探花精选

Caroline Dietrich

Caroline Dietrich

Statistician
Visiting address: Maria Aspmans gata 30A, 17164 Solna
Postal address: K2 Medicin, Solna, K2 KEP Ekstr枚m Smedby, 171 77 Stockholm
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About me

  • I am a biostatistician with over 15 years of experience working in register-based epidemiological research. I work in the Clinical Cancer Epidemiology Group at the Clinical Epidemiology Division (KEP). Currently, I split my time between applied research in lymphoma and colorectal cancer, and methods development in the field of cancer patient survival research.

Research

  • My main research interests are reproductive epidemiology and cancer patient survival, with a particular focus on survivorship and methods for multistate modelling.

    My current work in lymphoma focuses on follicular lymphoma (FL) and mantle-cell lymphoma (MCL), and is conducted in collaboration with professor Karin Ekstr枚m Smedby [1] and professor Ingrid Glimelius [2]. We have recently concluded a large data collection covering all geographical regions in Sweden, and based on this unique data, we are currently investigating timing of progression of disease (POD) and its impact on prognosis, as well as describe patterns and changes in immuno- and chemotherapy over successive treatment lines.

    This research is closely related to my work in multistate models, where we are implementing and illustrating how to incorporate multiple time scales. This can be of interest either as a means of relaxing the Markov assumption, or in the more general case where more than one time scale needs to be taken into account.

    I also work extensively in colorectal cancer research, mainly together with PhD students that I co-supervise. This work centers on CRCBaSe, a database for clinical epidemiological research on colorectal cancer that I have been part of building up. CRCBaSe is based on the Swedish quality of care register for colorectal cancer (SCRCR), and has been linked to several population-based registers in Sweden. More information about this mega linkage can be found here: This work is done in collaboration with professor Anna Martling [3] and docent Caroline Nordenvall [4].

    I defended my PhD thesis "Survivorship in Hodgkin lymphoma: Childbearing and treatment-related disease" in 2018. My main supervisor was professor Paul Dickman [5] and my co-supervisors were professor Magnus Bj枚rkholm [6], professor Paul Lambert [7], docent Sandra Eloranta [8] and professor Ingrid Glimelius [2].

    The four papers published as part of my PhD were:
    1. Pregnancy and the risk of relapse in patients diagnosed with Hodgkin lymphoma (J Clin Oncol, 2016) [9]
    2. Contemporarily treated patients with Hodgkin lymphoma have childbearing potential in line with matched comparators (J Clin Oncol, 2018) [10]
    3. Temporal trends in treatment-related incidence of diseases of the circulatory system among Hodgkin lymphoma patients (Int J Cancer, 2019) [11]
    4. A multistate model incorporating estimation of excess hazards and multiple time scales (Stat Med, 2021) [12]

    [1]
    [2]
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Teaching

  • I am currently co-supervisor of the following PhD students:

    Anna Nikkarinen is registered at the Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology, Uppsala University, since 2019. Anna is an MD and her thesis is on Mantle cell lymphoma with a focus on biology and targeted treatments. Her main supervisor is professor Ingrid Glimelius, and she plans to defend her thesis during 2025.

    Mehrnoosh Shahrivar is an MD and surgeon and initiated her graduate studies in 2020 at the Department of Molecular Medicine and Surgery (KI). The aim of her thesis is to analyse the colorectal cancer genetic profile, in combination with aspirin use, and its impact on prognosis and treatment. Mehrnoosh will be utilizing data from CRCBaSe as well as from the ongoing ALASCCA (Adjuvant Low Dose Aspirin in Colorectal Cancer) [1] trial. Her main supervisor is docent Caroline Nordenvall, and she plans to defend her thesis during 2025.

    Joshua Entrop has a master's degree in public health and is studying childbearing after modern-day intensive immuno-chemotherapy in young Hodgkin and non-Hodgkin lymphoma survivors. Joshua is registered at the Clinical Epidemiology Division since 2020 with main supervisor docent Sandra Eloranta, and will defend his thesis in January 2025.

    Malin Ljunggren is an MD and is studying patient selection for curative-intended treatments for stage IV colorectal cancer, with special focus on patients with peritoneal metastases (PM). She registered in 2021 at the Department of Molecular Medicine and Surgery (KI) with main supervisor docent Caroline Nordenvall, and plans to defend her thesis during 2025.

    Johanna Borg Bruchfeld investigates sex-related differences in incidence and outcomes among patients with lymphoma from both an epidemiological and a biological perspective. Johanna is an MD and has been registered as a PhD student at the Department of Medicine Solna (KI) since 2019. Her main supervisor is Tove W盲sterlid.

    [1] /en/mmk/alascca-study

Articles

  • Article: INTERNATIONAL JOURNAL OF CANCER. 2024
    Shahrivar M; Dietrich CE; Glimelius B; Saraste D; Martling A; Buchli C; Nordenvall C
  • Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2024
    Godtfredsen SJ; Yonis H; Baech J; Al-Hussainy NR; Riddersholm S; Kober L; Schou M; Christensen JH; Hutchings M; Dahl-Sorensen RB; Kamper P; Dietrich CE; Andersen MP; Torp-Pedersen C; Sogaard P; El-Galaly TC; Kragholm KH
  • Article: EJHAEM. 2024;5(3):516-526
    Wasterlid T; Dietrich CE; Oksanen A; Spangberg LD; Wahlin BE; Enblad G; Andersson P-O; Kimby E; Smedby KE
  • Article: COLORECTAL DISEASE. 2024;26(2):300-308
    Sakari T; Skoldberg F; Dietrich CE; Nordenvall C; Karlbom U
  • Article: TRANSPLANT INTERNATIONAL. 2024;37:13173
    Benoni H; Nordenvall C; Hellstrom V; Dietrich CE; Martling A; Smedby KE; Eloranta S
  • Article: BLOOD ADVANCES. 2023;7(18):5304-5313
    Nikkarinen A; Lokhande L; Amini R-M; Jerkeman M; Porwit A; Molin D; Enblad G; Kolstad A; Raety R; Hutchings M; Weibull CE; Hollander P; Ek S; Glimelius I
  • Article: INTERNATIONAL JOURNAL OF CANCER. 2023;153(4):723-731
    Entrop JP; Weibull CE; Smedby KE; Jakobsen LH; Ovlisen AK; Molin D; Glimelius I; Marklund A; Holte H; Fossa A; Smeland KB; El-Galaly TC; Eloranta S
  • Article: BRITISH JOURNAL OF HAEMATOLOGY. 2023;202(4):785-795
    Entrop JP; Weibull CE; Smedby KE; Jakobsen LH; Ovlisen AK; Glimelius I; Marklund A; Larsen TS; Holte H; Fossa A; Smeland KB; El-Galaly TC; Eloranta S
  • Article: LEUKEMIA. 2023;37(5):1103-1112
    Berggren DM; Garelius H; Hjelm PW; Nilsson L; Rasmussen B; Weibull CE; Lambe M; Lehmann S; Hellstrom-Lindberg E; Jadersten M; Ejerblad E
  • Article: ACTA ONCOLOGICA. 2023;62(4):342-349
    Weibull CEE; Boman SE; Glimelius B; Syk I; Matthiessen P; Smedby KEE; Nordenvall C; Martling A
  • Article: HEMASPHERE. 2023;7(3):e838
    Weibull CE; Wasterlid T; Wahlin BE; Andersson P-O; Ekberg S; Lockmer S; Enblad G; Crowther MJ; Kimby E; Smedby KE
  • Article: INTERNATIONAL JOURNAL OF CANCER. 2023;152(3):363-373
    Ljunggren M; Weibull CE; Palmer G; Osterlund E; Glimelius B; Martling A; Nordenvall C
  • Article: CANCERS. 2023;15(3):688
    Lundqvist E; Myrberg IH; Boman SE; Saraste D; Weibull CE; Landerholm K; Haapaniemi S; Martling A; Myrelid P; Nordenvall C
  • Article: AMERICAN JOURNAL OF HEMATOLOGY. 2023;98(1):23-30
    Radkiewicz C; Bruchfeld JB; Weibull CE; Jeppesen ML; Frederiksen H; Lambe M; Jakobsen L; El-Galaly TC; Smedby KE; Wasterlid T
  • Article: CANCER MEDICINE. 2023;12(1):315-324
    Shahrivar M; Weibull CE; Ekstrom Smedby K; Glimelius B; Syk I; Matthiessen P; Nordenvall C; Martling A
  • Article: COLORECTAL DISEASE. 2023;25(1):9-15
    Rutegard M; Moshtaghi-Svensson J; Weibull CE; Ottander U; Nordenvall C; Sund M
  • Article: BJS OPEN. 2022;6(6):zrac140
    Rosander E; Holm T; Sjovall A; Hjern F; Weibull CE; Nordenvall C
  • Journal article: HEMASPHERE. 2022;6(Suppl):35
    Bj枚rkholm M; Weibull CE; Dickman P
  • Journal article: HEMASPHERE. 2022;6(Suppl ):37
    P081: Treatment-related circulatory diseases and mortality in Hodgkin lymphoma patients using multi-state modelling and relative survival
    Baech J; Jakobsen LH; El-Galaly TC; Molin D; Glimelius I; Entrop JP; Crowther MJ; Smedby KE; Eloranta S; Weibull CE
  • Journal article: HEMASPHERE. 2022;6(Suppl ):30
    T065: Reproduction patterns among Classical Hodgkin Lymphoma Survivors Treated with BEACOPP and ABVD in Sweden, Denmark, and Norway
    Entrop JP; Weibull CE; Smedby KE; Jakobsen LH; 酶vlisen AK; Molin D; Glimelius I; Marklund A; Holte H; Foss氓 A; Smeland KB; El-Galaly TC; Eloranta S
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All other publications

  • Letter: ACTA ONCOLOGICA. 2023;62(12):1942-1944
    Weibull CE; Sjoberg J; Dickman PW; Bjorkholm M
  • Published conference paper: BLOOD ADVANCES. 2023;7(5):866-874
    Ekberg S; Smedby KE; Albertsson-Lindblad A; Jerkeman M; Weibull CE; Glimelius I
  • Conference publication: BLOOD. 2022;140:2292-2295
    Maurer MJ; Prochazka VK; Flowers CR; Jakobsen LH; Villa D; Weibull CE; Cahn EJ; Smith A; Ghesquieres H; Kridel R; Gandhi M; Cheah CY; Hawkes E; Seymour JF; Freeman CL; Clausen MR; Wahlin BE; Friedberg JW; Casulo C; Habermann TM; Wang Y; Nastoupil LJ; Brown PDN; Belada D; Janikova A; Mocikova H; Furst T; Burack R; Martin P; Cohen JB; Lossos IS; Kahl BS; Link BK; Smedby KE; Sehn LH; Trneny M; El-Galaly TCC; Cerhan JR
  • Conference publication: BLOOD. 2022;140:9411-9412
    Baech J; Jakobsen LH; El-Galaly TCC; Molin D; Glimelius I; Entrop JPP; Crowther M; Smedby KE; Eloranta S; Weibull CE
  • Conference publication: BLOOD. 2022;140:1079-1081
    Entrop JPP; Weibull CE; Smedby KE; Jakobsen LH; Oevlisen AK; Glimelius I; Marklund A; Larsen TS; Holte H; Fossa A; Smeland KB; El-Galaly TCC; Eloranta S
  • Conference publication: BLOOD. 2022;140:3620-3621
    Wasterlid T; Warnqvist A; Weibull CE; Wahlin BE; Andersson P-O; Enblad G; Kimby E; Smedby KE
  • Preprint: RESEARCH SQUARE. 2022
    Weibull C; W盲sterlid T; Wahlin B; Andersson P-OA; Ekberg S; Lockmer S; Enblad G; Crowther M; Kimby E; Smedby KE
  • Letter: HAEMATOLOGICA. 2022;107(3):740-743
    Albertsson-Lindblad A; Palsdottir T; Smedby KE; Weibull CE; Glimelius I; Jerkeman M
  • Conference publication: BLOOD. 2021;138:3527
    Maurer MJ; Prochazka VK; Flowers CR; Jakobsen LH; Villa D; Weibull C; Cahn EJ; Ghesquieres H; Kridel R; Gandhi M; Cheah CY; Hawkes E; Seymour JF; Freeman CL; Clausen MR; Wahlin B; Link BK; Smedby KE; Sehn LH; Trneny M; El-Galaly TC; Cerhan JR
  • Meeting abstract: BLOOD. 2021;138:2534
    Radkiewicz C; Bruchfeld JB; Weibull C; Lambe M; Jakobsen LH; El-Galaly TC; Smedby KE; W盲sterlid T
  • Letter: BLOOD CANCER JOURNAL. 2021;11(5):100
    Wasterlid T; Hasselblom S; Joelsson J; Weibull CE; Rassidakis G; Sander B; Smedby KE
  • Preprint: ARXIV. 2021
    Broomfield J; Weibull CE; Crowther MJ
  • Preprint: ARXIV. 2020
    Weibull CE; Lambert PC; Eloranta S; Andersson TML; Dickman PW; Crowther MJ
  • Conference publication: BLOOD. 2020;136:3-4
    Jerkeman M; Palsdottir T; Glimelius I; Albertsson-Lindblad A; Weibull C; Ellin F; Sonnevi K; Lewerin C; Brandefors L; Smedby KE
  • Preprint: MEDRXIV. 2020
    Hothorn T; Bopp M; G眉nthard HF; Keiser O; Roelens M; Weibull CE; Crowther MJ
  • Conference publication: BLOOD. 2019;134:2841
    Ovlisen AK; Jakobsen LH; Kragholm KH; Hutchings M; Frederiksen H; Kamper P; Eloranta S; Weibull C; Glimelius I; Smedby KEE; Severinsen MT; El-Galaly TCC
  • Conference publication: BLOOD. 2019;134:4572
    Glimelius I; Smedby KE; Albertsson-Lindblad A; Eloranta S; Jerkeman M; Weibull C
  • Preprint: SSRN ELECTRONIC JOURNAL. 2019
    Glimelius I; Smedby KE; Eloranta S; Jerkeman M; Weibull CE
  • Conference publication: BLOOD. 2018;132:2891
    Glimelius I; Smedby KE; Jerkeman M; Eloranta S; Weibull C
  • Thesis / dissertation: 2018
    Weibull, Caroline E
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Grants

  • Cancer survivorship and cutting-edge biostatistics: Statistical methods development for studies of late effects and prognostic markers
    Swedish Cancer Society
  • Cancer survivorship and cutting-edge biostatistics: Statistical methods development for studies of late effects and prognostic markers
    脜ke Wiberg Foundation

Employments

  • Statistician, Department of Medicine, 探花精选, 2019-

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Medical Epidemiology and Biostatistics, 探花精选, 2018
  • Master of Science, Mathematical Statistics, Department of Mathematics, Stockholm University, 2009

Supervisor

  • Jonatan Hedberg, Approaches for dealing with missing tumour stage at diagnosis with applications to colorectal cancer and its impact on work-related outcomes, 2024
  • Johanna Borg Bruchfeld, Sex-related differences in incidence and outcomes among patients with lymphoma: epidemiological and biological perspectives, /en/people/johanna-borg-bruchfeld, 2021
  • Malin Ljunggren, Metastatic colorectal cancer - identifying the patients that receive and benefit from treatment with curative intent, /en/people/malin-ljunggren, 2021
  • Joshua Entrop, Childbearing after modern-day intensive immunochemotherapy in young Hodgkin and non-Hodgkin lymphoma survivors, /en/people/joshua-entrop, 2020
  • Mehrnoosh Shahrivar, Aspirin use, genetic profile and prognosis in patients with colorectal cancer, /en/people/mehrnoosh-shahrivar, 2020
  • Anna Nikkarinen, Mantle Cell Lymphoma: Biology and Treatment, , 2019

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