探花精选

Cesare Patrone

Cesare Patrone

Senior Lecturer/Clinical Position | Docent
Telephone: +46852487575
Visiting address: S枚dersjukhuset, Sjukhusbacken 17, 11883 Stockholm
Postal address: S1 Klinisk forskning och utbildning, S枚dersjukhuset, S1 KI S脰S Forskning Internmedicin, 118 83 Stockholm
Part of:

About me

  • Associate Professor/Senior Lecturer
    Researh Group: /en/kisos/the-neurocardiometabol-group
    In February 2009 I was recruited to 探花精选 to start up a
    research group about the neurological complications of type 2 diabetes, with
    main focus on stroke. I am responsible for planning, coordinating and
    executing work in the area of experimental stroke in diabetes.
    *2001-2009*: Senior Researcher and Manager at Neuronova AB, Stockholm, Sweden
    *2000-2001: *Postdoctoral Fellow, 探花精选, Stockholm, Sweden
    *1998-2000:* Postdoctoral Fellow, Uppsala University, Sweden
    *1998: *PhD in Neurobiology, Milano University, Italy
    Research grants and awards as PI
    1) The Swedish Research Council (Vetenskaspr氓det); 2022-2025
    2) Hj盲rnfonden 2022
    3) Hj盲rnfonden 2021
    4) Diabetesfonden; 2020-2021
    5) The Swedish Research Council (Vetenskaspr氓det); 2018-2021
    6) European Foundation for the Study of Diabetes/Sanofi European Diabetes
    Research Programme in Macrovascular Complications; 2019
    7) Award 鈥淚nvestigator Study IIS鈥 Boehringer Ing. Sweden; 2018
    8) Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; 2012-2017
    9) 脜hl茅n Stiftelse; 2012-2018
    10) O. E. och Edla Johanssons Stiftelse; 2016-2018
    11) Magnus Bergvalls Stiftelse; 2011-2016
    12) STROKE Riksf枚rbundet; 2018-2020
    13) Diabetesfonden; 2014-2015
    14) Novo Nordisk Foundation; 2014
    15) Syskonen Svensson Stiftelse; 2017
    16) European Foundation for the Study of Diabetes; 2013
    17) Diabetes Wellness; 2010
    18) Stohnes stiftelse; 2010, 2012, 2015
    19) STROKE Riksf枚rbundet; 2011-2014
    20) European Foundation for the Study of Diabetes; 2009
    2018 Assess the structure of examination of projects, Workshop, Karolinska
    Institutet
    2013 Docent in neuroscience, 探花精选
    2011 Course in "Assessment in Higher Education", 探花精选
    2011 Basic Course in Education for University Teachers, Karolinska
    Institutet
    2010 Introductory Doctoral Supervision Course, 探花精选
    2010 Work environment issues and manager responsibilities , Karolinska
    Institutet
    2009 Laboratory Animal Science (FELASA) certificate, 探花精选
    2008 Applied Project Management Courses, Wenell Management AB, Stockholm
    2007 Courses in Clinical Trials, Trial Form Support AB, Lund
    1998 PhD in Neurobiology, University of Milan, Italy.
    1992 University of Milan, Italy, Laurea and M.Sc. Biological Sciences

Research

  • *Stroke and Diabetes*
    The focus is along two research lines, see also the Research Group at:
    /en/kisos/the-neurocardiometabol-group
    * The identification of efficacious preclinical therapies for the treatment
    of stroke in diabetes.
    * The study of the cellular mechanisms at the basis of the neurological
    complications of diabetes.
    Stroke affects several million people worldwide, of which a substantial
    proportion of cases present in patients suffering from diabetes. Diabetes is
    widespread and represents a leading cause of death. About 90 % of the 探花精选
    and social costs associated with diabetes are dominated by care for
    macrovascular complications such as stroke. Therefore it is important to
    identify strategies aimed at prevent stroke in diabetes but also improve
    post-stroke recovery in diabetic individuals.
    -We recently showed that decreasing weight in diabetes to the extent that
    glucose metabolism is normalized significantly improves stroke recovery:

    [1]The findings have been published in /Cardiovascular Diabetology/
    -GLP-1R agonists are commonly used drugs for the treatment of type 2
    diabetes. We were the first in 2012 to show that the activation of the
    glucagon-like receptor 1 (GLP-1R) is neuroprotective against stroke in type 2
    diabetic rodents. The findings have been published in /Clinical Science/:
    [2]
    In 2021, we showed that this pharmacological strategy can also improve
    post-stroke functional recovery. The findings have been published in the
    /British Journal of Pharmacology/
    [3]
    -We demonstrated a similar stroke efficacy as for the GLP-1R agonists for
    another class of clinically used drugs against diabetes called DPP-4
    inhibitors. The findings were published in /Diabetes/ in
    2012 [4] and 2021
    [5].
    See also the press release about the findings 2012
    [6]
    -We identified several cellular mechanisms that are induced by diabetes and
    play a detrimental role in the impairment of stroke recovery. Among the most
    recent publications are the findings recently published in /Clinical
    Science / [7] and
    /Acta Neuropathologica Communications
    / [8]
    [1]
    [2]
    [3]
    [4]
    [5]
    [6]
    [7]
    [8]

Teaching

  • *July 2013- ongoing*, Project Coordinator/Examiner in degree projects in
    medicine, Department of Medical Epidemiology and Biostatistics [1], KI. The
    position involves reviewing the students鈥 work-plan, half time and final
    thesis, arrange seminars and examine the work.
    *2015- 2020* Visiting Professor (1 week/year), Univ. of Piemonte Orientale,
    Novara, Italy
    [1] ;amp;l=en

Articles

  • Article: BIOSCIENCE REPORTS. 2024;44(7):BSR20240249
    Vieira JPP; Karampatsi D; Vercalsteren E; Darsalia V; Patrone C; Duarte JMN
  • Article: CARDIOVASCULAR DIABETOLOGY. 2024;23(1):88
    Vercalsteren E; Karampatsi D; Buizza C; Nystr枚m T; Klein T; Paul G; Patrone C; Darsalia V
  • Article: DIABETES. 2023;72(3):405-414
    Elabi OF; Karampatsi D; Vercalsteren E; Lietzau G; Nystroem T; Klein T; Darsalia V; Patrone C; Paul G
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(4):3989
    Vercalsteren E; Karampatsi D; Dekens D; Letsiou A; Zabala A; Romanitan M; Klein T; Nystrom T; Darsalia V; Patrone C
  • Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2022;42(6):1995-2002
    Lietzau G; Ntika S; Pintana H; Tracy L; Klein T; Nystrom T; Darsalia V; Patrone C; Krizhanovskii C
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(4):677-694
    Augestad IL; Dekens D; Karampatsi D; Elabi O; Zabala A; Pintana H; Larsson M; Nystrom T; Paul G; Darsalia V; Patrone C
  • Article: CARDIOVASCULAR DIABETOLOGY. 2021;20(1):240
    Karampatsi D; Zabala A; Wilhelmsson U; Dekens D; Vercalsteren E; Larsson M; Nystrom T; Pekny M; Patrone C; Darsalia V
  • Article: CARDIOVASCULAR DIABETOLOGY. 2021;20(1):202
    Zabala A; Darsalia V; Lind M; Svensson A-M; Franzen S; Eliasson B; Patrone C; Jonsson M; Nystrom T
  • Article: BIOSCIENCE REPORTS. 2021;41(6):BSR20210736
    Hammarlund ME; Darsalia V; Mjornstedt F; Pattanaik B; Mallard C; Rocha-Ferreira E; Patrone C; Johansson ME
  • Article: CELLULAR AND MOLECULAR NEUROBIOLOGY. 2021;41(3):591-603
    Chiazza F; Pintana H; Lietzau G; Nystrom T; Patrone C; Darsalia V
  • Article: ACS CHEMICAL NEUROSCIENCE. 2020;11(21):3590-3602
    Lietzau G; Nystrom T; Wang Z; Darsalia V; Patrone C
  • Article: DIABETES. 2020;69(9):1961-1973
    Augestad IL; Pintana H; Larsson M; Krizhanovskii C; Nystrom T; Klein T; Darsalia V; Patrone C
  • Article: NEUROBIOLOGY OF AGING. 2020;89:12-23
    Lietzau G; Magni G; Kehr J; Yoshitake T; Candeias E; Duarte AI; Pettersson H; Skogsberg J; Abbracchio MP; Klein T; Nystrom T; Ceruti S; Darsalia V; Patrone C
  • Article: ALZHEIMERS & DEMENTIA. 2020;16(2):316-325
    Wang Z; Marseglia A; Shang Y; Dintica C; Patrone C; Xu W
  • Article: DIABETES OBESITY & METABOLISM. 2020;22(2):182-190
    Zabala A; Darsalia V; Holzmann MJ; Franzen S; Svensson A-M; Eliasson B; Patrone C; Nystrom T; Jonsson M
  • Article: BIOSCIENCE REPORTS. 2020;40(1):BSR20193156
    Lundberg M; Curbo S; Bohman H; Agartz I; Ogren S-O; Patrone C; Mansouri S
  • Article: ACTA NEUROLOGICA SCANDINAVICA. 2019;140(6):443-448
    Larsson M; Castren M; Lindstrom V; von Euler M; Patrone C; Wahlgren N; Nathanson D
  • Article: CARDIOVASCULAR DIABETOLOGY. 2019;18(1):91
    Larsson M; Patrone C; von Euler M; Holst JJ; Nathanson D
  • Article: CLINICAL SCIENCE. 2019;133(13):1367-1386
    Pintana H; Lietzau G; Augestad IL; Chiazza F; Nystrom T; Patrone C; Darsalia V
  • Article: CARDIOVASCULAR DIABETOLOGY. 2018;17(1):60
    Chiazza F; Tammen H; Pintana H; Lietzau G; Collino M; Nystrom T; Klein T; Darsalia V; Patrone C
  • Show more

All other publications

  • Editorial comment: DIABETES OBESITY & METABOLISM. 2024;26(7):2527-2530
    Darsalia V; Vercalsteren E; Karampatsi D; Romanitan MO; Mazya MV; Nystrom T; Patrone C
  • Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(5):2618
    Bayassi-Jakowicka M; Lietzau G; Czuba E; Patrone C; Kowianski P
  • Review: FRONTIERS IN NEUROLOGY. 2019;10:493
    Darsalia V; Johansen OE; Lietzau G; Nystrom T; Klein T; Patrone C
  • Review: NEUROPHARMACOLOGY. 2018;136(Pt B):280-286
    Darsalia V; Klein T; Nystrom T; Patrone C
  • Corrigendum: DIABETES OBESITY & METABOLISM. 2018;20(4):1086
    Darsalia V; Larsson M; Lietzau G; Nathanson D; Nystrom T; Klein T; Patrone C
  • Editorial comment: CARDIOVASCULAR DIABETOLOGY. 2018;17(1):32
    Darsalia V; Larsson M; Klein T; Patrone C
  • Review: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2015;35(5):718-723
    Darsalia V; Larsson M; Nathanson D; Klein T; Nystrom T; Patrone C
  • Review: REVIEWS IN ENDOCRINE & METABOLIC DISORDERS. 2014;15(3):233-242
    Darsalia V; Nathanson D; Nystrom T; Klein T; Sjoholm A; Patrone C
  • Editorial comment: LANCET DIABETES & ENDOCRINOLOGY. 2014;2(3):256-262
    Patrone C; Eriksson O; Lindholm D
  • Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2004;76(2):205-215
    Mercer A; R枚nnholm H; Holmberg J; Lundh H; Heidrich J; Zachrisson O; Ossoinak A; Fris茅n J; Patrone C
  • Addendum: EUROPEAN JOURNAL OF NEUROSCIENCE. 1997;9(7):1552
    Agrati P; Ma ZQ; Patrone C; Picotti GB; Pellicciari C; Bondiolotti G; Bottone MG; Maggi A
  • Published conference paper: BRAIN RESEARCH BULLETIN. 1997;44(4):519-523
    Agrati P; Garnier M; Patrone C; Pollio G; Santagati S; Vegeto E; Maggi A

Employments

  • Senior Lecturer/Clinical Position, Department of Clinical Science and Education, S枚dersjukhuset, 探花精选, 2018-

Degrees and Education

  • Docent, 探花精选, 2013

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