探花精选

Federico Iovino

Federico Iovino

Principal Researcher | Docent
Telephone: +46852487121
Visiting address: Solnav盲gen 9, Biomedicum, kvarter D7, 17165 Solna
Postal address: C4 Neurovetenskap, C4 Forskning Iovino, 171 77 Stockholm

About me

  • Associate Professor (Docent), Principal Investigator and Group Leader

    Between 2009 and 2013, I performed my PhD in Medical Microbiology under the supervision of Prof. Jan Maarten van Dijl and Prof. Grietje Molema studying how Streptococcus pneumoniae interact with endothelial cells causing meningitis. In 2010, I have been visiting PhD student in the lab of Prof. Carlos Orihuela in the Department of Microbiology and Immunology at the University of Texas Health Science Center in San Antonio, USA.

    After my PhD graduation in November 2013, I started my postdoc in December 2013 at the 探花精选, Department of Microbiology, Tumor and Cell Biology (MTC) where I continued my studies on pneumococcal meningitis. My postdoc studies have been published in the leading journals Journal of Clinical Investigation (2016), Journal of Experimental Medicine (2017), and Journal of Infectious Diseases (2018).
    I was awarded in 2018 with the Four-year funding for Assistant Professor position by the 探花精选 Board of Research and in 2020 with the Starting Grant in Medicine and Health from the Swedish Research Council (Vetenskapsr氓det). Because of my profound interest in nervous system infections, in January 2021 I have started my own independent laboratory of Neuro-Infections and Neuroinflammation at the Department of Neuroscience at 探花精选. I was appointed Docent (Associate Professor) in Medical Microbiology in December 2021 and Principal Researcher (Senior Forskare) in April 2023.

     

    PRINCIPAL INVESTIGATOR APPOINTMENTS

    2023: Principal Researcher (Senior Forskare), Department of Neuroscience, KI.

    2021: Docentship (Associate Professorship) in Medical Microbiology, Department of Neuroscience, KI.

    2021: Group Leader, Department of Neuroscience, KI.

    2018: Assistant Professorship in Medical Science, KI.


    BIBLIOMETRICS
    Total number of publications on Pubmed: 30 (Pubmed link:
    Total number of last-author and corresponding-author publications: 10
    Total number of first-author publications: 16
    Citations and h-index:
    Total Impact Points: 210

Research

  • In my laboratory, we investigate molecular mechanisms of bacterial interaction with brain cells during meningoencephalitis pathogenesis. In particular, we are interested in elucidating the interactions between bacteria and neurons leading to neuronal cell death, pathological hallmark of the neurological disabilities experienced by 70% of the individuals affected with bacterial meningoencephalitis. Our goal is to understand the molecular properties of bacteria-neuron interaction and develop strategies to block it in order to prevent neuronal damage. In addition, we are also interested in understanding how brain immunity reacts towards bacteria attacking the central nervous system. Microglia, the brain immune sentinels, can recognize proteins either surface-exposed or secreted by the bacteria and initiate phagocytosis to eliminate the pathogen threat. Our goal is to identify such proteins and use them as immunotherapy to stimulate microglia to excert a quick and efficient bacterial elimination.

Teaching

  • TEACHING AT KI

    Course coordinator and Lecturer: 鈥淚nterplay between neuro-infections and neurodegenerative diseases鈥, PhD Course, Neuroscience Doctoral Program (2023-ongoing); 鈥淏acteriology鈥 Course, Biomedicine Bachelor Program (2016-2022).
    Lecturer: Infection and Immunology, and Medical Microbiology, 鈥淚llness and Disease鈥 Course, Study Program of Medicine; 鈥淧neumococcal Infections鈥, 鈥淐ellular and Molecular Infection鈥 PhD course.
    Laboratory teacher: 鈥淢edical Microbiology鈥 Course, Study Program of Medicine; 鈥淏acteriology鈥 Laboratory Course, Biomedicine Bachelor Program.
    Examining teacher: 鈥淔rontiers in Biomedicine鈥 Course, Biomedicine Master Program.

Articles

  • Journal article: JAMA NETWORK OPEN. 2024;7(12):e2445497
    Mohanty S; Johansson Kostenniemi U; Silfverdal SA; Salomonsson S; Iovino F; Bencina G; Tsoumani E; Bruze G
  • Article: NEUROBIOLOGY OF DISEASE. 2024;195:106484
    Farmen K; Tofi帽o-Vian M; Wellfelt K; Olsson L; Iovino F
  • Article: ISCIENCE. 2024;27(4):109583
    Serra S; Iannotti V; Ferrante M; Tofi帽o-Vian M; Baxendale J; Silberberg G; Kohler TP; Hammerschmidt S; Ulijasz AT; Iovino F
  • Article: JAMA NETWORK OPEN. 2024;7(1):e2352402
    Mohanty S; Johansson Kostenniemi U; Silfverdal SA; Salomonsson S; Iovino F; Sarpong EM; Bencina G; Bruze G
  • Article: MBIO. 2022;13(5):e0188622-e01822
    Generoso JS; Thorsdottir S; Collodel A; Dominguini D; Santo RRE; Petronilho F; Barichello T; Iovino F
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(23):e2122386119
    Narciso AR; Iovino F; Thorsdottir S; Mellroth P; Codemo M; Spoerry C; Righetti F; Muschiol S; Normark S; Nannapaneni P; Henriques-Normark B
  • Article: PLOS PATHOGENS. 2021;17(3):e1009432
    Tabusi M; Thorsdottir S; Lysandrou M; Narciso AR; Minoia M; Srambickal CV; Widengren J; Henriques-Normark B; Iovino F
  • Article: EMBO MOLECULAR MEDICINE. 2020;12(11):e12695
    Subramanian K; Iovino F; Tsikourkitoudi V; Merkl P; Ahmed S; Berry SB; Aschtgen M-S; Svensson M; Bergman P; Sotiriou GA; Henriques-Normark B
  • Article: CHEMICAL COMMUNICATIONS. 2020;56(51):6989-6992
    Iovino F; Merkl P; Spyrogianni A; Henriques-Normark B; Sotiriou GA
  • Article: BIOSENSORS & BIOELECTRONICS. 2019;132:286-293
    Henning DF; Merkl P; Yun C; Iovino F; Xie L; Mouzourakis E; Moularas C; Deligiannakis Y; Henriques-Normark B; Leifer K; Sotiriou GA
  • Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:173-181
    Iovino F; Sender V; Henriques-Normark B
  • Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:53-59
    Iovino F; Henriques-Normark B
  • Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:35-39
    Iovino F; Henriques-Normark B
  • Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:195-202
    Sierakowiak A; Henriques-Normark B; Iovino F
  • Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):476-484
    Iovino F; Thorsdottir S; Henriques-Normark B
  • Article: MBIO. 2018;9(2):e00559-e00518
    Codemo M; Muschiol S; Iovino F; Nannapaneni P; Plant L; Wai SN; Henriques-Normark B
  • Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(6):1619-1630
    Iovino F; Engelen-Lee J-Y; Brouwer M; van de Beek D; van der Ende A; Seron MV; Mellroth P; Muschiol S; Bergstrand J; Widengren J; Henriques-Normark B
  • Article: JOURNAL OF CLINICAL INVESTIGATION. 2016;126(8):2821-2826
    Iovino F; Hammarlof DL; Garriss G; Brovall S; Nannapaneni P; Henriques-Normark B
  • Article: INFECTION AND IMMUNITY. 2014;82(9):3555-3566
    Iovino F; Molema G; Bijlsma JJE
  • Article: MBIO. 2014;5(4):e00984-e00914
    Iovino F; Gradstedt H; Bijlsma JJ
  • Article: PLOS ONE. 2014;9(5):e97914
    Iovino F; Molema G; Bijlsma JJE
  • Article: PLOS ONE. 2013;8(7):e68408
    Iovino F; Orihuela CJ; Moorlag HE; Molema G; Bijlsma JJE
  • Article: PLOS ONE. 2013;8(6):e65626
    Gradstedt H; Iovino F; Bijlsma JJE
  • Show more

All other publications

  • Preprint: BIORXIV. 2023
    Farmen K; Tofi帽o-Vian M; Wellfelt K; Olson L; Iovino F
  • Review: FRONTIERS IN NEUROLOGY. 2023;14:822575
    Barichello T; Rocha Catal茫o CH; Rohlwink UK; van der Kuip M; Zaharie D; Solomons RS; van Toorn R; Tutu van Furth M; Hasbun R; Iovino F; Namale VS
  • Book: 2022
    Encyclopedia of Infection and Immunity
  • Preprint: BIORXIV. 2022
    Generoso JS; Thorsdottir S; Collodel A; Dominguini D; Santo RRE; Petronilho F; Barichello T; Iovino F
  • Editorial comment: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(5):539-540
    Iovino F; Henriques-Normark B
  • Editorial comment: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021;11:790761
    Barichello T; Iovino F
  • Review: FRONTIERS IN CELLULAR NEUROSCIENCE. 2021;15:680858
    Farmen K; Tofino-Vian M; Iovino F
  • Preprint: BIORXIV. 2020
    Tabusi M; Thorsdottir S; Lysandrou M; Narciso AR; Minoia M; Henriques-Normark B; Iovino F
  • Review: MOLECULAR MICROBIOLOGY. 2020;113(3):650-658
    Iovino F; Nannapaneni P; Henriques-Normark B; Normark S
  • Book: 2019
    Streptococcus pneumoniae Methods and Protocols
    Iovino F
  • Review: FRONTIERS IN MICROBIOLOGY. 2019;10:576
    Thorsdottir S; Henriques-Normark B; Iovino F
  • Review: TRENDS IN MICROBIOLOGY. 2016;24(4):307-315
    Iovino F; Seinen J; Henriques-Normark B; van Diji JM
  • Review: CELLULAR MICROBIOLOGY. 2013;15(6):870-881
    Iovino F; Brouwer MC; van de Beek D; Molema G; Bijlsma JJEY

Grants

  • Medicin 2025, projektmedel
    ALF (Region Stockholm)
    1 January 2025 - 31 December 2024
  • 脜hl茅n Foundation
    脜hl茅n Foundation
    1 January 2025
  • Engineered endolysins to fight antibiotic-resistant streptococcal infections and neutralize toxins
    Swedish Research Council
    1 January 2025 - 31 December 2026
  • Project Grant
    Gun & Bertil's Stohne Foundation
    1 January 2025
  • Etablering av en ny neuroprotektiv terapi f枚r att f枚rhindra h枚rselneds盲ttning orsakad av hj盲rninfektioner
    Stiftelsen Tysta Skolan
    1 June 2024
  • Supporting innovators to fight drug-resistant infections
    INCATE
    1 May 2024
  • Blocking bacterial interaction with neurons: a new therapeutic strategy to prevent permanent neurological damage caused by brain infections
    Magnus Bergvall Foundation
    1 February 2024
  • The bacteria-neuron blockade, the FIRST therapeutic approach to prevent permanent neurological damage caused by infections
    Gun & Bertil Stohne Foundation
    1 January 2024
  • Preventing neurological disabilities caused by perinatal brain infections
    脜hl茅n Foundation
    1 January 2024
  • Novel fusion proteins with bacteriocidic, anti-neurotoxic and antibiotic synergistic properties to improve pneumococcal meningitis treatment
    HKH Crown Princess Lovisa's Association for Childcare
    1 November 2023 - 1 November 2024
  • Preventing permanent severe hearing loss caused by brain infections
    Tysta Skolan Foundation
    1 May 2023
  • A new therapeutic approach to prevent permanent neurological disabilities in infants and children affected by brain infections
    Wera Ekstr枚m Fund for Pediatric Research
    1 February 2023
  • Bakteriell interaktion med neuroner: ett nytt terapeutiskt m氓l mot hj盲rninfektioner
    Magnus Bergvall Foundation
    1 February 2023
  • Blockade of pneumococcal鈥恘euron interaction to prevent neuronal damage in bacterial meningitis
    European Society of Clinical Microbiology and Infectious Diseases
    1 January 2023 - 1 January 2024
  • Establishment of the first therapeutic approach to prevent permanent neurological disabilities caused by brain bacterial infections
    Bjarne Alhstr枚m Memorial Fund
    1 January 2023
  • Prevention of neurological disabilities caused by perinatal brain infections
    脜hl茅n Foundation
    1 January 2023
  • Bacterial interaction with neurons: a new therapeutic target against brain infections
    Magnus Bergvall Foundation
    1 January 2022
  • Preventing irreparable neurological damage after bacterial meningitis by blocking pathogen interaction with neurons
    Tore Nilson Foundation
    1 January 2022
  • Preventing neuronal loss that leads to Parkinson's and Alzheimer's diseases
    Foundation of the Elderly
    1 May 2021
  • Swedish Research Council
    1 January 2021 - 31 December 2024
  • F枚rhindra irreparabel neurologisk skada efter bakteriell meningit genom att blockera patogeninteraktion med neuroner
    Magnus Bergvall Foundation
    1 January 2021
  • Bacterial Meningitis: Understanding Bacterial Interactions with Microglia and Neurons to Develop New Methods to Boost the Brain Immune System and Prevent Neuronal Damage
    Tore Nilson Foundation
    1 January 2021
  • Understanding bacterial invasion of the brain: Interactions of Streptococcus pneumoniae with microglia and neurons.
    脜ke Wibergs Stiftelse
    1 January 2020
  • Understanding bacterial invasion of the brain
    Loo & Hans Osterman Foundation
    1 November 2019
  • Start-up Grant
    StratNeuro
    1 June 2019
  • Bacterial Meningitis: Understanding Bacterial Interactions with Microglia and Neurons to Develop New Methods to Boost the Brain Immune System and Prevent Neuronal Damage
    Petrus och Augusta Hedlunds Stiftelse
    1 June 2019
  • Block pneumococcal-neuron interaction to protect neurons from bacterial infections
    Clas Groschinsky Foundation
    1 June 2019
  • Improving antimicrobial treatments in cancer patients
    Jeansson Foundation
    1 January 2019
  • New therapeutic and prophylactic strategies to cure and prevent bacterial meningitis
    HKH Crown Princess Lovisa's Association for Children Healthcare
    1 January 2019
  • New therapeutic strategies to cure and prevent bacterial meningitis State
    探花精选 Research Foundations
    1 January 2019
  • Brain cancer and bacterial meningitis: how to prevent bacterial penetration of the blood-brain barrier in patients with brain cancer.
    脜ke Wiberg Foundation
    1 January 2019
  • Faculty-funded Assistant Professor position
    探花精选
    3 December 2018
  • Bacterial meningitis: Molecular mechanisms of bacterial entry into the brain across the blood-brain barrier and new therapeutic approaches to block it.
    Petrus and Augusta Hedlund Foundation
    1 June 2018
  • Bacterial meningitis: Understanding bacterial invasion of the brain
    Fredrik och Ingrid Thurings Stiftelse
    1 January 2018
  • New therapeutic strategies to cure and prevent bacterial meningitis
    Jeansson Foundation
    1 January 2018
  • New therapeutic strategies to cure and prevent bacterial meningitis
    脜ke Wiberg Foundation
    1 January 2018
  • Etablering av en ny neuroprotektiv terapi f枚r att f枚rhindra h枚rselneds盲ttning orsakad av hj盲rninfektioner
    Stiftelsen Tysta Skolan
  • Show more

Employments

  • Principal Researcher, Department of Neuroscience, 探花精选, 2023-
  • Postdoctoral researcher, Microbiology, Tumor and Cell Biology (MTC), 探花精选, 2013-2015

Degrees and Education

  • Docent, 探花精选, 2021
  • PhD degree, Medical Microbiology, Medical Microbiology, University of Groningen, 2013

Leadership and responsibility assignments

  • Responsible for a section, Principal Investigator representative, Neuroscience, 探花精选, 2022-
  • Responsible for a section, Safety representative, Neuroscience, 探花精选, 2022-

Distinction and awards

  • World Expert Recognition, Expertscape, , 2021
  • Prize for research in Clinical Neurology, Bjarne Ahlstr枚m Memorial Fund, , 2020

Supervision

  • Simona Serra, 2023
  • Niels Vander Elst, 2023
  • Miguel Tofi帽o-Vian, 2021
  • Kristine Farmen, 2021

Editorial work

  • "In vitro and In vivo models for CNS infections", part of the 鈥淢ethods in Molecular Biology鈥 series, Editor-in-chief, 2022
  • Frontiers in Cellular and Infection Microbiology, Editorial board member, 2021
  • Section Clinical Infectious Diseases, Encyclopedia of Infection and Immunity (Elsevier), Associate editor, , 2020
  • "Streptococcus pneumoniae", part of the 鈥淢ethods in Molecular Biology鈥 series, Editor-in-chief, , 2018

Journal reviewing

  • Nature Communications, Cell Systems, PNAS, eBioMedicine (The Lancet), Scientific Reports (Nature publishing group), BMC Journal of Bio探花精选 Science, PLOS One, Journal of Neuroinflammation, Molecular Neurobiology, Brain Research, Cellular and Molecular Neurobiology, Journal of Neuroimmunology, Neurotoxicology and Teratology, Neuroscience Letters, Journal of Innate Immunity, Journal of Immunology, mBio (American Society of Microbiology), PLOS Pathogens, Infection & Immunity, Molecular Microbiology, Journal of Bacteriology, The International Journal of Medical Microbiology, Microbiology (Microbiology Society), Microbial Pathogenesis, Pathogens and Disease (FEMS), Virulence, Frontiers in Cellular and Infection Microbiology, Frontiers in Immunology, Frontiers in Pediatrics, Frontiers in Bioengineering and Biotechnology, Current Research in Microbial Sciences, Infection and Drug Resistance, Heliyon (Cell Press), Experimental and Molecular Pathology, Annals of Medicine, BMJ (British Medical Journal) Case Reports, Journal of Pediatric Infectious Disease Society., Anonymous peer review, 2018

Other expert reviewer/evaluation assignment

  • Evaluator of research applications in international competition, Grant reviewer / Evaluation panel member, European Society of Clinical Microbiology and Infectious Diseases, 2021

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