̽»¨¾«Ñ¡

Fredrik Wermeling

Fredrik Wermeling

Principal Researcher | Docent
Visiting address: D2:01, Karolinska Universitetssjukhuset, 17177 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Wermeling F, 171 77 Stockholm
Part of:

About me

  • Using experimental systems and patient material we study the immune system
    with a specific interest related to inflammation, autoimmune disease and
    cancer.
    A major part of the different projects in the lab involves using CRISPR-based
    custom screens as a discovery platform to understand complex biological
    processes and to identify novel drug targets.
    Currently several projects in the lab relates to our interest in signaling
    downstream of the IL-4 receptor (IL-4R). The basis for this interest was the
    unexpected finding that the expression of the IL-4R on myeloid cells is
    essential for the activity of a drug (IVIG) used to treat patients with
    autoimmune disease, and that this receptor is highly regulated during
    inflammation (Anthony et al, 2011, Nature and Wermeling et al, 2013, PNAS).
    The Wermeling Laboratory is located at the Center for Molecular Medicine
    (CMM), Karolinska University Hospital, Solna, Sweden. The group is part of
    the Devision of Rheumatology, Department of Medicine, ̽»¨¾«Ñ¡,
    Solna.
    Wenner-Gren fellow, 2010
    Ingvar Carlsson Award (SSF), 2013
    Senior Investigator Award from Swedish Cancer Foundation, 2022

Teaching

  • More than 200h teaching in several KI programs, including Medical, Optometry,
    Biomedicine, and various master programs and PhD courses.

Articles

  • Article: NATURE COMMUNICATIONS. 2024;15(1):6419
    Kakhki MP; Giordano A; Cucuzza CS; Badam TVS; Samudyata S; Lemee MV; Stridh P; Gkogka A; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Hillert J; Olsson T; Kockum I; Sellgren CM; Golzio C; Kular L; Jagodic M
  • Article: ISCIENCE. 2024;27(6):109862
    Ingelshed K; Melssen MM; Kannan P; Chandramohan A; Partridge AW; Jiang L; Wermeling F; Lane DP; Nestor M; Spiegelberg D
  • Article: JOURNAL OF NUCLEAR MEDICINE. 2024;65(2):294-299
    Puuvuori E; Shen Y; Hulsart-Billstrom G; Mitran B; Zhang B; Cheung P; Wegrzyniak O; Ingvast S; Persson J; Stahl S; Korsgren O; Lofblom J; Wermeling F; Eriksson O
  • Article: MOLECULAR ONCOLOGY. 2024;18(2):317-335
    Zaghmi A; Aybay E; Jiang L; Shang M; Steinmetz-Spah J; Wermeling F; Kogner P; Korotkova M; Ostling P; Jakobsson P-J; Seashore-Ludlow B; Larsson K
  • Article: SCIENTIFIC REPORTS. 2023;13(1):4583
    Lerma Clavero A; Boqvist PL; Ingelshed K; Bosdotter C; Sedimbi S; Jiang L; Wermeling F; Vojtesek B; Lane DP; Kannan P
  • Article: JOURNAL OF LIPID RESEARCH. 2022;63(12):100310
    Steinmetz-Spah J; Liu J; Singh R; Ekoff M; Boddul S; Tang X; Bergqvist F; Idborg H; Heitel P; Ronnberg E; Merk D; Wermeling F; Haeggstrom JZ; Nilsson G; Steinhilber D; Larsson K; Korotkova M; Jakobsson P-J
  • Article: JOURNAL OF AUTOIMMUNITY. 2022;133:102903
    Sakuraba K; Krishnamurthy A; Sun J; Zheng X; Xu C; Peng B; Engstrom M; Jakobsson P-J; Wermeling F; Catrina S; Gronwall C; Catrina AI; Rethi B
  • Article: CANCER RESEARCH COMMUNICATIONS. 2022;2(9):1075-1088
    Ingelshed K; Spiegelberg D; Kannan P; Pavenius L; Hacheney J; Jiang L; Eisinger S; Lianoudaki D; Lama D; Castillo F; Bosdotter C; Kretzschmar WW; Al-Radi O; Fritz N; Villablanca EJ; Karlsson MCI; Wermeling F; Nestor M; Lane DP; Sedimbi SK
  • Article: JOURNAL OF AUTOIMMUNITY. 2022;131:102857
    Iyer VS; Boddul SV; Johnsson A-K; Raposo B; Sharma RK; Shen Y; Kasza Z; Lim KW; Chemin K; Nilsson G; Malmstrom V; Phan AT; Wermeling F
  • Article: ONCOSCIENCE. 2022;9:27-29
    Jiang L; Wermeling F
  • Article: CANCER RESEARCH. 2022;82(1):36-45
    Jiang L; Ingelshed K; Shen Y; Boddul SV; Iyer VS; Kasza Z; Sedimbi S; Lane DP; Wermeling F
  • Article: SCIENTIFIC REPORTS. 2021;11(1):24512
    Sharma RK; Boddul SV; Yoosuf N; Turcinov S; Dubnovitsky A; Kozhukh G; Wermeling F; Kwok WW; Klareskog L; Malmstrom V
  • Article: BIOMEDICINES. 2021;9(8):961
    Kumar S; Koenig J; Schneider A; Wermeling F; Boddul S; Theobald SJ; Vollmer M; Kloos D; Lachmann N; Klawonn F; Lienenklaus S; Talbot SR; Bleich A; Wenzel N; von Kaisenberg C; Keck J; Stripecke R
  • Article: TRANSLATIONAL RESEARCH. 2021;229:69-82
    Sundstrom Y; Shang M-M; Panda SK; Gronwall C; Wermeling F; Gunnarsson I; Lundberg IE; Sundstrom M; Jakobsson P-J; Berg L
  • Article: JOURNAL OF TRANSLATIONAL AUTOIMMUNITY. 2021;4:100087
    Boddul SV; Sharma RK; Dubnovitsky A; Raposo B; Gerstner C; Shen Y; Iyer VS; Kasza Z; Kwok WW; Winkler AR; Klareskog L; Malmstrom V; Bettini M; Wermeling F
  • Article: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2021;19:5360-5370
    Shen Y; Jiang L; Iyer VS; Raposo B; Dubnovitsky A; Boddul SV; Kasza Z; Wermeling F
  • Article: HAEMATOLOGICA. 2020;105(5):1339-1350
    Record J; Sendel A; Kritikou JS; Kuznetsov NV; Brauner H; He M; Nagy N; Oliveira MMS; Griseti E; Haase CB; Dahlstrom J; Boddul S; Wermeling F; Thrasher AJ; Liu C; Andersson J; Claesson H-E; Winqvist O; Burns SO; Bjorkholm M; Westerberg LS
  • Journal article: CANCER IMMUNOLOGY RESEARCH. 2020;8(3_Supplement):a79
    Ingelshed K; Lianoudaki D; Lama D; Sohn S; Fritz N; Jiang L; Wermeling F; Karlsson M; Lane DP; Sedimbi SK
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):3103-3113
    Panda SK; Wigerblad G; Jiang L; Jimenez-Andrade Y; Iyer VS; Shen Y; Boddul SV; Guerreiro-Cacais AO; Raposo B; Kasza Z; Wermeling F
  • Article: ACS SENSORS. 2020;5(1):217-224
    Xu X; Makaraviciute A; Abdurakhmanov E; Wermeling F; Li S; Danielson UH; Nyholm L; Zhang Z
  • Show more

All other publications

  • Letter: BLOOD ADVANCES. 2024;8(15):3941-3945
    Mo J; Wermeling F; Nilsson G; Dahlin JS
  • Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:837
    Raposo B; Afonso MG; Israelsson L; Stalesen R; Wahamaa H; Hansson M; Hensvold A; Wermeling F; Mueller D; Rethi B; Gronwall C; Klareskog L; Malmstrom V
  • Letter: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(5):724-726
    Raposo B; Afonso M; Israelsson L; Waehaemaa H; Stalesen R; Wermeling F; Hensvold AH; Groenwall C; Rethi B; Klareskog L; Malmstrom V
  • Preprint: BIORXIV. 2022
    Clavero AL; Boqvist PL; Ingelshed K; Bosdotter C; Sedimbi S; Jiang L; Wermeling F; Vojtesek B; Lane D; Kannan P
  • Preprint: BIORXIV. 2022
    Raposo B; Afonso M; Israelsson L; Wähämaa H; Stålesen R; Wermeling F; Hensvold A; Grönwall C; Rethi B; Klareskog L; Malmström V
  • Preprint: MEDRXIV. 2022
    Kakhki MP; Cucuzza CS; Giordano A; Badam TV; Strid P; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Kockum I; Hillert J; Olsson T; Kular L; Jagodic M
  • Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2022;28(3_SUPPL):226-227
    Kakhki MP; Cucuzza CS; Gyllenberg A; Badam TVS; Liu Y; Boddul S; James T; Wermeling F; Gustafsson M; Casaccia P; Kockum I; Hillert J; Olsson T; Kular L; Jagodic M
  • Conference publication: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2022;49(SUPPL 1):S279-S280
    Puuvuori E; Shen Y; Zhang B; Billstrom GH; Persson J; Stahl S; Korsgren O; Lofblom J; Wermeling F; Eriksson O
  • Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:1193-1194
    Sun J; Sakuraba K; Krishnamurthy A; Zheng X; Afonso MG; Xu C; Peng B; Jakobsson P-J; Engstrom M; Wermeling F; Catrina S; Gronwall C; Catrina A; Rethi B
  • Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:3446
    Kumar R; Dubnovitsky A; Gerstner C; Yoosuf N; Turcinov S; Boddul S; Wermeling F; Klareskog L; Padyukov L; Malmstrom V
  • Conference publication: HUMAN GENE THERAPY. 2022;33(7-8):A30
    Iyer V; Phan AT; Wermeling F
  • Preprint: RESEARCH SQUARE. 2021
    Sharma R; Boddul S; Yoosuf N; Turcinov S; Dubnovitsky A; Kozhukh G; Wermeling F; Kwok W; Klareskog L; Malmström V
  • Preprint: BIORXIV. 2021
    Jiang L; Ingelshed K; Shen Y; Boddul SV; Iyer VS; Kasza Z; Sedimbi S; Lane DP; Wermeling F
  • Preprint: BIORXIV. 2021
    Shen Y; Jiang L; Iyer VS; Raposo B; Boddul S; Kasza Z; Wermeling F
  • Conference publication: EUROPEAN JOURNAL OF IMMUNOLOGY. 2021;51:397
    Shen Y; Jiang L; Iyer VS; Raposo B; Boddul SV; Kasza Z; Wermeling F
  • Preprint: BIORXIV. 2020
    Sundström Y; Shang M-M; Panda SK; Grönwall C; Wermeling F; Gunnarsson I; Lundberg I; Sundström M; Jakobsson P-J; Berg L
  • Review: COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL. 2020;18:2237-2246
    Iyer VS; Jiang L; Shen Y; Boddul SV; Panda SK; Kasza Z; Schmierer B; Wermeling F
  • Conference publication: CANCER IMMUNOLOGY RESEARCH. 2020;8(3):71
    Ingelshed K; Lianoudaki D; Lama D; Sohn S; Fritz N; Jiang L; Wermeling F; Karlsson M; Lane DP; Sedimbi SK
  • Conference publication: ARTHRITIS & RHEUMATOLOGY. 2020;72
    Kumar R; Yoosuf N; Boddul S; Gerstner C; Turcinov S; Dubnovitsky A; Wermeling F; Chemin K; Malmstrom V
  • Preprint: ARXIV. 2019
    Farinotti AB; Wigerblad G; Nascimento D; Bas DB; Urbina CM; Nandakumar KS; Sandor K; Xu B; Abdelmoaty S; Hunt MA; Möller KÄ; Baharpoor A; Sinclair J; Jardemark K; Lanner JT; Khmaladze I; Borm LE; Zhang L; Wermeling F; Cragg MS; Lengqvist J; Chabot-Doré A-J; Diatchenko L; Belfer I; Collin M; Kultima K; Heyman B; Jimenez-Andrade JM; Codeluppi S; Holmdahl R; Svensson CI
  • Show more

Employments

  • Principal Researcher, Department of Medicine, ̽»¨¾«Ñ¡, 2022-

Degrees and Education

  • Docent, ̽»¨¾«Ñ¡, 2021
  • Degree Of Doctor Of Philosophy, Department of Medicine, Solna, ̽»¨¾«Ñ¡, 2010
  • Master Of Medical Science, ̽»¨¾«Ñ¡, 2009

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