探花精选

Carolina Hagberg

Carolina Hagberg

Principal Researcher | Docent
Visiting address: BioClinicum, Plan 8,Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Kardiov m Hagberg C, 171 77 Stockholm

About me

  • The Hagberg team integrates vascular biology with nutrient biochemistry to study how our adipose tissue handles overnutrition, and if we can uncouple obesity from the development of metabolic diseases.

    Originally from Helsinki, Finland, I did my Ph.D. with Ulf Eriksson at MBB, 探花精选 (KI) studying the metabolic role of the vascular growth factor VEGF-B, which was published in two consecutive Nature papers (Hagberg et al, Nature 2010 &
  • 2012). I then went on for a postdoctoral visit to EPFL in Switzerland in the laboratory of Profs. Auwerx and Schoonjans to study energy metabolism and mitochondrial function. Returning to KI I joined the lab of Kirsty Spalding (at that time situated at ICMC in KI Huddinge) to study human adipose tissue and its role in metabolic disease, finding that mature adipocytes endoreplicate during obesity and in response to chronic insulin stimulation can become senescent (Li &
  • Hagberg et al, Nature Medicine 2021). I also was involved in developing novel methods to study mature adipocytes, a notoriously difficult cell type to study due to their high lipid content (Hagberg et al, Cell Reports 2018).

    In 2019, after receiving a KI faculty-funded position as Assistant Professor, I got the chance to set up my own lab, relocating to the Cardiovascular
    Medicine Division at the Department of Medicine Solna (and also part of CMM), where I now head a group of nice scientists. In 2019 I also received a VR Starting Grant, and our research has been awarded numerous other grants such Diabetes Wellness Foundation, EFSD, Novo Nordisk Foundation, 脜ke Wiberg, Jeanssons Stiftelser and KI KID funding. The lab has just published our first paper, describing a novel 3D in vitro model to study human
    adipose tissue development and hypertrophy called HUVAS (Human Unilocular Vascularized Adipocyte Spheroids, Ioannidou et al, Journal of
    Physiology, 2021). In 2022 I became Docent in Cell- and Molecular Biology. More information can be found at www.Hagberglab.com .

    Current position:
    03/2023 Principal Researcher (Senior Forskare) at the Dept. of MedS, 探花精选

    Education:
    2006 M.Sc. in Biochemistry, University of Helsinki, Finland
    2011 PhD in Cell and Molecular Biology, 探花精选, Sweden

    Professional Experience:
    2001-2002 Research student at the Folkh盲lsan Institute of Genetics, Helsinki, Finland
    2002- 2003 Research internship at INTS/INSERM, Paris, France
    2004-2005 Master thesis student in Ralf Pettersson Lab, LICR, 探花精选, Sweden
    2006-2011 PhD student in Ulf Eriksson lab, CMB/MBB, 探花精选, Sweden
    2013 Postdoc in the Auwerx/Schoonjans lab at EPFL, IBI, EPFL, Switzerland
    2014-2018 Postdoc in Kirsty Spalding lab at ICMC, MedH, Karolinska Insitutet, Sweden
    2019-2022 Assistant Professor and Team leader at Dept. of MedS, 探花精选
    2022- Promoted to full Group Leader at Dept. of MedS, Karolinska Institute
    2022 - Associate Professor (Docent) in Cell and Molecular Biology at 探花精选
    2023- Group Leader at the Centre for Molecular Medicine (CMM), 探花精选

    Commissions of trust:
    2019-2020 Chair of the 探花精选 Junior Faculty
  • Vice-chair in 2018
    2019-2020 Junior Faculty representative at 探花精选鈥檚 Faculty Council
    2020- Board member of the KI Respiratory and Circulatory research Network (KIRCNET), Vice-chair 2023-->

  • 2020- Editorial Board member for the popular science journal Medisinsk Vetenskap, 2020-

    Grant reviewer for French National Research Agency (ANR), UK NC3Rs, Swiss national Science Foundation (SNSF), Netherlands Organisation for Health Research and Development (ZonMW), The BHF-DZHK-DHF Partnership Awards, and 探花精选 KID grants.

    Awards and Honors:
    - Prize *for 鈥淏est Swedish pre-clinical doctoral thesis 2011 within the field of diabetes鈥 by the Swedish Association of Diabetology
    - Prize* for 鈥淏est M.Sc. thesis in Biochemistry in 2006鈥 at the University of Helsinki
    - Faculty-funded position as Assistant Professor at 探花精选 (2019-2022)
    - Faculty-funded position as Principal Researcher at 探花精选 (2023-2024)

    Meeting Organization:
    2019-2020 Organizer of KI Discovers seminar series (Nobel forum and online, Stockholm, Sweden)
    2019, 2020, 2021 Organizer of the Cardiovascular Program (CVP) conference (Stockholm, Sweden)
    2021- Organizer of several KIRKNET symposia (Stockholm, Sweden and online)
    2023 Co-organizer of the 29th Scandinavian Society for Atherosclerosis Research (SSAR) meeting (Humlebaek, Denmark)
    2023 Co-organizing the first Swedish Cardiometabolic Mid-career Network meeting with support by Hj盲rt-Lung Fonden (Sweden)

    Short bibliographic overview (October 2023):
    Total number of publications: 24 (with one in revision)
  • 5 as first author, 7 as corresponding author.
    Citations: 1, 840 (WoS)
  • 2, 762 (GS). H-index=15, i10-index=18. Sum of Latest Known Journal Impact Factor: 420

Research

  • Our research centers around obesity and obesity-induced conditions such as insulin resistance and dyslipidemia, asking why weight gain leads to disease development in some, but not all, obese individuals. We believe the answer lies in how the adipose tissue expands and functions, and that by identifying early pathological triggers connected to adipose tissue nutrient uptake and utilization, we could better understand the pathological processes connected to weight gain. Our goal is to enable the development of preventive treatment strategies that could protect overweight patients against falling ill in the first place, improving both patient care and life quality. Given my background in vascular biology and our current location at the Cardiovascular Medicine Division at 探花精选, we have a particular interest in the reciprocal interaction between adipocytes and blood vessels, both during differentiation and in health and disease. To understand human adipose tissue physiology, we use a combination of clinical fat biopsies and 3D cultured /in vitro/ adipose tissue models, and use inducable research animals to study inter-organ cross-talk and systemic metabolism /in vivo/. Current projects focus on the regulatory role of the vascular endothelium, on deciphering how cholesterol loading impacts adipose tissue function, and on the metabolic demands of cell growth. We are a young, dynamic research group located on the 8th floor of BioClinicum in Solna always open for students and interesting opportunities to collaborate.

Teaching

  • - Lecturer on several graduate and undergraduate courses in genetics, cell biology, adipose biology and vascular biology (KI, 2007- present).
    - Vice-responsible for the course Fr氓n 脛gg till Embryo for KI 探花精选 students (2014-2015)
    - Principal supervisor for 3 postdocs, 2 PhD students and co-supervisor for 7 PhD students.
    - Principal thesis or internship supervisor for 10 BSc and MSc students.

Articles

  • Article: LAB ANIMAL. 2024;53(11):336-346
    Carvalho LRRA; Shimari M; Boeder AM; Zhuge Z; Cai M; Leijding C; Gastaldello S; Kleschyov AL; Schiffer TA; Guimaraes DD; Picozzi G; Lund LH; Fellstrom B; Weitzberg E; Lundberg JO; Hagberg CE; Pironti G; Andersson DC; Carlstrom M
  • Article: NATURE CARDIOVASCULAR RESEARCH. 2024;3(3):356-371
    Di Nunzio G; Hellberg S; Zhang Y; Ahmed O; Wang J; Zhang X; Bjoerck HM; Chizh V; Schipper R; Aulin H; Francis R; Fagerberg L; Gistera A; Metso J; Manfe V; Franco-Cereceda A; Eriksson P; Jauhiainen M; Hagberg CE; Olofsson PS; Malin SG
  • Article: FRONTIERS IN ENDOCRINOLOGY. 2024;15:1396965
    Davidsen LI; Hagberg CE; Goitea V; Lundby SM; Larsen S; Ebbesen MF; Stanic N; Topel H; Kornfeld J-W
  • Article: BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION. 2023;51(5):508-519
    Lange S; Sotak M; Hagberg CE; Bagunu G; Vigmo S; B枚rgeson E
  • Article: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2023;80:102057
    Lauschke VM; Hagberg CE
  • Journal article: 2022
    Q L; CE H; HS C; S L; MT H; F S; P C; I A; E T; MJ H; M K; N A; N K; M A; C K; J B; A T; KL S
  • Journal article: ATHEROSCLEROSIS. 2022;355:24
    Chemaly M; Suur B; Schipper R; Jin H; Hagberg C; Matic LP
  • Article: ISCIENCE. 2022;25(7):104602
    Sotak M; Rajan MR; Clark M; Harms M; Rani A; Kraft JD; Tandio D; Shen T; Borkowski K; Fiehn O; Newman JW; Quiding-Jarbrink M; Biorserud C; Apelgren P; Staalesen T; Hagberg CE; Boucher J; Wallenius V; Lange S; Borgeson E
  • Article: JOURNAL OF PHYSIOLOGY. 2022;600(4):869-883
    Ioannidou A; Alatar S; Schipper R; Baganha F; Ahlander M; Hornell A; Fisher RM; Hagberg CE
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(1):520
    Sotak M; Rajan MR; Clark M; Biorserud C; Wallenius V; Hagberg CE; Borgeson E
  • Article: NATURE MEDICINE. 2021;27(11):1941-1953
    Li Q; Hagberg CE; Silva Cascales H; Lang S; Hyvonen MT; Salehzadeh F; Chen P; Alexandersson I; Terezaki E; Harms MJ; Kutschke M; Arifen N; Kramer N; Aouadi M; Knibbe C; Boucher J; Thorell A; Spalding KL
  • Article: FRONTIERS IN RESEARCH METRICS AND ANALYTICS. 2021;6:594424
    Andersson ER; Hagberg CE; H盲gg S
  • Article: CELL REPORTS. 2019;27(1):213-225.e5
    Harms MJ; Li Q; Lee S; Zhang C; Kull B; Hallen S; Thorell A; Alexandersson I; Hagberg CE; Peng X-R; Mardinoglu A; Spalding KL; Boucher J
  • Article: CELL REPORTS. 2018;24(10):2746-2756.e5
    Hagberg CE; Li Q; Kutschke M; Bhowmick D; Kiss E; Shabalina IG; Harms MJ; Shilkova O; Kozina V; Nedergaard J; Boucher J; Thorell A; Spalding KL
  • Article: CELL AND TISSUE RESEARCH. 2016;365(1):51-63
    Muhl L; Moessinger C; Adzemovic MZ; Dijkstra MH; Nilsson I; Zeitelhofer M; Hagberg CE; Huusko J; Falkevall A; Yla-Herttuala S; Eriksson U
  • Article: DIABETES. 2016;65(4):861-873
    Mehlem A; Palombo I; Wang X; Hagberg CE; Eriksson U; Falkevall A
  • Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2015;308(9):E822-E829
    Abreu-Vieira G; Hagberg CE; Spalding KL; Cannon B; Nedergaard J
  • Article: CELL METABOLISM. 2014;19(6):1034-1041
    Pirinen E; Canto C; Jo YS; Morato L; Zhang H; Menzies KJ; Williams EG; Mouchiroud L; Moullan N; Hagberg C; Li W; Timmers S; Imhof R; Verbeek J; Pujol A; van Loon B; Viscomi C; Zeviani M; Schrauwen P; Sauve AA; Schoonjans K; Auwerx J
  • Article: NATURE PROTOCOLS. 2013;8(6):1149-1154
    Mehlem A; Hagberg CE; Muhl L; Eriksson U; Falkevall A
  • Article: NATURE. 2012;490(7420):426-430
    Hagberg CE; Mehlem A; Falkevall A; Muhl L; Fam BC; Ortsater H; Scotney P; Nyqvist D; Samen E; Lu L; Stone-Elander S; Proietto J; Andrikopoulos S; Sjoholm A; Nash A; Eriksson U
  • Article: PLOS ONE. 2010;5(11):e14109
    Albrecht I; Kopfstein L; Strittmatter K; Schomber T; Falkevall A; Hagberg CE; Lorentz P; Jeltsch M; Alitalo K; Eriksson U; Christofori G; Pietras K
  • Article: NATURE. 2010;464(7290):917-921
    Hagberg CE; Falkevall A; Wang X; Larsson E; Huusko J; Nilsson I; van Meeteren LA; Samen E; Lu L; Vanwildemeersch M; Klar J; Genove G; Pietras K; Stone-Elander S; Claesson-Welsh L; Yla-Herttuala S; Lindahl P; Eriksson U
  • Article: CIRCULATION. 2009;119(6):845-856
    Laehteenvuo JE; Laehteenvuo MT; Kivelae A; Rosenlew C; Falkevall A; Klar J; Heikura T; Rissanen TT; Vaehaekangas E; Korpisalo P; Enholm B; Carmeliet P; Alitalo K; Eriksson U; Ylae-Herttuala S
  • Article: JOURNAL OF MEDICAL GENETICS. 2004;41(10):e115
    Diesen C; Saarinen A; Pihko H; Rosenlew C; Cormand B; Dobyns WB; Dieguez J; Valanne L; Joensuu T; Lehesjoki AE
  • Show more

All other publications

  • Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2024;25(4):270-289
    Hagberg CE; Spalding KL
  • Corrigendum: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2024;25(4):333
    Hagberg CE; Spalding KL
  • Review: AGEING RESEARCH REVIEWS. 2024;94:102194
    Maestri A; Garagnani P; Pedrelli M; Hagberg CE; Parini P; Ehrenborg E
  • Editorial comment: SIGNAL TRANSDUCTION AND TARGETED THERAPY. 2023;8(1):314
    Hagberg CE
  • Editorial comment: ADIPOCYTE. 2022;11(1):413-419
    Baganha F; Schipper R; Hagberg CE
  • Review: OBESITY REVIEWS. 2022;23(4):e13403
    Ioannidou A; Fisher RM; Hagberg CE
  • Review: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2022;10:1003118
    Borgeson E; Boucher J; Hagberg CE
  • Conference publication: ATHEROSCLEROSIS. 2022;355:E54-E55
    Chemaly M; Suur B; Schipper R; Jin H; Hagberg C; Matic LP
  • Preprint: BIORXIV. 2021
    Ioannidou A; Alatar S; 脜hlander M; Hornell A; Fisher R; Hagberg C
  • Preprint: BIORXIV. 2019
    Andersson E; Hagberg C; H盲gg S
  • Review: PHYSIOLOGY. 2013;28(2):125-134
    Hagberg C; Mehlem A; Falkevall A; Muhl L; Eriksson U
  • Thesis / dissertation: 2011
    Hagberg, Carolina

Grants

  • Swedish Research Council
    1 January 2020 - 31 December 2023
  • Swedish Research Council
    1 January 2013 - 31 August 2014

Employments

  • Principal Researcher, Department of Medicine, 探花精选, 2023-

Degrees and Education

  • Docent, 探花精选, 2022
  • Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, 探花精选, 2011

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