探花精选

brun ulfhake

brun ulfhake

Professor Emeritus/Emerita
Visiting address: Alfred Nobels all茅 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Klin Fysiologi, 141 52 Huddinge
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About me

  • Brun Ulfhake was born in Stockholm in 1952, and received his M.D. from 探花精选 in 1980. He combined his 探花精选 studies with researching. In 1982 he received his Ph.D. with a dissertation about electrical characteristics, function and structure in central nerve cells. Thereafter he was active in the clinic as an anesthesiologist and diving physician, while at the same time he carried out neurobiological research at 探花精选. In 1988 he was appointed Associate Professor, and in 1994 was appointed University Lecturer. For a period in the beginning of the 1990s, Brun Ulfhake was a postdoctor with NIH in USA, and since 1991 has carried out research at 探花精选 on the connection between our genetic material and changes in the function of the nerve system during aging. Brun Ulfhake was appointed Professor in Anatomy at 探花精选 on March 1, 2001. In August 2019 Brun Ulfhake retired from the professorship in Anatomy at the Department of Neuroscience and was re-hired as senior professor at the Department of Laboratory medicine
    Brun Ulfhake has had a number of engagements within both teaching at Karolinska institutet as the Director of Anatomy Education, as well as being engaged in laboratory animal ethical matters. Between January 1, 2013, and March 2018, Brun Ulfhake served as the Director for Comparative Medicine.

Research

  • Aging is inescapable, but at the same time an unequal process where certain persons live well over 100 years, while others have a much shorter life. The deciding factor is the integration of our genetic material and our behavior with random and fixed environmental factors and epigenetic changes. The research aims at creating understanding for which genes and the regulation thereof that lie behind those deficiencies in function that arise with increasing age. This knowledge can then be used to alleviate the negative consequences of aging for the individual.
    Recent publications:
    1. A systematic review of the development and application of home cage monitoring in laboratory mice and rats.
    Kahnau P, Mieske P, Wilzopolski J, Kalliokoski O, Mandillo S, H枚lter SM, Voikar V, Amfim A, Badurek S, Bartelik A, Caruso A, 膶ater M, Ey E, Golini E, Jaap A, Hrncic D, Kiryk A, Lang B, Loncarevic-Vasiljkovic N, Meziane H, Radzevi膷ien臈 A, Rivalan M, Scattoni ML, Torquet N, Trifkovic J, Ulfhake B, Th枚ne-Reineke C, Diederich K, Lewejohann L, Hohlbaum K.
    BMC Biol. 2023 Nov 13;21(1):256. doi: 10.1186/s12915-023-01751-7.
    PMID: 37953247
    2. The 3Ranker: An AI-based Algorithm for Finding Non-animal Alternative Methods.
    van Beuningen N, Alkema S, Hijlkema N, Ulfhake B, Frias R, Ritskes-Hoitinga M, Alkema W.
    Altern Lab Anim. 2023 Nov;51(6):376-386. doi: 10.1177/02611929231210777. Epub 2023 Oct 21.
    PMID: 37864460
    3. Emergence and Progression of Behavioral Motor Deficits and Skeletal Muscle Atrophy across the Adult Lifespan of the Rat.
    Gr枚nholdtKlein M, Gorzi A, Wang L, Edstr枚m E, Rullman E, Altun M, Ulfhake B.
    Biology (Basel). 2023 Aug 28;12(9):1177. doi: 10.3390/biology12091177.
    PMID: 37759577 Free PMC article.
    4. Bouts of rest and physical activity in C57BL/6J mice.
    Pernold K, Rullman E, Ulfhake B.
    PLoS One. 2023 Jun 26;18(6):e0280416. doi: 10.1371/journal.pone.0280416. eCollection 2023.
    PMID: 37363906 Free PMC article.
    5. A multicentre study on spontaneous in-cage activity and micro-environmental conditions of IVC housed C57BL/6J mice during consecutive cycles of bi-weekly cage-change.
    Ulfhake B, Lerat H, Honetschlager J, Pernold K, Rynekrov谩 M, Escot K, Recordati C, Kuiper RV, Rosati G, Rigamonti M, Zordan S, Prins JB.
    PLoS One. 2022 May 25;17(5):e0267281. doi: 10.1371/journal.pone.0267281. eCollection 2022.
    PMID: 35613182 Free PMC article.
    6. Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms.
    Zhu R, Yan T, Feng Y, Liu Y, Cao H, Peng G, Yang Y, Xu Z, Liu J, Hou W, Wang X, Li Z, Deng L, Wang S, Li J, Han Q, Li H, Shan G, Cao Y, An X, Yan J, Zhang Z, Li H, Qu X, Zhu J, Zhou S, Wang J, Zhang F, Gao J, Jin R, Xu D, Ma YQ, Huang T, Peng S, Zheng Z, Stambler I, Gilson E, Lim LW, Moskalev A, Cano A, Chakrabarti S, Ulfhake B, Su H, Xu H, Xu S, Wei F, Brown-Borg HM, Min KJ, Ellison-Hughes G, Caruso C, Jin K, Zhao RC.
    Cell Res. 2021 Dec;31(12):1244-1262. doi: 10.1038/s41422-021-00573-y. Epub 2021 Oct 26.
    PMID: 34702946 Free PMC article.
    7. Sarcopenia: What Is the Origin of This Aging-Induced Disorder?
    Gustafsson T, Ulfhake B.
    Front Genet. 2021 Jul 2;12:688526. doi: 10.3389/fgene.2021.688526. eCollection 2021.
    PMID: 34276788 Free PMC article. Review.
    8. Major oscillations in spontaneous home-cage activity in C57BL/6 mice housed under constant conditions.
    Pernold K, Rullman E, Ulfhake B.
    Sci Rep. 2021 Mar 2;11(1):4961. doi: 10.1038/s41598-021-84141-9.
    PMID: 33654141 Free PMC article.
    9. Impairment of DHA synthesis alters the expression of neuronal plasticity markers and the brain inflammatory status in mice.
    Talamonti E, Sasso V, To H, Haslam RP, Napier JA, Ulfhake B, Pernold K, Asadi A, Hessa T, Jacobsson A, Chiurchi霉 V, Viscomi MT.
    FASEB J. 2020 Feb;34(2):2024-2040. doi: 10.1096/fj.201901890RR. Epub 2019 Dec 11.
    PMID: 31909582 Free PMC article.
    10. Longitudinal Muscle and Myocellular Changes in Community-Dwelling Men Over Two Decades of Successful Aging-The ULSAM Cohort Revisited.
    Skoglund E, Gr枚nholdt-Klein M, Rullman E, Thornell LE, Str枚mberg A, Hedman A, Cederholm T, Ulfhake B, Gustafsson T.
    J Gerontol A Biol Sci Med Sci. 2020 Mar 9;75(4):654-663. doi: 10.1093/gerona/glz068.
    PMID: 31002330
    11. Muscle atrophy and regeneration associated with behavioural loss and recovery of function after sciatic nerve crush.
    Gr枚nholdt-Klein M, Altun M, Beckl茅n M, Dickman Kahm E, Fahlstr枚m A, Rullman E, Ulfhake B.
    Acta Physiol (Oxf). 2019 Nov;227(3):e13335. doi: 10.1111/apha.13335. Epub 2019 Jul 2.
    PMID: 31199566
    12. Towards large scale automated cage monitoring - Diurnal rhythm and impact of interventions on in-cage activity of C57BL/6J mice recorded 24/7 with a non-disrupting capacitive-based technique.
    Pernold K, Iannello F, Low BE, Rigamonti M, Rosati G, Scavizzi F, Wang J, Raspa M, Wiles MV, Ulfhake B.
    PLoS One. 2019 Feb 4;14(2):e0211063. doi: 10.1371/journal.pone.0211063. eCollection 2019.
    PMID: 30716111 Free PMC article.

Articles

  • Article: ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2023;51(6):376-386
    van Beuningen N; Alkema S; Hijlkema N; Ulfhake B; Frias R; Ritskes-Hoitinga M; Alkema W
  • Article: BIOLOGY-BASEL. 2023;12(9):1177
    Gronholdtklein M; Gorzi A; Wang L; Edstrom E; Rullman E; Altun M; Ulfhake B
  • Article: PLOS ONE. 2023;18(6):e0280416
    Pernold K; Rullman E; Ulfhake B
  • Article: PLOS ONE. 2022;17(5):e0267281
    Ulfhake B; Lerat H; Honetschlager J; Pernold K; Rynekrova M; Escot K; Recordati C; Kuiper RV; Rosati G; Rigamonti M; Zordan S; Prins J-B; Roman G
  • Article: CELL RESEARCH. 2021;31(12):1244-1262
    Zhu R; Yan T; Feng Y; Liu Y; Cao H; Peng G; Yang Y; Xu Z; Liu J; Hou W; Wang X; Li Z; Deng L; Wang S; Li J; Han Q; Li H; Shan G; Cao Y; An X; Yan J; Zhang Z; Li H; Qu X; Zhu J; Zhou S; Wang J; Zhang F; Gao J; Jin R; Xu D; Ma Y-Q; Huang T; Peng S; Zheng Z; Stambler I; Gilson E; Lim LW; Moskalev A; Cano A; Chakrabarti S; Ulfhake B; Su H; Xu H; Xu S; Wei F; Brown-Borg HM; Min K-J; Ellison-Hughes G; Caruso C; Jin K; Zhao RC
  • Article: SCIENTIFIC REPORTS. 2021;11(1):4961
    Pernold K; Rullman E; Ulfhake B
  • Article: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2020;75(4):654-663
    Skoglund E; Gronholdt-Klein M; Rullman E; Thornell LE; Stromberg A; Hedman A; Cederholm T; Ulfhake B; Gustafsson T
  • Article: FASEB JOURNAL. 2020;34(2):2024-2040
    Talamonti E; Sasso V; To H; Haslam RP; Napier JA; Ulfhake B; Pernold K; Asadi A; Hessa T; Jacobsson A; Chiurchiu V; Viscomi MT
  • Article: ACTA PHYSIOLOGICA. 2019;227(3):e13335
    Gronholdt-Klein M; Altun M; Becklen M; Kahm ED; Fahlstrom A; Rullman E; Ulfhake B
  • Article: PLOS ONE. 2019;14(2):e0211063
    Pernold K; Iannello F; Low BE; Rigamonti M; Rosati G; Scavizzi F; Wang J; Raspa M; Wiles MV; Ulfhake B
  • Article: HUMAN MOLECULAR GENETICS. 2015;24(5):1305-1321
    Baek J-H; Schmidt E; Viceconte N; Strandgren C; Pernold K; Richard TJC; Van Leeuwen FW; Dantuma NP; Damberg P; Hultenby K; Ulfhake B; Mugnaini E; Rozell B; Eriksson M
  • Article: NUCLEIC ACIDS RESEARCH. 2015;43(D1):D1171-D1175
    Meehan TF; Chen C-K; Koscielny G; Relac M; Wilkinson P; Flicek P; Parkinson H; Castro A; Fessele S; Steinkamp R; Hagn M; Raess M; de Angelis MH; Bottomley J; Ramirez-Solis R; Smedley D; Ball S; Blake A; Fray M; Kenyon J; Mallon A-M; Brown S; Massimi M; Matteoni R; Tocchini-Valentini G; Herault Y; Kollias G; Ulfhake B; Demengeot J; Fremond C; Bosch F; Montoliu L; Soininen R; Schughart K; Brakebusch C; Sedlacek R; Ruelicke T; McKerlie C; Malissen B; Iraqi F; Jonkers J; Russig H; Huylebroeck D
  • Article: EXPERIMENTAL GERONTOLOGY. 2013;48(11):1173-1179
    Mannstrom P; Ulfhake B; Kirkegaard M; Ulfendahl M
  • Article: AGE. 2012;34(6):1435-1452
    Fahlstrom A; Zeberg H; Ulfhake B
  • Article: JOURNAL OF PHYSIOLOGY-LONDON. 2012;590(23):6187-6197
    Yamada T; Ivarsson N; Hernandez A; Fahlstrom A; Cheng AJ; Zhang S-J; Bruton JD; Ulfhake B; Westerblad H
  • Article: NEUROBIOLOGY OF AGING. 2011;32(10):1868-1880
    Fahlstrom A; Yu Q; Ulfahke B
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(51):39597-39608
    Altun M; Besche HC; Overkleeft HS; Piccirillo R; Edelmann MJ; Kessler BM; Goldberg AL; Ulfhake B
  • Article: PHYSIOLOGY & BEHAVIOR. 2007;92(5):911-923
    Altun M; Bergman E; Edstrom E; Johnson H; Ulfhake B
  • Article: PHYSIOLOGY & BEHAVIOR. 2007;92(1-2):129-135
    Edstrom E; Altun M; Bergman E; Johnson H; Kullberg S; Ramirez-Leon V; Ulfhake B
  • Article: MUSCLE & NERVE. 2007;36(2):223-233
    Altun M; Edstrom E; Spooner E; Flores-Moralez A; Bergman E; Tollet-Egnell P; Norstedt G; Kessler BM; Ulfhake B
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All other publications

  • Review: BMC BIOLOGY. 2023;21(1):256
    Kahnau P; Mieske P; Wilzopolski J; Kalliokoski O; Mandillo S; Hoelter SM; Voikar V; Amfim A; Badurek S; Bartelik A; Caruso A; Cater M; Ey E; Golini E; Jaap A; Hrncic D; Kiryk A; Lang B; Loncarevic-Vasiljkovic N; Meziane H; Radzeviciene A; Rivalan M; Scattoni ML; Torquet N; Trifkovic J; Ulfhake B; Thoene-Reineke C; Diederich K; Lewejohann L; Hohlbaum K
  • Preprint: PREPRINTS.ORG. 2023
    Gr枚nholdtKlein M; Gorzi A; Wang L; Edstr枚m E; Rullman E; Altun M; Ulfhake B
  • Preprint: BIORXIV. 2023
    Kahnau P; Mieske P; Wilzopolski J; Kalliokoski O; Mandillo S; H枚lter SM; Voikar V; Amfim A; Badurek S; Bartelik A; Caruso A; 膶ater M; Ey E; Golini E; Jaap A; Hrncic D; Kiryk A; Lang B; Loncarevic-Vasiljkovic N; Meziane H; Radzevi膷ien臈 A; Rivalan M; Scattoni ML; Torquet N; Trifkovic J; Ulfhake B; Th枚ne-Reineke C; Diederich K; Lewejohann L; Hohlbaum K
  • Preprint: BIORXIV. 2023
    Pernold K; Rullman E; Ulfhake B
  • Review: FRONTIERS IN GENETICS. 2021;12:688526
    Gustafsson T; Ulfhake B
  • Preprint: BIORXIV. 2020
    Pernold K; Rullman E; Ulfhake B
  • Letter: JOURNAL OF APPLIED PHYSIOLOGY. 2012;113(4):680-684
    Dardevet D; Savary-Auzeloux I; Remond D; Mosoni L
  • Book chapter: SENESCENCE. 2012;p.
    Altun M; Gr枚nholdt-Klein M; Wang L; Ulfhake B
  • Letter: JOURNAL OF APPLIED PHYSIOLOGY. 2012;113(4):683-684
    Thornell L-E; Gustafsson T; Cederholm T; Ulfhake B
  • Review: JOURNAL OF COMPARATIVE NEUROLOGY. 2005;488(2):152-179
    VanderHorst VGJM; Gustafsson J; Ulfhake B
  • Book chapter: PERIPHERAL NEUROPATHY. 2005;p. 483-507
    COWEN T; ULFHAKE B; KING RHM
  • Book chapter: PERIPHERAL NEUROPATHY. 2005;p. v-xv
    AL-CHALABI A; BAMIOU D-E; BANKS RW; BAROHN RJ; BENSTEAD TJ; BERGER AR; BERTHOLD C-H; BHARUCHA AE; BIRCH R; BONKOVSKY HL; BOOTH AM; BOSCH EP; BOSTOCK H; BRADKE F; BRADY RO; BRIMIJOIN S; BUCK D; BUNGE RP; BURKE D; BURKE JP; BURNS TM; CAMILLERI M; CARNEY JA; CHALK C; CHANCE PF; CHIU SY; COLLINS MP; COOTE JH; CORBETT JJ; CORNBLATH DR; COWEN T; CUDIA P; DARRAS BT; DAVIES JL; DE GROAT WC; DISPENZIERI A; DOMBOVY ML; DONAGHY M; DYCK PJ; DYCK PJB; ENGEL AG; ENGELSTAD J; FERRANTE MA; FRAHER JP; FREEMAN MW; FREEMAN R; FRITSCHE TR; GABRE毛LS-FESTEN A; GARDNER ED; GIANNINI C; GILDEN DH; GOEBEL HH; GOLD R; GRANT IA; GREGSON NA; GRIFFIN JW; GROVES MJ; HABERMANN TM; HAHN AF; HALL S; HALLIWILL JR; HANNA MG; HARDING AE; HARTUNG H-P; HERSKOVITZ S; H枚KE A; HUGHES RAC; HUXLEY C; JACOBSON RR; JACOBY A; JESSEN KR; JOHNSON DM; JONES HR; JOYNER MJ; KATIRJI B; KAUFMAN KR; KELLY JJ; KENNEDY WR; KIERNAN MC; KIESEIER BC; KIMURA J; KING RHM; KISSEL JT; KLEIN CM; KLEIN CJ; KLEOPA KA; KLINGELE CJ; KREULEN DL; KYLE RA; LACROIX C; LAGERLUND TD; LAMBERT EH; LAWSON SN; LEAVITT JA; LEIGH PN; LLEWELYN JG; LOPATE G; LOW PA; LUPSKI JR; LUXON LM; MARTINI R; MATHIAS CJ; MCARTHUR JC; MCDONALD ES; MCLEOD JG; MCMANIS PG; MELTON LJ; MESSING A; MICHELS VV; MIRSKY R; O'BRIEN PC; O'HANLON GM; O'NEILL GN; PATERSON DJ; PESTRONK A; PLEASURE D; POLLARD JD; POLYDEFKIS M; POTTUMARTHY S; REILLY MM; ROBERTSON A; ROMAN GC; ROWBOTHAM MC; RYAN MM; RYDMARK M; SABIN TD; SAID G; SAPERSTEIN DS; SCARAVILLI F; SCHAUMBURG HH; SCHERER SS; SCHIFFMANN R; SCHMELZ M; SCOTT JJA; SHEIKH K; SHEPHERD JT; SHY ME; SINGER W; SMITH BE; SORENSON EJ; SPIES JM; ST脜LBERG EV; STEVENS JC; STOLL G; SUAREZ GA; SUTER U; SWIFT TR; TAYLOR BV; TEFFERI A; THIBODEAU SN; THOMAS PK; THOMPSON PD; THORLAND EC; TOMLINSON DR; TOREBJ脰RK E; TOYKA KV; TRONTELJ JV; TYLER KL; ULFHAKE B; VANHOUTTE PM; WANG AK; WARNER LE; WEBSTER HD; WEERASURIYA A; WENDELSCHAFER-CRABB G; WIJDICKS EFM; WILBOURN AJ; WILLISON HJ; WINDEBANK AJ; WITTE H; WOOD JD; YOUNGE BR; ZOCHODNE DW
  • Published conference paper: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL. 2002;96(1):43-49
    Ulfhake B; Bergman E; Fundin BT
  • Review: MOLECULAR NEUROBIOLOGY. 2000;21(3):109-135
    Ulfhake B; Bergman S; Edstr枚m E; Fundin BT; Johnson H; Kullberg S; Ming Y
  • Published conference paper: JOURNAL OF CHEMICAL NEUROANATOMY. 2000;18(1-2):75-86
    H枚kfelt T; Arvidsson U; Cullheim S; Millhorn D; Nicholas AP; Pieribone V; Seroogy K; Ulfhake B
  • Book chapter: 1999;p. 25-33
    Carlsson K; Ulfhake B
  • Review: JOURNAL OF COMPARATIVE NEUROLOGY. 1999;410(3):368-386
    Bergman E; Fundin BT; Ulfhake B
  • Review: BRAIN RESEARCH. 1999;832(1-2):63-83
    Bergman E; Carlsson K; Liljeborg A; Manders E; H枚kfelt T; Ulfhake B
  • Review: BRAIN RESEARCH. 1999;69(1):21-34
    Johnson H; H枚kfelt T; Ulfhake B
  • Review: JOURNAL OF COMPARATIVE NEUROLOGY. 1996;375(2):303-319
    Bergman E; Johnson H; Zhang X; Hokfelt T; Ulfhake B
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Grants

  • A longitudinal approach to characterize loss of muscle mass and function in aging humans
    Swedish Research Council for Sport Science
    1 January 2024 - 31 December 2023
  • A longitudinal approach to characterize loss of muscle mass and function in aging humans
    Swedish Research Council for Sport Science
    1 January 2023 - 31 December 2023
  • Swedish Research Council
    1 January 2021 - 31 December 2023
  • Swedish Research Council
    1 January 2009 - 31 December 2011

Employments

  • Professor Emeritus/Emerita, Department of Laboratory Medicine, 探花精选, 2025-2028
  • Professor, Senior, Department of Laboratory Medicine, 探花精选, 2019-2024

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