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Hugh Robinson

Hugh Robinson

Affiliated to Research
Visiting address: Solnav盲gen 9, Biomedicum C4, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa FK Genetisk och farmakologisk epidemiologi, 171 77 Stockholm
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About me

  • Associate Professor, Department of Physiology, Development and Neuroscience,
    University of Cambridge, UK.

Research

  • .. *Cancer Neuroscience*
    My lab carries out research in the emerging field of cancer neuroscience:
    how cancer cells use neural mechanisms, how they interact with the nervous
    system, and how cancer arises in, or metastasizes to the brain. We focus on
    how ion channels control membrane potential and intracellular calcium
    signalling in cancer cells. Cancers such as pancreatic neuroendocrine
    tumours, small-cell lung cancer and some breast and prostate cancers show
    neural or neuroendocrine characteristics, including excitability and
    vesicular release of peptides and neurotransmitters. We want to understand
    how such signalling participates in the invasiveness and progression of these
    cancers. As well as these neuroendocrine-differentiated cancers, we are
    interested in how brain-metastatic cancer cells interact with neurons, and
    how neurotransmitter signalling at synapses promotes survival, invasion and
    growth of brain metastases, for example of breast cancer. We use a
    combination of patch-clamp and optical recording techniques, cell culture and
    computational modelling.
    *Selected Recent Publications*
    Zeberg H, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, Hevers W,
    Robinson HPC, Kelso J, and P盲盲bo S (2020). A Neanderthal sodium channel
    increases pain sensitivity in present-day humans. C*urrent Biology
    *30:3465鈥3469 (See also: 鈥淣eanderthal gene linked to pain sensitivity鈥
    News, Nature 583:665).
    Zeng Q, Michael IP, Zhang P, Saghafinia S, Knott G, Jiao W, McCabe BD,
    Galv谩n, JA, Robinson HPC, Zlobec I, Ciriello G, Hanahan D (2019) /Synaptic
    proximity enables NMDAR signalling to promote brain
    metastasis/. *Nature *573:526鈥531. (See also /News and Views: /Barria A
    (2019) Dangerous liaisons as tumour cells form synapses with
    neurons. /Nature /573:499鈥501).
    Li, L., Zeng, Q., Bhutkar, A., Galv谩n, J.A., Karamitopoulou, E.,
    Noordermeer, D., Peng, M.-W., Piersigilli, A., Perren, A., Zlobec, I.,
    Robinson, H., Iruela-Arispe M.L. and Hanahan, D. (2018)./ GKAP acts as a
    genetic modulator of NMDAR signaling to govern invasive tumor
    growt/h. *Cancer Cell *33, 1鈥16.
    Mendon莽a, P.R.F., Kyle, V., Yeo, S.-H., Colledge, W.H., and Robinson, H.P.C.
    (2018). /Kv4.2 channel activity controls intrinsic firing dynamics of
    arcuate kisspeptin neurons: Kv4.2 potassium channels and firing irregularity
    in kisspeptin neurons/. *J. Physiol. *596, 885鈥899.
    Robinson, H.P.C., and Li, L. (2017). /Autocrine, paracrine and necrotic NMDA
    receptor signalling in mouse pancreatic neuroendocrine tumour cells/. *Open
    Biol.* 7, 170221.
    Scheppach, C., and Robinson, H.P.C. (2017). /Fluctuation analysis in
    nonstationary conditions: single Ca/2+/ channel current in pyramidal
    neurons./ *Biophys. J.* 113, 2383鈥2395.
    Butler, J.L., Mendonca, P.R.F., Robinson, H.P.C., and Paulsen, O.
    (2016)./ Intrinsic Cornu Ammonis Area 1 theta-nested gamma oscillations
    induced by optogenetic theta frequency stimulation./ *J. Neurosci. *36,
    4155鈥4169.
    Mendon莽a, P.R., Vargas-Caballero, M., Erd茅lyi, F., Szab贸, G., Paulsen, O.,
    and Robinson, H.P. (2016). /Stochastic and deterministic dynamics of
    intrinsically irregular firing in cortical inhibitory
    interneurons./ *Elife* 5, e16475.

Articles

  • Article: CURRENT BIOLOGY. 2020;30(17):3465-3469.e4
    Zeberg H; Dannemann M; Sahlholm K; Tsuo K; Maricic T; Wiebe V; Hevers W; Robinson HPC; Kelso J; Paeaebo S
  • Article: NATURE. 2019;573(7775):526-531
    Zeng Q; Michael IP; Zhang P; Saghafinia S; Knott G; Jiao W; McCabe BD; Galv谩n JA; Robinson HPC; Zlobec I; Ciriello G; Hanahan D
  • Article: CANCER CELL. 2018;33(4):736-751.e5
    Li L; Zeng Q; Bhutkar A; Galv谩n JA; Karamitopoulou E; Noordermeer D; Peng M-W; Piersigilli A; Perren A; Zlobec I; Robinson H; Iruela-Arispe ML; Hanahan D
  • Article: JOURNAL OF PHYSIOLOGY. 2018;596(5):885-899
    Mendon莽a PRF; Kyle V; Yeo S-H; Colledge WH; Robinson HPC
  • Article: BIOPHYSICAL JOURNAL. 2017;113(11):2383-2395
    Scheppach C; Robinson HPC
  • Article: OPEN BIOLOGY. 2017;7(12):170221
    Robinson HPC; Li L
  • Article: ELIFE. 2016;5:e16475
    Mendon莽a PR; Vargas-Caballero M; Erd茅lyi F; Szab贸 G; Paulsen O; Robinson HP
  • Article: JOURNAL OF NEUROSCIENCE. 2016;36(15):4155-4169
    Butler JL; Mendon莽a PRF; Robinson HPC; Paulsen O
  • Article: DEVELOPMENT. 2015;142(18):3178-3187
    Kirwan P; Turner-Bridger B; Peter M; Momoh A; Arambepola D; Robinson HPC; Livesey FJ
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 2015;113(2):537-549
    Zeberg H; Robinson HPC; Arhem P
  • Article: FRONTIERS IN NEUROINFORMATICS. 2014;8:38
    Vella M; Cannon RC; Crook S; Davison AP; Ganapathy G; Robinson HPC; Silver RA; Gleeson P
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 2013;109(11):2739-2756
    Li X; Morita K; Robinson HPC; Small M
  • Article: FRONTIERS IN COMPUTATIONAL NEUROSCIENCE. 2013;7:134
    Carmeli C; Bonifazi P; Robinson HPC; Small M
  • Article: JOURNAL OF NEUROSCIENCE. 2012;32(41):14064-14073
    Catterall WA; Raman IM; Robinson HPC; Sejnowski TJ; Paulsen O
  • Article: NATURE NEUROSCIENCE. 2012;15(3):477-S1
    Shi Y; Kirwan P; Smith J; Robinson HPC; Livesey FJ
  • Article: JOURNAL OF NEUROPHYSIOLOGY. 2011;106(4):1901-1922
    Tateno T; Robinson HPC
  • Article: COGNITIVE NEURODYNAMICS. 2011;5(3):241-251
    Li X; Morita K; Robinson HPC; Small M
  • Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2011;34(2):199-212
    Kim N-K; Robinson HPC
  • Article: JOURNAL OF MATHEMATICAL BIOLOGY. 2010;61(4):501-526
    Small M; Robinson HPC; Kleppe IC; Tse CK
  • Article: PLOS COMPUTATIONAL BIOLOGY. 2010;6(9):e1000951
    Gouwens NW; Zeberg H; Tsumoto K; Tateno T; Aihara K; Robinson HPC
  • Show more

All other publications

  • Published conference paper: BIOSYSTEMS. 2007;89(1-3):110-116
    Tateno T; Robinson HPC
  • Meeting abstract: NEUROSCIENCE RESEARCH. 2007;58:s28
    Robinson HPC; de Polavieja GG; Juusola M
  • Review: JOURNAL OF PHYSIOLOGY. 2006;575(Pt 2):361-365
    Yano K; Subkhankulova T; Livesey FJ; Robinson HPC
  • Published conference paper: LECTURE NOTES IN COMPUTER SCIENCE (INCLUDING SUBSERIES LECTURE NOTES IN ARTIFICIAL INTELLIGENCE AND LECTURE NOTES IN BIOINFORMATICS). 2005;3561:150-155
    de Polavieja GG; Harsch A; Robinson H; Juusola M

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