̽»¨¾«Ñ¡

Helen HÃ¥kansson

Helen HÃ¥kansson

Professor Emeritus/Emerita
Telephone: +46852487527
Mobile phone: +46705854078
Visiting address: Nobels väg 13, 17177 Stockholm
Postal address: C6 Institutet för miljömedicin, C6 CVD-NUT-EPI Åkesson, 171 77 Stockholm
Part of:

About me

  • My research is about receptor-mediated toxicity, prevention and health risk assessment.

Research

  • My research generates data, which is used to support national and international health risk assessment work in the areas of persistent organic pollutants and other health hazardous chemicals. The studies aim to clarify the molecular mechanisms of action, identify critical effects and effect levels, and to establish safe exposure levels for humans. Such knowledge is needed to develop specific and sensitive effect- and exposure markers, which in turn, can be used to improve the possibilities to establish casual relationships in human studies, and also to develop specific and sensitive test methods within the health based risk and safety control of various categories of chemicals.

    The experimental research in my group focuses on receptor-mediated toxicity and its consequences on hormonal and metabolic pathways. I have, since long, a particular interest in the retinoid system and it´s crosstalk with the Ah-receptor both in normal and toxicological situations. Disease categories that are relevant for my research include bone and vascular abnormalities, cancer, fertility problems, behavioral influences and different types of metabolic disorders. Right now, we use different model systems to clarify how different types of chemicals interfere with bone development and homeostasis.

    Financing:
    EU DG RES
    EU DG SANCO
    FORMAS
    Swedish Environmental Protection Agency

    Five selected publications:

    Beronius A, Rudén C, Hanberg A, Håkansson H (2009)
    Health risk assessment procedures for endocrine disrupting compounds within different regulatory frameworks in the European Union
    Reg Tox Pharmacol. DOI: 10.1016/j.yrtph.2009.05.019

    Beronius A, Rudén C, Håkansson H, Hanberg A (2009)
    Risk to all or none? - A comparative analysis of controversies in the health risk assessment of Bisphenol A
    Reproductive Toxicology (accepted)

    Carpi D, Korkalainen M, Airoldi L, Fanelli R, Hakansson H, Muhonen V, Tuukkanen J, Viluksela M, Pastorelli R (2009)
    Dioxin-sensitive proteins in differentiating osteoblasts: effects on bone formation in vitro
    Toxicological Sciences, 108, 330-343.

    Schuchardt JP, Wahlström D, Rüegg J, Giese N, Stefan M, Hopf H, Pongratz I, Håkansson H, Eichele G, Pettersson K, Nau H (2009)
    The endogenous retinoid metabolite S-4-oxo-9-cis-13, 14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo
    FEBS J, 276, 3043-3059.

    Van der Ven LT, Van de Kuil T, Leonards PEG, Slob W, Lilienthal H, Litens S, Herlin M, HÃ¥kansson H, Canton RF, Van den Berg M, Visser TJ, van Loveren H, Vos JG, Piersma AH (2009)
    Endocrine effects of hexabromocyclododecane (HBCD) in a one-generation reproduction study in Wistar rats
    Toxicology Letters, 185, 51-62.

Articles

  • Article: REPRODUCTIVE TOXICOLOGY. 2022;107:123-139
    Silva AV; Chu I; Feeley M; Bergman A; Hakansson H; Oberg M
  • Article: REPRODUCTIVE TOXICOLOGY. 2021;105:25-43
    Herlin M; Sanchez-Perez I; Esteban J; Korkalainen M; Barber X; Finnila MAJ; Hamscher G; Joseph B; Viluksela M; Hakansson H
  • Article: JOURNAL OF NUTRITIONAL BIOCHEMISTRY. 2021;95:108762
    Pohjanvirta R; Karppinen I; Galban-Velazquez S; Esteban J; Hakansson H; Sankari S; Linden J
  • Article: REPRODUCTIVE TOXICOLOGY. 2021;102:109-127
    Alarcon S; Esteban J; Roos R; Heikkinen P; Sanchez-Perez I; Adamsson A; Toppari J; Koskela A; Finnila MAJ; Tuukkanen J; Herlin M; Hamscher G; Leslie HA; Korkalainen M; Halldin K; Schrenk D; Hakansson H; Viluksela M
  • Article: REPRODUCTIVE TOXICOLOGY. 2021;101:33-49
    Esteban J; Sanchez-Perez I; Hamscher G; Miettinen HM; Korkalainen M; Viluksela M; Pohjanvirta R; Hakansson H
  • Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2019;370:56-64
    Pikkarainen A; Lehtonen M; Hakansson H; Auriola S; Viluksela M
  • Article: ARCHIVES OF TOXICOLOGY. 2019;93(4):1157-1167
    Kucheryavenko O; Lurman G; Lehmann A; Braz J; Niemann L; Chahoud I; Mantovani A; Hakansson H; Schneider S; Strauss V; Coder PS; Freyberger A; O'Connor JC; Rauch M; Renko K; Solano MLM; Andersson N; Blanck O; Ritz V; Solecki R
  • Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2017;326:54-65
    Mahiout S; Linden J; Esteban J; Sanchez-Perez I; Sankari S; Pettersson L; Hakansson H; Pohjanvirta R
  • Article: ARCHIVES OF TOXICOLOGY. 2017;91(2):1001-1006
    Solecki R; Kortenkamp A; Bergman A; Chahoud I; Degen GH; Dietrich D; Greim H; Hakansson H; Hass U; Husoy T; Jacobs M; Jobling S; Mantovani A; Marx-Stoelting P; Piersma A; Ritz V; Slama R; Stahlmann R; van den Berg M; Zoeller RT; Boobis AR
  • Article: PLOS ONE. 2017;12(9):e0185241
    Romero AN; Herlin M; Finnila M; Korkalainen M; Hakansson H; Viluksela M; Sholts SB
  • Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2016;301:14-21
    Koskela A; Finnila MA; Korkalainen M; Spulber S; Koponen J; Hakansson H; Tuukkanen J; Viluksela M
  • Article: ARCHIVES OF TOXICOLOGY. 2016;90(3):701-715
    van Esterik JCJ; Sales LB; Dolle MET; Hakansson H; Herlin M; Legler J; van der Ven LTM
  • Article: TOXICOLOGY. 2015;337:30-38
    Sholts SB; Korkalainen M; Simanainen U; Miettinen HM; Hakansson H; Viluksela M
  • Article: TOXICOLOGY IN VITRO. 2015;29(5):876-883
    Herlin M; Oberg M; Ringblom J; Joseph B; Korkalainen M; Viluksela M; Heimeier RA; Hakansson H
  • Article: TOXICOLOGY REPORTS. 2015;2:472-481
    Sholts SB; Esteban J; Herlin M; Viluksela M; Hakansson H
  • Article: TOXICOLOGY LETTERS. 2014;229(1):41-51
    Esteban J; Elabbas LE; Borg D; Herlin M; Akesson A; Barber X; Hamscher G; Nau H; Bowers WJ; Nakai JS; Viluksela M; Hakansson H
  • Article: JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES. 2014;77(5):223-245
    Elabbas LE; Esteban J; Barber X; Hamscher G; Nau H; Bowers WJ; Nakai JS; Herlin M; Akesson A; Viluksela M; Borg D; Hakansson H
  • Article: PLOS ONE. 2014;9(8):e104639
    Viluksela M; Heikkinen P; van der Ven LTM; Rendel F; Roos R; Esteban J; Korkalainen M; Lensu S; Miettinen HM; Savolainen K; Sankari S; Lilienthal H; Adamsson A; Toppari J; Herlin M; Finnila M; Tuukkanen J; Leslie HA; Hamers T; Hamscher G; Al-Anati L; Stenius U; Dervola K-S; Bogen I-L; Fonnum F; Andersson PL; Schrenk D; Halldin K; Hakansson H
  • Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2013;273(1):219-226
    Herlin M; Finnila MAJ; Zioupos P; Aula A; Risteli J; Miettinen HM; Jamsa T; Tuukkanen J; Korkalainen M; Hakansson H; Viluksela M
  • Article: ENVIRONMENT INTERNATIONAL. 2013;59:112-123
    Borg D; Lund B-O; Lindquist N-G; Hakansson H
  • Show more

All other publications

  • Editorial comment: REPRODUCTIVE TOXICOLOGY. 2022;107:40-42
    Hakansson H
  • Review: REPRODUCTIVE TOXICOLOGY. 2020;93:250-258
    Grignard E; Hakansson H; Munn S
  • Editorial comment: TOXICOLOGY LETTERS. 2016;259:151-155
    Wilks MF; Blaauboer BJ; Schulte-Hermann R; Wallace HM; Galli CL; Haag-Gronlund M; Matovic V; Teixeira JP; Zilliacus J; Basaran N; Bonefeld-Jorgensen EC; Bourrinet P; Brueller W; Claude N; Miranda JP; Gundert-Remy U; Hakansson H; Kovatsi L; Liesivuori J; Lindeman B; Lison D; Leconte I; Martinez-Lopez E; Murias M; Michel C; Scheepers PTJ; Stanley L; Tsatsakis A
  • Corrigendum: TOXICOLOGY. 2011;280(3):178
    van der Ven LTM; van de Kuil T; Verhoef A; Leonards PEG; Slob W; Canton RF; Germer S; Hamers T; Visser TJ; Litens S; Hakansson H; Fery Y; Schrenk D; van den Berg M; Piersma AH; Vos JG
  • Letter: REPRODUCTIVE TOXICOLOGY. 2009;28(4):563-567
    Bondesson M; Jonsson J; Pongratz I; Olea N; Cravedi J-P; Zalko D; Hakansson H; Halldin K; Di Lorenzo D; Behl C; Manthey D; Balaguer P; Demeneix B; Fini JB; Laudet V; Gustafsson J-A
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S197-S198
    Herlin M; Aula A; Miettinen HM; Korkalainen M; Finnila M; Tuukkanen J; Hakansson H; Viluksela M
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S248
    Elabbas L; Finnilae MAJ; Herlin M; Stern N; Trossvik C; Bowers JW; Chu I; Tuukkanen J; Akesson A; Hakansson H
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S15
    Galli CL; Hakansson H; Trice S; Blaauboer BJ; Kahl R; Gerevini M
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S146
    Javier E; Elabbas L; Giese N; Bowers WJ; Chu I; Hamscher G; Hakansson H
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S199
    Hakansson H; Herlin M; Stern N; Kalantari F; Sand S; Larsson S; Tuomisto JT; Tuomisto J; Tuukkanen J; Jamsa T; Lind PM; Viluksela M
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S244
    Westerholm E; Boix J; Miettinen HM; Roos R; Antunes-Fernandes E; Westerink R; van Duursen M; Stenberg M; Carreira SC; Machala M; Silins I; Stenius U; Halldin K; Hanberg A; Hakansson H
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S240
    Zilliacus J; Hanberg A; Hakansson H
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S147
    Borg D; Bogdanska J; Sundstrom M; Nobel S; Hakansson H; Bergman A; DePierre J; Halldin K; Bergstrom U
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S104
    Miettinen HM; Heikkinen P; Korkalainen M; Antunes-Fernandes E; van Duursen M; Leslie H; Hamscher G; Andersson PL; Halldin K; Hakansson H; Viluksela M
  • Meeting abstract: TOXICOLOGY LETTERS. 2009;189:S103
    Viluksela M; Heikkinen P; van der Ven L; Miettinen HM; Korkalainen M; Savolainen K; Lilienthal H; Adamsson A; Toppari J; Finnila M; Tuukkanen J; Hamscher G; Andersson PL; Schrenk D; Halldin K; Hakansson H
  • Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S52
    Litens S; Esteban J; Schrenk D; Germer S; Van der Ven L; Hakansson H
  • Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S76
    Zilliacus J; Hanberg A; Hakansson H
  • Meeting abstract: TOXICOLOGY LETTERS. 2008;180:S245
    Westerholm E; Oeberg M; Hakansson H
  • Review: TOXICOLOGICAL SCIENCES. 2006;93(2):223-241
    Van den Berg M; Birnbaum LS; Denison M; De Vito M; Farland W; Feeley M; Fiedler H; Hakansson H; Hanberg A; Haws L; Rose M; Safe S; Schrenk D; Tohyama C; Tritscher A; Tuomisto J; Tysklind M; Walker N; Peterson RE
  • Meeting abstract: TOXICOLOGY LETTERS. 2006;164:S74
    Sand S; Fletcher N; von Rosen D; Victorin K; Viluksela M; Tuomisto JT; Tuomisto J; Filipsson AF; Hakansson H
  • Show more

Employments

  • Professor Emeritus/Emerita, Institute of Environmental Medicine, ̽»¨¾«Ñ¡, 2024-2027

Degrees and Education

  • Docent, Karolinska institutet, 1993

News from KI

Events from KI