探花精选

Juraj Secnik

Juraj Secnik

Affiliated to Research
Visiting address: Blickag氓ngen 16, 14152 Huddinge
Postal address: H1 Neurobiologi, v氓rdvetenskap och samh盲lle, H1 Klinisk geriatrik Religa, 171 77 Stockholm
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About me

  • 2015/2016 - R&D trainee, focus on dementia and diabetes mellitus
    2016 - Graduated from Charles University in Prague as 探花精选 doctor (M.D.)
    2016 - Admitted to doctoral studies at 探花精选

Research

  • There is lack of high-quality evidence for pharmacological care in dementia, especially in multimorbid patients. Moreover dementia patients are
    prescribed significant number of chronic medication with high chance of interactions and side effects. Using large unrestricted Swedish cohorts can
    provide good evidence on which medication should be used and which omitted in this understudied population. My work revolves around high-risk patients diagnosed with different dementia disorders and diabetes. Linking the data from the Swedish Dementia Registry with other registers provides high-quality information on antidiabetic, dementia, cardiovascular and psychotropic medication and their associations with mortality rates, incidence of stroke, cardiovascular events and cognitive decline. In addition, with the help of data on dementia-free controls we can assess the changes in clinical care made in connection to dementia diagnosis and assess their efficacy. Diabetes is associated with significantly higher risk of dementia, therefore proper diabetes management and biochemical control (e.g. glucose levels, HbA1c) is the cornerstone of dementia prevention in this cohort. We collaborate with the large AMORIS study (~800, 000 subjects) started in the 1980's and 1990's, which provides data on baseline and repeated blood biochemistry measurements taken as part of the health check-ups with the possibility to follow-up patients using the linkages with other registers. AMORIS gives a unique opportunity to study long-term changes in blood biochemistry prior to dementia in a massive cohort.
    Overall aims of my PhD project:
    1. Finding beneficial and detrimental pharmacological treatments in patients with diabetes mellitus and dementia.
    Focus on:
    - antidiabetic, dementia, cardiovascular and psychotropic medication
    - changes in pharmacological care before and after dementia diagnosis
    - differences in mortality, stroke, myocardial infarction, cognitive
    decline associated with the use of specific medication
    2. Determining how the metabolic changes in mid-life contribute to risk of dementia.
    Focus on:
    - changes in blood glucose, lipid and inflammatory biochemistry associated with different dementia diagnoses
    - long-term biochemical trajectories in the lead up to dementia diagnosis
    Keywords: Clinical epidemiology, pharmacoepidemiology, diabetes, dementia

Teaching

  • Co-supervisor to master students:
    2016/2017 - Pontus Dannberg (Medicine)
    2017/2018 - Abbe Ulgr茅n (Biomedicine)
    2018 - Oliver Edner (Medicine)
    2018 - Hugo S枚derstr枚m (Medicine)
    2019 - Sofia Lim (Medicine)
    2019 - Filippa Martinsson (Medicine)
    2020 - Ramin Sasani (Medicine)
    2020 - Sara Fadhil (Medicine)
    Co-supervisor to 探花精选 doctors:
    2017 - Hamsah Al-Qashqri

Articles

  • Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):5
    Secnik J; Eriksdotter M; Xu H; Annetorp M; SweGeroCOVID Project; Rytarowski A; Johnell K; H盲gg S; Religa D
  • Article: FRONTIERS IN PSYCHIATRY. 2023;14:1039239
    Martinkova JN; Ferretti MT; Ferrari A; Lerch O; Matuskova V; Secnik J; Hort J
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2022;87(3):1307-1318
    Schwertner E; Pereira JB; Xu H; Secnik J; Winblad B; Eriksdotter M; Nagga K; Religa D
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2022;86(1):245-257
    Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
  • Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):197
    Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
  • Journal article: ALZHEIMERS & DEMENTIA. 2021;17(S10)
    Hoang MT; K氓reholt I; von Koch L; Xu H; Secnik J; Religa D; Tan EC; Johnell K; Garcia鈥怭tacek S
  • Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2021;22(10):2100-2107
    Minh TH; Kareholt I; von Koch L; Xu H; Secnik J; Religa D; Tan ECK; Johnell K; Garcia-Ptacek S
  • Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2021;22(7):1477-1483.e3
    Xu H; Garcia-Ptacek S; Secnik J; Edlund A-K; Westling K; Hoang MT; Johnell K; Tan ECK; Religa D; Eriksdotter M
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;81(3):1253-1261
    Zupanic E; von Euler M; Winblad B; Xu H; Secnik J; Kramberger MG; Religa D; Norrving B; Garcia-Ptacek S
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;81(1):179-188
    Schwertner E; Zelic R; Secnik J; Johansson B; Winblad B; Eriksdotter M; Religa D
  • Article: JOURNAL OF INTERNAL MEDICINE. 2021;289(4):508-522
    Kalar I; Xu H; Secnik J; Schwertner E; Kramberger MG; Winblad B; von Euler M; Eriksdotter M; Garcia-Ptacek S
  • Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S10)
    Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia鈥怭tacek S; Religa D
  • Journal article: ALZHEIMERS & DEMENTIA. 2020;16(S10)
    Xu H; Garcia鈥怭tacek S; Secnik J; Hoang MT; Tan EC; Religa D; Eriksdotter M
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;76(4):1581-1594
    Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
  • Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;73(3):1013-1021
    Zupanic E; Kramberger MG; Von Euler M; Norrving B; Winblad B; Secnik J; Fastbom J; Eriksdotter M; Garcia-Ptacek S
  • Article: BMJ OPEN DIABETES RESEARCH & CARE. 2020;8(1):e000833
    Secnik J; Schwertner E; Alvarsson M; Hammar N; Fastbom J; Winblad B; Garcia-Ptacek S; Religa D; Eriksdotter M
  • Article: TRANSPLANT IMMUNOLOGY. 2019;57:101229
    Secnik PJ; Jabor A; Lavrikova P; Secnik J; Malikova P; Pokorna E; Franekova J
  • Journal article: INNOVATION IN AGING. 2019;3(Supplement_1):s421
    Religa D; Schwertner E; Garcia-ptacek S; Johansson B; N盲gga K; Winblad B; Eriksdotter M; Secnik J
  • Journal article: ALZHEIMERS & DEMENTIA. 2019;15(7S_Part_22):p1186
    Secnik J; Schwertner E; Alvarsson M; Hammar N; Fastbom J; Winblad B; Garcia-Ptacek S; Religa D; Eriksdotter M
  • Article: JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 2019;20(3):323-329.e2
    Schwertner E; Secnik J; Garcia-Ptacek S; Johansson B; Nagga K; Eriksdotter M; Winblad B; Religa D
  • Show more

All other publications

  • Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2022;29:146
    Secnik J; Eriksdotter M; Rytarowski A; Annetorp M; Johnell K; Hagg S; Religa D
  • Preprint: MEDRXIV. 2021
    Schwertner E; Pereira J; Xu H; Secnik J; Winblad B; Eriksdotter M; Nagga K; Religa D
  • Doctoral thesis: 2021
    Secnik J
  • Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2020;27:1019-1020
    Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
  • Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2019;26:360
    Religa D; Schwertner E; Secnik J; Garcia-Ptacek S; Johansson B; Eriksdotter ME; Nagga K; Winblad B
  • Conference publication: EUROPEAN PSYCHIATRY. 2019;56:S175-S176
    Religa D; Schwertner E; Soderstrom H; Secnik J; Winblad B; Eriksdotter M
  • Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2018;25:486
    Zupanic E; Kareholt I; Norrving B; Secnik J; von Euler M; Winblad B; Religa D; Kramberger MG; Johnell K; Eriksdotter ME; Garcia-Ptacek S
  • Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2018;25:675
    Secnik J; Schwertner E; Johnell K; Fastbom J; Alvarsson M; Winblad B; Garcia-Ptacek S; Eriksdotter M; Religa D
  • Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2017;24:103
    Religa D; Secnik J; Cermakova P; Fereshtehnejad S-M; Dannberg P; Johnell K; Fastbom J; Winblad B; Eriksdotter ME

Employments

  • Affiliated to Research, Department of Neurobiology, Care Sciences and Society, 探花精选, 2024-2027

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, 探花精选, 2021

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