探花精选

Hanna Bj枚rck

Hanna Bj枚rck

Senior Research Specialist | Docent
Visiting address: BioClinicum, Plan 8,Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Kardio Bj枚rck H, 171 77 Stockholm
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About me

  • I鈥檓 a senior research specialist and group leader within the Division of Cardiology, Dept of Medicine, Solna. I鈥檓 involved in several research projects at 探花精选 and the Karolinska University Hospital with the overarching aim of understanding the underlying pathological and molecular mechanism of aneurysmal disease. I did my Ph.D. with Professor Toste L盲nne at the Department of Medical and Health Sciences at Link枚ping University where I focused on vessel wall integrity in relation to flow-disturbances and genetics. I have continued along this path, and 


  • today, I'm specifically interest in mechanisms underlying endothelial integrity and flow-dependent vascular effects in the pathology of ascending aortic aneurysm.


    Postdoctoral Fellow. Atherosclerosis Research Unit, Department of Medicine Solna, 探花精选, Stockholm, Sweden. March 2012 鈥 2016.
    Ph.D. in Physiology, January 2012. Division of Cardiovascular Medicine, Department of Medical and Health Sciences, Link枚ping University, Link枚ping,  


  • Sweden.

    M.Sc. in Molecular Biology, 2006, Uppsala University

Research

  • The long-term interest of my team is to investigate the pathological and molecular mechanism underlying aneurysmal disease. Specifically, we focus on ascending aortic aneurysms (AscAA), both degenerative forms and aneurysm occurring in association with bicuspid aortic valve disease, with specific interest in endothelial integrity and flow-dependent vascular effects. Our studies are translational and includes epidemiological studies on a large and unique patient cohort, combined with molecular /in vitro/ using modern techniques.


    Ascending aortic aneurysm (AscAA) is a silent disease and a potentially fatal condition if aortic wall rupture or dissection occurs. AscAA entails destructive changes of the medial layer of the aortic wall but the precise pathogenic mechanism behind its development is unclear. The most significant risk factor for AscAA formation, however, is being born with a bicuspid aortic valve (BAV), with as many as 50% of all BAV patients requiring 


  • ascending aortic surgical repair at some point during their lifetime. BAV is the most common congenital heart malformation with a prevalence of 0.5-1.5%.A unique clinical cohort is the basis for our research, which aims to clarify the disease mechanisms underlying aortic aneurysm formation. Our biobank includes >
  • 2400 patients undergoing valve replacement and/or repair of the ascending aorta, and today, our cohort is one of the largest and most comprehensive in the world. The biobank consists of DNA, plasma, serum, and tissue biopsies from all patients. Uniquely, we have collected biopsies from multiple tissues from the same individual of the first 600 patients (ascending aorta, internal thoracic artery, heart, and liver). Also, smooth muscle cells and endothelial cells from patient ascending aortas have been isolated for functional in vitro studies. We integrate multiomic analysis, epidemiology, and genetics to identify candidategenes and pathways. Functional evaluations are performed using cell culture and in vitro 
  • analyses.

Teaching

  • Course director, "Molecular Medicine - Cardiometabolic and Infectious
    Diseases鈥 (1BI048),
    Lecturer on undergraduate and PhD courses at the Department of Medicine,
    Solna.

Articles

  • Article: EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING. 2024;25(10):1384-1393
    Hammareus F; Trenti C; Bjorck HM; Engvall J; Lekedal H; Krzynska-Trzebiatowska A; Kylhammar D; Lindenberger M; Lundberg AK; Nilsson F; Nilsson L; Swahn E; Jonasson L; Dyverfeldt P
  • Article: HEPATOLOGY. 2024
    Saliba-Gustafsson P; Justesen JM; Ranta A; Sharma D; Bielczyk-Maczynska E; Li J; Najmi LA; Apodaka M; Aspichueta P; Bjorck HM; Eriksson P; Schurr TM; Franco-Cereceda A; Gloudemans M; Mujica E; den Hoed M; Assimes TL; Quertermous T; Carcamo-Orive I; Park CY; Knowles JW
  • Article: PLOS GENETICS. 2024;20(6):e1011285
    Fegraeus K; Rosengren MK; Naboulsi R; Orlando L; Abrink M; Jouni A; Velie BD; Raine A; Egner B; Mattsson CM; Lang K; Zhigulev A; Bjorck HM; Franco-Cereceda A; Eriksson P; Andersson G; Sahlen P; Meadows JRS; Lindgren G
  • Article: BMJ OPEN. 2024;14(3):e067977
    Gaye B; Vignac M; Gadin JR; Ladouceur M; Caidahl K; Olsson C; Franco-Cereceda A; Eriksson P; Bjorck HM
  • Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(3):356-371
    Di Nunzio G; Hellberg S; Zhang Y; Ahmed O; Wang J; Zhang X; Bjoerck HM; Chizh V; Schipper R; Aulin H; Francis R; Fagerberg L; Gistera A; Metso J; Manfe V; Franco-Cereceda A; Eriksson P; Jauhiainen M; Hagberg CE; Olofsson PS; Malin SG
  • Journal article: EUROPEAN HEART JOURNAL. 2023;44:ehad655.2030
    Hammareus F; Trenti C; Bjorck HM; Engvall J; Eriksson P; Lekedal H; Lundberg A; Nilsson L; Swahn E; Jonasson L; Dyverfeldt P
  • Article: JOURNAL OF MOLECULAR MEDICINE. 2023;101(10):1323-1333
    Freiholtz D; Bergman O; Pradhananga S; Lang K; Poujade F-A; Granath C; Olsson C; Franco-Cereceda A; Sahlen P; Eriksson P; Bjorck HM
  • Article: CLINICAL PROTEOMICS. 2023;20(1):31
    Carland C; Png G; Malarstig A; Kho PF; Gustafsson S; Michaelsson K; Lind L; Tsafantakis E; Karaleftheri M; Dedoussis G; Ramisch A; Macdonald-Dunlop E; Klaric LK; Joshi P; Chen YM; Bjoerck H; Eriksson P; Carrasco-Zanini J; Wheeler E; Suhre K; Gilly A; Zeggini E; Vinuela AT; Dermitzakis EF; Wilson J; Langenberg C; Thareja G; Halama A; Schmidt F; Zanetti D; Assimes T
  • Journal article: ATHEROSCLEROSIS. 2023;379:s54
    Freiholtz D; Bergman O; Lang K; Poujade F-A; Paloschi V; Granath C; Lindeman J; Olsson C; Franco-Cereceda A; Eriksson P; Bjorck HM
  • Journal article: ATHEROSCLEROSIS. 2023;379:s31
    Freiholtz D; Bergman O; Poujade F-A; Granath C; Lang K; Olsson C; Franco-Cereceda A; Bjorck HM; Eriksson P
  • Article: JOURNAL OF MOLECULAR MEDICINE. 2023;101(7):801-811
    Freiholtz D; Bergman O; Lang K; Poujade F-A; Paloschi V; Granath C; Lindeman JHN; Olsson C; Franco-Cereceda A; Eriksson P; Bjorck HM
  • Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2023;43
    Freiholtz D; Bergman O; Corbascio CO; Lang K; Olsson C; Franco-Cereceda A; Eriksson P; Gistera A; Bjorck HM
  • Article: ANNALS OF THORACIC SURGERY. 2022;114(5):1665-1670
    Vignac M; Bjorck HM; Olsson C; Eriksson MJ; Jouven X; Michos ED; Franco-Cereceda A; Eriksson P; Gaye B
  • Journal article: ATHEROSCLEROSIS. 2022;355:37
    Zhigulev A; L氓ng K; Pradhananga S; Spalinskas R; Franco-Cereceda A; Bj枚rck H; Eriksson P; Sahl茅n P
  • Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2022;11(9):e024346
    Granath C; Freiholtz D; Bredin F; Olsson C; Franco-Cereceda A; Bjorck HM
  • Article: EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2022;61(2):388-392
    Vignac M; Ntika S; Olsson C; Franco-Cereceda A; Bjorck HM
  • Article: JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE. 2021;8(11):143
    Ntika S; Jois H; Lang K; Olsson C; Franco-Cereceda A; Bjorck HM; Krizhanovskii C
  • Article: OPEN HEART. 2021;8(2):e001857
    Granath C; Mohamed SA; Olsson C; Grattan M; Mertens L; Franco-Cereceda A; Bjorck HM
  • Article: BIOMEDICINES. 2021;9(6):697
    Ntika S; Tracy LM; Franco-Cereceda A; Bjorck HM; Krizhanovskii C
  • Article: BIORESEARCH OPEN ACCESS. 2020;9(1):269-278
    Granath C; Noren H; Bjorck H; Simon N; Olesen K; Rodin S; Grinnemol K-H; Osterholm C
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All other publications

  • Preprint: MEDRXIV. 2024
    Freiholtz D; L氓ng K; Bergman O; Olsson C; Koski MG; Dismorr M; 脰sterholm C; Caidahl K; Franco-Cereceda A; Eriksson P; Gister氓 A; Bj枚rck HM
  • Book chapter: AORTIC VALVE DISEASE - RECENT ADVANCES: CARDIOLOGY AND CARDIOVASCULAR MEDICINE. 2024;p.
    Freiholtz D; Eriksson P; M. Bj枚rck H
  • Preprint: MEDRXIV. 2024;MEDRXIV
    Saliba-Gustafsson P; Justesen JM; Ranta A; Sharma D; Bielczyk-Maczynska E; Li J; Najmi LA; Apodaka M; Aspichueta P; Bj枚rck HM; Eriksson P; Franco-Cereceda A; Gloudemans M; Mujica E; den Hoed M; Assimes TL; Quertermous T; Carcamo-Orive I; Park CY; Knowles JW
  • Conference publication: AORTA. 2023;11(05):1-18
    Freiholtz D; Bergman O; L氓ng K; Corbascio C脰; Olsson C; Franco-Cereceda A; Eriksson P; Gister氓 A; Bj枚rck HM
  • Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:s756-s757
    Ahmed O; Shavva VS; Dai W; Tarnawski L; Malin S; Franco-Cereceda A; Eriksson P; Bjorck H; Olofsson P
  • Preprint: RESEARCH SQUARE. 2023
    Carland C; Png G; Malarstig A; Kho PF; Gustafsson S; Michaelsson K; Lind L; Tsafantakis E; Karaleftheri M; Dedoussis G; Ramisch A; Macdonald-Dunlop E; Klaric L; Joshi PK; Chen Y; Bj枚rck HM; Eriksson P; Carrasco-Zanini J; Wheeler E; Suhre K; Gilly A; Zeggini E; Vi帽uela A; Dermitzakis ET; Wilson JF; Langenberg C; Thareja G; Halama A; Schmidt F; Consortium S; Zanetti D; Assimes T
  • Preprint: BIORXIV. 2023
    Mannion A; Zhao H; Zhang Y; von Wright Y; Bergman O; Bj枚rck H; Saharinen P; Holmgren L
  • Preprint: BIORXIV. 2022
    Hellberg S; Ahmed O; Zhang Y; Di Nunzio G; Bj枚rck HM; Francis R; Fagerberg L; Gister氓 A; Zhang X; Metso J; Manf茅 V; Soto Y; Franco-Cereceda A; Eriksson P; Jauhiainen M; Olofsson PS; Malin SG
  • Conference publication: AORTA. 2022;10:a1-a56
    Granath C; Astrom DF; Bredin F; Olsson C; Franco-Cereceda A; Bjorck H
  • Conference publication: AORTA. 2022;10:a1-a56
    Bergman O; Freiholtz D; Poujade F-A; Granath C; L氓ng K; Ohlsson C; Franco-Cereceda A; Eriksson P; Bj枚rck H
  • Conference publication: ATHEROSCLEROSIS. 2022;355:E68-E69
    Zhigulev A; Lang K; Pradhananga S; Spalinskas R; Franco-Cereceda A; Bjorck H; Eriksson P; Sahlen P
  • Preprint: RESEARCH SQUARE. 2021
    Gaye B; Vignac M; G氓din JR; Ladouceur M; Caidahl K; Olsson C; Franco-Cereceda A; Eriksson P; Bj枚rck HM
  • Meeting abstract: ATHEROSCLEROSIS. 2019;287:E287
    Vignac M; Gaye B; Bjorck HM; Olsson C; Franco-Cereceda A; Eriksson P
  • Meeting abstract: ATHEROSCLEROSIS. 2019;287:E277
    Gaye B; Vignac M; Bjorck HM; Olsson C; Franco-Cereceda A; Eriksson P
  • Meeting abstract: CIRCULATION. 2019;139
    Gaye B; Bjorck HM; Ladouceur M; Vignac M; Olsson C; Cereceda AF; Eriksson P
  • Review: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2019;6:182
    Maleki S; Poujade F-A; Bergman O; Gadin JR; Simon N; Lang K; Franco-Cereceda A; Body SC; Bjorck HM; Eriksson P
  • Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2018;114:S47
    Bjorck H; Du L; Pulignani S; Paloschi V; Lundstromer K; Kostina A; Evangelista A; Maleki S; Franco-Cereceda A; Eriksson P
  • Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2018;114:S83
    Kostina A; Kiselev A; Bjorck H; Irtyuga O; Sergushichev A; Baranov Y; Eriksson P; Kostareva A; Malashicheva A
  • Corrigendum: FRONTIERS IN PHYSIOLOGY. 2017;8:730
    Gillis E; Kumar AA; Luyckx I; Preuss C; Cannaerts E; van de Beek G; Wieschendorf B; Alaerts M; Bolar N; Vandeweyer G; Meester J; Wunnemann F; Gould RA; Zhurayev R; Zerbino D; Mohamed SA; Mital S; Mertens L; Bjorck HM; Franco-Cereceda A; McCallion AS; Van Laer L; Verhagen JMA; van de Laar IMBH; Wessels MW; Messas E; Goudot G; Nemcikova M; Krebsova A; Kempers M; Salemink S; Dufinhouwer T; Jeunemaitre X; Albuisson J; Eriksson P; Andelfinger G; Dietz HC; Verstraeten A; Loeys BL
  • Conference publication: CARDIOVASCULAR RESEARCH (CVR). 2016;111:S104
    Bhattachariya A; Cottrill KA; Du L; Bjorck HM; Maleki S; Franco-Cereceda A; Chan SY; Eriksson P
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Grants

  • Swedish Research Council
    1 January 2021 - 31 December 2023
  • Swedish Heart-Lung Foundation
    1 January 2019 - 31 December 2021
  • Swedish Research Council
    1 January 2017 - 31 December 2020

Employments

  • Senior Research Specialist, Department of Medicine, 探花精选, 2021-

Degrees and Education

  • Docent, 探花精选, 2022

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