̽ѡ

Ingemar Björkhem

Ingemar Björkhem

Professor Emeritus/Emerita | Docent
Visiting address: Blickagången 6, 14157 Huddinge
Postal address: H5 Laboratoriemedicin, H5 BCM Daniel Hagey, 141 52 Huddinge
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About me

  • I got my education at the Karolinska Institute and have had positions as
    professor of “biochemical research on atherosclerosis” and senior
    physicican in Clinical Chemistry during the years 1986-2008. I am senior
    professor at the division of clinical chemistry, department of laboratory
    medicine, at the Karolinska University Hospital Huddinge since 2012. At
    present I work about 70% with research.
    1986. Adolf Windaus prize for ”Outstanding contributions in the field of
    bile acid research”, Freiburg, Germany
  • 1993. Honorary Professor,
    Institute of Microcirculation, Chinese Academy of Medical Sciences,
    Beijing, China
  • 1996. Astrup Legat, Copenhagen
  • 2008. Honorary Professor
    University of Qindau and University of Taian, China
  • 2000. Member of the
    Norwegian Academy of Science
  • 2000. Doctor medicinae honoris causa,
    University of Oslo
  • 2006. The Schroepfer Award
  • 2006. Selected to held the
    “Nikkilä Memorial lecture”
  • 2008. Selected to held the “Turner
    Lecture” , Chicago
  • Member of the Nobel Assembly 1989-2008.

Research

  • I have worked on different aspects of cholesterol since 1963 when I started
    my PhD studies. In particular I have been involved in the elucidation of the
    mechanisms and regulation of the enzymes involved in the degradation of
    cholesterol into bile acids. During the last two decades I have focused on
    the regulatory mechanisms behind cholesterol homeostasis in the brain, and in
    particular the role of oxysterols. We made the key discovery that side-chain
    oxidized oxysterols , in contrats to cholesterol, are able to pass the
    blood-brain barrier. We have shown that these oxysterols are important for
    regulation of cholesterol synthesis, glucose uptake by the brain, generation
    of beta amyloid and several other processes. We utilize unique mouse models
    as well as clinical materials in our research involving collaborations with
    different clinical disciplines.

Articles

  • Article: GLIA. 2023;71(6):1414-1428
    Alanko V; Gaminde-Blasco A; Quintela-Lopez T; Loera-Valencia R; Solomon A; Bjorkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Sandebring-Matton A
  • Article: BRAIN SCIENCES. 2022;12(11):1450
    Porru E; Edstrom E; Arvidsson L; Elmi-Terander A; Fletcher-Sandersjoo A; Sandblom AL; Hansson M; Duell F; Bjorkhem I
  • Article: MOLECULAR NEUROBIOLOGY. 2021;58(12):6063-6076
    Loera-Valencia R; Ismail M-A; Goikolea J; Lodeiro M; Mateos L; Bjorkhem I; Puerta E; Romao MA; Gomes CM; Merino-Serrais P; Maioli S; Cedazo-Minguez A
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3194-3204
    Parrado-Fernandez C; Leoni V; Saeed A; Rodriguez-Rodriguez P; Sandebring-Matton A; Cordoba-Beldad CM; Bueno P; Gali CC; Panzenboeck U; Cedazo-Minguez A; Bjorkhem I
  • Article: ALZHEIMER'S RESEARCH AND THERAPY. 2021;13(1):56
    Sandebring-Matton A; Goikolea J; Bjorkhem I; Paternain L; Kemppainen N; Laatikainen T; Ngandu T; Rinne J; Soininen H; Cedazo-Minguez A; Solomon A; Kivipelto M
  • Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2021;206:105794
    Abdel-Khalik J; Hearn T; Dickson AL; Crick PJ; Yutuc E; Austin-Muttitt K; Bigger BW; Morris AA; Shackleton CH; Clayton PT; Iida T; Sircar R; Rohatgi R; Marschall H-U; Sjovall J; Bjorkhem I; Mullins JGL; Griffiths WJ; Wang Y
  • Article: JOURNAL OF LIPID RESEARCH. 2021;62:100065
    Pedrelli M; Parini P; Kindberg J; Arnemo JM; Bjorkhem I; Aasa U; Westerstahl M; Walentinsson A; Pavanello C; Turri M; Calabresi L; Oorni K; Camejo G; Frobert O; Hurt-Camejo E
  • Article: AQUACULTURE. 2020;528:735552
    Krogdahl A; Hansen AKG; Kortner TM; Bjorkhem I; Krasnov A; Berge GM; Denstadli V
  • Article: SCANDINAVIAN JOURNAL OF CLINICAL AND LABORATORY INVESTIGATION. 2020;80(5):395-400
    Porru E; Edstrom E; Saeed AA; Eggertsen G; Lovgren-Sandblom A; Roda A; Bjorkhem I
  • Article: BRITISH JOURNAL OF NUTRITION. 2020;123(10):1081-1093
    Hansen AKG; Kortner TM; Denstadli V; Masoval K; Bjorkhem I; Grav HJ; Krogdahl A
  • Article: BMC VETERINARY RESEARCH. 2020;16(1):32
    Hansen AKG; Kortner TM; Krasnov A; Bjorkhem I; Penn M; Krogdahl A
  • Article: MOLECULAR THERAPY: METHODS & CLINICAL DEVELOPMENT. 2019;15:359-370
    Hauser S; Poenisch M; Schelling Y; Hoeflinger P; Schuster S; Teegler A; Betten R; Gustafsson J-A; Huebener-Schmid J; Schlake T; Chevessier-Tuennesen F; Horscroft N; Bjorkhem I; Schoels L
  • Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;195:105475
    Crick PJ; Yutuc E; Abdel-Khalik J; Saeed A; Betsholtz C; Genove G; Bjorkhem I; Wang Y; Griffiths WJ
  • Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;190:115-125
    Luetjohann D; Bjorkhem I; Friedrichs S; Kerksiek A; Lovgren-Sandblom A; Geilenkeuser W-J; Ahrends R; Andrade I; Ansorena D; Astiasaran I; Baila-Rueda L; Barriuso B; Becker S; Bretillon L; Browne RW; Caccia C; Ceglarek UH; Cenarro A; Crick PJ; Fauler G; Garcia-Llatas G; Gray R; Griffiths WJ; Gylling H; Harding S; Helmschrodt C; Iuliano L; Janssen H-G; Jones P; Kaipiainen L; Kannenberg F; Jesus Lagarda M; Leoni V; Lottenberg AM; MacKay DS; Matysik S; McDonald J; Menendez-Carreno M; Myrie SB; Nunes VS; Ostlund RE; Polisecki E; Ramos F; Rideout TC; Schaefer EJ; Schmitz G; Wang Y; Zerbinati C; Diczfalusy U; Schoett H-F
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(11):4169-4176
    Theofilopoulos S; de Oliveira WAA; Yang S; Yutuc E; Saeed A; Abdel-Khalik J; Ullgren A; Cedazo-Minguez A; Bjorkhem I; Wang Y; Griffiths WJ; Arenas E
  • Article: CEREBRAL CORTEX. 2019;29(1):429-446
    Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Bjorkhem I; DeFelipe J; Cedazo-Minguez A
  • Article: BIOCHIMIE. 2018;153:26-32
    Luetjohann D; Bjorkhem I; Friedrichs S; Kerksiek A; Geilenkeuser W-J; Lovgren-Sandblom A; Ansorena D; Astiasaran I; Baila-Rueda L; Barriuso B; Bretillon L; Browne RW; Caccia C; Cenarro A; Crick PJ; Fauler G; Garcia-Llatas G; Griffiths WJ; Iuliano L; Jesus Lagarda M; Leoni V; Lottenberg AM; Matysik S; McDonald J; Rideout TC; Schmitz G; Nunes VS; Wang Y; Zerbinati C; Diczfalusy U; Schoett H-F
  • Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(10):5151-5154
    Parrado-Fernandez C; Blennow K; Hansson M; Leoni V; Cedazo-Minguez A; Bjorkhem I
  • Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2018;1863(9):968-979
    Sun Y; Kopp S; Strutz J; Gali CC; Zandl-Lang M; Fanaee-Danesh E; Kirsch A; Cvitic S; Frank S; Saffery R; Bjorkhem I; Desoye G; Wadsack C; Panzenboeck U
  • Article: JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY. 2018;8(2):162-168
    Johansson H; Mork L-M; Li M; Sandblom AL; Bjorkhem I; Hoijer J; Ericzon B-G; Jorns C; Gilg S; Sparrelid E; Isaksson B; Nowak G; Ellis E
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All other publications

  • Editorial comment: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2024;460:123020
    Sennfalt S; Gustavsson P; Malmgren H; Gilland E; Almqvist H; Oscarson M; Engvall M; Bjorkhem I; Nilsson D; Lagerstedt-Robinson K; Svenningsson P; Paucar M
  • Editorial comment: ANNALS OF NEUROLOGY. 2021;89(2):418-419
    Paucar M; Almqvist H; Bjorkhem I; Svenningsson P
  • Other: INNOVATIONS IN CLINICAL NEUROSCIENCE. 2021;18(1-3):11-16
    Bountouvi E; Giorgi M; Papadopoulou A; Blennow K; Björkhem I; Tsirouda M; Kanellakis S; Fryganas A; Spanou M; Georgaki I; Asprogeraka S; Dinopoulos A
  • Letter: JOURNAL OF NEUROLOGY. 2020;267(2):572-573
    Luetjohann D; Stellaard F; Bjoerkhem I
  • Review: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2019;188:86-89
    Bjorkhem I; Leoni V; Svenningsson P
  • Other: LAKARTIDNINGEN. 2018;115:E9YY
    Eggertsen G; Puschmann A; Hall S; Wärme A-K; Kvorning O; Olin M; Eriksson M; Björkhem I
  • Letter: JOURNAL OF INTERNAL MEDICINE. 2018;283(6):604-606
    Jiao H; Olin M; Hansson M; Eggertsen G; Eriksson M; Angelin B; Bjorkhem I
  • Review: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):534-553
    Olsson AG; Angelin B; Assmann G; Binder CJ; Bjoerkhem I; Cedazo-Minguez A; Cohen J; von Eckardstein A; Farinaro E; Mueller-Wieland D; Parhofer KG; Parini P; Rosenson RS; Starup-Linde J; Tikkanen MJ; Yvan-Charvet L
  • Review: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2017;169:10-21
    Heverin M; Ali Z; Olin M; Tillander V; Joibari MM; Makoveichuk E; Leitersdorf E; Warner M; Olivercrona G; Gustafsson J-A; Bjorkhem I
  • Letter: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2017;375:245-247
    Paucar M; Almqvist H; Jelic V; Hagman G; Jorneskog G; Holmin S; Bjorkhem I; Svenningsson P
  • Review: CURRENT OPINION IN LIPIDOLOGY. 2013;24(4):283-287
    Bjorkhem I
  • Review: BIOCHIMIE. 2013;95(3):448-454
    Bjorkhem I
  • Editorial comment: JOURNAL OF LIPID RESEARCH. 2011;52(8):1447-1449
    Diczfalusy U; Bjorkhem I
  • Letter: NATURE IMMUNOLOGY. 2011;12(7):577
    Bjorkhem I; Diczfalusy U; Olsson T; Russell DW; McDonald JG; Wang Y; Griffiths WJ
  • Review: JOURNAL OF LIPID RESEARCH. 2010;51(9):2489-2503
    Bjorkhem I; Leoni V; Meaney S
  • Meeting abstract: CHEMISTRY AND PHYSICS OF LIPIDS. 2010;163:S12-S13
    Vihervaara T; Uronen R-L; Wohlfahrt G; Bjoerkhem I; Ikonen E; Olkkonen VM
  • Meeting abstract: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2009;283(1-2):246
    Bjorkhem I
  • Review: MOLECULAR ASPECTS OF MEDICINE. 2009;30(3):171-179
    Bjorkhem I; Cedazo-Minguez A; Leoni V; Meaney S
  • Published conference paper: LIPIDS. 2007;42(1):5-14
    Bjorkhem I
  • Review: JOURNAL OF INTERNAL MEDICINE. 2006;260(6):493-508
    Bjorkhem I
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Employments

  • Professor Emeritus/Emerita, Department of Laboratory Medicine, ̽ѡ, 2023-2026

Degrees and Education

  • Docent, 1969

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