̽»¨¾«Ñ¡

Cecilia Götherström

Cecilia Götherström

Principal Researcher | Docent
Telephone: +46852483395
Visiting address: Hälsovägen, Enheten för obstetrik och gynekologi K65, 14186 Stockholm
Postal address: H9 Klinisk vetenskap, intervention och teknik, H9 CLINTEC Obstetrik o gynekologi, 141 52 Huddinge
Part of:

About me

  • My goal is to develop cell therapies that will have an impact on the health
    of persons with severe disorders. An evidence of this is that I have brought
    a cell therapy from the bench to the bedside.
    I am driven by challenges, which has led me to initiate, lead and
    successfully fulfill several complex projects and educations in the field of
    regenerative medicine in the academia, the health care sector and in the
    industry. My motto in life and work is courage and passion, courage for
    daring to discover new paths, and passion, which is to always go the extra
    mile.
    * Established and lead Sweden’s altruistic Umbilical Cord Blood Bank at
    Karolinska University Hospital 2010-2016.
    * Secured >
  • 73 million SEK as main Principle Investigator &
  • >
  • 30 million
    SEK as co-Principle Investigator.
    * Established an approved GMP-production of mesenchymal stem cells.
    * Initiated and lead the European Horizon 2020 BOOSTB4 project and clinical
    trial.
    * Established two approved and ongoing clinical trials investigating MSC
    transplantation as a treatment of brittle bone disease (Osteogenesis
    Imperfecta) in children.
    * Initiated the first clinical trial on prenatal stem cell transplantation
    in the world.
    *Associate Professor (Docent) 2014, ̽»¨¾«Ñ¡, Stockholm,
    Sweden*.
    Subject: Stem Cell Science
    *PhD 2004, ̽»¨¾«Ñ¡, Stockholm, Sweden.*
    Subject: Allogeneic stem cell transplantation &
  • transplantation research
    Thesis: Characterization of human fetal mesenchymal stem cells
    *MSc 2001, Södertörns University College, Stockholm, Sweden.*
    Subject: Molecular Cell Biology
    Degree thesis: Clinical aspects on maternal cells in the fetus

Research

  • Cells derived from the fetal and perinatal tissues have more potential than
    cells derived from adult tissues. Promising candidates for clinical
    translation are mesenchymal stem cells (MSC).
    My interest in these cells is based on their multipotentiality, low
    immunogenicity and tissue repairing effects in combination with a minimal
    oncogeneic risk.
    *1. BOOSTB4 and BOOST2B: Developing MSC as a therapy for Osteogenesis
    Imperfecta*
    In the BOOSTB4 and BOOST2B clinical trials fetal MSC are investigated as a
    therapy for severe types of Osteogenesis Imperfecta (inherited brittle bone
    disease). Previous case studies performed by us at KI have demonstrated a
    potential positive effect. The manufacturing of the MSC is led by Dr
    Götherström and is performed at Karolinska Center for Cell Therapy at
    Karolinska University Hospital.
    Boost Brittle Bones Before Birth (*BOOSTB4*) is a European consortium lead
    by Dr Götherström. The trial is investigating the safety and efficacy of
    this innovation in the treatment of Osteogenesis Imperfecta in the
    pediatric population. In the project we will also evaluate ethical standards
    and risks, acceptability and stakeholders views and experiences and health
    economics.
    Four doses of fetal MSC will be administered after birth (group 1,

Teaching

  • * Director of Studies, Doctoral Program in Regenerative Medicine,
    ̽»¨¾«Ñ¡ 2008-2015.
    * Organizer of 5 doctoral courses and 9 scientific conferences in the
    regenerative medicine field.
    * 250+ hours of teaching on all levels.
    * PhD thesis examiner >
  • 10 times, halftime examiner 6 times, and defence
    chair 5 times.
    * Main supervisor for 2 graduated PhD students 2018, and co-supervisor for 3
    PhD students 2009-2014.
    * Supervisor of >
  • 10 Master, Bachelor, foreign exchange and summer project
    students 2005-2023.

Articles

  • Article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(35):2303622
    Arndt T; Chatterjee U; Shilkova O; Francis J; Lundkvist J; Johansson D; Schmuck B; Greco G; Nordberg AE; Li Y; Wahlberg LU; Langton M; Johansson J; Goetherstroem C; Rising A
  • Article: BMJ OPEN. 2024;14(6):e079767
    Sagar RL; Astrom E; Chitty LS; Crowe B; David AL; Devile C; Forsmark A; Franzen V; Hermeren G; Hill M; Johansson M; Lindemans C; Lindgren P; Nijhuis W; Oepkes D; Rehberg M; Sahlin N-E; Sakkers R; Semler O; Sundin M; Walther-Jallow L; Verweij EJTJ; Westgren M; Goetherstrom C
  • Article: STEM CELL RESEARCH AND THERAPY. 2024;15(1):77
    Gencer EB; Lor YK; Abomaray F; El Andaloussi S; Pernemalm M; Sharma N; Hagey DW; Gorgens A; Gustafsson MO; Le Blanc K; Toonsi MA; Walther-Jallow L; Goetherstrom C
  • Article: THE LANCET CHILD AND ADOLESCENT HEALTH. 2022;6(9):643-653
    de Coppi P; Loukogeorgakis S; Gotherstrom C; David AL; Aimeida-Poradaierry G; Chan JKY; Deprest J; Wong KKY; Tam PKH
  • Article: ARCHIVES OF DISEASE IN CHILDHOOD. 2022;107(4):351-358
    Larsson SM; Hellstrom-Westas L; Hillarp A; Akeson PK; Domellof M; Askelof U; Gotherstrom C; Andersson O
  • Article: DISABILITY AND HEALTH JOURNAL. 2022;15(1):101168
    Hill M; Hammond J; Sharmin M; Lewis C; Heath M; Crowe B; Gotherstrom C; Chitty LS; DeVile C
  • Article: CLINICAL OBSTETRICS AND GYNECOLOGY. 2021;64(4):898-903
    Gotherstrom C; David AL; Walther-Jallow L; Astrom E; Westgren M
  • Article: CELLS. 2021;10(7):1713
    Lin C; Ekblad-Nordberg A; Michaelsson J; Gotherstrom C; Hsu C-C; Ye H; Johansson J; Rising A; Sundstrom E; Akesson E
  • Article: INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY. 2021;43(3):378-386
    Larsson SM; Hillarp A; Karlsland akeson P; Hellstrom-Westas L; Domellof M; Askelof U; Gotherstrom C; Andersson O
  • Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;9:612714
    Abomaray F; Wagner AK; Chrobok M; Ekblad-Nordberg A; Gidlof S; Alici E; Gotherstrom C
  • Article: MOLECULAR THERAPY. 2020;28(11):2316-2319
    Sagar R; Almeida-Porada G; Blakemore K; Chan JKY; Choolani M; Gotherstrom C; Jaulent A; MacKenzie TC; Mattar C; Porada CD; Peranteau WH; Schneider H; Shaw SW; Waddington SN; Westgren M; David AL
  • Article: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2019;13(9):1518-1527
    Chamorro CI; Asghar M; Ekblad A; Farnert A; Gotherstrom C; Fossum M
  • Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27(8):1244-1253
    Hill M; Lewis C; Riddington M; Crowe B; DeVile C; David AL; Semler O; Westgren M; Gotherstrom C; Chitty LS
  • Article: BEST PRACTICE AND RESEARCH: CLINICAL OBSTETRICS AND GYNAECOLOGY. 2019;58:142-153
    Sagar R; Gotherstrom C; David AL; Westgren M
  • Article: CELL TRANSPLANTATION. 2019;28(5):522-528
    Kanold AMJ; Westgren M; Gotherstrom C
  • Article: JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2018;12(5):1177-1185
    Ekblad A; Westgren M; Fossum M; Goetherstroem C
  • Article: STEM CELLS INTERNATIONAL. 2018;2018:7318513-12
    Abomaray F; Gidlof S; Bezubik B; Engman M; Gotherstrom C
  • Article: BMJ OPEN. 2017;7(12):e017215
    Askelof U; Andersson O; Domellof M; Fasth A; Hallberg B; Hellstrom-Westas L; Pettersson K; Westgren M; Wiklund IE; Gotherstrom C
  • Article: ELIFE. 2017;6:e26787
    Groen CM; Mcgrath C; Campbell KA; Gotherstrom C; Windebank AJ; Landazuri N
  • Article: STEM CELLS INTERNATIONAL. 2017;2017:1626741-10
    Ekblad A; Fossum M; Gotherstrom C
  • Show more

All other publications

  • Review: PRENATAL DIAGNOSIS. 2023;43(13):1622-1637
    Sagar RL; Walther-Jallow L; Gotherstrom C; Westgren M; David AL
  • Editorial comment: CLINICAL AND TRANSLATIONAL MEDICINE. 2021;11(4):e385
    Ramesh S; Daniel D; Gotherstrom C; Madhuri V
  • Review: CURRENT OSTEOPOROSIS REPORTS. 2020;18(4):337-343
    Gotherstrom C; Walther-Jallow L
  • Review: STEM CELLS TRANSLATIONAL MEDICINE. 2020;9(2):148-157
    Ekblad-Nordberg A; Walther-Jallow L; Westgren M; Gotherstrom C
  • Review: DISABILITY AND HEALTH JOURNAL. 2019;12(3):340-349
    Hill M; Lewis C; Riddington M; Crowe B; DeVile C; Gotherstrom C; Chitty L
  • Corrigendum: CELL AND TISSUE BANKING. 2019;20(2):329-330
    Al-Saqi SH; Saliem M; Quezada HC; Ekblad A; Jonasson AF; Hovatta O; Gotherstrom C
  • Review: CURRENT STEM CELL REPORTS. 2018;4(1):61-68
    Sagar R; Walther-Jallow L; David AL; Gotherstrom C; Westgren M
  • Review: PRENATAL DIAGNOSIS. 2015;35(9):827-832
    Westgren M; Gotherstrom C
  • Review: FRONTIERS IN PHARMACOLOGY. 2014;5:223
    Chan JKY; Gotherstrom C
  • Published conference paper: TRANSPLANTATION. 2007;84(1):S35-S37
    Gotherstrom C
  • Meeting abstract: TRANSPLANTATION AND CELLULAR THERAPY. 2007;13(2):47
    Ringden O; Uzunel M; Sundberg B; Lonnies L; Nava S; Gotherstrom C; Gustafsson J; Henningsohn L; Le Blanc K
  • Thesis / dissertation: 2004
    Götherström, Cecilia

Employments

  • Principal Researcher, Department of Clinical Science, Intervention and Technology, ̽»¨¾«Ñ¡, 2022-

Degrees and Education

  • Docent, ̽»¨¾«Ñ¡, 2014
  • Doctor Of Philosophy, Department of Laboratory Medicine, ̽»¨¾«Ñ¡, 2004

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