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Eckardt Treuter

Eckardt Treuter

Professor | Docent
Visiting address: Blickagången 16, 14152 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 BioNut Treuter, 171 77 Stockholm
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About me

  • Eckardt Treuter has been leading a research team as a professor at the ̽»¨¾«Ñ¡ since 2007. He has more than three decades research experience in the regulation of gene expression, epigenomics, nuclear receptor signalling, metabolic and inflammatory disease pathways. He has completed his PhD at the Martin Luther University Halle-Wittenberg in Germany with a dissertation about stress-regulated transcription factors. He did his postdoc at the ̽»¨¾«Ñ¡ where he identified nuclear receptor-associated proteins using unbiased screenings. Since then the study of these proteins, many of which are now known as fundamental transcriptional coregulators, has remained his key interest.

Research

  • Epigenetic control of metabolism and inflammation by transcriptional coregulators

    Our research aims at better understanding how the epigenome controls metabolic and inflammatory pathways in the context of obesity, type 2 diabetes, fatty liver disease and atherosclerosis. Epigenetic alterations that trigger changes in epigenome activity and gene expression are fundamental reprogramming events that contribute to the development of these diseases. However, the underlying regulatory mechanisms, the critical components, and the causal relationship of these associations are currently poorly defined. With an emphasis on so-called coregulators we address these issues utilizing a multidisciplinary approach, including molecular biology, biochemistry, genomics and epigenomics approaches, genetically modified cell, tissue and mouse models, and collaborations with clinicians to study human material. We also develop proof-of-concept models for the therapeutic targeting of epigenome components, such as chromatin-modifying complexes and enhancers.

    Transcription factors (>
  • 1600) and associated coregulators (>
  • 300) play central roles in linking epigenome alterations to transcriptional reprogramming, as they shape the chromatin/enhancer landscape (i.e. the epigenome) and determine signal responses. Although these processes are well studied for many transcription factors and coactivators, our understanding of the precise roles of corepressors is currently lacking behind. It is further poorly understood whether and how the dysregulation of specific coregulators contributes to, or potentially even causes, disease.

    Our search for candidates that might be particularly relevant for metabolic and inflammatory disease pathways revealed a potential key role of a fundamental corepressor complex, consisting of the core subunits histone deacetylase HDAC3, G-protein pathway suppressor 2 (GPS2), and the related corepressors NCOR and SMRT. Although these subunits were originally identified as nuclear receptor-associated proteins, we know today that the complex controls many other transcription factors and multiple cellular pathways. Our studies have demonstrated the involvement of the complex in the regulation of cholesterol metabolism and transport, in anti-inflammatory crosstalk mechanisms, in adipose tissue inflammation and hypertrophy, and in hepatic fatty acid oxidation and lipogenesis. Intriguingly, alterations of GPS2 expression in adipocytes and macrophages associate with systemic inflammation and diabetic risk in obese humans, suggesting the identified pathways to be conserved and clinically relevant. Thus, our current hypothesis is that inappropriate complex function, in part due to altered expression and modification of the core subunit GPS2, triggers epigenetic reprogramming and thereby alters the susceptibility to metabolic-inflammatory signals that contribute to disease.

    We now attempt to evaluate the hypothesis using a variety of genetically modified disease models, and in response to different dietary and pharmacological interventions. For example, we have begun to investigate the role of corepressor-mediated epigenome alterations in monocytes/macrophages in linking type 2 diabetes to the progression of atherosclerosis. In another project, we would like to understand how post-translational modifications of individual subunits modulate epigenomic and transcriptional activities of the corepressor complex (and postulated sub-complexes), and how these modifications change in response to different signals and during the development of type 2 diabetes, atherosclerosis and fatty liver disease.

    Besides a better understanding of coregulator-mediated epigenome alterations during the development of metabolic-inflammatory diseases, we also expect novel insights into epigenetic memory and crosstalk mechanisms between metabolic ‘master’ cell types such as macrophages, adipocytes and hepatocytes. These insights may help to develop novel epigenome-based strategies for the prevention and treatment of metabolic-inflammatory diseases.

Articles

  • Article: ADVANCED SCIENCE. 2024;11(20):2307201
    de la Rosa JV; Tabraue C; Huang Z; Orizaola MC; Martin-Rodriguez P; Steffensen KR; Zapata JM; Bosca L; Tontonoz P; Alemany S; Treuter E; Castrillo A
  • Article: SCIENCE ADVANCES. 2024;10(1):eadi2689
    Ludzki AC; Hansen M; Zareifi D; Jalkanen J; Huang Z; Omar-Hmeadi M; Renzi G; Klingelhuber F; Boland S; Ambaw YA; Wang N; Damdimopoulos A; Liu J; Jernberg T; Petrus P; Arner P; Krahmer N; Fan R; Treuter E; Gao H; Ryden M; Mejhert N
  • Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(20):e169671
    Wang T; Dong Y; Huang Z; Zhang G; Zhao Y; Yao H; Hu J; Tueksammel E; Cai H; Liang N; Xu X; Yang X; Schmidt S; Qiao X; Schlisio S; Stromblad S; Qian H; Jiang C; Treuter E; Bergo MO
  • Article: NATURE. 2023;618(7964):365-373
    Paredes A; Justo-Mendez R; Jimenez-Blasco D; Nunez V; Calero I; Villalba-Orero M; Alegre-Marti A; Fischer T; Gradillas A; Sant'Anna VAR; Were F; Huang Z; Hernansanz-Agustin P; Contreras C; Martinez F; Camafeita E; Vazquez J; Ruiz-Cabello J; Area-Gomez E; Sanchez-Cabo F; Treuter E; Bolanos JP; Estebanez-Perpina E; Ruperez FJ; Barbas C; Enriquez JA; Ricote M
  • Article: NUCLEIC ACIDS RESEARCH (NAR). 2023;51(3):1067-1086
    Huang Z; Efthymiadou A; Liang N; Fan R; Treuter E
  • Article: STAR PROTOCOLS. 2022;3(2):101338
    Huang Z; Wang C; Treuter E; Fan R
  • Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2022;42(5):659-676
    Rykaczewska U; Zhao Q; Saliba-Gustafsson P; Lengquist M; Kronqvist M; Bergman O; Huang Z; Lund K; Waden K; Pons Vila Z; Caidahl K; Skogsberg J; Vukojevic V; Lindeman JHN; Roy J; Hansson GK; Treuter E; Leeper NJ; Eriksson P; Ehrenborg E; Razuvaev A; Hedin U; Matic L
  • Article: MOLECULAR CELL. 2021;81(5):953-968.e9
    Huang Z; Liang N; Goni S; Damdimopoulos A; Wang C; Ballaire R; Jager J; Niskanen H; Han H; Jakobsson T; Bracken AP; Aouadi M; Venteclef N; Kaikkonen MU; Fan R; Treuter E
  • Article: MOLECULAR METABOLISM. 2020;42:101066
    Barilla S; Liang N; Mileti E; Ballaire R; Lhomme M; Ponnaiah M; Lemoine S; Soprani A; Gautier J-F; Amri E-Z; Le Goff W; Venteclef N; Treuter E
  • Article: CELL REPORTS. 2020;32(11):108141
    Drareni K; Ballaire R; Alzaid F; Goncalves A; Chollet C; Barilla S; Nguewa J-L; Dias K; Lemoine S; Riveline J-P; Roussel R; Dalmas E; Velho G; Treuter E; Gautier J-F; Venteclef N
  • Article: NATURE COMMUNICATIONS. 2019;10(1):1684
    Liang N; Damdimopoulos A; Goni S; Huang Z; Vedin L-L; Jakobsson T; Giudici M; Ahmed O; Pedrelli M; Barilla S; Alzaid F; Mendoza A; Schroder T; Kuiper R; Parini P; Hollenberg A; Lefebvre P; Francque S; Van Gaal L; Staels B; Venteclef N; Treuter E; Fan R
  • Article: THE FASEB JOURNAL. 2019;33(2):1631-1643
    Huang Z; Liang N; Damdimopoulos A; Fan R; Treuter E
  • Article: CELL REPORTS. 2019;26(4):984-995.e6
    Becares N; Gage MC; Voisin M; Shrestha E; Martin-Gutierrez L; Liang N; Louie R; Pourcet B; Pello OM; Luong TV; Goni S; Pichardo-Almarza C; Roberg-Larsen H; Diaz-Zuccarini V; Steffensen KR; O'Brien A; Garabedian MJ; Rombouts K; Treuter E; Pineda-Torra I
  • Article: METHODS IN MOLECULAR BIOLOGY. 2019;1951:167-178
    Liang N; Fan R; Goñi S; Treuter E
  • Article: CELL REPORTS. 2018;24(11):2957-2971.e6
    Drareni K; Ballaire R; Barilla S; Mathew MJ; Toubal A; Fan R; Liang N; Chollet C; Huang Z; Kondili M; Foufelle F; Soprani A; Roussel R; Gautier J-F; Alzaid F; Treuter E; Venteclef N
  • Journal article: DIABETES AND METABOLISM. 2017;43(2):a34
    Drareni K; Toubal A; Al azaid F; Ballaire R; Barilla S; Foufelle F; Treuter E; Venteclef N
  • Article: NATURE MEDICINE. 2016;22(7):780-791
    Fan R; Toubal A; Goni S; Drareni K; Huang Z; Alzaid F; Ballaire R; Ancel P; Liang N; Damdimopoulos A; Hainault I; Soprani A; Aron-Wisnewsky J; Foufelle F; Lawrence T; Gautier J-F; Venteclef N; Treuter E
  • Article: MUCOSAL IMMUNOLOGY. 2014;7(6):1416-1428
    Jakobsson T; Vedin L-L; Hassan T; Venteclef N; Greco D; D'Amato M; Treuter E; Gustafsson J-A; Steffensen KR
  • Article: ONCOGENE. 2014;33(34):4340-4351
    Zhu J; Zhao C; Kharman-Biz A; Zhuang T; Jonsson P; Liang N; Williams C; Lin C-Y; Qiao Y; Zendehdel K; Stroemblad S; Treuter E; Dahlman-Wright K
  • Journal article: DIABETES AND METABOLISM. 2013;39:a101
    Venteclef N; Clément K; Treuter E; Toubal A
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All other publications

  • Thesis / dissertation: 2023
    Wang, Ting
  • Corrigendum: NATURE. 2023;619(7968):E24
    Paredes A; Justo-Mendez R; Jimenez-Blasco D; Nunez V; Calero I; Villalba-Orero M; Alegre-Marti A; Fischer T; Gradillas A; Sant'Anna VAR; Were F; Huang Z; Hernansanz-Agustin P; Contreras C; Martinez F; Camafeita E; Vazquez J; Ruiz-Cabello J; Area-Gomez E; Sanchez-Cabo F; Treuter E; Bolanos JP; Estebanez-Perpina E; Ruperez FJ; Barbas C; Enriquez JA; Ricote M
  • Review: OBESITY. 2021;29(12):2013-2025
    Barilla S; Treuter E; Venteclef N
  • Corrigendum: ONCOGENE. 2019;38(2):299-300
    Zhu J; Zhao C; Kharman-Biz A; Zhuang T; Jonsson P; Liang N; Williams C; Lin C-Y; Qiao Y; Zendehdel K; Stromblad S; Treuter E; Dahlman-Wright K
  • Book chapter: HANDBOOK OF NUTRITION, DIET, AND EPIGENETICS. 2019;p. 233-263
    Alzaïd F; Jakobsson T; Treuter E; Venteclef N
  • Review: FRONTIERS IN ENDOCRINOLOGY. 2019;10:411
    Liang N; Jakobsson T; Fan R; Treuter E
  • Book chapter: HANDBOOK OF NUTRITION, DIET, AND EPIGENETICS. 2018;p. 1-31
    Alzaïd F; Jakobsson T; Treuter E; Venteclef N
  • Review: FEBS LETTERS. 2017;591(19):2959-2977
    Treuter E; Fan R; Huang Z; Jakobsson T; Venteclef N
  • Preprint: BIORXIV. 2017
    Becares N; Gage MC; Martin-Gutierrez L; Shrestha E; Louie R; Pourcet B; Pello OM; Luong TV; Goñi S; Liang N; Pichardo C; Røberg-Larsen H; Diaz V; Steffensen KR; Garabedian MJ; Rombouts K; Treuter E; Pineda-Torra I
  • Conference publication: DIABETOLOGIA. 2017;60:S261
    Drareni K; Barilla S; Alzaid F; Ballaire R; Treuter E; Venteclef N
  • Review: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2016;233:95-135
    Giudici M; Goni S; Fan R; Treuter E
  • Book chapter: COMPENDIUM OF INFLAMMATORY DISEASES. 2016;p. 994-1016
    Venteclef N; Jakobsson T; Treuter E
  • Other: MEDECINE/SCIENCES. 2014;30(1):15-18
    Toubal A; Treuter E; Venteclef N
  • Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2013;24(12):625-634
    Toubal A; Treuter E; Clement K; Venteclef N
  • Book chapter: ENCYCLOPEDIA OF INFLAMMATORY DISEASES. 2013;p. 1-24
    Venteclef N; Jakobsson T; Treuter E
  • Review: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2012;130(3-5):169-179
    Ehrlund A; Treuter E
  • Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2012;33(7):394-404
    Jakobsson T; Treuter E; Gustafsson J-A; Steffensen KR
  • Conference publication: DIABETES AND METABOLISM. 2012;38:A30-A31
    Toubal A; Allili R; Pelloux V; Barsh G; Clement K; Treuter E; Venteclef N
  • Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1812(8):909-918
    Treuter E; Venteclef N
  • Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2011;22(8):333-343
    Venteclef N; Jakobsson T; Steffensen KR; Treuter E
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Grants

  • Role of monocyte enhancers and silencers in inflammatory type 2 diabetes
    Novo Nordisk Foundation
    1 January 2024 - 31 December 2025
  • Swedish Research Council
    1 January 2023 - 31 December 2026
  • Role of transcriptional corepressors in epigenetic mechanisms underlying atherosclerosis and nonalcoholic fatty liver disease
    Novo Nordisk Foundation
    1 January 2023 - 31 December 2023
  • Swedish Cancer Society
    1 January 2022
  • Swedish Research Council
    1 December 2020 - 31 December 2022

Employments

  • Professor, Department of Medicine, Huddinge, ̽»¨¾«Ñ¡, 2024-

Degrees and Education

  • Docent, ̽»¨¾«Ñ¡, 2005

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