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Andrea Fossati

Assistant Professor
Visiting address: Solnav盲gen 9, Biomedicum, 17165 Solna
Postal address: C1 Mikrobiologi, tum枚r- och cellbiologi, C1 P & CF Nyl茅n Fossati, 171 77 Stockholm
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About me

  • Dr. Fossati obtained his PhD in Proteomics and Systems Biology working with Ruedi Aebersold at the Institute of Molecular System Biology (ETH Zurich), where he developed next-generation interaction proteomics approaches for high-throughput generation of interaction networks. As a postdoc with Nevan Krogan he studied virus-host interactions for prokaryotic and eukaryotic viruses using a combination of proteomics and functional genomics. In 2023 he got awarded a Data-driven Life Science starting grant to establish his own research group in Stockholm at MTC in 2024.

Research

  • Much like human cells, bacteria are susceptible to fatal viral infections. These bacterial viruses (bacteriophages, i.e phages) have gained significant attention in recent years as one of the most promising alternatives to antibiotics to tackle the emerging problem of drug-resistant bacteria.

    However, just like our cells have immune systems aimed at eliminating viral infections, bacteria possess powerful phage defense systems which greatly reduce the efficacy of therapy using phages. Likewise, phages evolved mechanisms to escape these bacterial defenses resulting in the numerous anti-defense systems widespread across phage families.

    Our lab鈥檚 main goal is to discover these bacterial defense systems, understand their composition and viral triggers as well as identifying phage mechanisms to evade them. Driving this goal is the desire to combat phage resistance mechanisms to make bacteria more susceptible to phage predation. In other words, we want to tilt the scale of the phage-bacterial warfare towards the phage by disabling the bacterial immunity.

Articles

  • Journal article: SCIENCE. 2024;385(6706):eadl5763
    Lin Z; Schaefer K; Lui I; Yao Z; Fossati A; Swaney DL; Palar A; Sali A; Wells JA
  • Journal article: CELL HOST & MICROBE. 2024;32(7):1050-1058.e7
    Mozumdar D; Fossati A; Stevenson E; Guan J; Nieweglowska E; Rao S; Agard D; Swaney DL; Bondy-Denomy J
  • Article: NATURE METHODS. 2024;21(4):635-647
    Frommelt F; Fossati A; Uliana F; Wendt F; Xue P; Heusel M; Wollscheid B; Aebersold R; Ciuffa R; Gstaiger M
  • Article: NATURE COMMUNICATIONS. 2024;15(1):276
    Teuscher AC; Statzer C; Goyala A; Domenig SA; Schoen I; Hess M; Hofer AM; Fossati A; Vogel V; Goksel O; Aebersold R; Ewald CY
  • Article: SCIENCE ADVANCES. 2023;9(49):eadj4884
    Chen X; Haribowo AG; Baik AH; Fossati A; Stevenson E; Chen YR; Reyes NS; Peng T; Matthay MA; Traglia M; Pico AR; Jarosz DF; Buchwalter A; Ghaemmaghami S; Swaney DL; Jain IH
  • Article: CELL. 2023;186(21):4597-4614.e26
    Bouhaddou M; Reuschl A-K; Polacco BJ; Thorne LG; Ummadi MR; Ye C; Rosales R; Pelin A; Batra J; Jang GM; Xu J; Moen JM; Richards AL; Zhou Y; Harjai B; Stevenson E; Rojo A; Ragazzini R; Whelan MVX; Furnon W; De Lorenzo G; Cowton V; Syed AM; Ciling A; Deutsch N; Pirak D; Dowgier G; Mesner D; Turner JL; McGovern BL; Rodriguez ML; Leiva-Rebollo R; Dunham AS; Zhong X; Eckhardt M; Fossati A; Liotta NF; Kehrer T; Cupic A; Rutkowska M; Mena I; Aslam S; Hoffert A; Foussard H; Olwal CO; Huang W; Zwaka T; Pham J; Lyons M; Donohue L; Griffin A; Nugent R; Holden K; Deans R; Alviles P; Lopez-Martin JA; Jimeno JM; Obernier K; Fabius JM; Soucheray M; Huttenhain R; Jungreis I; Kellis M; Echeverria I; Verba K; Bonfanti P; Beltrao P; Sharan R; Doudna JA; Sobrido LM; Patel AH; Palmarini M; Miorin L; White K; Swaney DL; Garcia-Sastre A; Jolly C; Zuliani-Alvarez L; Towers GJ; Krogan NJ
  • Article: NATURE COMMUNICATIONS. 2023;14(1):6030
    Haas KM; Mcgregor MJ; Bouhaddou M; Polacco BJ; Kim E-Y; Nguyen TT; Newton BW; Urbanowski M; Kim H; Williams MAP; Rezelj VV; Hardy A; Fossati A; Stevenson EJ; Sukerman E; Kim T; Penugonda S; Moreno E; Braberg H; Zhou Y; Metreveli G; Harjai B; Tummino TA; Melnyk JE; Soucheray M; Batra J; Pache L; Martin-Sancho L; Carlson-Stevermer J; Jureka AS; Basler CF; Shokat KM; Shoichet BK; Shriver LP; Johnson JR; Shaw ML; Chanda SK; Roden DM; Carter TC; Kottyan LC; Chisholm RL; Pacheco JA; Smith ME; Schrodi SJ; Albrecht RA; Vignuzzi M; Zuliani-Alvarez L; Swaney DL; Eckhardt M; Wolinsky SM; White KM; Hultquist JF; Kaake RM; Garcia-Sastre A; Krogan NJ
  • Article: NATURE COMMUNICATIONS. 2023;14(1):5156
    Fossati A; Mozumdar D; Kokontis C; Mendez-Moran M; Nieweglowska E; Pelin A; Li Y; Guo B; Krogan NJ; Agard DA; Bondy-Denomy J; Swaney DL
  • Article: JOURNAL OF PROTEOME RESEARCH. 2023;22(5):1520-1536
    Bludau I; Nicod C; Martelli C; Xue P; Heusel M; Fossati A; Uliana F; Frommelt F; Aebersold R; Collins BC
  • Article: MOLECULAR SYSTEMS BIOLOGY. 2023;19(4):msb202211024
    Uliana F; Ciuffa R; Mishra R; Fossati A; Frommelt F; Keller S; Mehnert M; Birkeland ES; van Drogen F; Srejic N; Peter M; Tapon N; Aebersold R; Gstaiger M
  • Article: BRIEFINGS IN BIOINFORMATICS. 2022;23(4):bbac239
    Sharma VS; Fossati A; Ciuffa R; Buljan M; Williams EG; Chen Z; Shao W; Pedrioli PGA; Purcell AW; Martinez MR; Song J; Manica M; Aebersold R; Li C
  • Journal article: NATURE. 2022;604(7905):E14
    Thorne LG; Bouhaddou M; Reuschl A-K; Zuliani-Alvarez L; Polacco B; Pelin A; Batra J; Whelan MVX; Hosmillo M; Fossati A; Ragazzini R; Jungreis I; Ummadi M; Rojc A; Turner J; Bischof ML; Obernier K; Braberg H; Soucheray M; Richards A; Chen K-H; Harjai B; Memon D; Hiatt J; Rosales R; McGovern BL; Jahun A; Fabius JM; White K; Goodfellow IG; Takeuchi Y; Bonfanti P; Shokat K; Jura N; Verba K; Noursadeghi M; Beltrao P; Kellis M; Swaney DL; Garcia-Sastre A; Jolly C; Towers GJ; Krogan NJ
  • Article: CELL HOST & MICROBE. 2022;30(3):373-387.e7
    Escalera A; Gonzalez-Reiche AS; Aslam S; Mena I; Laporte M; Pearl RL; Fossati A; Rathnasinghe R; Alshammary H; van de Guchte A; Farrugia K; Qin Y; Bouhaddou M; Kehrer T; Zuliani-Alvarez L; Meekins DA; Balaraman V; McDowell C; Richt JA; Bajic G; Sordillo EM; Dejosez M; Zwaka TP; Krogan NJ; Simon V; Albrecht RA; van Bakel H; Garcia-Sastre A; Aydillo T
  • Article: NATURE. 2022;602(7897):487-495
    Thorne LG; Bouhaddou M; Reuschl A-K; Zuliani-Alvarez L; Polacco B; Pelin A; Batra J; Whelan MVX; Hosmillo M; Fossati A; Ragazzini R; Jungreis I; Ummadi M; Rojc A; Turner J; Bischof ML; Obernier K; Braberg H; Soucheray M; Richards A; Chen K-H; Harjai B; Memon D; Hiatt J; Rosales R; McGovern BL; Jahun A; Fabius JM; White K; Goodfellow IG; Takeuchi Y; Bonfanti P; Shokat K; Jura N; Verba K; Noursadeghi M; Beltrao P; Kellis M; Swaney DL; Garcia-Sastre A; Jolly C; Towers GJ; Krogan NJ
  • Article: JOURNAL OF PROTEOME RESEARCH. 2021;20(8):4031-4040
    Fossati A; Richards AL; Chen K-H; Jaganath D; Cattamanchi A; Ernst JD; Swaney DL
  • Article: NATURE METHODS. 2021;18(5):520-527
    Fossati A; Li C; Uliana F; Wendt F; Frommelt F; Sykacek P; Heusel M; Hallal M; Bludau I; Capraz T; Xue P; Song J; Wollscheid B; Purcell AW; Gstaiger M; Aebersold R
  • Article: NATURE COMMUNICATIONS. 2021;12(1):1693
    Uliana F; Vizovisek M; Acquasaliente L; Ciuffa R; Fossati A; Frommelt F; Goetze S; Wollscheid B; Gstaiger M; De Filippis V; Keller UAD; Aebersold R
  • Article: METHODS IN MOLECULAR BIOLOGY. 2021;2259:269-294
    Fossati A; Frommelt F; Uliana F; Martelli C; Vizovisek M; Gillet L; Collins B; Gstaiger M; Aebersold R

All other publications

  • Preprint: BIORXIV. 2024
    Trip DSL; van Oostrum M; Memon D; Frommelt F; Baptista D; Panneerselvam K; Bradley G; Licata L; Hermjakob H; Orchard S; Trynka G; McDonagh E; Fossati A; Aebersold R; Gstaiger M; Wollscheid B; Beltrao P
  • Preprint: BIORXIV. 2024
    Mozumdar D; Fossati A; Stevenson E; Guan J; Nieweglowska E; Rao S; Agard D; Swaney DL; Bondy-Denomy J
  • Preprint: BIORXIV. 2023;BIORXIV
    Lin Z; Schaefer K; Lui I; Yao Z; Fossati A; Swaney DL; Palar A; Sali A; Wells JA
  • Preprint: BIORXIV. 2023
    Silas S; Carion H; Makarova KS; Laderman E; Godinez DS; Johnson M; Fossati A; Swaney D; Bocek M; Koonin EV; Bondy-Denomy J
  • Preprint: BIORXIV. 2023
    Frommelt F; Fossati A; Uliana F; Wendt F; Peng X; Heusel M; Wollscheid B; Aebersold R; Ciuffa R; Gstaiger M
  • Preprint: BIORXIV. 2023;BIORXIV
    Fossati A; Mozumdar D; Kokontis C; M猫ndez-Moran M; Nieweglowska E; Pelin A; Li Y; Guo B; Krogan NJ; Agard DA; Bondy-Denomy J; Swaney DL
  • Preprint: BIORXIV. 2022
    Bouhaddou M; Reuschl A-K; Polacco BJ; Thorne LG; Ummadi MR; Ye C; Rosales R; Pelin A; Batra J; Jang GM; Xu J; Moen JM; Richards A; Zhou Y; Harjai B; Stevenson E; Rojc A; Ragazzini R; Whelan MVX; Furnon W; De Lorenzo G; Cowton V; Syed AM; Ciling A; Deutsch N; Pirak D; Dowgier G; Mesner D; Turner JL; McGovern BL; Rodriguez ML; Leiva-Rebollo R; Dunham AS; Zhong X; Eckhardt M; Fossati A; Liotta N; Kehrer T; Cupic A; Rutkowska M; Mena N; Aslam S; Hoffert A; Foussard H; Pham J; Lyons M; Donahue L; Griffin A; Nugent R; Holden K; Deans R; Aviles P; L贸pez-Mart铆n JA; Jimeno JM; Obernier K; Fabius JM; Soucheray M; H眉ttenhain R; Jungreis I; Kellis M; Echeverria I; Verba K; Bonfanti P; Beltrao P; Sharan R; Doudna JA; Martinez-Sobrido L; Patel A; Palmarini M; Miorin L; White K; Swaney DL; Garc铆a-Sastre A; Jolly C; Zuliani-Alvarez L; Towers GJ; Krogan NJ
  • Preprint: BIORXIV. 2022
    Teuscher AC; Statzer C; Goyala A; Domenig SA; Schoen I; Hess M; Hofer AM; Fossati A; Vogel V; Goksel O; Aebersold R; Ewald CY
  • Preprint: BIORXIV. 2022
    Uliana F; Ciuffa R; Mishra R; Fossati A; Frommelt F; Mehnert M; Birkeland ES; Peter M; Tapon N; Aebersold R; Gstaiger M
  • Preprint: BIORXIV. 2021
    Bludau I; Nicod C; Martelli C; Xue P; Heusel M; Fossati A; Uliana F; Frommelt F; Aebersold R; Collins B
  • Preprint: BIORXIV. 2021
    Escalera A; Gonzalez-Reiche AS; Aslam S; Mena I; Pearl RL; Laporte M; Fossati A; Rathnasinghe R; Alshammary H; van de Guchte A; Bouhaddou M; Kehrer T; Zuliani-Alvarez L; Meekins DA; Balaraman V; McDowell C; Richt JA; Bajic G; Sordillo EM; Krogan N; Simon V; Albrecht RA; van Bakel H; Garcia-Sastre A; Aydillo T
  • Preprint: RES SQ. 2021;RES SQ
    Gupta M; Azumaya CM; Moritz M; Pourmal S; Diallo A; Merz GE; Jang G; Bouhaddou M; Fossati A; Brilot AF; Diwanji D; Hernandez E; Herrera N; Kratochvil HT; Lam VL; Li F; Li Y; Nguyen HC; Nowotny C; Owens TW; Peters JK; Rizo AN; Schulze-Gahmen U; Smith AM; Young ID; Yu Z; Asarnow D; Billesb酶lle C; Campbell MG; Chen J; Chen K-H; Chio US; Dickinson MS; Doan L; Jin M; Kim K; Li J; Li Y-L; Linossi E; Liu Y; Lo M; Lopez J; Lopez KE; Mancino A; Moss FR; Paul MD; Pawar KI; Pelin A; Pospiech TH; Puchades C; Remesh SG; Safari M; Schaefer K; Sun M; Tabios MC; Thwin AC; Titus EW; Trenker R; Tse E; Tsui TKM; Wang F; Zhang K; Zhang Y; Zhao J; Zhou F; Zhou Y; Zuliani-Alvarez L; QCRG Structural Biology Consortium; Agard DA; Cheng Y; Fraser JS; Jura N; Kortemme T; Manglik A; Southworth DR; Stroud RM; Swaney DL; Krogan NJ; Frost A; Rosenberg OS; Verba KA
  • Preprint: BIORXIV. 2021;BIORXIV
    Gupta M; Azumaya CM; Moritz M; Pourmal S; Diallo A; Merz GE; Jang G; Bouhaddou M; Fossati A; Brilot AF; Diwanji D; Hernandez E; Herrera N; Kratochvil HT; Lam VL; Li F; Li Y; Nguyen HC; Nowotny C; Owens TW; Peters JK; Rizo AN; Schulze-Gahmen U; Smith AM; Young ID; Yu Z; Asarnow D; Billesb酶lle C; Campbell MG; Chen J; Chen K-H; Chio US; Dickinson MS; Doan L; Jin M; Kim K; Li J; Li Y-L; Linossi E; Liu Y; Lo M; Lopez J; Lopez KE; Mancino A; Moss FR; Paul MD; Pawar KI; Pelin A; Pospiech TH; Puchades C; Remesh SG; Safari M; Schaefer K; Sun M; Tabios MC; Thwin AC; Titus EW; Trenker R; Tse E; Tsui TKM; Wang F; Zhang K; Zhang Y; Zhao J; Zhou F; Zhou Y; Zuliani-Alvarez L; QCRG Structural Biology Consortium; Agard DA; Cheng Y; Fraser JS; Jura N; Kortemme T; Manglik A; Southworth DR; Stroud RM; Swaney DL; Krogan NJ; Frost A; Rosenberg OS; Verba KA
  • Preprint: BIORXIV. 2021
    Fossati A; Richards AL; Chen K-H; Jaganath D; Cattamanchi A; Ernst JD; Swaney DL
  • Preprint: BIORXIV. 2021
    Sharma V; Fossati A; Ciuffa R; Buljan M; Williams E; Chen Z; Shao W; Pedrioli PGA; Purcell A; Rodr铆guez Mart铆nez M; Song J; Manica M; Aebersold R; Li C
  • Preprint: SSRN ELECTRONIC JOURNAL. 2021
    Merino AE; Gonzalez-Reiche AS; Aslam S; Mena I; Pearl RL; Laporte M; Fossati A; Rathnasinghe R; Alshammary H; van de Guchte A; Bouhaddou M; Kehrer T; Zuliani-Alvarez L; Meekins DA; Balaraman V; McDowell C; Richt JA; Bajic G; Sordillo EM; Krogan NJ; Simon V; Albrecht R; van Bakel H; Garcia-Sastre A; Aydillo T
  • Preprint: BIORXIV. 2020
    Uliana F; Vizovi拧ek M; Acquasaliente L; Ciuffa R; Fossati A; Frommelt F; Gstaiger M; De Filippis V; Keller UAD; Aebersold R
  • Preprint: BIORXIV. 2020
    Fossati A; Li C; Sykacek P; Heusel M; Frommelt F; Uliana F; Hallal M; Bludau I; Klemens CT; Xue P; Purcell A; Gstaiger M; Aebersold R

Grants

  • KID grant
    探花精选
    1 January 2025 - 1 November 2024
  • KI networks in research
    探花精选
    1 January 2025 - 1 January 2027
  • Strategic Research Area 探花精选
    1 January 2025 - 1 January 2027
  • SciLifeLab & Wallenberg National Program for Data- Driven Life Science (DDLS)
    Knut och Alice Wallenbergs Stiftelse
    1 January 2024 - 31 December 2029
  • Swedish Research Council
    1 December 2023 - 30 November 2027
  • RED Equipment Grant
    SciLifeLab

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