̽»¨¾«Ñ¡

David Marlevi

David Marlevi

Postdoctoral Researcher | Assistant Professor
Visiting address: Eugeniavägen 3, Karolinska universitetssjukhuset, NKS A8:01, 17176 Stockholm
Postal address: K1 Molekylär medicin och kirurgi, K1 MMK Klinisk fysiologi, 171 76 Stockholm

About me

  • I am a research lead in quantitative cardiovascular imaging, developing
    data-driven image analysis tools to tackle urgent clinical challenges across
    the heart, aorta, and brain.
    I am a bio̽»¨¾«Ñ¡ engineer with a focus on translational cardiovascular
    imaging. Specifically, I am intrigued by the translation of image-based
    engineering into clinical practice, using data-driven utilities to enhance
    diagnosis, improve prognosis, and provide fundamental mecanistic
    understanding of cardiovascular disease.
    After graduating from the joint doctoral program in Medical Technology from
    the Royal Institute of Technology (KTH) and KI with a thesis entitled
    "", I spent two 


  • years as a postdoctoral fellow at the Massachusetts Institute of Technology
    (MIT), funded by a Knut and Alice Wallenberg foundation scholarship and
    working under the tutelage of Prof. Elazer R. Edelman (). At 

  • MIT, I worked on AI-driven image analysis to monitor intravascular
    interventions, as well as lead lab efforts on novel vascular drug delivery
    systems. In 2021, I returned to Sweden and KI as a research lead in
    quantitative cardiovascular imaging, working closely with clinical and
    technical fellows at both KI and the Karolinska University Hospital to
    translate advanced image technologies into clinical practice. Specific
    focuses has been on hemodynamic mapping by full-field phase-contrast magnetic
    resonance imaging (4D Flow MRI), with coupled physics-informed analysis
    allowing for regional hemodynamic quantifications across the cardiovascular
    system.

     


  • * Early Career Award – Translational Science, Society for Cardiovascular
    Magnetic Resonance (SCMR), 2021
    * Runner-up, Best presentation in Basic science, 1st Annual Marvin M. Kirsh
    Resident Research Symposium, University of Michigan, 2021
    * Potchen-Pasariello Award – Best presentation in Clinical Science,
    Society for Magnetic Resonance Angiography (SMRA), 2020
    * Trainee grant, IEEE Nuclear Science Symposium and Medical Imaging
    Conference, 2015
    * Travel award, IEEE International Ultrasonics Symposium, 2015
    * KTH Best graduate student of the year, KTH Royal Institute of Technology,
    2014
    * Endeavour Research Award, Australian Government Research Award fellowship
    * Henrik Göransson Sandviken scholarship, 2011
    * Hjalmar Berwalds minne för framstående matematiska studier, 2010

Research

  • Non-invasive estimation of cardiovascular pressure gradients:
    Regional quantification of cardiovascular pressure gradients is critical for
    diagnosis, treatment planning, and risk prediction of many cardiovascular
    disease. Still, for a large number of conditions, non-invasive assessment is
    obstructed by inherent method limitations, and a wide range of clinical
    instances exist where regional pressure behaviour remains unexplored. To
    tackle this, we have recently deployed a combination
    of physics-informed image analysis (invoking fundamental fluid mechanical
    description of blood flow) and full-field flow imaging (4D Flow MRI) to allow
    for arbitrary probing of pressure gradients across previously inaccessible
    compartments. Here, we seek to extend these utilities to further understand
    early hemodynamic changes indicative of later physiological impairement,
    including validation, implementation, and clincial utility across spatial
    (large / small vessels), temporal (fast / slow flows) and flow (laminar /
    turbulent) scales.

     


  • Super-resolution 4D Flow MRI:
    The advent of full-field flow imaging by 4D Flow MRI has fundamentally
    changed our ability to interrogate complex hemodynamic behaviour in a direct
    clinical setting. However, spatiotemporal limitations exist based on the
    clinical time frames in which the systems can be used, obstructing assessment
    of regional or highly transient flow events. To tackle this, we have recently
    employed deep residual networks to enhance spatial image resolution,
    effectively pushing quantitative 4D imaging into challenging intracranial
    vessels. Now, we seek to extend the same utilities into temporally
    challenging flows such as in the heart, or through complex aortic disease.
    Further inclusion of so called physics-informed networks are also expected to
    expand clinical impact and versatility of 4D Flow MRI across a wide
    cardiovascular application range.

Articles

  • Article: BMC NEUROLOGY. 2024;24(1):111
    Svensson JE; Bolin M; Thor D; Williams PA; Brautaset R; Carlsson M; Sorensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Moren AF; Kivipelto M; Plaven-Sigray P
  • Journal article: JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE. 2024;26:100615
    Hardy B; Marway P; Jorge CAC; Marlevi D; Burris N; Nordsletten D
  • Journal article: ATHEROSCLEROSIS. 2023;379:s180
    Chemaly M; Marlevi D; Iglesias M-J; Lengquist M; Kronqvist M; Bos D; Van Dam-Nolen DHK; Van Der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; De Vries MR; Kooi ME; Hedin U
  • Article: INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING. 2023;39(6):1189-1202
    Long D; McMurdo C; Ferdian E; Mauger CA; Marlevi D; Nash MP; Young AA
  • Article: BIOMOLECULES. 2023;13(6):882
    Chemaly M; Marlevi D; Iglesias M-J; Lengquist M; Kronqvist M; Bos D; van Dam-Nolen DHK; van der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; de Vries MR; Kooi ME; Hedin U
  • Article: EUR HEART J IMAGING METHODS PRACT. 2023;1(1):qyad014
    Abdula G; Ramos JG; Marlevi D; Fyrdahl A; Engblom H; Sörensson P; Giese D; Jin N; Sigfridsson A; Ugander M
  • Journal article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2023;43
    Chemaly M; Marlevi D; Mareque MJI; Lengquist M; Kronqvist M; Bos D; van Dam-Nolen DHK; van der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; De Vries MR; Kooi ME; Hedin U
  • Article: JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE. 2023;25(1):5
    Fernandes JF; Gill H; Nio A; Faraci A; Galli V; Marlevi D; Bissell M; Ha H; Rajani R; Mortier P; Myerson SG; Dyverfeldt P; Ebbers T; Nordsletten DA; Lamata P
  • Article: COMPUTERS IN BIOLOGY AND MEDICINE. 2023;152:106364
    Buckler AJ; Marlevi D; Skenteris NT; Lengquist M; Kronqvist M; Matic L; Hedin U
  • Journal article: JVS - VASCULAR SCIENCE. 2023;4:100142
    Chemaly M; Marlevi D; Mareque MJI; Lengquist M; Kronqvist M; Bos D; van Dam-Nolen DHK; van der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; De Vries MR; Kooi ME; Hedin U
  • Article: ANNALS OF BIOMEDICAL ENGINEERING. 2022;50(12):1771-1786
    Williams JG; Marlevi D; Bruse JL; Nezami FR; Moradi H; Fortunato RN; Maiti S; Billaud M; Edelman ER; Gleason TG
  • Article: JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. 2022;15(5):1075-1085
    de Vecchi A; Faraci A; Fernandes JF; Marlevi D; Bellsham-Revell H; Hussain T; Laji N; Ruijsink B; Wong J; Razavi R; Anderson D; Salih C; Pushparajah K; Nordsletten D; Lamata P
  • Article: JOURNAL OF MEDICAL IMAGING. 2022;9(4):044006
    Karmakar A; Olender ML; Marlevi D; Shlofmitz E; Shlofmitz RA; Edelman ER; Nezami FR
  • Article: JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. 2022;15(4):692-707
    Marlevi D; Mariscal-Harana J; Burris NS; Sotelo J; Ruijsink B; Hadjicharalambous M; Asner L; Sammut E; Chabiniok R; Uribe S; Winter R; Lamata P; Alastruey J; Nordsletten D
  • Article: BIOMEDICAL PHYSICS AND ENGINEERING EXPRESS. 2022;8(5):055012
    Nordenfur T; Caidahl K; Grishenkov D; Maksuti E; Marlevi D; Urban MW; Larsson M
  • Article: COMPUTERIZED MEDICAL IMAGING AND GRAPHICS. 2022;97:102051
    Olender ML; Niu Y; Marlevi D; Edelman ER; Nezami FR
  • Article: MAGNETIC RESONANCE IN MEDICINE. 2021;86(6):3096-3110
    Marlevi D; Schollenberger J; Aristova M; Ferdian E; Ma Y; Young AA; Edelman ER; Schnell S; Figueroa CA; Nordsletten DA
  • Article: SCIENTIFIC REPORTS. 2021;11(1):22540
    Narayanan B; Olender ML; Marlevi D; Edelman ER; Nezami FR
  • Article: JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2021;18(182):20210436
    Kadry K; Olender ML; Marlevi D; Edelman ER; Nezami FR
  • Article: JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE. 2021;23(1):51
    Marlevi D; Sotelo JA; Grogan-Kaylor R; Ahmed Y; Uribe S; Patel HJ; Edelman ER; Nordsletten DA; Burris NS
  • Article: MEDICAL IMAGE ANALYSIS. 2021;68:101948
    Marlevi D; Balmus M; Hessenthaler A; Viola F; Fovargue D; Vecchi AD; Lamata P; Burris NS; Pagani FD; Engvall J; Edelman ER; Ebbers T; Nordsletten DA
  • Journal article: IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES. 2020;4(3):300-310
    Marlevi D; Kohr H; Buurlage J-W; Gao B; Batenburg KJ; Colarieti-Tosti M
  • Article: MEDICAL IMAGE ANALYSIS. 2020;60:101627
    Marlevi D; Ha H; Dillon-Murphy D; Fernandes JF; Fovargue D; Colarieti-Tosti M; Larsson M; Lamata P; Figueroa CA; Ebbers T; Nordsletten DA
  • Article: SCIENTIFIC REPORTS. 2020;10(1):403
    Marlevi D; Mulvagh SL; Huang R; DeMarco JK; Ota H; Huston JIII; Winter R; Macedo TA; Abdelmoneim SS; Larsson M; Pellikka PA; Urban MW
  • Article: SCIENTIFIC REPORTS. 2019;9(1):1375
    Marlevi D; Ruijsink B; Balmus M; Dillon-Murphy D; Fovargue D; Pushparajah K; Bertoglio C; Colarieti-Tosti M; Larsson M; Lamata P; Figueroa CA; Razavi R; Nordsletten DA
  • Article: PHYSICS IN MEDICINE AND BIOLOGY. 2018;63(23):235008
    Marlevi D; Maksuti E; Urban MW; Winter R; Larsson M
  • Article: SCIENTIFIC REPORTS. 2018;8(1):15540
    De Vecchi A; Marlevi D; Nordsletten DA; Ntalas I; Leipsic J; Bapat V; Rajani R; Niederer SA
  • Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1757
    Dillon-Murphy D; Marlevi D; Ruijsink B; Qureshi A; Chubb H; Kerfoot E; O'Neill M; Nordsletten D; Aslanidi O; de Vecchi A
  • Article: IEEE TRANSACTIONS ON MEDICAL IMAGING. 2017;36(11):2261-2275
    Larsson D; Spuhler JH; Petersson S; Nordenfur T; Colarieti-Tosti M; Hoffman J; Winter R; Larsson M
  • Article: JOURNAL OF INSTRUMENTATION. 2017;12:c05009
    Bennati P; Dasu A; Colarieti-Tosti M; Lonn G; Larsson D; Fabbri A; Galasso M; Cinti N; Pellegrini R; Pani R
  • Article: ULTRASOUND IN MEDICINE AND BIOLOGY. 2016;42(1):308-321
    Maksuti E; Widman E; Larsson D; Urban MW; Larsson M; Bjallmark A
  • Article: PHYSICS IN MEDICINE AND BIOLOGY. 2015;60(8):3151-3174
    Widman E; Maksuti E; Larsson D; Urban MW; Bjallmark A; Larsson M
  • Article: ANNALS OF BIOMEDICAL ENGINEERING. 2014;42(5):950-959
    Larsson D; Luisier B; Kersh ME; Dall'ara E; Zysset PK; Pandy MG; Pahr DH
  • Article: JOURNAL OF BIOMECHANICS. 2013;46(15):2659-2666
    Kersh ME; Zysset PK; Pahr DH; Wolfram U; Larsson D; Pandy MG
  • Show more

All other publications

  • Preprint: MEDRXIV. 2024
    Svensson J; Bolin M; Thor D; Williams P; Brautaset R; Carlsson M; Sörensson P; Marlevi D; Spin-Neto R; Probst M; Hagman G; Morén AF; Kivipelto M; Plavén-Sigray P
  • Preprint: MEDRXIV. 2024
    Abdula G; Bergqvist P; Castaings J; Fyrdahl A; Giese D; Jin N; Testud F; Sörensson P; Sigfridsson A; Ugander M; Marlevi D
  • Preprint: MEDRXIV. 2024
    Mustafic M; Jandér R; Marlevi D; Rickenlund A; Rück A; Saleh N; Abdi S; Eriksson MJ; Damlin A
  • Preprint: ARXIV. 2023
    Ericsson L; Hjalmarsson A; Akbar MU; Ferdian E; Bonini M; Hardy B; Schollenberger J; Aristova M; Winter P; Burris N; Fyrdahl A; Sigfridsson A; Schnell S; Figueroa CA; Nordsletten D; Young AA; Marlevi D
  • Preprint: ARXIV. 2023
    Ericsson L; Hjalmarsson A; Akbar MU; Ferdian E; Bonini M; Hardy B; Schollenberger J; Aristova M; Winter P; Burris N; Fyrdahl A; Sigfridsson A; Schnell S; Figueroa CA; Nordsletten D; Young AA; Marlevi D
  • Editorial comment: EUROPEAN HEART JOURNAL. 2023;44(19):1676-1678
    Marlevi D
  • Preprint: MEDRXIV. 2023
    Abdula G; Ramos J; Marlevi D; Fyrdahl A; Engblom H; Sörensson P; Giese D; Jin N; Sigfridsson A; Ugander M
  • Published conference paper: LECTURE NOTES IN COMPUTER SCIENCE (INCLUDING SUBSERIES LECTURE NOTES IN ARTIFICIAL INTELLIGENCE AND LECTURE NOTES IN BIOINFORMATICS). 2023;13958:425-434
    Sabry M; Lamata P; Sigfridsson A; Keramati H; Fyrdahl A; Ugander M; Yacoub MH; Marlevi D; De Vecchi A
  • Review: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2021;77(19):2413-2431
    Marlevi D; Edelman ER
  • Corrigendum: SCIENTIFIC REPORTS. 2020;10(1):12214
    Marlevi D; Mulvagh SL; Huang R; DeMarco JK; Ota H; Huston J; Winter R; Macedo TA; Abdelmoneim SS; Larsson M; Pellikka PA; Urban MW
  • Thesis / dissertation: 2019
    Marlevi, David

Grants

  • European Research Council
    1 May 2023 - 1 May 2028
  • Swedish Research Council
    1 January 2023 - 31 December 2026

Employments

  • Assistant Professor, Department of Molecular Medicine and Surgery, ̽»¨¾«Ñ¡, 2025-2030
  • Postdoctoral Researcher, Department of Molecular Medicine and Surgery, ̽»¨¾«Ñ¡, 2021-2024
  • Postdoctoral Researcher, Institute for Medical Engineering & Science, Massachusetts Institute of Technology, 2019-2021

Degrees and Education

  • Doctor Of Philosophy, Department of Clinical Sciences, Danderyd Hospital, ̽»¨¾«Ñ¡, 2019

Supervisor

  • Oliver Welin Odeback, Data-driven 4D Flow MRI for non-invasive quantification of intracranial hemodynamics, 2023
  • Pia Callmer, 2023

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