̽»¨¾«Ñ¡

Fredrik Lanner

Fredrik Lanner

Principal Researcher
Telephone: +46852483671
Visiting address: Hälsovägen, Enheten för obstetrik och gynekologi C1:77, 14181 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLT Obstetrik o gynekologi Lanner, 141 52 Huddinge

Research

  • The Lanner lab aims to:
    1. Uncover the fundamental principles underlying how the first cell types established in the early human embryo from totipotent morula, to blastocyst, implantation and gastrulation. For this we are utilising embryo culture and stem cell based embryo models.

    2. Develop embryonic stem cell based strategies. We have establish a first
    clinically compliant good manufacturing practice (GMP) grade human embryonic
    stem cell line, KARO1.

    3. Treatment of Diabetes. We are actively working to establish methodology to efficiently produce glucose responsive pancreatic islets with correct cellular composition.

    4. Treatment of age-related macula degeneration (AMD). During collaborative agreement with St. Erik Eye Hospital and Novo Nordisk A/S we have
    manufacture hESC-RPE cells according to our developed protocol and performed preclinical toxicology and functionality testing. With support from The Erling Person foundation we are planning to perform first in human clinical trial aiming to treat AMD.

    5. Treatment of retinopathy we are now establishing efficient methods to establish photoreceptors to be transplanted alone or together with RPE cells.

    Current Lab members:
    Dr. Elisabeth Moussaud, Research Coordinator Lanner and Damdimopoulou labs

    Dr. Cheng Zhao, Research Specialist shared with Sophie Petropoulos. Bioinformatics in embryo and stem cell biology.

    Dr. Sanjiv Risal, Research Specialist at the unit, working with reproductive medicine.
    Dr. Shivam Chandel, Postdoc. Developing insulin producing stem cell derived islets.
    Dr. Mathilde Bergamelli, Postdoc shared with Andres Salumets. Using blastoids to mimic embryo implantation biology.
    Dr. Jing Lyu, Postdoc performing epigenetic studies or early human embryos.

    Dr. Kristina Kiisholts, Postdoc studying Human Endometrium and Embryo interaction

    Dr. Laura Baque Vidal, Research Assistant. Treatment of AMD with stem cell derived RPE cells.
    Sara Saietz, PhD student. Embryonic stem cell-based treatment of retinal degenerative disease
    Frederik Bär, PhD student. Individualized iPSC-based treatment of blindness

    Celia Mesias Casares, PhD student. Building the early human embryo

    Eda Erbil, PhD student. Developing insulin producing stem cell derived islets.

    *Past Lab members*
    Dr. Sophie Petroploulos, PI at KI and University of Montreal
    Dr. Sebastian Hildebrand, Postdoc. Now working at Tecan
    Dr. Liselotte Antonsson, Now working at Stockholm University
    Dr. Sarita Panula, Postdoc. Now working at Procella Therapeutics.
    Dr. Sandra Petrus-Reurer, PhD and Postdoc, now working at Cambridge University.
    Dr. Sara Padrell Sánchez, PhD student now Director of Business Development at Akron Biotech
    Dr. John Paul Schell. PhD and then Postdoc in Professor Ken Chiens laboratory, KI
    Dr. Paschalis Efstathopoulos, Industrial Postdoc now working as Research scientist at Novo Nordisk
    Dr. Leni Wagner, PhD and Postdoc.
    Dr. Alvaro Plaza Reyes, PhD and Postdoc. Currently working at CABIMER, Spain
    Dr. Pankaj Kumar, Postdoc. Currently working as Senior Scientist at Strand Life Sciences, Begaluru
    Dr. Nicholas Ortega-Linard, Postdoc. Currently working as Business Development Manager at Olink, Sweden
    Dr. Heather Main, ATMP Sweden
    Dr Jere Weltner, Postdoc. Currently at University of Helsinki
    Dr. Breniere-Letuffe, Postdoc
    Hazel Reilly, Currently PhD student at ̽»¨¾«Ñ¡, Sweden
    Nerges Winblad, PhD student. Currently working at Karolinska University Hospital
    Mona Hedenskog, Previous lab manager, currently enjoying life.
    Nefeli Eirini Beri, Previous MSc student, Regulatory Affairs Postgraduate at Novartis
    Hugo Metzger, Previous Erasmus student
    Nashwan Jalal Markus, now working at the productive Unit Karolinska Hospital
    Haojiang Lu
    Philipp Schenk
    Angelos Gkikas
    Nariman Gharari

Articles

  • Article: NATURE METHODS. 2025;22(1):193-206
    Zhao C; Reyes AP; Schell JP; Weltner J; Ortega NM; Zheng Y; Bjorklund AK; Baque-vidal L; Sokka J; Torokovic R; Cox B; Rossant J; Fu J; Petropoulos S; Lanner F
  • Article: CYTOTHERAPY. 2024;26(4):340-350
    Baque-Vidal L; Main H; Petrus-Reurer S; Lederer AR; Beri N-E; Bar F; Metzger H; Zhao C; Efstathopoulos P; Saietz S; Wrona A; Jaberi E; Willenbrock H; Reilly H; Hedenskog M; Moussaud-Lamodiere E; Kvanta A; Villaescusa JC; La Manno G; Lanner F
  • Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2024;12:1341373
    Pottmeier P; Nikolantonaki D; Lanner F; Peuckert C; Jazin E
  • Article: NATURE. 2023;622(7983):562-573
    Oldak B; Wildschutz E; Bondarenko V; Comar M-Y; Zhao C; Aguilera-Castrejon A; Tarazi S; Viukov S; Pham TXA; Ashouokhi S; Lokshtanov D; Roncato F; Ariel E; Rose M; Livnat N; Shani T; Joubran C; Cohen R; Addadi Y; Chemla M; Kedmi M; Keren-Shaul H; Pasque V; Petropoulos S; Lanner F; Novershtern N; Hanna JH
  • Article: COMMUNICATIONS BIOLOGY. 2023;6(1):969
    Chan C-H; Lam Y-Y; Wong N; Geng L; Zhang J; Ahola V; Zare A; Li RA; Lanner F; Keung W; Cheung Y-F
  • Journal article: CYTOTHERAPY. 2023;25(6):s190
    Main H; Markland K; Lanner F; Christiansen MW
  • Article: HUMAN REPRODUCTION OPEN. 2022;2022(4):hoac043
    Koel M; Krjutskov K; Saare M; Samuel K; Lubenets D; Katayama S; Einarsdottir E; Vargas E; Sola-Leyva A; Lalitkumar PG; Gemzell-Danielsson K; Blesa D; Simon C; Lanner F; Kere J; Salumets A; Altmae S
  • Article: STEM CELL REPORTS. 2022;17(6):1458-1475
    Petrus-Reurer S; Lederer AR; Baque-Vidal L; Douagi I; Pannagel B; Khven I; Aronsson M; Bartuma H; Wagner M; Wrona A; Efstathopoulos P; Jaberi E; Willenbrock H; Shimizu Y; Villaescusa JC; Andre H; Sundstrom E; Bhaduri A; Kriegstein A; Kvanta A; La Manno G; Lanner F
  • Article: NATURE CELL BIOLOGY. 2022;24(6):845-857
    Kumar B; Navarro C; Winblad N; Schell JP; Zhao C; Weltner J; Baque-Vidal L; Salazar Mantero A; Petropoulos S; Lanner F; Elsasser SJ
  • Article: NATURE COMMUNICATIONS. 2021;12(1):5126
    Yang R; Goedel A; Kang Y; Si C; Chu C; Zheng Y; Chen Z; Gruber PJ; Xiao Y; Zhou C; Witman N; Leung C-Y; Chen Y; Fu J; Ji W; Lanner F; Niu Y; Chien K
  • Article: NATURE CELL BIOLOGY. 2021;23(1):49-60
    Posfai E; Schell JP; Janiszewski A; Rovic I; Murray A; Bradshaw B; Yamakawa T; Pardon T; El Bakkali M; Talon I; De Geest N; Kumar P; To SK; Petropoulos S; Jurisicova A; Pasque V; Lanner F; Rossant J
  • Article: STEM CELLS TRANSLATIONAL MEDICINE. 2020;9(8):936-953
    Petrus-Reurer S; Kumar P; Sanchez SP; Aronsson M; Andre H; Bartuma H; Reyes AP; Nandrot EF; Kvanta A; Lanner F
  • Article: STEM CELL RESEARCH. 2020;45:101810
    Main H; Hedenskog M; Acharya G; Hovatta O; Lanner F
  • Article: STEM CELL REPORTS. 2020;14(4):648-662
    Petrus-Reurer S; Winblad N; Kumar P; Gorchs L; Chrobok M; KathleenWagner A; Bartuma H; Lardner E; Aronsson M; Reyes AP; Andre H; Alici E; Kaipe H; Kvanta A; Lanner F
  • Article: NATURE COMMUNICATIONS. 2020;11(1):1609
    Reyes AP; Petrus-Reurer S; Sanchez SP; Kumar P; Douagi I; Bartuma H; Aronsson M; Westman S; Lardner E; Andre H; Falk A; Nandrot EF; Kvanta A; Lanner F
  • Article: NATURE COMMUNICATIONS. 2020;11(1):1357
    Fernandez-Alonso R; Bustos F; Budzyk M; Kumar P; Helbig AO; Hukelmann J; Lamond AI; Lanner F; Zhou H; Petsalaki E; Findlay GM
  • Article: NATURE COMMUNICATIONS. 2020;11(1):1147
    Wagner M; Yoshihara M; Douagi I; Damdimopoulos A; Panula S; Petropoulos S; Lu H; Pettersson K; Palm K; Katayama S; Hovatta O; Kere J; Lanner F; Damdimopoulou P
  • Article: HUMAN REPRODUCTION. 2019;34(11):2297-2310
    Panula S; Kurek M; Kumar P; Albalushi H; Padrell Sanchez S; Damdimopoulou P; Olofsson JI; Hovatta O; Lanner F; Stukenborg J-B
  • Article: NATURE COMMUNICATIONS. 2019;10(1):1636
    Gelali E; Girelli G; Matsumoto M; Wernersson E; Custodio J; Mota A; Schweitzer M; Ferenc K; Li X; Mirzazadeh R; Agostini F; Schell JP; Lanner F; Crosetto N; Bienko M
  • Article: DEVELOPMENTAL BIOLOGY. 2019;447(1):3-13
    Tguiko O; Jatsenko T; Grace LKP; Kurg A; Vermeesch JR; Lanner F; Altmae S; Salumets A
  • Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(131)
    Petrus-Reurer S; Bartuma H; Aronsson M; Westman S; Lanner F; Kvanta A
  • Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2018;(131)
    Petrus-Reurer S; Bartuma H; Aronsson M; Westman S; Lanner F; Kvanta A
  • Article: SCIENTIFIC REPORTS. 2017;7(1):9540
    Hildebrand S; Hultin S; Subramani A; Petropoulos S; Zhang Y; Cao X; Mpindi J; Kalloniemi O; Johansson S; Majumdar A; Lanner F; Holmgren L
  • Article: CELL STEM CELL. 2017;20(6):874-890.e7
    Collier AJ; Panula SP; Schell JP; Chovanec P; Reyes AP; Petropoulos S; Corcoran AE; Walker R; Douagi I; Lanner F; Rugg-Gunn PJ
  • Article: CELL REPORTS. 2017;19(6):1101-1109
    Nosi U; Lanner F; Huang T; Cox B
  • Article: ELIFE. 2017;6:e22906
    Posfai E; Petropoulos S; de Barrosl FRO; Schell JP; Jurisica I; Sandberg R; Lanner F; Rossant J
  • Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2017;58(2):1314-1322
    Petrus-Reurer S; Bartuma H; Aronsson M; Westman S; Lanner F; Andre H; Kvanta A
  • Article: NATURE BIOTECHNOLOGY. 2016;34(12):1264-1266
    Faridani OR; Abdullayev I; Hagemann-Jensen M; Schell JP; Lanner F; Sandberg R
  • Article: DEVELOPMENT. 2016;143(19):3459-3469
    Jouhilahti E-M; Madissoon E; Vesterlund L; Tohonen V; Krjutskov K; Reyes AP; Petropoulos S; Mansson R; Linnarsson S; Burglin T; Lanner F; Hovatta O; Katayama S; Kere J
  • Article: GENOME RESEARCH. 2016;26(10):1342-1354
    Chen G; Schell JP; Benitez JA; Petropoulos S; Yilmaz M; Reinius B; Alekseenko Z; Shi L; Hedlund E; Lanner F; Sandberg R; Deng Q
  • Article: SCIENTIFIC REPORTS. 2016;6:28995
    Madissoon E; Jouhilahti E-M; Vesterlund L; Tohonen V; Krjutskov K; Petropoulous S; Einarsdottir E; Linnarssons S; Lanner F; Mansson R; Hovatta O; Burglin TR; Katayama S; Kere J
  • Article: CELL. 2016;165(4):1012-1026
    Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
  • Article: STEM CELL REPORTS. 2016;6(1):9-17
    Reyes AP; Petrus-Reurer S; Antonsson L; Stenfelt S; Bartuma H; Panula S; Mader T; Douagi I; Andre H; Hovatta O; Lanner F; Kvanta A
  • Article: DEVELOPMENT. 2013;140(22):4533-4543
    Li L; Liu C; Biechele S; Zhu Q; Song L; Lanner F; Jing N; Rossant J
  • Article: DEVELOPMENT. 2013;140(14):2961-2971
    Biechele S; Cockburn K; Lanner F; Cox BJ; Rossant J
  • Article: STEM CELLS AND DEVELOPMENT. 2013;22(9):1360-1369
    Lanner F; Lee KL; Ortega GC; Sohl M; Li X; Jin S; Hansson EM; Claesson-Welsh L; Poellinger L; Lendahl U; Farnebo F
  • Article: CELL. 2013;152(5):1008-1020
    Findlay GM; Smith MJ; Lanner F; Hsiung MS; Gish GD; Petsalaki E; Cockburn K; Kaneko T; Huang H; Bagshaw RD; Ketela T; Tucholska M; Taylor L; Bowtell DD; Moffat J; Ikura M; Li SSC; Sidhu SS; Rossant J; Pawson T
  • Article: DEVELOPMENTAL CELL. 2012;22(4):887-901
    Rugg-Gunn PJ; Cox BJ; Lanner F; Sharma P; Ignatchenko V; McDonald ACH; Garner J; Gramolini AO; Rossant J; Kislinger T
  • Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;413(3):426-431
    Liu L; Lanner F; Lendahl U; Das D
  • Article: EMBO JOURNAL. 2011;30(9):1778-1789
    Fussner E; Djuric U; Strauss M; Hotta A; Perez-Iratxeta C; Lanner F; Dilworth FJ; Ellis J; Bazett-Jones DP
  • Article: DEVELOPMENTAL BIOLOGY. 2010;348(2):153-166
    Das D; Lanner F; Main H; Andersson ER; Bergmann O; Sahlgren C; Heldring N; Hermanson O; Hansson EM; Lendahl U
  • Journal article: DEVELOPMENT. 2010;137(18):e1
    Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U
  • Article: JOURNAL OF CELL SCIENCE. 2010;123(17):2931-2942
    Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U
  • Article: DEVELOPMENT. 2010;137(5):715-724
    Yamanaka Y; Lanner F; Rossant J
  • Article: STEM CELLS. 2010;28(2):191-200
    Lanner F; Lee KL; Sohl M; Holmborn K; Yang H; Wilbertz J; Poellinger L; Rossant J; Farnebo F
  • Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;391(1):24-27
    Sohl M; Lanner F; Farnebo F
  • Article: GENE. 2009;437(1-2):54-59
    Sohl M; Lanner F; Farnebo F
  • Article: INTERNATIONAL JOURNAL OF CANCER. 2008;123(2):389-394
    Geli J; Kogner P; Lanner F; Natalishvili N; Juhlin C; Kiss N; Clark GJ; Ekstrom TJ; Farnebo F; Larsson C
  • Article: CIRCULATION RESEARCH. 2008;102(12):1483-1491
    Jin S; Hansson EM; Tikka S; Lanner F; Sahlgren C; Farnebo F; Baumann M; Kalimo H; Lendahl U
  • Article: STEM CELLS. 2007;25(12):2987-2995
    Li X; Edholm D; Lanner F; Breier G; Farnebo F; Dimberg A; Claesson-Welsh L
  • Article: ENDOCRINE-RELATED CANCER. 2007;14(1):125-134
    Geli J; Kiss N; Lanner F; Foukakis T; Natalishvili N; Larsson O; Kogner P; Hoog A; Clark GJ; Ekstrom TJ; Backdahl M; Farnebo F; Larsson C
  • Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2007;27(3):487-493
    Lanner F; Sohl M; Farnebo F
  • Show more

All other publications

  • Corrigendum: NATURE METHODS. 2025;22(3):636
    Zhao C; Reyes AP; Schell JP; Weltner J; Ortega NM; Zheng Y; Bjorklund AK; Baque-Vidal L; Sokka J; Trokovic R; Cox B; Rossant J; Fu J; Petropoulos S; Lanner F
  • Editorial comment: STEM CELLS. 2023;41(2):105-110
    Yoshihara M; Wagner M; Damdimopoulos A; Zhao C; Petropoulos S; Katayama S; Kere J; Lanner F; Damdimopoulou P
  • Letter: STEM CELLS. 2023;41(2):205-206
    Yoshihara M; Wagner M; Damdimopoulos A; Zhao C; Petropoulos S; Katayama S; Kere J; Lanner F; Damdimopoulou P
  • Editorial comment: NATURE. 2021;600(7888):223-224
    Goedel A; Lanner F
  • Editorial comment: CELL STEM CELL. 2021;28(9):1503-1504
    Weltner J; Lanner F
  • Review: STEM CELL REPORTS. 2021;16(5):1117-1141
    Posfai E; Lanner F; Mulas C; Leitch HG
  • Preprint: BIORXIV. 2021
    Zhao C; Plaza Reyes A; Schell JP; Weltner J; Ortega N; Zheng Y; Björklund Å; Baqué-Vidal L; Sokka J; Torokovic R; Cox B; Rossant J; Fu J; Petropoulos S; Lanner F
  • Editorial comment: OBSTETRICAL & GYNECOLOGICAL SURVEY. 2020;75(6):354-355
    Wagner M; Yoshihara M; Douagi I; Damdimopoulos A; Panula S; Petropoulos S; Lu H; Pettersson K; Palm K; Katayama S; Hovatta O; Kere J; Lanner F; Damdimopoulou P
  • Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2018;52:1-6
    Ortega NM; Winblad N; Reyes AP; Lanner F
  • Editorial comment: CELL STEM CELL. 2018;23(2):155-157
    Reyes AP; Lanner F
  • Editorial comment: NATURE. 2017;548(7668):398-400
    Winblad N; Lanner F
  • Review: DEVELOPMENT. 2017;144(1):3-7
    Reyes AP; Lanner F
  • Corrigendum: CELL. 2016;167(1):285
    Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
  • Corrigendum: SCIENTIFIC REPORTS. 2016;6:32053
    Madissoon E; Jouhilahti E-M; Vesterlund L; Tohonen V; Krjutskov K; Petropoulos S; Einarsdottir E; Linnarsson S; Lanner F; Mansson R; Hovatta O; Burglin TR; Katayama S; Kere J
  • Review: JOURNAL OF INTERNAL MEDICINE. 2016;280(3):252-264
    Petropoulos S; Panula SP; Schell JP; Lanner F
  • Editorial comment: OBSTETRICAL & GYNECOLOGICAL SURVEY. 2016;71(1):29-30
    Zhang H; Panula S; Petropoulos S; Edsgard D; Busayavalasa K; Liu L; Li X; Risal S; Shen Y; Shao J; Liu M; Li S; Zhang D; Zhang X; Gerner RR; Sheikhi M; Damdimopoulou P; Sandberg R; Douagi I; Gustafsson J-A; Liu L; Lanner F; Hovatta O; Liu K
  • Letter: NATURE MEDICINE. 2015;21(10):1116-1118
    Zhang H; Panula S; Petropoulos S; Edsgard D; Busayavalasa K; Liu L; Li X; Risal S; Shen Y; Shao J; Liu M; Li S; Zhang D; Zhang X; Gerner RR; Sheikhi M; Damdimopoulou P; Sandberg R; Douagi I; Gustafsson J-A; Liu L; Lanner F; Hovatta O; Liu K
  • Review: EXPERIMENTAL CELL RESEARCH. 2014;321(1):32-39
    Lanner F
  • Review: DEVELOPMENT. 2010;137(20):3351-3360
    Lanner F; Rossant J
  • Doctoral thesis: 2008
    Lanner F

Grants

  • Ming Wai Lau Centre for Reparative Medicine (MWLC)
    1 January 2024 - 31 December 2026
  • Swedish Research Council
    1 December 2023 - 30 November 2028
  • Knut and Alice Wallenberg Foundation
    1 January 2015 - 1 January 2020
  • Swedish Research Council
    1 January 2014 - 31 December 2018
  • Mammalian preimplantation development and pluripotency –Man is not a mouse
    Ragnar Söderberg Foundation
    1 January 2014 - 31 December 2018
  • Uncovering early mammalian development and pluripotency
    Swedish Foundation for Strategic Research
    1 September 2013 - 31 August 2016
  • Swedish Research Council
    1 July 2012 - 30 June 2013
  • Studies on how pluripotent stem cells are regulated in the early embryo
    Swedish Research Council
    1 July 2009 - 30 June 2011

Employments

  • Principal Researcher, Department of Clinical Science, Intervention and Technology, ̽»¨¾«Ñ¡, 2022-

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, ̽»¨¾«Ñ¡, 2008

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