探花精选

Angel Cedazo Minguez

Angel Cedazo Minguez

Professor | Docent
Telephone: +46852483527
Visiting address: Blickag氓ngen 6, 14157 Huddinge
Postal address: H1 Neurobiologi, v氓rdvetenskap och samh盲lle, H1 Neurogeriatrik Maioli, 171 77 Stockholm
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About me

  • My research is focused on understanding the molecular mechanism behind risk factor for neurodegenerative disorders. I combine my activities at KI with being Vice-president for Strategic Initiatives and Scientific Relations at Sanofi and I am located in Paris (France). So far, I have published 100+ articles and directed 10 PhD thesis. 



  • Positions
    From 2017- Professor in Molecular Neurogeriatrics, KI
    From 2022- Vice-president. Strategic Initiatives and Scientific Relations. SANOFI
    From 2017- 2022 Head of Neurodegeneration Research, SANOFI
    From 2006- 2017 Deputy Head of KI-Alzheimer disease research center / Neurogeriatrics
    From 2014- 2017 Codirector of Swedish Brain Power. A national network of centers of excellence in Neurodegenerative disorders.
    From 2014- 2017 Vice-Head of the department of neurobiology, care sciences and society

    Education
    2017 Professor. 探花精选
    2011 Senior University Lecturer. 探花精选.
    2010 Associate Professor. 探花精选.
    2010 Course for future academic leaders (MAL). 探花精选.
    2002 Ph.D. in medicine (Neuroscience). 探花精选. Thesis: Apolipoprotein E and Alzheimer's disease: Signals and effects

    Academic honours, awards and prizes
    2013. Deputy Head (prefekt) of the Department of Neurobiology, Care Sciences and Society (NVS) at KI.
    2009-2012. Vice-Head of the Department of Neurobiology, Care Sciences and Society at KI
    2009- present. Member of the Committee for Research and Education at the Geriatric Department of the Swedish Medical Research Council (FoU r氓d)
    2006, 2007 and 2008. Erik R枚nnbergs award for research in geriatric medicine from the Bank of Sweden Tercentenary Foundation
    2003 and 2004. Hj盲rnfonden postdoc (Swedish Brain Foundation)
    2003. Svenska Lundbeck stiftelsen.

Research

  • Over the years, genetic and epidemiological studies have reported gene or environmental factors that increase the risk for Alzheimer's Disease (AD), suggesting that it is a disease of multifactorial origin. We aim to contribute to understand the effects of risk factors for AD, and to define to which extent these factors are secondary actors or driving forces for cognitive decline.

    Apolipoprotein E, hypercholesterolemia and AD

    ApoE is the main cholesterol transporter and the presence of the E4 isoform is the major risk factor for AD. High cholesterol levels in blood is another risk factor. Our hypothesis is that ApoE4 acts in synergy with environmental factors (like hypercholesterolemia) to affect signaling pathways involved in neurodegeneration. We use several in vivo and in vitro models to explore this hypothesis.

    Functions of oxysterols in brain

    The metabolism of cholesterol results in the production of several oxysterols, of which the peripherally-produced 27OHC and the brain-produced 24S-OH have been suggested to play a role in AD pathogenesis. However very little is known about the biological role of these oxysterols, with the exception of its affinity for LXR receptors. We have discovered new functions of 24S-OH and 27OHC in brain, related with memory consolidation and vascular regulation. Our findings suggest that these molecules are much more than subproducts of the cellular metabolism, and can be regarded as signalling molecules of importance for normal brain function as well as for neurodegeneration.

    Thioredoxin and AD

    Oxidative stress (OS) is one of the pathological events occurring in AD. Thioredoxin-1 (TRX1) modulate the redox homeostasis and inhibit the apoptosis signal-regulating kinase (ASK1). We reported that the TRX1 levels is impaired in AD. We showed that Abeta neurotoxicity is mediated by TRX1 oxidations and ASK1 activation. Recently, we have described the presence of a truncated form of TRX1 (TRX80) in the brain. TRX80 is dramatically reduced in AD. Also we found that TRX80 as a protective role on Amyloid-beta neurotoxicity and aggregation. So, far TRX80 is the only endogenous anti-Amyloid beta aggregant peptide described.

Selected publications

  • Article: MOLECULAR PSYCHIATRY. 2021;26(4):1410-1423
    Gerenu G; Persson T; Goikolea J; Calvo-Garrido J; Loera-Valencia R; Pottmeier P; Santiago C; Poska H; Presto J; Cedazo-Minguez A
  • Article: ALZHEIMER'S RESEARCH AND THERAPY. 2021;13(1):56
    Sandebring-Matton A; Goikolea J; Bjorkhem I; Paternain L; Kemppainen N; Laatikainen T; Ngandu T; Rinne J; Soininen H; Cedazo-Minguez A; Solomon A; Kivipelto M
  • Article: SCIENTIFIC REPORTS. 2021;11(1):3736
    Loera-Valencia R; Vazquez-Juarez E; Munoz A; Gerenu G; Gomez-Galan M; Lindskog M; DeFelipe J; Cedazo-Minguez A; Merino-Serrais P
  • Article: MOLECULAR PSYCHIATRY. 2021;26(1):322-340
    Zanni G; Goto S; Fragopoulou AF; Gaudenzi G; Naidoo V; Di Martino E; Levy G; Dominguez CA; Dethlefsen O; Cedazo-Minguez A; Merino-Serrais P; Stamatakis A; Hermanson O; Blomgren K
  • Article: CEREBRAL CORTEX. 2019;29(1):429-446
    Merino-Serrais P; Loera-Valencia R; Rodriguez-Rodriguez P; Parrado-Fernandez C; Ismail MA; Maioli S; Matute E; Jimenez-Mateos EM; Bjorkhem I; DeFelipe J; Cedazo-Minguez A
  • Article: BRAIN. 2017;140(12):3269-3285
    Rodriguez-Rodriguez P; Sandebring-Matton A; Merino-Serrais P; Parrado-Fernandez C; Rabano A; Winblad B; Avila J; Ferrer I; Cedazo-Minguez A
  • Article: LANCET NEUROLOGY. 2016;15(5):455-532
    Winblad B; Amouyel P; Andrieu S; Ballard C; Brayne C; Brodaty H; Cedazo-Minguez A; Dubois B; Edvardsson D; Feldman H; Fratiglioni L; Frisoni GB; Gauthier S; Georges J; Graff C; Iqbal K; Jessen F; Johansson G; Jonsson L; Kivipelto M; Knapp M; Mangialasche F; Melis R; Nordberg A; Rikkert MO; Qiu C; Sakmar TP; Scheltens P; Schneider LS; Sperling R; Tjernberg LO; Waldemar G; Wimo A; Zetterberg H
  • Article: AGING CELL. 2015;14(1):122-129
    Maioli S; Lodeiro M; Merino-Serrais P; Falahati F; Khan W; Puerta E; Codita A; Rimondini R; Ramirez MJ; Simmons A; Gil-Bea F; Westman E; Cedazo-Minguez A
  • Article: ANALYTICAL CHEMISTRY. 2012;84(20):8532-8540
    Ibanez C; Simo C; Martin-Alvarez PJ; Kivipelto M; Winblad B; Cedazo-Minguez A; Cifuentes A
  • Article: EMBO MOLECULAR MEDICINE. 2012;4(10):1097-1111
    Gil-Bea F; Akterin S; Persson T; Mateos L; Sandebring A; Avila-Carino J; Gutierrez-Rodriguez A; Sundstrom E; Holmgren A; Winblad B; Cedazo-Minguez A

Articles

  • Article: BRAIN. 2024;147(7):2384-2399
    Rodriguez-Rodriguez P; Arroyo-Garcia LE; Tsagkogianni C; Li L; Wang W; Vegvari A; Salas-Allende I; Plautz Z; Cedazo-Minguez A; Sinha SC; Troyanskaya O; Flajolet M; Yao V; Roussarie J-P
  • Article: SCIENCE ADVANCES. 2024;10(4):eadj1354
    Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Nikolidakis O; Daniilidou M; Delac L; Varshney MK; Arroyo-Garcia LE; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths WJ; Bjoerkhem I; Matton A; Nalvarte I; Merino-Serrais P; Cedazo-Minguez A; Maioli S
  • Article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2024;18:1347535
    Spanos F; Gerenu G; Goikolea J; Latorre-Leal M; Balleza-Tapia H; Gomez K; Alvarez-Jimenez L; Piras A; Gomez-Galan M; Fisahn A; Cedazo-Minguez A; Maioli S; Loera-Valencia R
  • Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2023;234:106387
    Goikolea J; Latorre-Leal M; Tsagkogianni C; Pikkupeura S; Gulyas B; Cedazo-Minguez A; Loera-Valencia R; Bjorkhem I; Rodriguez PR; Maioli S
  • Article: BRAIN COMMUNICATIONS. 2023;5(5):fcad228
    Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths WJ; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Matton A
  • Article: GLIA. 2023;71(6):1414-1428
    Alanko V; Gaminde-Blasco A; Quintela-Lopez T; Loera-Valencia R; Solomon A; Bjorkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Sandebring-Matton A
  • Article: ALZHEIMER'S RESEARCH AND THERAPY. 2022;14(1):37
    Goikolea J; Gerenu G; Daniilidou M; Mangialasche F; Mecocci P; Ngandu T; Rinne J; Solomon A; Kivipelto M; Cedazo-Minguez A; Sandebring-Matton A; Maioli S
  • Article: MOLECULAR NEUROBIOLOGY. 2021;58(12):6063-6076
    Loera-Valencia R; Ismail M-A; Goikolea J; Lodeiro M; Mateos L; Bjorkhem I; Puerta E; Romao MA; Gomes CM; Merino-Serrais P; Maioli S; Cedazo-Minguez A
  • Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(16):3194-3204
    Parrado-Fernandez C; Leoni V; Saeed A; Rodriguez-Rodriguez P; Sandebring-Matton A; Cordoba-Beldad CM; Bueno P; Gali CC; Panzenboeck U; Cedazo-Minguez A; Bjorkhem I
  • Article: AGING. 2021;13(11):14729-14744
    Eroli F; Johnell K; Latorre-Leal M; Hilmer S; Wastesson J; Cedazo-Minguez A; Maioli S
  • Journal article: MOLECULAR PSYCHIATRY. 2021;26(1):1-2
    Zanni G; Goto S; Fragopoulou AF; Gaudenzi G; Naidoo V; Di Martino E; Levy G; Dominguez CA; Dethlefsen O; Cedazo-Minguez A; Merino-Serrais P; Stamatakis A; Hermanson O; Blomgren K
  • Article: NEUROSCIENCE. 2020;448:14-27
    Sarlus H; Codita A; Wang X; Cedazo-Minguez A; Schultzberg M; Oprica M
  • Article: AGING. 2020;12(11):10147-10161
    Eroli F; Johnell K; Leal ML; Adamo C; Hilmer S; Wastesson JW; Cedazo-Minguez A; Maioli S
  • Article: NEUROBIOLOGY OF DISEASE. 2020;134:104645
    Hoglund K; Schussler N; Kvartsberg H; Smailovic U; Brinkmalm G; Liman V; Becker B; Zetterberg H; Cedazo-Minguez A; Janelidze S; Lefevre IA; Eyquem S; Hansson O; Blennow K
  • Article: FRONTIERS IN GENETICS. 2020;11:1022
    Panahi M; Rodriguez PR; Fereshtehnejad S-M; Arafa D; Bogdanovic N; Winblad B; Cedazo-Minguez A; Rinne J; Darreh-Shori T; Hase Y; Kalaria RN; Viitanen M; Behbahani H
  • Article: CELL DEATH AND DIFFERENTIATION. 2019;26(9):1545-1565
    Guerrero-Gomez D; Antonio Mora-Lorca J; Saenz-Narciso B; Jose Naranjo-Galindo F; Munoz-Lobato F; Parrado-Fernandez C; Goikolea J; Cedazo-Minguez A; Link CD; Neri C; Dolores Sequedo M; Vazquez-Manrique RP; Fernandez-Suarez E; Goder V; Pane R; Cabiscol E; Askjaer P; Cabello J; Miranda-Vizuete A
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(11):4169-4176
    Theofilopoulos S; de Oliveira WAA; Yang S; Yutuc E; Saeed A; Abdel-Khalik J; Ullgren A; Cedazo-Minguez A; Bjorkhem I; Wang Y; Griffiths WJ; Arenas E
  • Article: SCIENTIFIC REPORTS. 2019;9(1):3965
    Caberlotto L; Nguyen T-P; Lauria M; Priami C; Rimondini R; Maioli S; Cedazo-Minguez A; Sita G; Morroni F; Corsi M; Carboni L
  • Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(11):5439-5449
    Parrado-Fernandez C; Schneider B; Ankarcrona M; Conti MM; Cookson MR; Kivipelto M; Cedazo-Minguez A; Sandebring-Matton A
  • Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(10):5151-5154
    Parrado-Fernandez C; Blennow K; Hansson M; Leoni V; Cedazo-Minguez A; Bjorkhem I
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All other publications

  • Conference publication: GLIA. 2023;71:E633
    Goicolea J; Roussarie JP; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
  • Preprint: BIORXIV. 2022
    Daniilidou M; Eroli F; Alanko V; Goikolea J; Latorre-Leal M; Rodriguez-Rodriguez P; Griffiths W; Wang Y; Pacciarini M; Brinkmalm A; Zetterberg H; Blennow K; Rosenberg A; Bogdanovic N; Winblad B; Kivipelto M; Ibghi D; Cedazo-Minguez A; Maioli S; Sandebring-Matton A
  • Preprint: BIORXIV. 2022
    Rodriguez-Rodriguez P; Arroyo-Garcia LE; Li L; Tsagkogianni C; Wang W; Salas-Allende I; Plautz Z; Cedazo-Minguez A; Sinha S; Troyanskaya O; Flajolet M; Yao V; Roussarie J-P
  • Preprint: BIORXIV. 2022
    Goikolea J; Roussarie J-P; Gerenu G; Loera-Valencia R; Latorre-Leal M; Cedazo-Minguez A; Rodriguez-Rodriguez P; Maioli S
  • Conference publication: 2022;:219-227
    Teeple E; Joshi P; Pande R; Huang Y; Karambe A; Latta-Mahieu M; Sardi S; Cedazo-Minguez A; Klinger K; Flores-Morales A; Madden S; Rajpal D; Kumar D
  • Preprint: BIORXIV. 2021
    Teeple E; Joshi P; Pande R; Huang Y; Karambe A; Latta-Mahieu M; Sardi SP; Cedazo-Minguez A; Klinger KW; Flores-Morales A; Madden SL; Rajpal D; Kumar D
  • Preprint: BIORXIV. 2021
    Pande R; Huang Y; Teeple E; Joshi P; Flores-Morales A; Latta-Mahieu M; Sardi SP; Cedazo-Minguez A; Klinger KW; Madden SL; Rajpal D; Kumar D
  • Preprint: RESEARCH SQUARE. 2021
    Alanko V; Quintela-L贸pez T; Gaminde-Blasco A; Loera-Valencia R; Solomon A; Bj枚rkhem I; Cedazo-Minguez A; Maioli S; Tabacaru G; Latorre-Leal M; Matute C; Kivipelto M; Alberdi E; Matton A
  • Preprint: BIORXIV. 2021
    Latorre-Leal M; Rodriguez-Rodriguez P; Franchini L; Daniilidou M; Eroli F; Winblad B; Blennow K; Zetterberg H; Kivipelto M; Pacciarini M; Wang Y; Griffiths W; Bj枚rkhem I; Sandebring Matton A; Merino-Serrais P; Cedazo-Minguez A; Maioli S
  • Review: JOURNAL OF INTERNAL MEDICINE. 2019;286(4):398-437
    Loera-Valencia R; Cedazo-Minguez A; Kenigsberg PA; Page G; Duarte AI; Giusti P; Zusso M; Robert P; Frisoni GB; Cattaneo A; Zille M; Boltze J; Cartier N; Buee L; Johansson G; Winblad B
  • Corrigendum: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(6):4489
  • Preprint: BIORXIV. 2019
    Giulia Z; Shinobu G; Giulia G; Vinogran N; Gabriel L; Elena DM; Olga D; Angel C-M; Paula M-S; Ola H; Klas B
  • Preprint: BIORXIV. 2018
    Guerrero-G贸mez D; Mora-Lorca JA; S谩enz-Narciso B; Naranjo-Galindo FJ; Mu帽oz-Lobato F; Parrado-Fern谩ndez C; Cedazo-Minguez 脕; Link C; Neri C; Sequedo MD; V谩zquez-Manrique R; Fern谩ndez-Su谩rez E; Goder V; Pan茅 R; Cabiscol E; Askjaer P; Cabello J; Miranda-Vizuete A
  • Corrigendum: BRAIN. 2018;141(5):e43
  • Review: ALZHEIMER鈥橲 & DEMENTIA: TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS. 2017;3(4):571-578
    Medina M; Khachaturian ZS; Rossor M; Avila J; Cedazo-Minguez A
  • Review: JOURNAL OF INTERNAL MEDICINE. 2017;281(6):534-553
    Olsson AG; Angelin B; Assmann G; Binder CJ; Bjoerkhem I; Cedazo-Minguez A; Cohen J; von Eckardstein A; Farinaro E; Mueller-Wieland D; Parhofer KG; Parini P; Rosenson RS; Starup-Linde J; Tikkanen MJ; Yvan-Charvet L
  • Review: FRONTIERS IN PHARMACOLOGY. 2014;5:146
    Franco R; Cedazo-Minguez A
  • Review: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2014;2014:427318-11
    Persson T; Popescu BO; Cedazo-Minguez A
  • Corrigendum: NEUROSCIENCE LETTERS. 2012;514(2):219
    Mateos L; Persson T; Katoozi S; Gil-Bea FJ; Cedazo-Minguez A
  • Published conference paper: NEURODEGENERATIVE DISEASES. 2012;10(1-4):313-316
    Mateos L; Ismail M-A; Winblad B; Cedazo-Minguez A
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Employments

  • Professor, Department of Neurobiology, Care Sciences and Society, 探花精选, 2017-

Degrees and Education

  • Docent, 探花精选, 2010
  • Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, 探花精选, 2002

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