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Ismael Valladolid Acebes

Ismael Valladolid Acebes

Research Specialist
Visiting address: Anna Steckséns gata 53, 17176 Stockholm
Postal address: K1 Molekylär medicin och kirurgi, K1 MMK Signaltransduktion, 171 76 Stockholm

About me

  • As a leading researcher at ̽»¨¾«Ñ¡, I specialize in the complex signal transduction mechanisms of pancreatic beta-cells, a critical area for diabetes research. My work focuses on how glucose metabolism influences insulin secretion and how various receptor-operated signaling pathways maintain beta-cell function under physiological conditions. This research contributes to novel therapeutic strategies aimed at improving insulin regulation in diabetes. Collaborating with international labs, I am committed to advancing our understanding of cellular signaling in diabetes, fostering innovation, and contributing to the pharmaceutical industry’s search for effective treatments.

Research

  • My research interests center on the molecular pathways governing pancreatic beta-cell function, particularly in the context of diabetes. I explore how intracellular signaling networks influence beta-cell survival, proliferation, and insulin secretion, with a strong emphasis on understanding metabolic and environmental stressors that contribute to beta-cell dysfunction. By combining preclinical models, translational approaches, and clinical insights, my work aims to uncover novel therapeutic targets for diabetes treatment. I collaborate with leading international laboratories to bridge the gap between basic science and clinical application, focusing on innovative strategies to enhance insulin sensitivity and beta-cell regeneration. My research offers a unique opportunity to accelerate the development of cutting-edge therapies that could transform the treatment of diabetes and benefit the pharmaceutical industry.

Teaching

  • As a passionate educator in the fields of obesity, diabetes, and neuroscience, my teaching philosophy centers on integrating cutting-edge research with practical applications to enhance student learning. I strive to create an engaging and dynamic learning environment where students can explore the complex interplay between metabolic disorders and neurological processes.

     

    In my courses, I emphasize the importance of understanding the biological mechanisms underlying obesity and diabetes, and how these conditions intersect with neurological health. By incorporating the latest scientific advancements and real-world case studies, I aim to provide students with a comprehensive understanding of these critical areas. My approach is to foster critical thinking and encourage students to apply theoretical knowledge to practical problems, preparing them for careers in research, clinical practice, and beyond.

     

    Through interactive lectures, hands-on experiments, and collaborative projects, I guide students in exploring the multifaceted nature of obesity and diabetes. My goal is to empower them with the skills and knowledge needed to contribute meaningfully to this evolving field. I am committed to mentoring students and supporting their academic and professional growth, helping them to develop a deep and nuanced understanding of the complex interactions between metabolic and neurological health.

     

    By staying at the forefront of research and continuously updating my teaching materials, I ensure that students receive the most relevant and impactful education. My dedication to these subjects reflects my belief in their importance for advancing scientific knowledge and improving public health outcomes.

Articles

  • Journal article: BIOMEDICINES. 2024;12(11):2422
    Valladolid-Acebes I
  • Journal article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2024;12:1380564
    Lipovsek S; Dolensek J; Daris B; Valladolid-Acebes I; Vajs T; Leitinger G; Stozer A; Skelin Klemen M
  • Article: CELLULAR SIGNALLING. 2023;102:110535
    Ma J; Liu Y; Valladolid-Acebes I; Recio-Lopez P; Peng G; Li J; Berggren P-O; Juntti-Berggren L; Tong N
  • Article: BIOFACTORS. 2023;49(1):153-172
    Recio-Lopez P; Valladolid-Acebes I; Hadwiger P; Hossbach M; Krampert M; Prata C; Berggren P-O; Juntti-Berggren L
  • Article: LIFE SCIENCE ALLIANCE. 2022;5(12):e202201505
    Moruzzi N; Valladolid-Acebes I; Kannabiran SA; Bulgaro S; Burtscher I; Leibiger B; Leibiger IB; Berggren P-O; Brismar K
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;23(1):62
    Recio-Lopez P; Valladolid-Acebes I; Berggren P-O; Juntti-Berggren L
  • Article: SCIENCE ADVANCES. 2021;7(30):eabg5733
    Adori C; Daraio T; Kuiper R; Barde S; Horvathova L; Yoshitake T; Ihnatko R; Valladolid-Acebes I; Vercruysse P; Wellendorf AM; Gramignoli R; Bozoky B; Kehr J; Theodorsson E; Cancelas JA; Mravec B; Jorns C; Ellis E; Mulder J; Uhlen M; Bark C; Hokfelt T
  • Article: ANTIOXIDANTS. 2021;10(7):1070
    Dallner G; Bentinger M; Hussain S; Sinha I; Yang J; Schwank-Xu C; Zheng X; Swiezewska E; Brismar K; Valladolid-Acebes I; Tekle M
  • Article: METABOLITES. 2021;11(6):387
    Leibiger B; Moede T; Valladolid-Acebes I; Paschen M; Visa M; Leibiger IB; Berggren P-O
  • Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2021;25(10):4800-4813
    Moruzzi N; Lazzeri-Barcelo F; Valladolid-Acebes I; Moede T; Paschen M; Leibiger B; Berggren P-O; Leibiger IB
  • Article: SCIENCE ADVANCES. 2021;7(11):eabc2931
    Valladolid-Acebes I; Avall K; Recio-Lopez P; Moruzzi N; Bryzgalova G; Bjornholm M; Krook A; Alonso EF; Ericsson M; Landfors F; Nilsson SK; Berggren P-O; Juntti-Berggren L
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(4):1813
    Mir-Coll J; Moede T; Paschen M; Neelakandhan A; Valladolid-Acebes I; Leibiger B; Biernath A; Ammala C; Leibiger IB; Yesildag B; Berggren P-O
  • Article: NEUROPHARMACOLOGY. 2020;170:108070
    Narvaez M; Andrade-Talavera Y; Valladolid-Acebes I; Fredriksson M; Siegele P; Hernandez-Sosa A; Fisahn A; Fuxe K; Borroto-Escuela DO
  • Article: ROYAL SOCIETY OPEN SCIENCE. 2020;7(1):191171
    Grubelnik V; Markovic R; Lipovsek S; Leitinger G; Gosak M; Dolensek J; Valladolid-Acebes I; Berggren P-O; Stozer A; Perc M; Marhl M
  • Article: FASEB JOURNAL. 2019;33(1):204-218
    Paschen M; Moede T; Valladolid-Acebes I; Leibiger B; Moruzzi N; Jacob S; Garcia-Prieto CF; Brismar K; Leibiger IB; Berggren P-O
  • Article: DIABETOLOGIA. 2019;62(1):123-135
    Sevillano J; Gracia Sanchez-Alonso M; Zapateria B; Calderon M; Alcala M; Limones M; Pita J; Gramage E; Vicente-Rodriguez M; Horrillo D; Medina-Gomez G; Jesus Obregon M; Viana M; Valladolid-Acebes I; Herradon G; Pilar Ramos-Alvarez M
  • Article: NEUROSCIENCE LETTERS. 2018;674:75-80
    Daraio T; Valladolid-Acebes I; Brismar K; Bark C
  • Article: SCIENTIFIC REPORTS. 2017;7(1):7744
    Daraio T; Bombek LK; Gosak M; Valladolid-Acebes I; Klemen MS; Refai E; Berggren P-O; Brismar K; Rupnik MS; Bark C
  • Article: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2017;29(1):13-26
    Al-Qahtani SM; Bryzgalova G; Valladolid-Acebes I; Korach-Andre M; Dahlman-Wright K; Efendic S; Berggren P-O; Portwood N
  • Article: EUROPEAN JOURNAL OF NUTRITION. 2016;55(4):1615-1622
    Ibias J; Miguens M; del Rio D; Valladolid-Acebes I; Stucchi P; Ambrosio E; Martin M; Morales L; Ruiz-Gayo M; Del Olmo N
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(31):E4326-E4335
    Valladolid-Acebes I; Daraio T; Brismar K; Harkany T; Oegren SO; Hoekfelt TGM; Bark C
  • Article: NEUROREPORT. 2014;25(11):819-822
    Cano V; Valladolid-Acebes I; Hernández-Nuño F; Merino B; Del Olmo N; Chowen JA; Ruiz-Gayo M
  • Article: NEUROBIOLOGY OF LEARNING AND MEMORY. 2013;106:18-25
    Valladolid-Acebes I; Fole A; Martín M; Morales L; Cano MV; Ruiz-Gayo M; Del Olmo N
  • Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2012;302(4):E396-E402
    Valladolid-Acebes I; Merino B; Principato A; Fole A; Barbas C; Lorenzo MP; García A; Del Olmo N; Ruiz-Gayo M; Cano V
  • Article: ENDOCRINOLOGY. 2012;153(2):690-699
    Stucchi P; Gil-Ortega M; Merino B; Guzmán-Ruiz R; Cano V; Valladolid-Acebes I; Somoza B; Le Gonidec S; Argente J; Valet P; Chowen JA; Fernández-Alfonso M; Ruiz-Gayo M
  • Article: PLOS ONE. 2012;7(5):e36139
    Morales L; Del Olmo N; Valladolid-Acebes I; Fole A; Cano V; Merino B; Stucchi P; Ruggieri D; López L; Alguacil LF; Ruiz-Gayo M
  • Article: NEUROBIOLOGY OF LEARNING AND MEMORY. 2011;95(1):80-85
    Valladolid-Acebes I; Stucchi P; Cano V; Fernández-Alfonso MS; Merino B; Gil-Ortega M; Fole A; Morales L; Ruiz-Gayo M; Del Olmo N
  • Show more

All other publications

  • Conference publication: ACTA PHYSIOLOGICA. 2024;240:26-27
    Dolensek J; Klemen MS; Kopecky J; Paradiz E; Kercmar LJ; Bombek LK; Pohorec V; Rupnik MS; Valladolid-Acebes I; Stozer A
  • Review: SEMINARS IN LIVER DISEASE. 2023;43(02):149-162
    Adori M; Bhat S; Gramignoli R; Valladolid-Acebes I; Bengtsson T; Uhlen M; Adori C
  • Conference publication: DIABETOLOGIA. 2023;66(SUPPL 1):S220-S221
    Ballesteros-Pla C; Sevillano J; Sanchez-Alonso M; Limones M; Pita J; Pizarro Delgado J; Izquierdo A; Gomez GM; Valladolid-Acebes I; Herradon G; Alvarez MR
  • Book chapter: ELECTRON MICROSCOPY. 2022;p.
    Skelin Klemen M; Dolenšek J; Valladolid-Acebes I; Stožer A; Lipovšek S
  • Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(2):932
    Valladolid-Acebes I; Berggren P-O; Juntti-Berggren L
  • Conference publication: DIABETOLOGIA. 2021;64(SUPPL 1):96-97
    Recio-Lopez P; Berggren P-O; Juntti-Berggren L; Valladolid-Acebes I
  • Book chapter: CO-IMMUNOPRECIPITATION METHODS FOR BRAIN TISSUE: NEUROMETHODS. 2019;p. 123-135
    Borroto-Escuela DO; Narvaez M; Zannoni M; Contri C; Crespo-Ramírez M; di Palma M; Ambrogini P; Borroto-Escuela DY; Brito I; Pita-Rodríguez M; Valladolid-Acebes I; de la Mora MP; Fuxe K
  • Conference publication: DIABETOLOGIA. 2019;62:S122
    Moruzzi N; Valladolid-Acebes I; Paschen M; Moede T; Leibiger B; Berggren P-O; Leibiger IB
  • Conference publication: DIABETOLOGIA. 2019;62:S71-S72
    Valladolid-Acebes I; Recio-Lopez P; Berggren P-O; Juntti-Berggren L
  • Conference publication: DIABETOLOGIA. 2019;62:S293-S294
    Recio-Lopez P; Berggren P-O; Juntti-Berggren L; Valladolid-Acebes I
  • Book chapter: RECEPTOR-RECEPTOR INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM: NEUROMETHODS. 2018;p. 15-23
    Narvaez M; Corrales F; Brito I; Valladolid-Acebes I; Fuxe K; Borroto-Escuela DO
  • Book chapter: RECEPTOR-RECEPTOR INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM: NEUROMETHODS. 2018;p. 299-315
    Borroto-Escuela DO; Narvaez M; Valladolid-Acebes I; Shumilov K; Di Palma M; Wydra K; Schaefer T; Reyes-Resina I; Navarro G; Mudó G; Filip M; Sartini S; Friedland K; Schellekens H; Beggiato S; Ferraro L; Tanganelli S; Franco R; Belluardo N; Ambrogini P; Pérez de la Mora M; Fuxe K
  • Book chapter: RECEPTOR-RECEPTOR INTERACTIONS IN THE CENTRAL NERVOUS SYSTEM: NEUROMETHODS. 2018;p. 283-298
    Brito I; Narvaez M; Savelli D; Shumilov K; Di Palma M; Sartini S; Skieterska K; Van Craenenbroeck K; Valladolid-Acebes I; Zaldivar-Oro R; Filip M; Cuppini R; Rivera A; Liu F; Ambrogini P; Pérez de la Mora M; Fuxe K; Borroto-Escuela DO
  • Conference publication: ACTA PHYSIOLOGICA. 2017;221:82
    Dolensek J; Valladolid-Acebes I; Gosak M; Klemen MS; Bombek LK; Pohorec V; Berggren PO; Brismar K; Stozer A; Rupnik MS
  • Conference publication: ACTA PHYSIOLOGICA. 2017;221:14
    Daraio T; Bombek LK; Gosak M; Valladolid-Acebes I; Klemen MS; Refai E; Berggren PO; Brismar K; Rupnik MS; Bark C
  • Editorial comment: ADIPOCYTE. 2016;5(3):318-325
    Valladolid-Acebes I; Daraio T; Brismar K; Hokfelt T; Bark C
  • Conference publication: DIABETOLOGIA. 2015;58:S293-S294
    Ansurudeen I; Daraio T; Kolonelou C; Bark C; Brismar K; Valladolid-Acebes I
  • Conference publication: ACTA PHYSIOLOGICA. 2014;211:69
    Valladolid-Acebes I; Daraio T; Brismar K; Ogren SO; Hokfelt T; Bark IC

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