探花精选

Cenk Gurdap

Cenk Gurdap

Phd Student
Visiting address: SciLifeLab, Tomtebodav盲gen 23A, 17165 Solna
Postal address: K6 Kvinnors och barns h盲lsa, K6 Klinisk pediatrik Sezgin, 171 77 Stockholm

About me

  • I am interested in using the strengths of different techniques to develop cutting-edge methods to rule out some of the challenges in the field and identify the biophysical properties of cells or crucial biomolecules.

    * 2023-now PhD student, SciLifeLab, 探花精选, Stockholm, Sweden
    * 2020-2022 MSc in Molecular Techniques in Life Science, 探花精选-
    KTH Royal Institute of Technology-Stockholm University, Stockholm, Sweden
    * 2015-2020 BSc in Biology, Middle East Technical University, Ankara, Turkey

Research

  • Physical remodeling of our cells as a response to environmental changes is essential for their survival and function [1]. The ability of immune cells to pass through tight epithelial cell layers from circulating blood during infection [2], the ability of tumor cells to travel throughout the body during metastasis [3], migration potential of the cells after epithelial-to-mesenchymal transition [4] could be examples where cells undergo extensive remodeling. Although numerous studies aimed at finding protein markers during these key steps, there is a major gap in our understanding of how collective biophysical properties of the cells (such as stiffness, fluidity, and viscosity) alter during these crucial biological processes. Similarly, our understanding of how the biophysical properties of cells change in diseases is extremely limited. To gain a thorough mechanistic perception of cellular processes and diseases, it is essential to fill this gap and have a clear and quantitative picture of the biophysical remodeling of the cells during these processes. It is becoming clearer that biophysical principles can serve as the 鈥渃ause鈥 of many cellular processes rather than being only passive 鈥渃onsequences鈥 [5, 6]. Moreover, biophysical properties can vary without notable changes in protein or RNA levels. Therefore, these physical properties can be exploited as complementary to the current protein or nucleic acid markers to diagnose and treat diseases. Current biophysical technologies suffer from low sampling (one cell at a time), which is a major obstacle to apply them to 探花精选 problems that require measuring thousands of cells [7-9]. This bottleneck can only be overcome with high throughput methodologies that can robustly measure the biophysical properties.

    I aim to develop an imaging and cytometry pipeline (from optics to high throughput analysis) to map the collective biophysical properties of cells that are distinct in different cell types, states (e.g., young vs. old), and diseases (e.g., dyslipidemia). This will potentially pave the way for using biophysical properties for the prediction of disease phenotypes as a complementary aspect to current protein or nucleic acid markers.

    References:
    1) Ruprecht, V. et al. J Cell Sci 130, 51-61 (2017).
    2) Escribano, J. et al. PLoS computational biology 15, e1006395 (2019).
    3) Suresh, S. Acta biomaterialia 3, 413-438 (2007).

    4) Margaron, Y. et al. bioRxiv, 797654 (2019).

    5) James, J. R. & Vale, R. D. Nature 487, 64-69 (2012).

    6) Bizzarri, M. et al. Nature reviews. Molecular cell biology 20, 261-262 (2019).

    7) Sezgin, E. et al. Biophys J 113, 1321-1330 (2017).

    8) Sezgin, E. et al. Chemphyschem 16, 1387-1394 (2015).
    9) Sezgin, E. et al. Nature Protocols (2019).

Articles

  • Journal article: CHEM. 2025;11(3):102399
    Kriebisch CME; Bantysh O; Pellejero LB; Belluati A; Bertosin E; Dai K; de Roy M; Fu H; Galvanetto N; Gibbs JM; Gomez SS; Granatelli G; Griffo A; Guix M; Gurdap CO; Harth-Kitzerow J; Haugerud IS; Haefner G; Jaiswal P; Javed S; Karimi A; Kato S; Kriebisch BAK; Laha S; Lee P-W; Lipinski WP; Matreux T; Michaels TCT; Poppleton E; Ruf A; Slootbeek AD; Smokers IBA; Soria-Carrera H; Sorrenti A; Stasi M; Stevenson A; Thatte A; Tran M; van Haren MHI; Vuijk HD; Wickham SFJ; Zambrano P; Adamala KP; Alim K; Andersen ES; Bonfio C; Braun D; Frey E; Gerland U; Huck WTS; Juelicher F; Laohakunakorn N; Mahadavan L; Otto S; Saenz J; Schwille P; Goepfrich K; Weber CA; Boekhoven J
  • Journal article: JOURNAL OF BIOMOLECULAR NMR. 2024;78(4):249-264
    Annecke HTP; Eidelpes R; Feyrer H; Ilgen J; Guerdap CO; Dasgupta R; Petzold K
  • Journal article: BIOPHYSICAL JOURNAL. 2024;123(3):449a-450a
    Gurdap C; Andronico L; Cowgill J; Sezgin E
  • Journal article: BIOCONJUGATE CHEMISTRY. 2023;34(10):1923
    Sternstein C; Bohm T-M; Fink J; Meyr J; Ludemann M; Krug M; Kriukov K; Sezgin E; Ebert R; Seibel J
  • Article: BIOCONJUGATE CHEMISTRY. 2023;34(7):1221-1233
    Sternstein C; Boehm T-M; Fink J; Meyr J; Luedemann M; Krug M; Kriukov K; Gurdap CO; Sezgin E; Ebert R; Seibel J
  • Journal article: JOURNAL OF PSYCHOPHARMACOLOGY. 2022;36(11):1280-1293
    Akinola LS; Bagdas D; Alkhlaif Y; Jackson A; Gurdap CO; Rahimpour E; Carroll FI; Papke RL; Damaj MI
  • Article: BIOPHYSICAL JOURNAL. 2022;121(20):3826-3836
    Gurdap CO; Wedemann L; Sych T; Sezgin E
  • Article: PLOS ONE. 2022;17(7):e0264662
    Feyrer H; Gurdap CO; Marusic M; Schlagnitweit J; Petzold K
  • Journal article: BEHAVIOURAL PHARMACOLOGY. 2019;30(6):534-537
    Gurdap CO; Markwalter PSJ; Neddenriep B; Bagdas D; Damaj MI

All other publications

  • Review: NATURE PROTOCOLS. 2025;:1-29
    Carravilla P; Andronico L; Schlegel J; Urem YB; Sjule E; Ragaller F; Weber F; Gurdap CO; Ascioglu Y; Sych T; Lorent J; Sezgin E
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S83
    Gurdap C; Andronico L; Sezgin E
  • Preprint: BIORXIV. 2022
    Feyrer H; Gurdap CO; Maru拧i膷 M; Schlagnitweit J; Petzold K
  • Preprint: BIORXIV. 2021
    Gurdap CO; Wedemann L; Sych T; Sezgin E
  • Review: MEMBRANES. 2021;11(5):323
    Sych T; Gurdap CO; Wedemann L; Sezgin E

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