探花精选

Isabelle Magalhaes

Isabelle Magalhaes

Affiliated to Research | Docent
Visiting address: NEO Medicinaren 25, HERM plan 7, H盲lsov盲gen 7C (lastkaj), 14157 Hudding
Postal address: H7 Medicin, Huddinge, H7 Hematologi Uhlin Magalhaes, 171 77 Stockholm
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About me

  • Associate professor (Docent) in Immunology, 探花精选.
    Since March 2024, Team leader, 探花精选, Dept. of Medicine Huddinge, Center for Hematology and Regenerative Medicine (HERM).

    February 2023-February 2024, Team leader, 探花精选, Dept. of Clinical Science, Intervention and Technology.
    April 2019 - January 2023, Senior researcher, deputy group leader, Karolinska 

  • Institutet, Dept. of Oncology Pathology.

    April 2015 - March 2019, Assistant professor, 探花精选, Dept. of  

  • Oncology Pathology.
    September 2013 - March 2015, Postdoctoral fellow, U1016 INSERM, Institut  
  • Cochin, Dept. of Endocrinology, Metabolism and Diabetes (Paris, France).
    September 2010 - August 2013, Researcher, Karolinska University Hospital 
  • Huddinge &
  • 探花精选, Dept. of Laboratory Medicine.

    June 2009 - August 2010, Postdoctoral fellow, 探花精选, Dept. of Microbiology, Tumor and Cell Biology.
    2005-2009, PhD in Immunobiology, 探花精选, Dept. of 

  • Microbiology, Tumor and Cellular Biology.

    Thesis title: 鈥/CD8alpha/alpha+ T-cells and Immune Memory/鈥.

  • isAllowed=y
    2002, Master in Immunology (Dipl么me d鈥櫭﹖udes approfondies), Paris VII 
  • University &
  • Institut Pasteur (Paris, France).
    2000, Bachelor in Cellular Biology and Physiology, Rennes II University (Rennes, France).

Research

  • My goal is to contribute to the improvement of chimeric antigen receptor 

  • (CAR) T cell therapy for the treatment of cancer. Our group is working on the  
  • development of mesothelin (MSLN) CAR T cell therapy for the treatment of 
  • ovarian cancer. A preclinical model of orthotopic ovarian cancer in mice has 
  • been established in our group, which allows to test /in vivo/ the antitumor 
  • efficacy of MSLN CAR T cells.


    Recent publications:
    Schoutrop E, Poiret T, El-Serafi I, Zhao Y, He R, Moter A, Henriksson J,  

  • Hassan M, Magalhaes I*, Mattsson J*. Tuned activation of MSLN-CAR T cells
    induces superior antitumor responses in ovarian cancer models. [1]J 
  • Immunother Cancer. 2023 Feb
  • 11(2). doi: 10.1136/jitc-2022-005691.


    Schoutrop E, Moyano-Galceran L, Lheureux S, Mattsson J, Lehti K, Dahlstrand 

  • H, Magalhaes I. Molecular, cellular and systemic aspects of epithelial
    ovarian cancer and its tumor microenvironment. [2]Semin Cancer Biol. 2022 
  • Nov
  • 86(Pt 3):207-223. doi: 10.1016/j.semcancer.2022.03.027.


    Schoutrop E, Renken S, Micallef Nilsson I, Hahn P, Poiret T, Kiessling R,  

  • Wickstr枚m SL, Mattsson J, Magalhaes I. Trogocytosis and fratricide killing
    impede MSLN-directed CAR T cell functionality. 
  • [3]Oncoimmunology. 2022
  • 11(1):2093426. doi: 10.1080/2162402X.2022.2093426.


    Renken S, Nakajima T, Magalhaes I, Mattsson J, Lundqvist A, Arn茅r ESJ,  

  • Kiessling R, Wickstr枚m SL. Targeting of Nrf2 improves antitumoral responses
    by human NK cells, TIL and CAR T cells during oxidative stress. [4]J 
  • Immunother Cancer. 2022 Jun
  • 10(6). doi: 10.1136/jitc-2021-004458.


    Schoutrop E, El-Serafi I, Poiret T, Zhao Y, Gultekin O, He R, Moyano-Galceran 

  • L, Carlson JW, Lehti K, Hassan M, Magalhaes I*, Mattsson 
  • J*. Mesothelin-Specific CAR T Cells Target Ovarian Cancer. [5]Cancer 
  • Res. 2021 Jun 1
  • 81(11):3022-3035. doi: 10.1158/0008-5472.CAN-20-2701.


    Magalhaes I, Fernebro J, Abd Own S, Glaessgen D, Corvigno S, Remberger M,  

  • Mattsson J, Dahlstrand H. Mesothelin Expression in Patients with High-Grade 
  • Serous Ovarian Cancer Does Not Predict Clinical Outcome But Correlates with 
  • CD11c+ Expression in Tumor. [6]Adv Ther. 2020 Dec
  • 37(12):5023-5031. doi: 
  • 10.1007/s12325-020-01520-w.


    [1]
    [2]
    [3]
    [4]
    [5]
    [6]

Teaching

  • I organize since 2016 the /Antigen Presentation and T Cell Activation/ 

  • doctoral course (探花精选 #5739).

Articles

  • Journal article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2024;73(9):163
    El-Serafi I; Nilsson IM; Moter A; Duan Z; Mattsson J; Magalhaes I
  • Article: JOURNAL OF TRANSLATIONAL MEDICINE. 2024;22(1):273
    Poiret T; Vikberg S; Schoutrop E; Mattsson J; Magalhaes I
  • Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2023;11(2):e005691
    Schoutrop E; Poiret T; El-Serafi I; Zhao Y; He R; Moter A; Henriksson J; Hassan M; Magalhaes I; Mattsson J
  • Article: ONCOIMMUNOLOGY. 2022;11(1):2093426
    Schoutrop E; Renken S; Micallef Nilsson I; Hahn P; Poiret T; Kiessling R; Wickstrom SL; Mattsson J; Magalhaes I
  • Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):207-223
    Schoutrop E; Moyano-Galceran L; Lheureux S; Mattsson J; Lehti K; Dahlstrand H; Magalhaes I
  • Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2022;10(6):e004458
    Renken S; Nakajima T; Magalhaes I; Mattsson J; Lundqvist A; Arner ESJ; Kiessling R; Wickstrom SL
  • Article: CANCER RESEARCH. 2021;81(11):3022-3035
    Schoutrop E; El-Serafi I; Poiret T; Zhao Y; Gultekin O; He R; Moyano-Galceran L; Carlson JW; Lehti K; Hassan M; Magalhaes I; Mattsson J
  • Article: ADVANCES IN THERAPY. 2020;37(12):5023-5031
    Magalhaes I; Fernebro J; Abd Own S; Glaessgen D; Corvigno S; Remberger M; Mattsson J; Dahlstrand H
  • Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1300
    Solders M; Gorchs L; Tiblad E; Gidlof S; Leeansyah E; Dias J; Sandberg JK; Magalhaes I; Lundell A-C; Kaipe H
  • Article: ONCOIMMUNOLOGY. 2019;8(2):e1535730
    Radestad E; Klynning C; Stikvoort A; Mogensen O; Nava S; Magalhaes I; Uhlin M
  • Article: CYTOTHERAPY. 2018;20(7):941-951
    Alnabhan R; Gaballa A; Mork L-M; Mattsson J; Uhlin M; Magalhaes I
  • Article: JOURNAL OF IMMUNOTHERAPY. 2018;41(2):73-83
    Magalhaes I; Kalland I; Kochenderfer JN; Osterborg A; Uhlin M; Mattsson J
  • Article: CLINICAL TRANSPLANTATION. 2017;31(8)
    Magalhaes I; Uhlin M; Schaffer M; Sundin M; Hauzenberger D; Remberger M; Mattsson J
  • Article: SCIENTIFIC REPORTS. 2017;7(1):6123
    Solders M; Gorchs L; Erkers T; Lundell A-C; Nava S; Gidlof S; Tiblad E; Magalhaes I; Kaipe H
  • Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2017;59:29-36
    Rane L; Rahman S; Magalhaes I; Ambati A; Andersson J; Zumla A; Brighenti S; Maeurer MJ
  • Article: JOURNAL OF IMMUNOTHERAPY. 2017;40(4):132-139
    Omazic B; Ayoglu B; Lohr M; Segersvard R; Verbeke C; Magalhaes I; Potacova Z; Mattsson J; Terman A; Ghazi S; Albiin N; Kartalis N; Nilsson P; Poiret T; Liu Z; Heuchel R; Schwenk JM; Permert J; Maeurer MJ; Ringden O
  • Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1861
    Solders M; Erkers T; Gorchs L; Poiret T; Remberger M; Magalhaes I; Kaipe H
  • Article: ONCOTARGET. 2016;7(46):74686-74700
    Misra S; Selvam AK; Wallenberg M; Ambati A; Matolcsy A; Magalhaes I; Lauter G; Bjornstedt M
  • Article: ONCOTARGET. 2016;7(21):30230-30240
    Li Q; Rane L; Poiret T; Zou J; Magalhaes I; Ahmed R; Du Z; Vudattu N; Meng Q; Gustafsson-Jernberg A; Winiarski J; Ringden O; Maeurer M; Remberger M; Ernberg I
  • Article: IMMUNOLOGY. 2015;145(3):357-366
    Ambati A; Valentini D; Montomoli E; Lapini G; Biuso F; Wenschuh H; Magalhaes I; Maeurer M
  • Show more

All other publications

  • Preprint: BIORXIV. 2024
    Mihai IS; Selinger M; Boucheron N; Forsell M; Magalhaes I; Trygg J; Henriksson J
  • Review: METHODS IN MOLECULAR BIOLOGY. 2020;2098:3-21
    Magalhaes I; Solders M; Kaipe H
  • Review: EXPERT OPINION ON BIOLOGICAL THERAPY. 2019;19(8):811-827
    Magalhaes I; Carvalho-Queiroz C; Hartana CA; Kaiser A; Lukic A; Mints M; Nilsson O; Gr枚nlund H; Mattsson J; Berglund S
  • Review: IMMUNOTHERAPY. 2019;11(4):335-345
    Schurich A; Magalhaes I; Mattsson J
  • Review: FRONTIERS IN IMMUNOLOGY. 2019;10:2309
    Magalhaes I; Yogev O; Mattsson J; Schurich A
  • Review: EXPERT OPINION ON BIOLOGICAL THERAPY. 2017;17(6):691-699
    Berglund S; Magalhaes I; Gaballa A; Vanherberghen B; Uhlin M
  • Other: MEDECINE/SCIENCES. 2015;31(8-9):717-719
    Magalhaes I; Lehuen A
  • Letter: TRANSPLANTATION. 2014;98(12):e95-e96
    Maeurer M; Magalhaes I; Andersson J; Ljungman P; Sandholm E; Uhlin M; Mattsson J; Ringden O
  • Review: CURRENT OPINION IN IMMUNOLOGY. 2014;27:83-88
    Ghazarian L; Simoni Y; Magalhaes I; Lehuen A
  • Other: EUROPEAN JOURNAL OF IMMUNOLOGY. 2010;40(5):1228-1231
    Parida SK; Magalhaes I; Dubois P; Janetzki S
  • Thesis / dissertation: 2009
    Magalhaes, Isabelle
  • Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S116-S117
    Vudattu N; Magalhaes I; Ahmed R; Schmidt M; Khademi M; Olsson T; Maeurer M
  • Meeting abstract: JOURNAL OF IMMUNOTHERAPY. 2005;28(6):632
    Magalhaes I; Vudattu NK; Karbach J; Juelch M; Castelli C; Jaeger E; Maeurer M
  • Meeting abstract: JOURNAL OF IMMUNOTHERAPY. 2005;28(6):626-627
    Vudattu NK; Magalhaes I; Schmidt M; Maeurer M

Employments

  • Affiliated to Research, Department of Medicine, Huddinge, 探花精选, 2024-2026

Degrees and Education

  • Docent, 探花精选, 2021
  • Degree Of Doctor Of Philosophy, Department of Microbiology, Tumor and Cell Biology, 探花精选, 2009

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