探花精选

Dhifaf Sarhan

Dhifaf Sarhan

Assistant Professor | Docent
Visiting address: ,
Postal address: H5 Laboratoriemedicin, H5 Patologi, 141 52 Huddinge
Part of:

About me

  • Dhifaf Sarhan is Associate Professor (Docent), Group leader at the
    Department of Laboratory Medicine Huddinge (LABMED)/Division of Pathology, and the Division Head.
    Sarhan was recruited to the Department of Microbiology, Tumor and Cell
    biology as Assistant Professor in Tumor immunology/Immunotherapy in 2019 and
    as group leader at LABMED/Division of Pathology in 2021 focusing on deciphering immune interactions and responses in solid tumors. Sarhan completed her Ph.D. at the Department of Oncology-Pathology, 探花精选 in
    2014 focused on studying natural killer (NK) cells in the tumor microenvironment followed by postdoctoral training at the University of
    Minnesota. Her group research interest focuses on studying the
    consequences of the tumor microenvironment (TME) on shaping the immune
    effector cell function and memory aiming to remodel the TME to improved
    cancer immunotherapies in a sex-dependent manner.

    Honors and awards
    Junior Investigator Award, Swedish Cancer Society
    Jonas S枚derquist's scholarship
    Selected for 3-years CANCER CORE EUROPE advanced training program TRYTRAC in
    translational/clinical research and leadership
    World Immunotherapy Council, Young Investigator Award
    Best abstract, Cancer immunotherapy and immunomonitoring (CITIM)
    Pancreatic cancer fellow, Swedish Cancer Society
    Postdoctoral fellowship, 探花精选 and University of Minnesota,
    Minneapolis, Minnesota USA
    Award for research project, ImmunoTools
    Scholarship, Swedish Order of Freemasons

    Funding
    Current:
    Centrum for Innovative Medicine
    Swedish Cancer Society
    Radiumhemmetsforsknings fonder
    Stiftelsen Clas Groschinsky Minnesfonds
    KI Stiftelser och Fonder
    Stiftelsen Sigurd and Elsa Goljes Minne
    The Sj枚berg foundation

    Past:
    Jonas S枚derquist foundation
    Postdoctoral fellowship 探花精选, University of Minnesota
    Novo, NovoSeeds
    Lindhes Advokatbyr氓
    Robert Lundbergs minnesstiftelse

    Education
    2010-2014- PhD, Medical Sciences, 探花精选, Stockholm, Sweden
    2008-2010: M.S, Biomedicine, 探花精选
    2005-2008: B.S Molecular biology, Uppsala University, Uppsala, Sweden

    Teaching assignments
    Medicine program, Bio探花精选 science program, Bio探花精选 laboratory science, and doctoral education.

Research

  • *Research line I: Adaptive NK cell immunological memory in cancer*
    For decades NK cells were believed to lack the immunological memory, however
    recent groundbreaking research by us and others revealed the opposite. We
    discovered novel mechanisms used by a subset of NK cells with immunological
    memory, called adaptive NK cells, to resist the suppressive tumor
    environment. In this project we focus on investigating the molecular
    mechanisms behind NK cell memory to tumors and the crosstalk with antigen
    presenting cells like dendritic cells and B cells in cancer.

    *Research Line II: Studies of sex immune dimorphism in the TME
    We found that a G-protein coupled receptor has predictive value for female
    cancer patients and induce immune cell exhaustion. Hormone regulation of the ligand for this
    receptor has been shown to induce anti-inflammatory properties in
    macrophages. We revealed that this receptor impacts the immune landscape in pancreatic
    cancer TME biased by sex dimorphism. Extensive examination of the signal
    integration is needed to further elucidate its mechanism of action and
    clinical impact.

Teaching

  • Teaching in immunology and tumor immunology at 探花精选 and
    Uppsala University.

Articles

  • Article: NATURE COMMUNICATIONS. 2024;15(1):3837
    Wang K; Zerdes I; Johansson HJ; Sarhan D; Sun Y; Kanellis DC; Sifakis EG; Mezheyeuski A; Liu X; Loman N; Hedenfalk I; Bergh J; Bartek J; Hatschek T; Lehtio J; Matikas A; Foukakis T
  • Article: CANCER RESEARCH. 2023;83(10):1628-1645
    He F; Tay AHM; Calandigary A; Malki E; Suzuki S; Liu T; Wang Q; Fernandez-Moro C; Kaisso M; Olofsson-Sahl P; Melssen M; Sze SK; Bjornstedt M; Lohr MJ; Karlsson MCI; Heuchel R; Sarhan D
  • Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1230718
    Almazan NM; Sala BM; Sandalova T; Sun Y; Resink T; Cichocki F; Soderberg-Naucler C; Miller JS; Achour A; Sarhan D
  • Article: ISCIENCE. 2022;25(11):105317
    Sarhan D; Eisinger S; He F; Bergsland M; Pelicano C; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; Muhr J; Onfelt B; Schlisio S; Ravetch JV; Heuchel R; Lohr MJ; Karlsson MCI
  • Article: SEMINARS IN CANCER BIOLOGY. 2022;86(Pt 3):166-179
    He F; Furones AR; Landegren N; Fuxe J; Sarhan D
  • Article: NPJ PRECISION ONCOLOGY. 2021;5(1):97
    Gultekin O; Gonzalez-Molina J; Hardell E; Moyano-Galceran L; Mitsios N; Mulder J; Kokaraki G; Isaksson A; Sarhan D; Lehti K; Carlson JW
  • Article: EMBO REPORTS. 2021;22(3):embr202051329
    Chen Z; Yang Y; Neo SY; Shi H; Chen Y; Wagner AK; Larsson K; Tong L; Jakobsson P-J; Alici E; Wu J; Cao Y; Wang K; Liu LL; Mao Y; Sarhan D; Lundqvist A
  • Article: CANCER RESEARCH. 2021;81(4):956-967
    La Fleur L; Botling J; He F; Pelicano C; Zhou C; He C; Palano G; Mezheyeuski A; Micke P; Ravetch JV; Karlsson MCI; Sarhan D
  • Article: IMMUNITY. 2021;54(2):259-275.e7
    Evren E; Ringqvist E; Tripathi KP; Sleiers N; Rives IC; Alisjahbana A; Gao Y; Sarhan D; Halle T; Sorini C; Lepzien R; Marquardt N; Michaelsson J; Smed-Sorensen A; Botling J; Karlsson MCI; Villablanca EJ; Willinger T
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016
    Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjarvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikstrom SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
  • Article: JCI INSIGHT. 2020;5(5):130155
    Sarhan D; Wang J; Arvindam US; Hallstrom C; Verneris MR; Grzywacz B; Warlick E; Blazar BR; Miller JS
  • Article: METHODS IN MOLECULAR BIOLOGY. 2019;1913:153-166
    Sarhan D; Miller JS
  • Article: CANCER IMMUNOLOGY RESEARCH. 2018;6(7):766-775
    Sarhan D; Hippen KL; Lemire A; Hying S; Luo X; Lenvik T; Curtsinger J; Davis Z; Zhang B; Cooley S; Cichocki F; Blazar BR; Miller JS
  • Article: BLOOD ADVANCES. 2018;2(12):1459-1469
    Sarha D; Brandt L; Felices M; Guldevall K; Lenvik T; Hinderlie P; Curtsinger J; Warlick E; Spellma SR; Blazar BR; Weisdorf DJ; Cooley S; Vallera DA; Onfelt B; Miller JS
  • Article: TRANSPLANTATION AND CELLULAR THERAPY. 2018;24(6):1152-1162
    de Witte MA; Sarhan D; Davis Z; Felices M; Vallera DA; Hinderlie P; Curtsinger J; Cooley S; Wagner J; Kuball J; Miller JS
  • Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2018;67(3):483-494
    Bachanova V; Sarhan D; DeFor TE; Cooley S; Panoskaltsis-Mortari A; Blazar BR; Curtsinger JM; Burns L; Weisdorf DJ; Miller JS
  • Article: CANCER RESEARCH. 2017;77(20):5664-5675
    Cichocki F; Valamehr B; Bjordahl R; Zhang B; Rezner B; Rogers P; Gaidarova S; Moreno S; Tuininga K; Dougherty P; McCullar V; Howard P; Sarhan D; Taras E; Schlums H; Abbot S; Shoemaker D; Bryceson YT; Blazar BR; Wolchko S; Cooley S; Miller JS
  • Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2017;66(10):1333-1344
    Lovgren T; Sarhan D; Truxova I; Choudhary B; Maas R; Melief J; Nystrom M; Edback U; Vermeij R; Scurti G; Nishimura M; Masucci G; Karlsson-Parra A; Lundqvist A; Adamson L; Kiessling R
  • Article: ONCOIMMUNOLOGY. 2017;6(8):e1338238
    Sarhan D; Leijonhufvud C; Murray S; Witt K; Seitz C; Wallerius M; Xie H; Ullen A; Harmenberg U; Lidbrink E; Rolny C; Andersson J; Lundqvist A
  • Journal article: HEMATOLOGICAL ONCOLOGY. 2017;35(S2):261-262
    Bachanova V; Sarhan D; Defor T; Cooley S; Panoskaltsis鈥怣ortari A
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All other publications

  • Conference publication: 2024;:a1568
    Sarhan D; Heffinger L; Damdimopoulos A
  • Preprint: BIORXIV. 2024
    Khan ZA; Ghorbani M; Heffinger L; Damdimopoulos A; Moro CF; Bj枚rnstedt M; L枚hr J-M; Heuchel R; Chen MS; Sarhan D
  • Preprint: BIORXIV. 2024
    Almaz谩n NM; Rom谩n S; Sun Y; Br盲utigam L; Pantalone MR; Stragliotto G; Gultekin O; Saheli S; Lehti K; Naucl茅r CS; Sarhan D
  • Preprint: BIORXIV. 2024
    Sun Y; Rodgers-Furones A; Gultekin O; Khare S; Neo SY; Shi W; Galceran LM; Lam K-P; Dasgupta R; Fuxe J; Salehi S; Lehti K; Sarhan D
  • Preprint: BIORXIV. 2024
    Silva C; Folkesson E; Foroogh F; Gower M; Kleberg L; Xi P; Sahran D; Bruchfeld J; Correia-Neves M; K盲llenius G; Sundling C
  • Conference publication: 2023;:a1108
    Sun Y; Rodgers-Furones A; Suzuki S; Gultekin O; Galceran L; Salehi S; Lehti K; Sarhan D
  • Conference publication: 2023;:a1103-a1104
    Almazan NM; Sarhan D
  • Review: MATRIX BIOLOGY. 2023;121:217-228
    Closset L; Gultekin O; Salehi S; Sarhan D; Lehti K; Gonzalez-Molina J
  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
    Sarhan D; Hippen KL; Lemire A; Hying S; Luo X; Lenvik T; Curtsinger J; Davis Z; Zhang B; Cooley S; Cichocki F; Blazar BR; Miller JS
  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
    Sarhan D; Hippen KL; Lemire A; Hying S; Luo X; Lenvik T; Curtsinger J; Davis Z; Zhang B; Cooley S; Cichocki F; Blazar BR; Miller JS
  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
    Sarhan D; Hippen KL; Lemire A; Hying S; Luo X; Lenvik T; Curtsinger J; Davis Z; Zhang B; Cooley S; Cichocki F; Blazar BR; Miller JS
  • Other: AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR). 2023
    Sarhan D; Hippen KL; Lemire A; Hying S; Luo X; Lenvik T; Curtsinger J; Davis Z; Zhang B; Cooley S; Cichocki F; Blazar BR; Miller JS
  • Preprint: SSRN ELECTRONIC JOURNAL. 2022
    Sarhan D; Eisinger S; Pelicano C; Fei H; Driescher C; Westberg K; Benitez II; Humoud R; Palano G; Li S; Carannante V; 脰nfelt B; Schlisio S; Ravetch JV; Heuchel R; L枚hr MJ; Karlsson MCI
  • Meeting abstract: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2021;9:A927
    Sarhan D; He F; Calandigary A; Malki E; Moro CF; Kaisso M; Olofsson-Sahl P; Melssen M; Lohr M; Karlsson M; Heuchel R
  • Review: EUROPEAN JOURNAL OF CANCER. 2021;155:256-267
    Razaghi A; Poorebrahim M; Sarhan D; Bjornstedt M
  • Preprint: BIORXIV. 2021
    Gultekin O; Gonzalez-Molina J; Hardell E; Moyano-Galceran L; Mitsios N; Mulder J; Kokaraki G; Isaksson A; Sarhan D; Lehti K; Carlson J
  • Conference publication: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2020;8:A431
    La Fleur L; Botling J; He F; Pelicano C; Palano G; Mezheyeuski A; Micke P; Ravetch J; Karlsson M; Sarhan D
  • Conference publication: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2019;7
    Sarhan D
  • Book chapter: CELL AND GENE THERAPIES: ADVANCES AND CONTROVERSIES IN HEMATOPOIETIC TRANSPLANTATION AND CELL THERAPY. 2019;p. 181-200
    Sarhan D; Miller JS
  • Conference publication: CANCER RESEARCH. 2017;77:3752
    Cichocki F; Valamehr B; Bjordahl R; Zhang B; Sarhan D; Cooley S; Blazar B; Rezner B; Rogers P; Green C; Abbot S; Shoemaker D; Wolchko S; Miller JS
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Grants

  • Study sex immune dimorphism in the tumor microenvironment
    Cancer&Allergi fonden
    1 April 2024 - 1 April 2025
  • Study the therapeutic potential of adaptive NK cells in solid tumors
    Radiumhemmet Research funding
    1 January 2024 - 31 December 2026
  • Study adaptive NK cells in cancer
    Swedish Cancer Society
    1 January 2024 - 1 January 2027
  • Swedish Cancer Society
    1 January 2024
  • Sex immune dimorphism in cancer
    KI internal funding
    1 January 2023 - 1 January 2025
  • Studies of newly discovered adaptive NK cells with therapeutic potential in solid tumors
    Radiumhemmets Research funds
    1 January 2022 - 31 December 2024
  • Targeting FPR2 as a novel approach for immunotherapy in pancreatic cancer female patients 鈥 Studies of sexual immune dimorphism in the tumor microenvironment
    Centrum for innovative medicine
    1 January 2022 - 1 January 2025
  • Study aNK cells in GBM
    KI doctoral studies funding
    1 July 2021 - 1 July 2025
  • Study adaptive NK cell signaling in cancer
    Swedish Cancer Society
    1 February 2021 - 1 February 2027
  • Studies of the newly discovered adaptive NK cells in cancer
    Swedish Cancer Society
    1 January 2021 - 31 December 2024
  • Studies of newly discovered adaptive NK cells in cancer immunotherapy
    Stiftelsen Clas Groschinsky Minnesfonds
    1 January 2021 - 31 December 2024
  • New immunotherapy for pancreatic cancer by reprogramming macrophages
    Sj枚berg foundation
    1 January 2021 - 1 January 2024
  • Swedish Cancer Society
    1 January 2021
  • Decoding adaptive NK cell signaling
    Jonas S枚derquist's scholarship
    1 January 2020 - 1 January 2023

Employments

  • Assistant Professor, Department of Laboratory Medicine, 探花精选, 2021-2025

Degrees and Education

  • Docent, 探花精选, 2021
  • Degree Of Doctor Of Philosophy, Department of Oncology-Pathology, 探花精选, 2014
  • Degree Of Master Of Medical Science 120 Credits, 探花精选, 2010

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