探花精选

Jose Inzunza

Jose Inzunza

Researcher | Docent
Visiting address: Alfred Nobels all茅 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Klin Mikrobiologen KISCO, 171 77 Stockholm
Part of:

About me

  • My expertise is in the field of reproductive medicine, stem cell biology, estrogen nuclear receptors and regenerative medicine.

    Senior Researcher (Med. Dr.) / Associate Professor (Docent)

    I have received my PhD from the Department of Clinical Sciences, Division of Obstetrics and Gynecology at 探花精选 in 2003. The same year I received a position as a scientist at the Department of Biosciences and Nutrition, 探花精选, where I have been working with nuclear receptors with focus on the estrogen beta receptor role in the ovary and in the early differentiation of human embryonic stem cells. 



  • In 2004 I received a position as assistant professor at the same department. Since 1990 when I started working at 探花精选 as a specialist in cytogenetics, reproductive medicine, and clinic embryology, I have been active working with the development of new techniques in embryo micromanipulation and transgenesis. During my thesis I actively participated in the preimplantation genetic diagnosis (PGD) program at the in vitro fertilization (IVF) unit at Karolinska University Hospital. I have also from the very beginning been involved in the creation of the human embryonic stem cells laboratory at the same unit. Furthermore, includes active participation in the derivation and characterization of human embryonic stem cell (hESC) lines.

    I also served as a Scientific Consultant at the hESC laboratory at the IVF unit, Karolinska University Hospital.

    My research interests have always been focused on stem cell biology and marginsomatic cell reprogramming using somatic cell nuclear transfer (SCNT) both in human and mouse model, in order to understand the epigenetic mechanism and factors that could govern the pluripotence of the embryonic stem cells. My focus now as a director of the KISCO unit is to explore the potential of stem cells in developing 3D in vitro models for various human diseases and drug toxicity testing as well as in regenerative medicine.(/en/bionut/kisco-karolinska-institutet-stem-cell-organoid) 
  • We are also involved in conducting human embryonic stem cell courses as well as workshops on organoid culturing at Karolisnka Institutet, apart from providing training to researchers from national and international universities. The research team is interdisciplinary involving senior researchers, PhD students, Post Docs, molecular biologists, embryologists, and physicists.

    Docent Developmental Biology, 探花精选, Stockholm, Sweden, 2013.Ph.D
    Medical Sciences, 探花精选, Stockholm, Sweden, 2003.

    Official member of the south Stockholm/Link枚ping Regional Ethical Committee, 2009 to date.Swedish Medical Association, member from 2012.Deputy in SIG of Stem Cells, European Society of Human Reproduction and Embryology (ESHRE), 2003-2007.

Research

  • Research goals:

    Elucidate the role of the MMP-19 and TIM-1 in ovulation using ER尾 knockout mice.Orthotopic ovarian transplantation in elucidation of the ER尾 role in ovulation.Studying the implication of ERs in cellular differentiation and proliferation in hESC.Somatic cell nuclear transfer in order to obtain isogonics hESC (clinic collaboration).Genetic stability of human embryonic stem cells (hESC)-the role of the cytoskeleton.Development of in vitro 3D Organoids Diseases Models, from pluripotents stem cells.

Teaching

  • *Doctoral Program Coordinator in Developmental Biology and Cellular Signaling (2006-2012).Organizer of five doctoral courses in the field of stem cells and regenerative medicine.

    Organization of courses, teaching activities, and Doctoral courses:

    Organizer of the postgraduate-course at the Department of Biosciences and Nutrition, 探花精选 at Huddinge Hospital,  

  • on "Stem cells and organoids with focus on regenerative medicine"( 
  • 5562). 
  • (
    Organizer of the postgraduate-course at the Department of Biosciences and Nutrition, 探花精选 at Huddinge Hospital, on "Embryology I". (3150). 

  • Co-Organizer of the postgraduate-courses for the Department of CLINTEC, 探花精选 at Huddinge Hospital, on "Clinical Achievements of Reproductive Medicine".(2291). 

  • Organizer of the postgraduate-course at the Department of Biosciences and Nutrition, 探花精选. 鈥淐ryobiology in assisted reproductive technology course鈥 Course catalog number: (3089). 

  • Organizer of the postgraduate-course at the Department of Biosciences and Nutrition, 探花精选. "Gene Regulation in the Early Human Embryo". Course catalog number: (3080) 

  • Course leader for this course 鈥淏achelor鈥檚 in Nutrition 鈥淭he Human Body, Health and Disease" course code NU3001 
  • Stockholm University 

Articles

  • Article: CELLS. 2024;13(21):1811
    Jiang Y; Palomares AR; Munoz P; Nalvarte I; Acharya G; Inzunza J; Varshney M; Rodriguez-Wallberg KA
  • Article: F AND S SCIENCE. 2024;5(4):306-317
    Tohonen V; Antonson P; Boggavarapu NR; Ali H; Motaholi LA; Gustafsson J-A; Varshney M; Rodriguez-Wallberg KA; Katayama S; Nalvarte I; Inzunza J
  • Journal article: FERTILITY AND STERILITY. 2023;120(4):e194
    Jiang Y; Varshney M; Palomares AR; Inzunza J; Acharya G; Nalvarte I; Rodriguez-Wallberg KA
  • Article: STAR PROTOCOLS. 2023;4(3):102357
    Boskovic N; Yazgeldi G; Ezer S; Tervaniemi MH; Inzunza J; Deligiannis SP; Yasar B; Skoog T; Krjutskov K; Katayama S; Kere J
  • Journal article: HUMAN REPRODUCTION. 2023;38(Supplement_1)
    Jiang Y; Varshney M; Reyes Palomares A; Inzunza J; Rodriguez-Wallberg KA
  • Article: STEM CELLS TRANSLATIONAL MEDICINE. 2021;10(7):987-995
    Arias J; Yu J; Varshney M; Inzunza J; Nalvarte I
  • Article: NEUROTOXICITY RESEARCH. 2021;39(2):182-190
    Valdes R; Armijo A; Munoz P; Hultenby K; Hagg A; Inzunza J; Nalvarte I; Varshney M; Mannervik B; Segura-Aguilar J
  • Article: STEM CELL RESEARCH. 2021;51:102193
    Inzunza J; Arias-Fuenzalida J; Segura-Aguilar J; Nalvarte I; Varshney M
  • Article: NEUROENDOCRINOLOGY. 2021;111(1-2):27-44
    Varshney MK; Yu NY-L; Katayama S; Li X; Liu T; Wu W-F; Tohonen V; Krjutskov K; Kere J; Fan X; Inzunza J; Gustafsson J-A; Nalvarte I
  • Article: ENDOCRINE CONNECTIONS. 2018;7(12):1472-1479
    Yakimchuk K; Revanna CB; Huang D; Inzunza J; Okret S
  • Article: MOLECULAR PHARMACOLOGY. 2018;94(4):1220-1231
    Lupu D; Varshney MK; Mucs D; Inzunza J; Norinder U; Loghin F; Nalvarte I; Ruegg J
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(48):E10428-E10437
    Varshney MK; Inzunza J; Lupu D; Ganapathy V; Antonson P; Ruegg J; Nalvarte I; Gustafsson J-A
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(19):E3816-E3822
    Wu W-F; Maneix L; Insunza J; Nalvarte I; Antonson P; Kere J; Yu NY-L; Tohonen V; Katayama S; Einarsdottir E; Krjutskov K; Dai Y-B; Huang B; Su W; Warner M; Gustafsson J-A
  • Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2016;73(18):3583-3597
    Herrera A; Munoz P; Paris I; Diaz-Veliz G; Mora S; Inzunza J; Hultenby K; Cardenas C; Jana F; Raisman-Vozari R; Gysling K; Abarca J; Steinbusch HWM; Segura-Aguilar J
  • Article: ONCOTARGET. 2016;7(15):20718-20727
    Talaber G; Yakimchuk K; Guan J; Inzunza J; Okret S
  • Article: REPRODUCTION. 2016;151(3):253-259
    Nalvarte I; Tohonen V; Lindeberg M; Varshney M; Gustafsson J-A; Inzunza J
  • Article: REPRODUCTION. 2014;147(6):875-883
    Sultana T; Hou M; Stukenborg J-B; Tohonen V; Inzunza J; Chagin AS; Sollerbrant K
  • Article: PLOS ONE. 2014;9(9):e107712
    Lim ML; Ooi BNS; Jungebluth P; Sjoqvist S; Hultman I; Lemon G; Gustafsson Y; Asmundsson J; Baiguera S; Douagi I; Gilevich I; Popova A; Haag JC; Rodriguez AB; Lim J; Lieden A; Nordenskjold M; Alici E; Baker D; Unger C; Luedde T; Vassiliev I; Inzunza J; Ahrlund-Richter L; Macchiarini P
  • Article: NATURE COMMUNICATIONS. 2014;5:3195
    Rodin S; Antonsson L; Niaudet C; Simonson OE; Salmela E; Hansson EM; Domogatskaya A; Xiao Z; Damdimopoulou P; Sheikhi M; Inzunza J; Nilsson A-S; Baker D; Kuiper R; Sun Y; Blennow E; Nordenskjold M; Grinnemo K-H; Kere J; Betsholtz C; Hovatta O; Tryggvason K
  • Article: PLOS ONE. 2014;9(8):e102949
    Madissoon E; Tohonen V; Vesterlund L; Katayama S; Unneberg P; Inzunza J; Hovatta O; Kere J
  • Show more

All other publications

  • Preprint: BIORXIV. 2024;BIORXIV
    Demetriou A; Lindqvist B; Ali HG; Shamekh MM; Maioli S; Inzunza J; Varshney M; Nilsson P; Nalvarte I
  • Conference publication: HUMAN REPRODUCTION. 2023;38
    Jiang Y; Varshney M; Palomares AR; Inzunza J; Rodriguez-Wallberg KA
  • Review: NEURAL REGENERATION RESEARCH. 2022;17(9):1861-1866
    Segura-Aguilar J; Mannervik B; Inzunza J; Varshney M; Nalvarte I; Munoz P
  • Review: ANTIOXIDANTS. 2022;11(2):296
    Segura-Aguilar J; Munoz P; Inzunza J; Varshney M; Nalvarte I; Mannervik B
  • Review: VITAMINS AND HORMONES. 2021;116:313-326
    Nalvarte I; Varshney M; Inzunza J; Gustafsson J-A
  • Meeting abstract: TOXICOLOGY LETTERS. 2018;295:S109-S110
    Lupu D; Varshney M; Nalvarte I; Insunza J; Loghin F; Ruegg J
  • Conference publication: HUMAN REPRODUCTION. 2014;29:104
    Stavreus-Evers A; Ronqvist G; Ronquist GK; Larsson A; Inzunza J
  • Conference publication: HUMAN REPRODUCTION. 2011;26:I201
    Salehnia M; Hovatta O; Tohonen V; Inzunza J
  • Conference publication: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2009;29(7):E72
    Jiang ZY; Inzunza J; Gustafsson JA; Eriksson M; Parini P
  • Review: ENDOCRINE REVIEWS. 2006;27(6):677-706
    Ohnemus U; Uenalan M; Inzunza J; Gustafsson J-A; Paus R
  • Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21:S121
    Lindberg-Lagerquist MK; Windahl SH; Andersson N; Jochems C; Kallkopf A; Pettersson K; Inzunza J; Gustafsson J; Svensson L; Holmdahl R; van der Saag P; Carlsten H; Ohlsson C
  • Conference publication: JOURNAL OF CLINICAL ONCOLOGY. 2006;24(18):565S
    Hartman J; Lindberg K; Inzunza J; Wan J; Str枚m A; Gustafsson J
  • Thesis / dissertation: 2003
    Inzunza, Jos茅
  • Conference publication: AMERICAN JOURNAL OF HUMAN GENETICS. 1999;65(4):A165
    Iwarsson E; Malmgren H; Inzunza J; Ahrlund-Richter L; Rosenlund B; Fridstr枚m M; Sj枚blom P; Nordenskj枚ld M; Blennow E
  • Conference publication: HUMAN REPRODUCTION. 1998;13:330-331
    Iwarsson E; Lundquist M; Inzunza J; 脛hrlund-Richter L; Nordenskj枚ld M; Sj枚blom P; Lundkvist 脰; Simberg N; Blennow E
  • Conference publication: HUMAN REPRODUCTION. 1998;13:81-82
    Iwarsson E; 脛hrlund-Richter L; Inzunza J; Rosenlund B; Fridstr枚m M; Sj枚blom P; Nordenskj枚ld M; Blennow E
  • Review: LAKARTIDNINGEN. 1997;94(35):2919-2922
    Iwarsson E; Blennow ES; Anvret M; Nordenskj枚ld M; Inzunza J; Ahrlund-Richter L; Pousette A; Hillensj贸 T; Fridstr枚m M; Rosenlund B; Sj枚blom P
  • Conference publication: JOURNAL OF CELLULAR BIOCHEMISTRY. 1995;:226
    LARSSON S; HOTCHKISS G; ANDANG M; NYHOLM T; INZUNZA J; JANSSON I; AHRLUND-RICHTER L

Grants

  • Swedish Research Council
    1 January 2024 - 31 December 2026
  • High-throughput production and AI based screening of organoids for label-free drug development assay
    VINNOVA
    25 September 2023 - 24 September 2024
  • Swedish Research Council
    1 January 2017 - 31 December 2020

Employments

  • Researcher, Department of Laboratory Medicine, 探花精选, 2024-

Degrees and Education

  • Docent, 探花精选, 2013
  • Doctor Of Philosophy, Department of Clinical Science, Intervention and Technology, 探花精选, 2003

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