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André Fisahn

André Fisahn

Affiliated to Research | Docent
Visiting address: BioMedicum A4, Solnavägen 9, 17165 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Blomgren, 171 77 Stockholm
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About me

  • I am an Associate Professor of Neuroscience at the Center for Alzheimer Research. After receiving my PhD in Neurophysiology from Oxford University (UK) in 1999 I underwent 4 years of postdoctoral training at the National Institutes of Health (USA). Since 2004 I am a principal investigator at the Karolinska Institute.

Research

  • The overall aim of our work is to help explain on a cellular, synaptic and network level the clinically-documented changes of rhythmic network activity caused by various brain disorders that result in cognitive decline and memory deficits in patients. We focus on functional network dynamics and mechanisms of neuronal synchronization in physiological conditions as well as in animal models of neurodegenerative and neuropsychiatric disorders with the aim to identify and validate potential targets for therapeutic intervention and restoration of cognitive function.

    Our core hypothesis postulates that changes to the electrical behavior of neurons and neuronal networks are the first functional impairments in disorders that lead to cognitive decline, and as such are a very reliable functional biomarker. Our work has shown that such functional changes far precede the accumulation of disease-typical classical biomarkers such as amyloid-beta in Alzheimer's disease or alpha-synuclein in Parkinson's disease.

    We are particularly interested in the role of fast-spiking interneurons, which experience action potential de-synchronization in disease assays very early on. We believe that rescuing this de-synchronization and restoring normal neuronal network function is the key to identify efficacious treatments for cognitive brain disorders.

Articles

  • Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;119:286-300
    Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
  • Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585
    Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schroeder B; Nilsson P; Tambaro S
  • Article: EXPERIMENTAL NEUROLOGY. 2023;369:114545
    Isla AG; Balleza-Tapia H; Chu F; Chen G; Johansson J; Nilsson P; Fisahn A
  • Article: MOLECULAR PSYCHIATRY. 2023;28(6):2177-2188
    Andrade-Talavera Y; Fisahn A; Rodriguez-Moreno A
  • Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
    Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
  • Article: TRANSLATIONAL NEURODEGENERATION. 2023;12(1):6
    Arroyo-Garcia LE; Bachiller S; Ruiz R; Boza-Serrano A; Rodriguez-Moreno A; Deierborg T; Andrade-Talavera Y; Fisahn A
  • Article: PROGRESS IN NEUROBIOLOGY. 2022;219:102366
    Andrade-Talavera Y; Chen G; Pansieri J; -Garcia LEA; Toleikis Z; Smirnovas V; Johansson J; Morozova-Roche L; Fisahn A
  • Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
    Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
  • Article: COMMUNICATIONS BIOLOGY. 2022;5(1):245
    Emre C; Arroyo-Garcia LE; Do KV; Jun B; Ohshima M; Alcalde SG; Cothern ML; Maioli S; Nilsson P; Hjorth E; Fisahn A; Bazan NG; Schultzberg M
  • Article: NEUROBIOLOGY OF DISEASE. 2021;159:105514
    Andrade-Talavera Y; Chen G; Kurudenkandy FR; Johansson J; Fisahn A
  • Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567
    Arroyo-Garcia LE; Isla AG; Andrade-Talavera Y; Balleza-Tapia H; Loera-Valencia R; Alvarez-Jimenez L; Pizzirusso G; Tambaro S; Nilsson P; Fisahn A
  • Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):212
    Andrade-Talavera Y; Balleza-Tapia H; Dolz-Gaiton P; Chen G; Johansson J; Fisahn A
  • Article: JOURNAL OF PHYSIOLOGY. 2020;598(17):3711-3725
    Andrade-Talavera Y; Arroyo-Garcia LE; Chen G; Johansson J; Fisahn A
  • Article: NEUROPHARMACOLOGY. 2020;170:108070
    Narvaez M; Andrade-Talavera Y; Valladolid-Acebes I; Fredriksson M; Siegele P; Hernandez-Sosa A; Fisahn A; Fuxe K; Borroto-Escuela DO
  • Article: HIPPOCAMPUS. 2020;30(2):101-113
    Bjorefeldt A; Roshan F; Forsberg M; Zetterberg H; Hanse E; Fisahn A
  • Article: MOLECULAR NEUROBIOLOGY. 2020;57(2):1170-1185
    Balleza-Tapia H; Dolz-Gaiton P; Andrade-Talavera Y; Fisahn A
  • Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
    Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
  • Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(3):1462-1477
    Honcharenko D; Juneja A; Roshan F; Maity J; Galan-Acosta L; Biverstal H; Hjorth E; Johansson J; Fisahn A; Nilsson L; Stromberg R
  • Article: ELIFE. 2018;7:e37703
    Balleza-Tapia H; Crux S; Andrade-Talavera Y; Dolz-Gaiton P; Papadia D; Chen G; Johansson J; Fisahn A
  • Article: NATURE COMMUNICATIONS. 2017;8(1):2081
    Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
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All other publications

  • Review: PROGRESS IN NEUROBIOLOGY. 2022;210:102213
    Balleza-Tapia H; Arroyo-Garcia LE; Isla AG; Loera-Valencia R; Fisahn A
  • Review: EXPERIMENTAL NEUROLOGY. 2021;343:113743
    Isla AG; Balleza-Tapia H; Fisahn A
  • Published conference paper: JOURNAL OF NEUROSCIENCE RESEARCH. 2017;95(11):2195-2206
    Samokhina E; Popova I; Malkov A; Ivanov AI; Papadia D; Osypov A; Molchanov M; Paskevich S; Fisahn A; Zilberter M; Zilberter Y
  • Letter: NATURE METHODS. 2015;12(7):595-596
    Lian X; Bao X; Zilberter M; Westman M; Fisahn A; Hsiao C; Hazeltine LB; Dunn KK; Kamp TJ; Palecek SP
  • Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S246-S247
    Andersson R; Fisahn A; Lindskog M
  • Published conference paper: JOURNAL OF PHYSIOLOGY. 2005;562(1):65-72
    Fisahn A
  • Review: NATURE REVIEWS NEUROSCIENCE. 2001;2(1):11-23
    McBain CJ; Fisahn A

Employments

  • Affiliated to Research, Department of Women's and Children's Health, ̽»¨¾«Ñ¡, 2022-2025

Degrees and Education

  • Docent, Karolinska institutet, 2009

Supervisor

  • Daniela Papadia, Cellular and network mechanisms in neurodegenerative disorders : neurotoxicity and rescue strategies., , 2014

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