̽»¨¾«Ñ¡

Anna Rising

Anna Rising

Researcher
Visiting address: Blickagången 16, 14152 Flemingsberg
Postal address: H7 Medicin, Huddinge, H7 CeRM Rising, 171 77 Stockholm
Part of:

About me

  • Find out more about my research at my group page.

    Academic honours, awards and prizes:

    • Selected member of the Young Academy of Sweden 2015-2020.
    • Medal of Merit in Silver from the Swedish University of Agricultural
    Sciences, 2012.
    • Nicholson Award from Rockefeller University in 2012. Award: 25 000 USD.
    • Best Paper Award 2013. Materials.
    • Entered the list of Swedens 33 most interesting technology-driven companies
    in 2012 with Spiber Technologies AB
    • Winner of VINN NU competition (VINNOVA) in 2008 with Spiber Technologies AB

Research

  • Spider silk is well known for its extreme mechanical properties, this natural fiber is tougher than any other man-made fiber. This makes the fiber interesting as a high-performance sustainable fiber for technical applications, but spider silk has also been used in traditional medicine to stop bleedings and to improve wound healing. Silk reeled from spiders has successfully been employed to achieve nerve regeneration in both animal models and patients.

    Spider silk is stored at extreme concentrations (30-50% w/w, in an aqueous solution) in the spider’s silk glands and is transformed into a solid fiber within fractions of a second in a defined part of the spinning apparatus. Clearly, this process must be highly regulated, and we have recently revealed some of the physiological conditions along the spider silk spinning apparatus, as well as the molecular mechanisms that controls silk fiber formation. Based on these insights we have engineered a biomimetic artificial spinning device in which we can spin hundreds of meters of artificial spider silk. At SLU in Uppsala, we develop these fibers for technical applications (). At our lab at ̽»¨¾«Ñ¡, we produce fibers for development of treatments of injuries for which there is no or poor treatment options available due to the lack of suitable materials. Examples include critical sized peripheral nerve and bone defects.

    We are also interested in increasing our understanding of basic silk biology. During the past 400 million years spiders have evolved strategies to cope with massive protein production, storage and precise control of polymerization. By understanding how spiders manage to regulate protein solubility and assembly, we hope to also get insights into how other proteins form aggregates that are associated with disease, but also improve the artificial spider silk fibers we produce today.

    Another line of research concerns the spider silk proteins’ N-terminal domain (NT). NT plays an important role in fiber formation; it mediates solubility to silk proteins at high pH and rapid fiber formation when the pH is lowered (as in the silk production apparatus). We study NT to understand the molecular mechanisms behind these traits and aim to make use of our findings for biotechnological applications. For example, in one project we employ NT to produce protein-based drugs and drug candidates since NT seems to be Nature´s way of increasing solubility of aggregation prone proteins.

    Recently, we discovered that recombinant spider silk proteins form hydrogels when incubated at 37 degrees Celsius. This makes them very interesting for the development of injectables. Furthermore, the silk proteins can be fused to other proteins of interest and still form hydrogels. The hydrogels are in these cases composed of nano-sized fibrillar networks (composed of the spider silk proteins) which are highly decorated with the fusion protein moiety. We have also shown that stem cells can be successfully encapsulated in the gel with a high survival rate.

Articles

  • Article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(35):2303622
    Arndt T; Chatterjee U; Shilkova O; Francis J; Lundkvist J; Johansson D; Schmuck B; Greco G; Nordberg AE; Li Y; Wahlberg LU; Langton M; Johansson J; Goetherstroem C; Rising A
  • Article: ADVANCED FUNCTIONAL MATERIALS. 2024;34(23)
    Qi X; Wang H; Wang K; Wang Y; Leppert A; Iashchishyn I; Zhong X; Zhou Y; Liu R; Rising A; Landreh M; Johansson J; Chen G
  • Journal article: ADVANCED COMPOSITES AND HYBRID MATERIALS. 2024;7(5):163
    Greco G; Schmuck B; Del Bianco L; Spizzo F; Fambri L; Pugno NM; Veintemillas-Verdaguer S; Morales MP; Rising A
  • Journal article: ADVANCED FUNCTIONAL MATERIALS. 2024
    Romanuks V; Fridmanis J; Schmuck B; Bula AL; Lends A; Senkane K; Leitis G; Gaidukovs S; Smits K; Rising A; Smits G; Jaudzems K
  • Article: SCIENTIFIC REPORTS. 2023;13(1):22273
    Sonavane S; Westermark P; Rising A; Holm L
  • Article: ACS APPLIED POLYMER MATERIALS. 2023;5(11):9433-9444
    Jafari MJ; Backlund FG; Arndt T; Schmuck B; Greco G; Rising A; Barth A; Ederth T
  • Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2023;145(19):10659-10668
    Sahin C; Motso A; Gu X; Feyrer H; Lama D; Arndt T; Rising A; Gese GV; Haellberg BM; Marklund EG; Schafer NP; Petzold K; Teilum K; Wolynes PG; Landreh M
  • Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
    Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
  • Article: NATURE COMMUNICATIONS. 2022;13(1):4695
    Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Stromberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
  • Article: ADVANCED FUNCTIONAL MATERIALS. 2022;32(23):2200986
    Arndt T; Greco G; Schmuck B; Bunz J; Shilkova O; Francis J; Pugno NM; Jaudzems K; Barth A; Johansson J; Rising A
  • Journal article: ADVANCED FUNCTIONAL MATERIALS. 2022;32(23)
    Arndt T; Greco G; Schmuck B; Bunz J; Shilkova O; Francis J; Pugno NM; Jaudzems K; Barth A; Johansson J; Rising A
  • Article: STRUCTURE. 2022;30(5):733-742.e7
    Kaldmae M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Osterlund N; Ilag LL; Vaananen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
  • Article: SCIENTIFIC REPORTS. 2022;12(1):3507
    Greco G; Mirbaha H; Schmuck B; Rising A; Pugno NM
  • Article: MATERIALS. 2022;15(3):708
    Backlund FG; Schmuck B; Miranda GHB; Greco G; Pugno NM; Ryden J; Rising A
  • Article: METHODS IN MOLECULAR BIOLOGY. 2022;2406:113-130
    Kronqvist N; Rising A; Johansson J
  • Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:936887
    Sede M; Fridmanis J; Otikovs M; Johansson J; Rising A; Kronqvist N; Jaudzems K
  • Journal article: COMMUNICATIONS MATERIALS. 2022;3(1):83
    Schmuck B; Greco G; Backlund FG; Pugno NM; Johansson J; Rising A
  • Article: ACS CHEMICAL BIOLOGY. 2021;16(12):2864-2873
    Basabe-Burgos O; Landreh M; Rising A; Curstedt T; Johansson J
  • Article: FASEB JOURNAL. 2021;35(11):e21896
    Hansson ML; Chatterjee U; Francis J; Arndt T; Broman C; Johansson J; Skold MK; Rising A
  • Article: MATERIALS TODAY. 2021;50:16-23
    Schmuck B; Greco G; Barth A; Pugno NM; Johansson J; Rising A
  • Show more

All other publications

  • Review: ADVANCED FUNCTIONAL MATERIALS. 2024;34(35):2305040
    Schmuck B; Greco G; Pessatti TB; Sonavane S; Langwallner V; Arndt T; Rising A
  • Review: BIOPHYS REV (MELVILLE). 2023;4(3):031301
    Greco G; Schmuck B; Jalali SK; Pugno NM; Rising A
  • Letter: NANO LETTERS. 2023;23(12):5836-5841
    Leppert A; Chen G; Lama D; Sahin C; Railaite V; Shilkova O; Arndt T; Marklund EG; Lane DP; Rising A; Landreh M
  • Review: CHEMICAL REVIEWS. 2023;123(5):2155-2199
    Rising A; Harrington MJ
  • Conference publication: PROTEIN SCIENCE. 2023;32(12)
    Sahin C; Motso A; Gu X; Feyrer H; Lama D; Arndt T; Rising A; Gese GV; Hallberg M; Marklund EG; Schafer NP; Petzold K; Teilum K
  • Preprint: BIORXIV. 2022
    Sahin C; Motso A; Gu X; Feyrer H; Lama D; Arndt T; Rising A; Gese GV; Hällberg M; Marklund E; Schafer N; Petzold K; Teilum K; Wolynes P; Landreh M
  • Editorial comment: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(5):101913
    Sarr M; Kitoka K; Walsh-White K-A; Kaldmaee M; Metlans R; Tars K; Mantese A; Shan D; Landreh M; Rising A; Johansson J; Jaudzems K; Kronqvist N
  • Preprint: BIORXIV. 2021
    Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
  • Preprint: SSRN ELECTRONIC JOURNAL. 2021
    Kaldmäe M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Sau JW; Ng AS; Ghadessy F; Sabatier P; Vojtesek B; Sarr M; Sahin C; Österlund N; Ilag L; Väänänen V; Sedimbi S; Arsenain-Henriksson M; Zubarev R; Nilsson L; Koeck P; Rising A; Abelein A; Fritz N; johansson J; Lane DP; Landreh M
  • Conference publication: ACTA PHYSIOLOGICA. 2019;227:41
    Mikolka P; Zebialowicz J; Massaro F; Perchiazzi G; Basabe-Burgos O; Curstedt T; Feinstein R; Larsson A; Johansson J; Rising A
  • Conference publication: NEONATOLOGY. 2019;115(4):454-455
    Mikolka P; Curstedt T; Feinstein R; Larsson A; Rising A; Johansson J
  • Conference publication: CARDIOVASCULAR RESEARCH. 2018;114:S110-S111
    Ljung K; Andersson M; Floderus L; Nordling K; Corbascio M; Johansson J; Grinnemo KH; Osterholm C; Rising A
  • Conference publication: PROTEIN SCIENCE. 2017;26:142
    Burgos OB; Hagerstrand-Bjorkman M; Linderholm B; Rising A; Johansson J; Curstedt T
  • Conference publication: PROTEIN SCIENCE. 2017;26:18-19
    Sarr M; Kronqvist N; Reifenrath M; Chen G; Rising A; Johansson J
  • Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2016;17(8):E1290-1290
    Andersson M; Johansson J; Rising A
  • Review: JOURNAL OF INTERNAL MEDICINE. 2016;280(2):153-163
    Tjernberg LO; Rising A; Johansson J; Jaudzems K; Westermark P
  • Conference publication: NEONATOLOGY. 2016;109(4):390
    Kronqvist N; Burgos OB; Sarr M; Sjoberg L; Zebialowizc J; Nordling K; Rising A; Johansson J
  • Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016;193
    Watson A; Spalluto CM; Kronqvist N; Staples KJ; Rising A; Johansson J; Wilkinson TMA; Madsen J; Clark H
  • Review: JOURNAL OF BIOLOGICAL CHEMISTRY. 2015;290(44):26430-26436
    Landreh M; Rising A; Presto J; Jornvall H; Johansson J
  • Conference publication: NEONATOLOGY. 2015;107(4):376-377
    Basabe-Burgos O; Haegerstrand-Bjorkman M; Linderholm B; Nordling K; Stichtenoth G; Bergman P; Curstedt T; Johansson J; Rising A
  • Show more

Grants

  • Swedish Research Council
    1 January 2025 - 31 December 2028
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2024 - 31 December 2026
  • ArtSilkTex
    European Research Council
    1 September 2022 - 29 February 2024
  • Swedish Research Council
    1 January 2020 - 31 December 2023
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2020 - 31 December 2022
  • European Research Council
    1 May 2019 - 31 October 2024
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2019 - 14 February 2019
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2016 - 31 December 2018
  • Swedish Research Council
    1 January 2015 - 31 December 2018
  • Swedish Research Council
    1 January 2012 - 31 December 2012
  • Swedish Research Council
    1 July 2010 - 31 December 2010

Employments

  • Researcher, Department of Medicine, Huddinge, ̽»¨¾«Ñ¡, 2024-

Degrees and Education

  • Docent, Sveriges Lantbruksuniversitet (SLU), 2013

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