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Camilla Björkegren

Camilla Björkegren

Professor | Head of department
Telephone: +46852482928
Visiting address: Solnavägen 9, 17165 Stockholm
Postal address: C5 Cell- och molekylärbiologi, C5 CMB Björkegren, 171 77 Stockholm
Part of:

About me

  • Professor of Cell and Tumour Biology.

    Education
    1999-2001 Postdoctoral fellow, Prof. Kim Nasmyth’s group, Institute of Molecular Pahtology (IMP), Vienna, Austria.

    1997 PhD in Natural Sciences, Department of Cell Biology, Wenner-Gren Institute, Stockholm University, Sweden

    1990 Master degree in Natural Sciences, Department of Cell Biology, Wenner-Gren Institute, Stockholm University, Sweden

    Academic honours

    2022 Visiting Professor, The University of Tokyo

    2017 Center for Innovative Medicine, CIMED, Senior Investigator

    2014 Nicholson lecturer at Rockefeller University, NY, USA

    2013 Member of Swedish Royal Academy of Sciences, Class of Medical Sciences

    2008 Member of the European Molecular Biology Organization (EMBO)

    2008 European Ressearch council (ERC) starting grant

    2008 Fernströms prize to young researchers

    2007 Royal Swedish Academy of Sciences Research Fellow in Medical sciences

    Institutional responsibilties

    2005-present Vice chairman, Dept. of Cell and Molecular Biology, Karolinska Insitutet

Research

  • Chromosome dynamics and genome stability

    The molecular mechanisms that control chromosome dynamics and maintain genome stability are essential for life and prevent accumulation of disease-promoting chromosomal aberrations. With the aim to decipher these mechanisms, our projects focus on the evolutionary conserved family of SMC protein complexes (SMC: Structural Maintenance of Chromosomes) which we investigate using the budding yeast Saccharomyces cerevisiae model organism, and biochemical and structural in vitro analysis.

    Considered as an entity, the eukaryotic complexes cohesin, condensin and the Smc5/6 complex control most chromosome-based processes, including replication, segregation, repair and transcription. While it has become increasingly clear that SMC complexes act by structurally organizing chromosomes, their exact modes of action remain unclear. This is especially true for the Smc5/6 complex, which is the main object of investigation in our team.

    The Smc5/6 complex has mainly been functionally connected with DNA repair and recombination, and we have analyzed this function in both mitotic and meiotic cells. We have also shown that Smc5/6 has a non-repair function, and accumulates on replicated chromosomes in unchallenged cells. Intriguingly, this enrichment increases in linear correlation with the length of the chromosomes, and our investigations show that this is due to a functional connection between the Smc5/6 complex and DNA supercoiling. Supercoiling is the under- or over-twisting of the DNA double helix, and arises when the replication or transcription machineries pry the helix apart. If enzymes called topoisomerases do not remove the supercoils, they inhibit replication and transcription, and increase the risk of genomic instability. Our ongoing investigations aim to understand how transcription- and replication-induced supercoiling influences the function of SMC complexes, chromosome dynamics and genome stability.

Selected publications

  • Article: MOLECULAR CELL. 2024;84(5):867-882.e5
    Jeppsson K; Pradhan B; Sutani T; Sakata T; Igarashi MU; Berta DG; Kanno T; Nakato R; Shirahige K; Kim E; Bjorkegren C

Articles

  • Article: NATURE COMMUNICATIONS. 2024;15(1):1454
    Sanyal S; Kouznetsova A; Strom L; Bjorkegren C
  • Article: NATURE. 2023;616(7958):843-848
    Pradhan B; Kanno T; Igarashi MU; Loke MS; Baaske MD; Wong JSK; Jeppsson K; Bjorkegren C; Kim E
  • Article: SCIENCE ADVANCES. 2022;8(23):eabn7063
    Jeppsson K; Sakata T; Nakato R; Milanova S; Shirahige K; Bjorkegren C
  • Article: NATURE COMMUNICATIONS. 2020;11(1):138
    Sen I; Zhou X; Chernobrovkin A; Puerta-Cavanzo N; Kanno T; Salignon J; Stoehr A; Lin X-X; Baskaner B; Brandenburg S; Bjorkegren C; Zubarev RA; Riedel CG
  • Article: NATURE COMMUNICATIONS. 2018;9(1):3785
    Karlberg T; Hornyak P; Pinto AF; Milanova S; Ebrahimi M; Lindberg M; Pullen N; Nordstrom A; Loverli E; Caraballo R; Wong EV; Nareoja K; Thorsell A-G; Elofsson M; De la Cruz EM; Bjorkegren C; Schuler H
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(3):E884-884
    Bjorkegren C; Baranello L
  • Article: STRUCTURE. 2016;24(5):789-796
    Kouznetsova E; Kanno T; Karlberg T; Thorsell A-G; Wisniewska M; Kursula P; Sjogren C; Schuler H
  • Article: CELL REPORTS. 2015;12(9):1471-1482
    Kanno T; Berta DG; Sjogren C
  • Article: DNA REPAIR. 2015;28:83-92
    Carlborg KK; Kanno T; Carter SD; Sjogren C
  • Article: PLOS GENETICS. 2014;10(10):e1004680
    Jeppsson K; Carlborg KK; Nakato R; Berta DG; Lilienthal I; Kanno T; Lindqvist A; Brink MC; Dantuma NP; Katou Y; Shirahige K; Sjogren C
  • Article: PLOS GENETICS. 2013;9(11):e1003898
    Lilienthal I; Kanno T; Sjogren C
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(14):11374-11383
    Bustard DE; Menolfi D; Jeppsson K; Ball LG; Dewey SC; Shirahige K; Sjogren C; Branzei D; Cobb JA
  • Article: JOURNAL OF CELL SCIENCE. 2011;124(16):2735-2742
    Guerra L; Guidi R; Slot I; Callegari S; Sompallae R; Pickett CL; Astrom S; Eisele F; Wolf D; Sjogren C; Masucci MG; Frisan T
  • Article: NATURE. 2011;471(7338):392-396
    Kegel A; Betts-Lindroos H; Kanno T; Jeppsson K; Strom L; Katou Y; Itoh T; Shirahige K; Sjogren C
  • Article: SCIENCE. 2007;317(5835):242-245
    Stroem L; Karlsson C; Betts Lindroos H; Wedahl S; Katou Y; Shirahige K; Sjoegren C
  • Article: CURRENT OPINION IN CELL BIOLOGY. 2007;19(3):344-349
    Strom L; Sjogren C
  • Article: MOLECULAR CELL. 2006;22(6):755-767
    Lindroos HB; Ström L; Itoh T; Katou Y; Shirahige K; Sjögren C
  • Article: CELL CYCLE. 2005;4(4):536-539
    Ström L; Sjögren C
  • Article: MOLECULAR CELL. 2004;16(6):1003-1015
    Ström L; Lindroos HB; Shirahige K; Sjögren C
  • Article: CURRENT BIOLOGY. 2001;11(12):991-995
    Sjögren C; Nasmyth K
  • Show more

All other publications

  • Preprint: BIORXIV. 2024;BIORXIV
    Pradhan B; Pinto A; Kanno T; Tetiker D; Baaske MD; Cutt E; Chatzicharlampous C; Schüler H; Deep A; Corbett KD; Aragon L; Virnau P; Björkegren C; Kim E
  • Preprint: BIORXIV. 2023
    Jeppsson K; Pradhan B; Sutani T; Sakata T; Igarashi MU; Berta DG; Kanno T; Nakato R; Shirahige K; Kim E; Björkegren C
  • Preprint: BIORXIV. 2022
    Sanyal S; Kouznetsova A; Björkegren C
  • Editorial comment: EMBO JOURNAL. 2016;35(7):703-705
    Schuler H; Sjogren C
  • Editorial comment: EXPERIMENTAL CELL RESEARCH. 2014;329(1):1
    Sjogren C; Tarsounas M; Bartek J; Hoog C
  • Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2014;15(9):601-614
    Jeppsson K; Kanno T; Shirahige K; Sjogren C
  • Editorial comment: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2012;13(5):282
    Sjogren C
  • Review: CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2012;47(1):1-16
    Carter SD; Sjogren C
  • Review: EXPERIMENTAL CELL RESEARCH. 2010;316(9):1445-1453
    Sjogren C; Strom L
  • Review: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2010;75:179-187
    Kegel A; Sjögren C

Grants

  • Swedish Research Council
    1 January 2024 - 31 December 2027
  • The DNA double helix in health and disease. Analysis of how supercoiling affects chromosome folding and stability.
    Swedish Cancer Fondation
    1 January 2023 - 31 December 2025

Employments

  • Professor, Department of Cell and Molecular Biology, ̽»¨¾«Ñ¡, 2010-

Leadership and responsibility assignments

  • Head of department, Department of Cell and Molecular Biology, ̽»¨¾«Ñ¡, 2024-

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