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Björn Reinius

Björn Reinius

Principal Researcher
Telephone: +46852487820
Visiting address: Nobels väg 7, 17165 Solna
Postal address: C2 Medicinsk biokemi och biofysik, C2 MSB Reinius, 171 77 Stockholm
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About me

  • *Ragnar Söderberg Fellowship in Medicine [1]*
    *Swedish Research Council Starting grant [2]*
    *Åke Wiberg's Fundation (Medicine) [3]*
    *Faculty Funded Postion as Assistant Professor at KI (FoAss) [4]*
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Research

  • The Reinius laboratory's research is focused on revealing principal features
    of gene regulation, and in particular the regulation of active and inactive
    chromatin states. A main topic in the lab is X-chromosome inactivation.
    *Reinius lab webpage: *www.reiniuslab.com [1]
    *Publications*
    *bioRxiv. 2019: [2] Transcriptional kinetics of X-chromosome
    upregulation. *Larsson AJM, Coucoravas​ C, Sandberg R, Reinius B.
    *Cell Reports. 2019:* [3]* Single-cell RNA-seq reveals cellular heterogeneity
    of pluripotency transition and X-chromosome dynamics during early mouse
    development. *Cheng S*, Pei Y*, He L, Peng G, Reinius B, Tam PPL, Jing N,
    Deng Q.
    *Nature. 2019: [4]Genomic encoding of transcriptional burst
    kinetics. *Larsson AJM, Johnsson P, Hagemann-Jensen M, Hartmanis L, Faridani
    OR, Reinius B, Segerstolpe Å, Rivera CM, Ren B, Sandberg R.
    *Nature Genetics. 2018: [5]Reply to: High prevalence of clonal monoallelic
    expression. *Reinius B and Sandberg R.
    *Nature Communications. 2018:* [6] *Parental haplotype-specific single-cell
    transcriptomics reveal incomplete epigenetic reprogramming in human female
    germ cells.* Vértesy Á, Arindrarto W, Roost MS, Reinius B, Torrens-Juaneda
    V, Bialecka M, Moustakas I, Ariyurek Y, Kuijk E, Mei H, Sandberg R, van
    Oudenaarden A, Chuva de Sousa Lopes SM.
    *Molecular Cell. 2017:* [7] *Comparative Analysis of Single-Cell RNA
    Sequencing Methods. *Ziegenhain C, Vieth, Parekh S, Reinius B,
    Guillaumet-Adkins A, Smets M, Leonhardt H, Heyn H, Hellmann I, Enard W.
    *Nature Genetics. 2016: * [8]*Analysis of allelic expression patterns in
    clonal somatic cells by single-cell RNA-seq. *Reinius B*, Mold JE*, Ramsköld
    D, Deng Q, Johnsson P, Michaëlsson J, Frisén J, Sandberg R.
    *Bioinformatics. 2016: * [9]*scphaser: haplotype inference using single-cell
    RNA-seq data. *Edsgärd D, Reinius B, Sandberg R.
    *Cell. 2016: * [10]*Single-Cell RNA-Seq Reveals Lineage and X Chromosome
    Dynamics in Human Preimplantation Embryos. *Petropoulos S*, Edsgärd D*,
    Reinius B*, Deng Q, Panula SP, Codeluppi S, Plaza Reyes A, Linnarsson S,
    Sandberg R, Lanner F. (*Co-first author)
    *Genome Research. 2016: * [11]*Single-cell analyses of X Chromosome
    inactivation dynamics and pluripotency during differentiation. *Chen G,
    Schell JP, Benitez JA, Petropoulos S, Yilmaz M, Reinius B, Alekseenko Z, Shi
    L, Hedlund E, Lanner F, Sandberg R, Deng Q.
    *Nature Reviews Genetics. 2015: * [12]*Random monoallelic expression of
    autosomal genes: stochastic transcription and allele-level regulation.
    *Reinius B, Sandberg R.
    *Nature Communications. 2015: * [13]*MEG3 long noncoding RNA regulates the
    TGF-β pathway genes through formation of RNA-DNA triplex structures. *Mondal
    T, Subhash S, Vaid R, Enroth S, Uday S, Reinius B, Mitra S, Mohammed A, James
    AR, Hoberg E, Moustakas A, Gyllensten U, Jones SJ, Gustafsson CM, Sims AH,
    Westerlund F, Gorab E, Kanduri C.
    *Frontiers in Behavioral Neuroscience. 2015: * [14]*Conditional targeting of
    medium spiny neurons in the striatal matrix. *Reinius B, Blunder M, Brett FM,
    Eriksson A, Patra K, Jonsson J, Jazin E, Kullander K.
    *Genome Research. 2014:* [15]*Tn5 transposase and tagmentation procedures
    for massively scaled sequencing projects.* Picelli S, Björklund AK, Reinius
    B, Sagasser S, Winberg G, Sandberg R.
    *Science. 2014: * [16]*Single-cell RNA-seq reveals dynamic, random
    monoallelic gene expression in mammalian cells. *Deng Q*, Ramsköld D*,
    Reinius B, Sandberg R.
    *Human Molecular Genetics. 2013:* [17] *RNA-binding protein QKI regulates
    Glial fibrillary acidic protein expression in human astrocytes.* Radomska KJ,
    Halvardson J, Reinius B, Lindholm Carlström E, Emilsson L, Feuk L, Jazin E.
    *PLoS One. 2013: * [18]*Elevated expression of H19 and Igf2 in the female
    mouse eye.* Reinius B, Kanduri C.
    *BMC Genomics. 2012: * [19]*Abundance of female-biased and paucity of
    male-biased somatically expressed genes on the mouse X-chromosome. *Reinius
    B, Johansson MM, Radomska KJ, Morrow EH, Pandey GK, Kanduri C, Sandberg R,
    Williams RW, Jazin E.
    *Acta Universitatis Upsaliensis. 2011: * [20]*Sexually dimorphic gene
    expression in the mammalian brain. *Reinius B.
    *Neuron. 2010: * [21]*VGLUT2-dependent sensory neurons in the TRPV1
    population regulate pain and itch. *Lagerström MC, Rogoz K, Abrahamsen B,
    Persson E, Reinius B, Nordenankar K, Olund C, Smith C, Mendez JA, Chen ZF,
    Wood JN, Wallén-Mackenzie A, Kullander K.
    *BMC Genomics. 2010: * [22]*Female-biased expression of long non-coding RNAs
    in domains that escape X-inactivation in mouse. *Reinius B, Shi C, Hengshuo
    L, Sandhu KS, Radomska KJ, Rosen GD, Lu Lu, Kullander K, Williams RW, Jazin
    E.
    *Molecular Psychiatry. 2009: * [23]*Prenatal sex differences in the human
    brain. *Reinius B, Jazin E.
    *PLoS Genetics. 2008: * [24]*An evolutionarily conserved sexual signature in
    the primate brain.* Reinius B, Saetre P, Leonard JA, Blekhman R,
    Merino-Martinez R, Gilad Y, Jazin E.
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Articles

  • Article: NATURE COMMUNICATIONS. 2024;15(1):8373
    Noble JC; Lentini A; Hagemann-Jensen M; Sandberg R; Reinius B
  • Article: GENOME RESEARCH. 2023;33(3):299-313
    Vaid R; Mendez A; Thombare K; Burgos-Panadero R; Robinot R; Fonseca BF; Gandasi NR; Ringlander J; Hassan Baig M; Dong J-J; Cho JY; Reinius B; Chakrabarti LA; Nystrom K; Mondal T
  • Article: MED. 2022;3(9):636-643.e4
    Lentini A; Pereira A; Winqvist O; Reinius B
  • Article: NATURE COMMUNICATIONS. 2022;13(1):1854
    Lentini A; Cheng H; Noble JC; Papanicolaou N; Coucoravas C; Andrews N; Deng Q; Enge M; Reinius B
  • Article: NATURE GENETICS. 2022;54(3):306-317
    Johnsson P; Ziegenhain C; Hartmanis L; Hendriks G-J; Hagemann-Jensen M; Reinius B; Sandberg R
  • Article: INDOOR AIR. 2022;32(3):e13023
    de Sousa NR; Steponaviciute L; Margerie L; Nissen K; Kjellin M; Reinius B; Salaneck E; Udekwu KI; Rothfuchs AG
  • Article: CELL REPORTS. 2021;35(8):109174
    Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J
  • Article: PLOS COMPUTATIONAL BIOLOGY. 2021;17(3):e1008772
    Larsson AJM; Ziegenhain C; Hagemann-Jensen M; Reinius B; Jacob T; Dalessandri T; Hendriks G-J; Kasper M; Sandberg R
  • Article: SCIENCE IMMUNOLOGY. 2021;6(56):eabb7800
    Strunz B; Bister J; Jonsson H; Filipovic I; Crona-Guterstam Y; Kvedaraite E; Sleiers N; Dumitrescu B; Brannstrom M; Lentini A; Reinius B; Cornillet M; Willinger T; Gidlof S; Hamilton RS; Ivarsson MA; Bjorkstrom NK
  • Article: SCIENTIFIC REPORTS. 2021;11(1):1820
    Alekseenko A; Barrett D; Pareja-Sanchez Y; Howard RJ; Strandback E; Ampah-Korsah H; Rovsnik U; Zuniga-Veliz S; Klenov A; Malloo J; Ye S; Liu X; Reinius B; Elsasser SJ; Nyman T; Sandh G; Yin X; Pelechano V
  • Article: NATURE COMMUNICATIONS. 2020;11(1):4812
    Smyrlaki I; Ekman M; Lentini A; de Sousa NR; Papanicolaou N; Vondracek M; Aarum J; Safari H; Muradrasoli S; Rothfuchs AG; Albert J; Hoegberg B; Reinius B
  • Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832
    Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingstrom J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaelsson J; Marquardt N; Hammer Q; Stralin K; Bjorkstrom NK
  • Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2019;26(10):963-969
    Larsson AJM; Coucoravas C; Sandberg R; Reinius B
  • Article: CELL REPORTS. 2019;26(10):2593-2607.e3
    Cheng S; Pei Y; He L; Peng G; Reinius B; Tam PPL; Jing N; Deng Q
  • Article: NATURE. 2019;565(7738):251-254
    Larsson AJM; Johnsson P; Hagemann-Jensen M; Hartmanis L; Faridani OR; Reinius B; Segerstolpe A; Rivera CM; Ren B; Sandberg R
  • Article: NATURE COMMUNICATIONS. 2018;9(1):1873
    Vertesy A; Arindrarto W; Roost MS; Reinius B; Torrens-Juaneda V; Bialecka M; Moustakas I; Ariyurek Y; Kuijk E; Mei H; Sandberg R; van Oudenaarden A; Lopes SMCDS
  • Article: MOLECULAR CELL. 2017;65(4):631-643.e4
    Ziegenhain C; Vieth B; Parekh S; Reinius B; Guillaumet-Adkins A; Smets M; Leonhardt H; Heyn H; Hellmann I; Enard W
  • Article: NATURE GENETICS. 2016;48(11):1430-1435
    Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
  • Article: BIOINFORMATICS. 2016;32(19):3038-3040
    Edsgard D; Reinius B; Sandberg R
  • Article: GENOME RESEARCH. 2016;26(10):1342-1354
    Chen G; Schell JP; Benitez JA; Petropoulos S; Yilmaz M; Reinius B; Alekseenko Z; Shi L; Hedlund E; Lanner F; Sandberg R; Deng Q
  • Show more

All other publications

  • Letter: CURRENT BIOLOGY. 2023;33(10):R395-R396
    Lentini A; Reinius B
  • Letter: INDOOR AIR. 2022;32(11):e13169
    Rufino de Sousa N; Steponaviciute L; Margerie L; Nissen K; Kjellin M; Reinius B; Salaneck E; Udekwu KI; Rothfuchs AG
  • Corrigendum: INDOOR AIR. 2022;32(8):e13085
    Rufino de Sousa N; Steponaviciute L; Margerie L; Nissen K; Kjellin M; Reinius B; Salaneck E; Udekwu KI; Rothfuchs AG
  • Letter: NATURE GENETICS. 2018;50(9):1199-1200
    Reinius B; Sandberg R
  • Review: NATURE REVIEWS GENETICS. 2015;16(11):653-664
    Reinius B; Sandberg R
  • Letter: MOLECULAR PSYCHIATRY. 2009;14(11):987-989
    Reinius B; Jazin E

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