2193
    Krieg L; Didt K; Karkossa I; Bernhart SH; Kehr S; Subramanian N; Lindhorst A; Schaudinn A; Tabei S; Keller M; Stumvoll M; Dietrich A; von Bergen M; Stadler PF; Laurencikiene J; Krueger M; Blueher M; Gericke M; Schubert K; Kovacs P; Chakaroun R; Massier L
  • Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:996954
    Subramanian N; Tavira B; Hofwimmer K; Gutsmann B; Massier L; Abildgaard J; Juul A; Ryden M; Arner P; Laurencikiene J
  • Article: CIRCULATION. 2021;144(12):961-982
    Edgar L; Akbar N; Braithwaite AT; Krausgruber T; Gallart-Ayala H; Bailey J; Corbin AL; Khoyratty TE; Chai JT; Alkhalil M; Rendeiro AF; Ziberna K; Arya R; Cahill TJ; Bock C; Laurencikiene J; Crabtree MJ; Lemieux ME; Riksen NP; Netea MG; Wheelock CE; Channon KM; Ryden M; Udalova IA; Carnicer R; Choudhury RP
  • Article: ELIFE. 2021;10:e65996
    Sanchez-Ceinos J; Guzman-Ruiz R; Alberto Rangel-Zuniga O; Lopez-Alcala J; Moreno-Cano E; Del Rio-Moreno M; Luis Romero-Cabrera J; Perez-Martinez P; Maymo-Masip E; Vendrell J; Fernandez-Veledo S; Manuel Fernandez-Real J; Laurencikiene J; Ryden M; Membrives A; Luque RM; Lopez-Miranda J; Malagon MM
  • Article: ENDOCRINOLOGY. 2021;162(7):bqab096
    Bjork C; Subramanian N; Liu J; Acosta JR; Tavira B; Eriksson AB; Arner P; Laurencikiene J
  • Article: CELLULAR SIGNALLING. 2020;76:109786
    Negoita F; Vavakova M; Saell J; Laurencikiene J; Goeransson O
  • Article: CELL METABOLISM. 2020;31(2):375-390.e11
    Petrus P; Lecoutre S; Dollet L; Wiel C; Sulen A; Gao H; Tavira B; Laurencikiene J; Rooyackers O; Checa A; Douagi I; Wheelock CE; Arner P; McCarthy M; Bergo MO; Edgar L; Choudhury RP; Aouadi M; Krook A; Ryden M
  • Article: JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM (JCEM). 2019;104(10):4552-4562
    Acosta JR; Tavira B; Douagi I; Kulyte A; Arner P; Ryden M; Laurencikiene J
  • Article: CELLULAR SIGNALLING. 2019;55:73-80
    Sall J; Negoita F; Hansson B; Kopietz F; Linder W; Pettersson AML; Ekelund M; Laurencikiene J; Degerman E; Stenkula KG; Goransson O
  • Article: CELL REPORTS. 2018;25(3):551-560.e5
    Petrus P; Mejhert N; Corrales P; Lecoutre S; Li Q; Maldonado E; Kulyte A; Lopez Y; Campbell M; Acosta JR; Laurencikiene J; Douagi I; Gao H; Martinez-Alvarez C; Heden P; Spalding KL; Vidal-Puig A; Medina-Gomez G; Arner P; Ryden M
  • Article: DIABETES, OBESITY AND METABOLISM. 2018;20(10):2416-2425
    Arner P; Kulyte A; Batchelor K; Laurencikiene J; Livingston J; Ryden M
  • Article: JOURNAL OF ENDOCRINOLOGY. 2018;238(3):187-202
    Sutt S; Cansby E; Paul A; Amrutkar M; Nunez-Duran E; Kulkarni NM; Stahlman M; Boren J; Laurencikiene J; Howell BW; Enerback S; Mahlapuu M
  • Article: STEM CELL RESEARCH AND THERAPY. 2017;8(1):250
    Acosta JR; Joost S; Karlsson K; Ehrlund A; Li X; Aouadi M; Kasper M; Arner P; Ryden M; Laurencikiene J
  • Article: SCIENTIFIC DATA. 2017;4:170164
    Ehrlund A; Acosta JR; Bjork C; Heden P; Douagi I; Arner P; Laurencikiene J
  • Show more

All other publications

  • Corrigendum: CARDIOVASCULAR DIABETOLOGY. 2023;22(1):229
    Subramanian N; Hofwimmer K; Tavira B; Massier L; Andersson DP; Arner P; Laurencikiene J
  • Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S116-S117
    Hofwimmer K; Souza JDP; Subramanian N; Vujicic M; Asterholm IW; Ryden M; Boni-Schnetzler M; Meier DT; Donath MY; Laurencikiene J
  • Preprint: BIORXIV. 2021
    S谩nchez-Ceinos J; Guzm谩n-Ruiz R; Rangel-Z煤帽iga OA; L贸pez-Alcal谩 J; Moreno-Ca帽o E; del R铆o-Moreno M; Romero-Cabrera JL; P茅rez-Mart铆nez P; Maymo-Masip E; Vendrell J; Fern谩ndez-Veledo S; Fern谩ndez-Real JM; Laurencikiene J; Ryd茅n M; Membrives A; Luque RM; L贸pez-Miranda J; Malag贸n MM
  • Preprint: SSRN ELECTRONIC JOURNAL. 2020
    Sulen A; Li X; Barreby E; Azzimato V; Xu C; Morgantini C; Levi L; Jager J; Verdeguer F; Mah煤 I; Ozcan S; Domingos A; Li Q; Spalding KL; Gilleron J; Cormont M; Caravaca AS; Olofsson PS; N盲slund E; Laurencikiene J; Bleriot C; Ryd茅n M; Ginhoux F; Aouadi M
  • Conference publication: DIABETOLOGIA. 2019;62:S107
    Laurencikiene J; Hofwimmer K; Tavira B; Acosta J; Ryden M
  • Review: INTERNATIONAL JOURNAL OF OBESITY. 2012;36(12):1494-1502
    Laurencikiene J; Ryden M
  • Conference publication: JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS. 2010;3(2-3):97
    Pettersson A; Mejhert N; Naslund E; Bouloumie A; Dahlman I; Laurencikiene J; Amer P; Ryden M
  • Conference publication: JOURNAL OF IMMUNOLOGY. 2007;178
    Severinson E; Laurencikiene J
  • Conference publication: INTERNATIONAL JOURNAL OF OBESITY. 2007;31:S67
    Pettersson A; Laurencikiene J; Arvidsson Nordstroem E; Dahlman I; Murphy C; Dungner E; Leijonhufvud B-M; Ryden M; Arner P
  • Thesis / dissertation: 2004
    Laurencikiene, Jurga
  • Conference publication: THE FASEB JOURNAL. 2003;17(7):C101
    Laurencikiene J; Severinson E

Grants

  • The role of the immune component in human adipose tissue expansion in cardiometabolic diseases: does the sex matter
    探花精选
    1 June 2024 - 1 June 2028
  • Characterization of gender-specific differences in insulin sensitivity and type 2 diabetes through studies of human adipose tissue immune component.
    CIMED
    1 January 2024 - 31 December 2026
  • Type 2 diabetes and adipose tissue morphology: dual role and sex- specificity of the immune component
    EFSD and Novo Nordisk A/S Programme for Diabetes Research in Europe
    1 November 2023 - 1 November 2024
  • Swedish Research Council
    1 January 2017 - 31 December 2022
  • Swedish Research Council
    1 January 2013 - 31 December 2016

Employments

  • Researcher, Department of Medicine, Huddinge, 探花精选, 2024-

Degrees and Education

  • Docent, 探花精选, 2011
  • Doctor Of Philosophy, Department of Cell and Molecular Biology, 探花精选, 2004

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