探花精选

Andor Pivarcsi

Andor Pivarcsi

Principal Researcher | Docent
Visiting address: Cmm, L8:02, Karolinska Universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Derm o Ven Eidsmo L, 171 77 Stockholm
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About me

  • I am associate professor in experimental dermatology (since 2011). My group is located at the Center for Molecular Medicine, Solna.

Research

  • Our research is focused on skin non-coding RNAs (ncRNAs), in particular we investigate their involvement in the malignant transformation of skin cells as well as in the modulation of the innate immune response in the skin.

    1. Investigation of the role of non-coding RNAs in skin cancer
    Non-melanoma skin cancers, basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are the most common cancers in human. Until recently, very little was known about the expression and function of ncRNAs in human skin and its diseases. Non-melanoma skin cancers are primarily a consequence of cumulate sun exposure, which results in genetic and epigenetic changes leading to acquiring a cancer-phenotype. Although the genetic alterations contributing to non-melanoma skin cancers have been extensively characterized, the factors responsible for mediating their effects on cellular transformation, reprogramming of the tumor microenvironment is less known. Recently, ncRNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), have emerged as novel regulators of genetic programs in higher eukaryotes. My team has identified several non-coding RNAs that are expressed in the skin, however, their contribution to skin carcinogenesis remains poorly understood.



    Our aims are to (1) identify non-coding RNAs, microRNAs and long non-coding RNAs, that are involved in skin cancer (2) to identify the biochemical regulatory networks leading to their altered expression (3) to decipher their roles in the neoplastic transformation of skin epithelial cells (4) identify their roles in the regulation of gene networks. We study the molecular function and the pathways regulating their expression using cell culture assays and investigate their function in skin cancer and inflammation using animal disease models such as genetically modified animals, cancer growth and metastasis assays. Our long-term goal is to translate our findings into the clinical practice and modulate miRNA expression in the skin via synthetic miRNAs or miRNA inhibitors in order to treat skin cancer.

    2. Investigation of the role of non-coding RNAs in the innate immunity in the skin
    Another line of research in the lab is the investigation of the role non-coding RNAs in the innate immune response of skin cells. Healthy skin is colonized by bacteria, which are essential for the maintenance of heathy tissue homeostasis. My earlier research demonstrated that skin cells are able to recognize danger signals and upon activation keratinocytes they organize an immune response via the secretion of inflammatory mediators and chemokines. Although the trancriptomic changes assacoited with the innate immune response of skin cells has been chaeracteries, little has been known whenther and how these molecular alterations are regualted by ncRNAs. Our aim is to explore the role of non-coding RNAs in the regulation of the innate immune response of keratinocytes.

Articles

  • Article: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. 2020;34(6):1248-1256
    Pasquali L; Svedbom A; Srivastava A; Rosen E; Lindqvist U; Stahle M; Pivarcsi A; Sonkoly E
  • Article: SCIENTIFIC REPORTS. 2020;10(1):3637
    Das Mahapatra K; Pasquali L; Sondergaard JN; Lapins J; Nemeth IB; Baltas E; Kemeny L; Homey B; Moldovan L-I; Kjems J; Kutter C; Sonkoly E; Kristensen LS; Pivarcsi A
  • Article: ACTA DERMATO-VENEREOLOGICA. 2019;99(2):196-205
    Pasquali L; Srivastava A; Meisgen F; Das Mahapatra K; Xia P; Landen NX; Pivarcsi A; Sonkoly E
  • Article: ACTA DERMATO-VENEREOLOGICA. 2018;98(8):772-775
    Srivastava A; Stahle M; Pivarcsi A; Sonkoly E
  • Article: SCIENTIFIC REPORTS. 2018;8(1):12990
    Srivastava A; Karlsson M; Marionnet C; Bernerd F; Gueniche A; Rawadi CEL; Stahle M; Sonkoly E; Breton L; Pivarcsi A
  • Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(4):882-892
    Lohcharoenkal W; Das Mahapatra K; Pasquali L; Crudden C; Kular L; Ulum YZA; Zhang L; Landen NX; Girnita L; Jagodic M; Stahle M; Sonkoly E; Pivarcsi A
  • Article: PLOS ONE. 2018;13(11):e0206942
    Svedman FC; Lohcharoenkal W; Bottai M; Brage SE; Sonkoly E; Hansson J; Pivarcsi A; Eriksson H
  • Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(12):2630-2638
    Li X; Li D; Wang A; Chu T; Lohcharoenkal W; Zheng X; Grunler J; Narayanan S; Eliasson S; Herter EK; Wang Y; Ma Y; Ehrstrom M; Eidsmo L; Kasper M; Pivarcsi A; Sonkoly E; Catrina S-B; Stahle M; Landen NX
  • Article: SCIENTIFIC REPORTS. 2017;7(1):7797
    Li X; Li D; Wikstrom JD; Pivarcsi A; Sonkoly E; Stahle M; Landen NX
  • Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):550-561
    Srivastava A; Nikamo P; Lohcharoenkal W; Li D; Meisgen F; Landen NX; Stahle M; Pivarcsi A; Sonkoly E
  • Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(12):2485-2494
    Lohcharoenkal W; Harada M; Loven J; Meisgen F; Landen NX; Zhang L; Lapins J; Das Mahapatra K; Shi H; Nissinen L; Kahari V-M; Stahle M; Sonkoly E; Grander D; Arsenian-Henriksson M; Pivarcsi A
  • Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(8):3008-3026
    Li D; Wang A; Liu X; Meisgen F; Gruenler J; Botusan IR; Narayanan S; Erikci E; Li X; Blomqvist L; Du L; Pivarcsi A; Sonkoly E; Chowdhury K; Catrina S-B; Stahle M; Landen NX
  • Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015;135(6):1676-1685
    Li D; Li X; Wang A; Meisgen F; Pivarcsi A; Sonkoly E; Stahle M; Landen NX
  • Article: EXPERIMENTAL DERMATOLOGY. 2014;23(9):620-624
    Pivarcsi A; Stahle M; Sonkoly E
  • Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(7):1931-1940
    Meisgen F; Landen NX; Wang A; Rethi B; Bouez C; Zuccolo M; Gueniche A; Stahle M; Sonkoly E; Breton L; Pivarcsi A
  • Article: MOLECULAR ONCOLOGY. 2014;8(5):912-926
    Villegas VE; Rahman MF-U; Fernandez-Barrena MG; Diao Y; Liapi E; Sonkoly E; Stahle M; Pivarcsi A; Annaratone L; Sapino A; Ramirez Clavijo S; Burglin TR; Shimokawa T; Ramachandran S; Kapranov P; Fernandez-Zapico ME; Zaphiropoulos PG
  • Article: CARCINOGENESIS. 2014;35(5):1110-1120
    Gastaldi C; Bertero T; Xu N; Bourget-Ponzio I; Lebrigand K; Fourre S; Popa A; Cardot-Leccia N; Meneguzzi G; Sonkoly E; Pivarcsi A; Mari B; Barbry P; Ponzio G; Rezzonico R
  • Article: EXPERIMENTAL DERMATOLOGY. 2014;23(4):281-283
    Meisgen F; Landen NX; Bouez C; Zuccolo M; Gueniche A; Stahle M; Sonkoly E; Breton L; Pivarcsi A
  • Article: PLOS ONE. 2014;9(7):e103206
    Wang A; Landen NX; Meisgen F; Lohcharoenkal W; Stahle M; Sonkoly E; Pivarcsi A
  • Article: BRITISH JOURNAL OF DERMATOLOGY. 2013;169(3):563-570
    Pivarcsi A; Meisgen F; Xu N; Stahle M; Sonkoly E
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All other publications

  • Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2019;139(12):2547-2550.e12
    Srivastava A; Meisgen F; Pasquali L; Munkhammar S; Xia P; Stahle M; Landen NX; Pivarcsi A; Sonkoly E
  • Letter: ACTA DERMATO-VENEREOLOGICA. 2013;93(3):366-367
    Saaf A; Kockum I; Wahlgren C-F; Xu N; Sonkoly E; Stahle M; Nordenskjold M; Bradley M; Pivarcsi A
  • Published conference paper: EUROPEAN JOURNAL OF DERMATOLOGY. 2013;23:66-71
    Wei T; Xu N; Meisgen F; Stahle M; Sonkoly E; Pivarcsi A
  • Review: MUTATION RESEARCH - FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2011;717(1-2):46-53
    Sonkoly E; Pivarcsi A
  • Letter: EXPERIMENTAL DERMATOLOGY. 2010;19(9):854-856
    Wei T; Orfanidis K; Xu N; Janson P; Stahle M; Pivarcsi A; Sonkoly E
  • Review: INTERNATIONAL REVIEWS OF IMMUNOLOGY. 2009;28(6):535-561
    Sonkoly E; Pivarcsi A
  • Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2009;13(1):24-38
    Sonkoly E; Pivarcsi A
  • Review: CLINICAL AND EXPERIMENTAL DERMATOLOGY. 2008;33(3):312-315
    Sonkoly E; Stahle M; Pivarcsi A
  • Review: SEMINARS IN CANCER BIOLOGY. 2008;18(2):131-140
    Sonkoly E; Stahle M; Pivarcsi A
  • Editorial comment: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2007;127(4):746-748
    Pivarcsi A
  • Review: CURRENT ALLERGY AND ASTHMA REPORTS. 2005;5(4):284-290
    Pivarcsi A; Homey B
  • Corrigendum: JOURNAL OF IMMUNOLOGY. 2005;174(12):8219
    Gombert M; Dieu-Nosjean MC; Winterberg F; B眉nemann E; Kubitza RC; Da Cunha L; Haahtela A; Lehtim盲ki S; M眉ller A; Rieker J; Meller S; Pivarcsi A; Koreck A; Fridman WH; Zentgraf HW; Pavenst盲dt H; Amara A; Caux C; Kemeny L; Alenius H; Lauerma A; Ruzicka T; Zlotnik A; Homey B
  • Review: ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA. 2004;51(3):303-310
    Pivarcsi A; Kem茅ny L; Dobozy A
  • Editorial comment: DERMATOLOGY. 2003;206(2):96-105
    Koreck A; Pivarcsi A; Dobozy A; Kem茅ny L

Employments

  • Principal Researcher, Department of Medicine, 探花精选, 2022-

Degrees and Education

  • Docent, 探花精选, 2011

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