Jorge Ruas

About me
Publications
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CV
Public outreach and news

About me

Professor of Molecular Physiology and Principal Investigator of the Molecular and Cellular Exercise Physiology research group.

After receiving my Pharm.D. degree from the University of Lisbon, I moved to ̽��ѡ (KI) for my doctoral studies. During that time I investigated how cellular oxygen levels can regulate adaptive gene expression, and in 2005 received my Ph.D. in Medical Sciences.

In 2006 I moved to Boston to pursue postdoctoral studies at the Division of Metabolism and Chronic Disease at the Dana-Farber Cancer Institute and Harvard Medical School. During this period I focused on the study of transcriptional networks that control skeletal muscle physiology.

In July 2011 I setup my research group at the Department of Physiology and Pharmacology at KI, became Associate Professor in 2016, and Professor of Molecular Physiology in 2020. My group aims to identify the molecular mediators of the health benefits of exercise and to use this knowledge to develop novel disease therapies.

Academic honours, awards and prizes
2022 The Med. Dr. Axel Hirsch Prize 2022
2019 Novo Nordisk Foundation Ascending Investigator, Endocrinology and Metabolism
2017 The Leif C. Groop Award for Outstanding Diabetes Research
2016 Swedish Research Council Consolidator Grant
2015 Senior Researcher Award from ̽��ѡ
2014 Human Frontier Science Program Young Investigator Award
2013 Malin and Lennart Philipson Prize (link to ki.se/news)
Jorge Ruas - award winner 2013-2015 (link to Malin and Lennart Philipson's foundation website)
2012 Novo Nordisk Fonden Excellence Project Award
2012 Marie Curie Career Integration Grant
2011 Assistant Professor Grant from the Swedish Research Council
2011 Young Investigator Award in Diabetes. Strategic Research Programme in Diabetes at ̽��ѡ (Sweden).
2006 Wenner Gren Fellow

Research

Research in our laboratory is aimed at understanding the molecular mechanisms that mediate skeletal muscle adaptations to diverse challenges and their local and systemic consequences. We are particularly interested in understanding how exercised or sedentary skeletal muscle can crosstalk with other organs, and how it can affect individual health and disease.

Teaching

I teach several subjects to the Medicine and Biomedicine programs at KI, and participate as lecturer in diverse doctoral courses. I am also an invited professor at the Faculty of Pharmacy, University of Lisbon.

Articles

Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2025;328(2):E274-E285

Dumont KD; Jannig PR; Porsmyr-Palmertz M; Ruas JL
Article: ACTA DERMATO-VENEREOLOGICA. 2024;104:adv40796

Tayefi M; Svedbom A; Ivert LU; Lundqvist M; Ruas JL; Bradley M; Johansson EK
Article: NATURE COMMUNICATIONS. 2024;15(1):9826

Pham TCP; Raun SH; Havula E; Henriquez-Olguin C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig PR; Andersen NR; Kruse R; Ali MS; Irazoki A; Halling JF; Ringholm S; Needham EJ; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ortenblad N; Hojlund K; Kjaer M; Ruas JL; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
Article: AGING CELL. 2024;23(11):e14295

Dedic B; Westerberg L; Solis AM; Dumont KD; Ruas JL; Thorell A; Naslund E; Spalding KL
Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2024;224:s9-s10

Alves ES; van Deventer A; Jude B; Shorter E; Smith J; Steinz M; Gustafsson T; Rullman E; von Walden F; Svensson C; Zierath JR; Ruas JL; Lanner J
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10):2007-2015

Kamandulis S; Lukonaitiene I; Snieckus A; Brazaitis M; Mickevicius M; Cernych M; Ruas J; Schwieler L; Louvrou V; Erhardt S; Westerblad H; Venckunas T
Journal article: ELIFE. 2024;12

Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: ELIFE. 2024;12:rp92707

Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Karppinen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(34):e2319724121

Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Praestholm SM; Dias JM; Dumont KD; Liu Z; Liang Q; Edsgaerd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Teixeira AI; Yeo GW; Ruas JL
Article: MOLECULAR METABOLISM. 2024;82:101912

Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbuhler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; Haworth SM; Martinez-Redondo V; Liu Z; Carlstrom M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2024;103(1):151377

Nunes MJ; Carvalho AN; Sa-Lemos C; Colaco M; Cervenka I; Ciraci V; Santos SG; Ribeiro MM; Castanheira M; Jannig PR; Gama MJ; Castro-Caldas M; Rodrigues CMP; Rodrigues E; Ruas JL
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(2):166980

Caria I; Nunes MJ; Ciraci V; Carvalho AN; Ranito C; Santos SG; Gama MJ; Castro-Caldas M; Rodrigues CMP; Ruas JL; Rodrigues E
Article: NATURE NANOTECHNOLOGY. 2024;19(2):237-245

Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
Journal article: NATURE NANOTECHNOLOGY. 2024;19(2)

Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
Journal article: TOXICOLOGY LETTERS. 2023;384(Front. Cell Dev. Biol. 9 2021):s188-S193

Rodrigues JS; Faria-Pereira A; Camões SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Article: CELL REPORTS. 2023;42(1):112021

Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
Article: CELLS. 2022;11(19):2944

Tuomainen T; Naumenko N; Mutikainen M; Shakirzyanova A; Sczelecki S; Estall JL; Ruas JL; Tavi P
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(9):102328

Schihada H; Klompstra TM; Humphrys LJ; Cervenka I; Dadvar S; Kolb P; Ruas JL; Schulte G
Article: BMC BIOLOGY. 2022;20(1):169

Oehler D; Spychala A; Godecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Article: NATURE METABOLISM. 2022;4(6):739-758

Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: CARDIOVASCULAR RESEARCH. 2022;118(6):1520-1534

Naumenko N; Mutikainen M; Holappa L; Ruas JL; Tuomainen T; Tavi P
Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(638):eaba9112

Ilegems E; Bryzgalova G; Correia J; Yesildag B; Berra E; Ruas JL; Pereira TS; Berggren P-O
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:1043543

Rodrigues JS; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2022;322(1):C49-C62

Jonsson WO; Ponette J; Horwath O; Rydenstam T; Soderlund K; Ekblom B; Azzolini M; Ruas JL; Blomstrand E
Article: FASEB JOURNAL. 2021;35(12):e22010

Liu Z; Chaillou T; Santos Alves E; Mader T; Jude B; Ferreira DMS; Hynynen H; Cheng AJ; Jonsson WO; Pironti G; Andersson DC; Kenne E; Ruas JL; Tavi P; Lanner JT
Article: CELL METABOLISM. 2021;33(11):2215-2230.e8

Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Shvaikovskaya D; Zhengye L; Cervenka I; Khan N; Stec M; Oliveira M; Nijssen J; Martinez-Redondo V; Ducommun S; Azzolini M; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Article: NATURE COMMUNICATIONS. 2021;12(1):5948

Massart J; Sjogren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barres R; O'Gorman DJ; Zierath JR; Krook A
Article: METABOLITES. 2021;11(8):508

Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
Article: BIOTECHNOLOGY AND BIOENGINEERING. 2021;118(6):2234-2242

Song K-Y; Correia JC; Ruas JL; Teixeira AI
Article: BMC BIOLOGY. 2021;19(1):57

Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fao L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
Article: SCIENTIFIC REPORTS. 2021;11(1):6453

Moberg M; Apro W; Cervenka I; Ekblom B; van Hall G; Holmberg H-C; Ruas JL; Blomstrand E
Article: NATURE COMMUNICATIONS. 2021;12(1):1026

Wu H; Petitpre C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):541

Hahn M; van Krieken PP; Nord C; Alanentalo T; Morini F; Xiong Y; Eriksson M; Mayer J; Kostromina E; Ruas JL; Sharpe J; Pereira T; Berggren P-O; Ilegems E; Ahlgren U
Article: NURSING OPEN. 2020;7(5):1446-1452

Cronfalk BS; Akesson E; Nygren J; Nystrom A; Strandell A-M; Ruas J; von Euler M
Article: MOLECULAR METABOLISM. 2020;39:101012

Alves CRR; das Neves W; de Almeida NR; Eichelberger EJ; Jannig PR; Voltarelli VA; Tobias GC; Bechara LRG; Faria DDP; Alves MJN; Hagen L; Sharma A; Slupphaug G; Moreira JBN; Wisloff U; Hirshman MF; Negrao CE; de CGJ; Chammas R; Swoboda KJ; Ruas JL; Goodyear LJ; Brum PC
Article: MOLECULAR METABOLISM. 2020;34:72-84

Leveille M; Besse-Patin A; Jouvet N; Gunes A; Sczelecki S; Jeromson S; Khan NP; Baldwin C; Dumouchel A; Correia JC; Jannig PR; Boulais J; Ruas JL; Estall JL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986

Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:591476

Kelahmetoglu Y; Jannig PR; Cervenka I; Koch LG; Britton SL; Zhou J; Wang H; Robinson MM; Nair KS; Ruas JL
Article: REDOX BIOLOGY. 2020;28:101387

Peleli M; Ferreira DMS; Tarnawski L; Haworth SM; Xuechen L; Zhuge Z; Newton PT; Massart J; Chagin AS; Olofsson PS; Ruas JL; Weitzberg E; Lundberg JO; Carlstrom M
Article: SKELETAL MUSCLE. 2019;9(1):26

Ferreira DMS; Cheng AJ; Agudelo LZ; Cervenka I; Chaillou T; Correia JC; Porsmyr-Palmertz M; Izadi M; Hansson A; Martinez-Redondo V; Valente-Silva P; Pettersson-Klein AT; Estall JL; Robinson MM; Nair KS; Lanner JT; Ruas JL
Article: NATURE COMMUNICATIONS. 2019;10(1):2767

Agudelo LZ; Ferreira DMS; Dadyar S; Cervenka I; Ketscher L; Izadi M; Liu Z; Furrer R; Handschin C; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Ruas JL
Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13

Carvalho A; Ranito C; Tavares C; Castro-Caldas M; Rodrigues E; Ruas J; Van Horssen J; Gama M
Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13

Nunes M; Caria I; Carvalho A; Costa D; Castro-Caldas M; Gama M; Rodrigues E; Ruas J
Article: CARDIOVASCULAR RESEARCH. 2019;115(1):107-118

Karkkainen O; Tuomainen T; Mutikainen M; Lehtonen M; Ruas JL; Hanhineva K; Tavi P
Article: PHYSIOLOGICAL GENOMICS. 2018;50(12):1071-1082

Blackwell TA; Cervenka I; Khatri B; Brown JL; Rosa-Caldwell ME; Lee DE; Perry RAJ; Brown LA; Haynie WS; Wiggs MP; Bottje WG; Washington TA; Kong BC; Ruas JL; Greene NP
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(5):519-533

Dadvar S; Ferreira DMS; Cervenka I; Ruas JL
Article: EMBO MOLECULAR MEDICINE. 2018;10(8):e8613

Bayindir-Buchhalter I; Wolff G; Lerch S; Sijmonsma T; Schuster M; Gronych J; Billeter AT; Babaei R; Krunic D; Ketscher L; Spielmann N; de Angelis MH; Ruas JL; Mueller-Stich BP; Heikenwalder M; Lichter P; Herzig S; Vegiopoulos A
Journal article: IBJ PLUS. 2018

Agró M; Díaz Nido J; Giménez Cassina A; Katsu Jiménez Y; da Silva P; Ruas J
Article: MOLECULAR METABOLISM. 2018;9:28-42

Pettersson-Klein AT; Izadi M; Ferreira DMS; Cervenka I; Correia JC; Martinez-Redondo V; Southern M; Cameron M; Kamenecka T; Agudelo LZ; Porsmyr-Palmertz M; Martens U; Lundgren B; Otrocka M; Jenmalm-Jensen A; Griffin PR; Ruas JL
Article: CELL METABOLISM. 2018;27(2):378-392.e5

Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
Journal article: ANNALS OF RESEARCH IN SPORT AND PHYSICAL ACTIVITY. 2018;(ex2018):79-80

Ruas JL
Article: MOLECULAR METABOLISM. 2018;7:12-22

Mills R; Taylor-Weiner H; Correia JC; Agudelo LZ; Allodi I; Kolonelou C; Martinez-Redondo V; Ferreira DMS; Nichterwitz S; Comley LH; Lundin V; Hedlund E; Ruas JL; Teixeira AI
Journal article: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY. 2017;27(4):7218

Gabellini D; Musarò A
Article: ARCHIVES OF TOXICOLOGY. 2017;91(6):2469-2489

Cipriano M; Correia JC; Camoes SP; Oliveira NG; Cruz P; Cruz H; Castro M; Ruas JL; Santos JM; Miranda JP
Article: CELL REPORTS. 2017;18(3):636-646

Ruby MA; Massart J; Hunerdosse DM; Schonke M; Correia JC; Louie SM; Ruas JL; Naslund E; Nomura DK; Zierath JR
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(23):7049-7071

Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Laidinen S; Kokki K; Hynynen H; Yla-Herttuala S; Heinaniemi M; Ruas JL; Tavi P
Article: SCIENTIFIC REPORTS. 2016;6:30928

Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CMP; Bjorkhem I; Ruas JL; Rodrigues E
Article: SCIENCE TRANSLATIONAL MEDICINE. 2016;8(350):350ra103

Salah H; Li M; Cacciani N; Gastaldello S; Ogilvie H; Akkad H; Namuduri AV; Morbidoni V; Artemenko KA; Balogh G; Martinez-Redondo V; Jannig P; Hedstrom Y; Dworkin B; Bergquist J; Ruas J; Vigh L; Salviati L; Larsson L
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(15):4371-4388

Kalamgi RC; Salah H; Gastaldello S; Martinez-Redondo V; Ruas JL; Fury W; Bai Y; Gromada J; Sartori R; Guttridge DC; Sandri M; Larsson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184

Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016;310(10):C836-C840

Schlittler M; Goiny M; Agudelo LZ; Venckunas T; Brazaitis M; Skurvydas A; Kamandulis S; Ruas JL; Erhardt S; Westerblad H; Andersson DC
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(50):15492-15497

Place N; Ivarsson N; Venckunas T; Neyroudard D; Brazaitis M; Cheng AJ; Ochala J; Kamandulis S; Girard S; Volungevicius G; Pauzas H; Mekideche A; Kayser B; Martinez-Redondo V; Ruas JL; Bruton J; Truffert A; Lanner JT; Skurvydas A; Westerblad H
Article: MOLECULAR METABOLISM. 2015;4(12):891-902

Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(44):15756-15761

White JP; Wrann CD; Rao RR; Nair SK; Jedrychowski MP; You J-S; Martinez-Redondo V; Gygi SP; Ruas JL; Hornberger TA; Wu Z; Glass DJ; Piao X; Spiegelman BM
Article: CELL. 2014;159(1):33-45

Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Article: CELL. 2014;157(6):1279-1291

Rao RR; Long JZ; White JP; Svensson KJ; Lou J; Lokurkar I; Jedrychowski MP; Ruas JL; Wrann CD; Lo JC; Camera DM; Lachey J; Gygi S; Seehra J; Hawley JA; Spiegelman BM
Article: MOLECULAR CANCER. 2014;13:54

Aesoy R; Gradin K; Aasrud KS; Hoivik EA; Ruas JL; Poellinger L; Bakke M
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(2):E157-E167

Sczelecki S; Besse-Patin A; Abboud A; Kleiner S; Laznik-Bogoslavski D; Wrann CD; Ruas JL; Haibe-Kains B; Estall JL
Journal article: FASEB JOURNAL. 2013;27(S1):940.18

White J; Ruas J; Rao R; Kleiner S; Wu J; Spiegelman B
Article: CELL. 2012;151(6):1319-1331

Ruas JL; White JP; Rao RR; Kleiner S; Brannan KT; Harrison BC; Greene NP; Wu J; Estall JL; Irving BA; Lanza IR; Rasbach KA; Okutsu M; Nair KS; Yan Z; Leinwand LA; Spiegelman BM
Article: GENES & DEVELOPMENT. 2011;25(12):1232-1244

Lustig Y; Ruas JL; Estall JL; Lo JC; Devarakonda S; Laznik D; Choi JH; Ono H; Olsen JV; Spiegelman BM
Article: CELL METABOLISM. 2011;13(2):160-169

Wu J; Ruas JL; Estall JL; Rasbach KA; Choi JH; Ye L; Bostroem P; Tyra HM; Crawford RW; Campbell KP; Rutkowski DT; Kaufman RJ; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(50):21866-21871

Rasbach KA; Gupta RK; Ruas JL; Wu J; Naseri E; Estall JL; Spiegelman BM
Article: DEVELOPMENT. 2010;137(20):3489-3499

Chakkalakal JV; Nishimune H; Ruas JL; Spiegelman BM; Sanes JR
Article: NATURE. 2010;466(7305):451-456

Choi JH; Banks AS; Estall JL; Kajimura S; Bostroem P; Laznik D; Ruas JL; Chalmers MJ; Kamenecka TM; Blueher M; Griffin PR; Spiegelman BM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(4):2601-2609

Ruas JL; Berchner-Pfannschmidt U; Malik S; Gradin K; Fandrey J; Roeder RG; Pereira T; Poellinger L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22510-22515

Estall JL; Ruas JL; Choi CS; Laznik D; Badman M; Maratos-Flier E; Shulman GI; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(50):21401-21406

Chinsomboon J; Ruas J; Gupta RK; Thom R; Shoag J; Rowe GC; Sawada N; Raghuram S; Arany Z
Article: GENES & DEVELOPMENT. 2008;22(10):1397-1409

Kajimura S; Seale P; Tomaru T; Erdjument-Bromage H; Cooper MP; Ruas JL; Chin S; Tempst P; Lazar MA; Spiegelman BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373

Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
Article: NATURE. 2008;451(7181):1008-1012

Arany Z; Foo S-Y; Ma Y; Ruas JL; Bommi-Reddy A; Girnun G; Cooper M; Laznik D; Chinsomboon J; Rangwala SM; Baek KH; Rosenzweig A; Spiegelman BM
Article: FASEB JOURNAL. 2007;21(8):1821-1830

Ronkainen V-P; Ronkainen JJ; Hannninen SL; Leskinen H; Ruas JL; Pereira T; Poellinger L; Vuolteenaho O; Tavi P
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641

Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
Article: DEVELOPMENTAL CELL. 2005;9(5):617-628

Gustafsson MV; Zheng XW; Pereira T; Gradin K; Jin SB; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
Article: JOURNAL OF CELL SCIENCE. 2005;118(2):301-311

Ruas JL; Poellinger L; Pereira T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):6816-6823

Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(41):38723-38730

Ruas JL; Poellinger L; Pereira T
Article: PHARMACOGENETICS AND GENOMICS. 1997;7(4):333-335

Ruas JL; Lechner MC
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All other publications

Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167373

Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Juhlin CC; von Kriegsheim A; Cao Y; Schlisio S
Preprint: BIORXIV. 2024

Horwath O; Cornet L; Strömlind H; Moberg M; Edman S; Söderlund K; Checa A; Ruas JL; Blomstrand E
Preprint: RESEARCH SQUARE. 2024

Sylow L; Pham TCP; Raun S; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen A; Jannig P; Andersen N; Kruse R; Ali M; Halling J; Ringholm S; Needham E; Hansen S; Lemminger A; Schjerling P; Petersen M; de Almeida M; Jensen T; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski J; Nielsen J; Qvortrup K; Pilegaard H; Richter E
Preprint: BIORXIV. 2023

Pham TCP; Raun SH; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig P; Andersen NR; Kruse R; Ali MS; Halling JF; Ringholm S; Needham E; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
Preprint: BIORXIV. 2023

Wadsworth B; Leiwe M; Minogue E; Cunha P; Engman V; Brombach C; Asvestis C; Sah-Teli S; Marklund E; Koivunen P; Ruas J; Rundqvist H; Lanner J; Johnson R
Preprint: BIORXIV. 2023;BIORXIV

Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Præstholm SM; Dumont K; Liu Z; Liang Q; Edsgärd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Yeo GW; Ruas JL
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:839

Jude B; Chibalin A; Ducommun S; Zierath J; Von Walden F; Ruas J; Krook A; Lanner J
Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:S741

Praestholm SM; Correia J; Ruas J
Conference publication: ACTA PHYSIOLOGICA. 2023;239

Jude B; Tagadirt L; Santos-Alves E; Mader T; Chibalin AV; Ducommun S; Zierath JR; Von Walden F; Krook A; Ruas JL; Lanner JT
Conference publication: TOXICOLOGY LETTERS. 2023;384:S188

Saraiva Rodrigues J; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2023;79:85

Ruas JL
Conference publication: ACTA PHYSIOLOGICA. 2023;239

Ruas J
Conference publication: WOUND REPAIR AND REGENERATION. 2023;31:S19

Rodrigues JS; Faria-Pereira A; Camoes SP; Serras AS; Jannig PR; Morais VA; Ruas JL; Miranda JP
Corrigendum: NATURE METABOLISM. 2022;4(10):1421

Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Conference publication: FASEB JOURNAL. 2022;36

Addinsall AB; Cacciani N; Akkad H; Moruzzi N; Maestri A; Shevchenko G; Bergquist J; Ruas J; Larsson L
Editorial comment: CELL. 2022;185(8):1444-1444.e1

Jannig PR; Dumesic PA; Spiegelman BM; Ruas JL
Preprint: BIORXIV. 2022

Oehler D; Spychala A; Gödecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Preprint: SSRN ELECTRONIC JOURNAL. 2022

Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Petropoulos S; Chen X; Ruas JL; Wu J; Deng Q
Conference publication: FEBS OPEN BIO. 2022;12:34

Ruas J
Review: TRENDS IN MOLECULAR MEDICINE. 2021;27(10):946-954

Joisten N; Ruas JL; Braidy N; Guillemin GJ; Zimmer P
Preprint: BIORXIV. 2021

Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Svaikovskaya D; Zhengye L; Cervenka I; Oliveira M; Nijssen J; Martínez-Redondo V; Stec M; Khan N; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3582

Oehler D; Goedecke A; Spychala A; Lai K; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
Editorial comment: SCIENCE. 2020;368(6490):470-471

Correia JC; Ruas JL
Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2020;318(5):C818-C830

Martin KS; Azzolin M; Ruas JL
Preprint: BIORXIV. 2019

Léveillé M; Besse-Patin A; Jouvet N; Gunes A; Jeromson S; Khan NP; Sczelecki S; Baldwin C; Dumouchel A; Correia J; Jannig P; Boulais J; Ruas JL; Estall JL
Conference publication: TOXICOLOGY LETTERS. 2019;314:S288

Rodrigues JS; Cipriano M; Correia J; Camoes SP; Oliveira N; Castro M; Ruas J; Miranda J
Review: SCIENCE. 2017;357(6349):eaaf9794

Cervenka I; Agudelo LZ; Ruas JL
Editorial comment: ACTA PHYSIOLOGICA. 2017;219(1):14-16

Jannig PR; Ruas JL
Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17

Chaillou T; Hynynen H; Ferreira D; Pironti G; Andersson D; Ruas J; Tavi P; Lanner J
Book chapter: HORMONES, METABOLISM AND THE BENEFITS OF EXERCISE: RESEARCH AND PERSPECTIVES IN ENDOCRINE INTERACTIONS. 2017;p. 83-91

Valente-Silva P; Ruas JL
Conference publication: ACTA PHYSIOLOGICA. 2017;219:20

Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Hynynen H; Laidinen S; Yla-Herttuala S; Heinaniemi M; Ruas J; Tavi P
Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186

Chaillou T; Hynynen H; Ferreira D; Pironti G; Kenne E; Andersson DC; Ruas JL; Tavi P; Lanner JT
Letter: ACTA NEUROPSYCHIATRICA. 2016;28(4):244-245

Zepf FD; Stewart RM; Guillemin GJ; Ruas JL
Review: DIABETOLOGIA. 2015;58(9):1969-1977

Martinez-Redondo V; Pettersson AT; Ruas JL
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2015;26(6):305-314

Correia JC; Ferreira DMS; Ruas JL
Conference publication: DIABETOLOGIA. 2015;58:S300

Mudry JM; Ruas JL; Erhardt S; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
Corrigendum: CELL. 2015;160(1-2):351

Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson A; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009;29(7):E16-E17

Arany ZP; Foo S-Y; Chinsomboon J; Girnun G; Cooper M; Ruas J; Bommi-Reddy A; Rangwala S; Baek KH; Rosenzweig A; Spiegelman B
Review: CURRENT OPINION IN LIPIDOLOGY. 2007;18(5):508-514

Ruas JL; Lendahl U; Poellinger L
Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2005;16(4-5):514-522

Ruas JL; Poellinger L
Doctoral thesis: 2005

Ruas JL
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Grants

Regulation of Adipose Tissue Function by Neuroendocrine Communication
Novo Nordisk Foundation
1 October 2023 - 30 September 2024
Um outro olhar para a prescrição do exercício: Exercício a diferentes horas do dia e o ciclo circadiano em pessoas com diabetes tipo 2 e aqueles que se encontram em risco
Fundação para a Ciência e Tecnologia
1 March 2023 - 28 February 2025
Swedish Research Council
1 January 2023 - 31 December 2026
Regulation of Adipose Tissue Neuroendocrine Communication by Kynurenine Metabolites
Novo Nordisk Foundation
1 October 2021 - 30 September 2023
T.R.A.I.N., a novel target in Non-Alcoholic Fatty Liver Disease (NAFLD): Disease Mechanisms, Biomarkers, and Therapeutics.
Novo Nordisk Foundation
1 July 2019 - 30 June 2024
Research Institute for Medicines
Fundação para a Ciência e Tecnologia
1 January 2019 - 31 December 2019
PGC-1alpha Isoforms as novel Therapeutic targets in ParkinsON's Disease
Fundação para a Ciência e Tecnologia
1 August 2018 - 31 July 2022
Swedish Research Council
1 January 2017 - 31 December 2022
Molecular Mechanisms Regulating Skeletal Muscle Function and their Systemic Impact
Novo Nordisk Foundation
1 January 2017 - 1 January 2020
Swedish Research Council
1 January 2016 - 31 December 2019
Swedish Research Council
1 January 2015 - 31 December 2018
Japan Society for the Promotion of Science
1 January 2015 - 31 December 2017
Modeling information flow between tissues during metabolic adaptation and dysfunction
International Human Frontier Science Program Organization
1 May 2014 - 30 April 2017
Mechanisms of Skeletal Muscle Adaptations to Exercise
Novo Nordisk Foundation
19 March 2012 - 18 March 2017
Swedish Research Council
1 January 2011 - 31 December 2014
Swedish Research Council
1 January 2011 - 31 December 2014
MECHANISM OF HYPOXIA DEPENDENT TRANSCRIPTION ACTIVATION MEDIATED BY THE HYPOXIA-INDUCIBLE FACTOR-1
Fundação para a Ciência e Tecnologia
1 July 1999 - 30 June 2003
STUDY OF THE POLYMORPHISM OF THE CYP2AG AND CYP2C19 GENES IN PORTUGUESE POPULATIONS.
Fundação para a Ciência e Tecnologia
1 August 1996 - 31 July 1998

Employments

Professor, Department of Physiology and Pharmacology, ̽��ѡ, 2020-

Degrees and Education

Docent, ̽��ѡ, 2016
Doctor Of Philosophy, Department of Cell and Molecular Biology, ̽��ѡ, 2005
Pharm.D., University of Lisbon, 1995

Visiting research fellowships

Postdoc, Harvard Medical School, Postdoc in Molecular Muscle Physiology, 2006-2011

̽��ѡ

About me

Research

Teaching

Articles

All other publications

Grants

Employments

Degrees and Education

Visiting research fellowships

News from KI

Events from KI

̽����ѡ

Jorge Ruas

About me

Research

Teaching

Articles

All other publications

Grants

Employments

Degrees and Education

Visiting research fellowships

News from KI

Events from KI

̽��ѡ