̽ѡ

Anders Mutvei

Principal Researcher | Docent
Visiting address: Institutionen för Labmed / ANA Futura, Alfred Nobels Allé 8, 14152 Huddinge
Postal address: H5 Laboratoriemedicin, H5 Patologi Mutvei, 141 52 Huddinge
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About me

  • www.mutveilab.se

    Our laboratory is focused on characterizing the essential signaling and metabolic processes that tumor cells hijack and reprogram to promote tumorigenesis and drug resistance. We are particularly interested in understanding the role of lysosomes in these processes. Our long-term goal is to translate this knowledge into lysosome-based pharmacological remedies for the clinic.

    Lysosomes are catabolic endosomes that break down macromolecules. Due to this function, they were historically perceived as mere “housekeeping” organelles responsible for disposing of macromolecular waste. However, over the past decade, it has become increasingly evident that lysosomes have critical roles beyond degradation, which frequently becomes dysregulated in tumors. This includes controlling the cellular synthesis of new biomolecules - processes which tumor cells need to rewire in order to grow and survive.

    In our lab, we investigate how tumor-associated changes in the lysosomal pool affect tumor metabolism, aggressiveness and resistance to therapies. We are particularly interested in the fact that tumor cells often display abnormally increased levels of lysosomes, and to characterize how this drives disease progression. Our work employs cutting-edge imaging techniques, large-scale omics approaches (proteomics, metabolomics, etc.), and classical biochemical methods.

Articles

  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2023;299(5):104644
    Ibrahim YH; Pantelios S; Mutvei AP
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(6):102030
    Buel GR; Dang HQ; Asara JM; Blenis J; Mutvei AP
  • Article: NATURE METABOLISM. 2022;4(4):435-443
    Gomes AP; Ilter D; Low V; Drapela S; Schild T; Mullarky E; Han J; Elia I; Broekaert D; Rosenzweig A; Nagiec M; Nunes JB; Schaffer BE; Mutvei AP; Asara JM; Cantley LC; Fendt S-M; Blenis J
  • Article: NATURE. 2020;585(7824):283-287
    Gomes AP; Ilter D; Low V; Endress JE; Fernández-García J; Rosenzweig A; Schild T; Broekaert D; Ahmed A; Planque M; Elia I; Han J; Kinzig C; Mullarky E; Mutvei AP; Asara J; de Cabo R; Cantley LC; Dephoure N; Fendt S-M; Blenis J
  • Article: NATURE COMMUNICATIONS. 2020;11(1):1416
    Mutvei AP; Nagiec MJ; Hamann JC; Kim SG; Vincent CT; Blenis J
  • Article: CANCER CELL. 2019;36(4):402-417.e13
    Gomes AP; Ilter D; Low V; Rosenzweig A; Shen Z-J; Schild T; Rivas MA; Er EE; McNally DR; Mutvei AP; Han J; Ou Y-H; Cavaliere P; Mullarky E; Nagiec M; Shin S; Yoon S-O; Dephoure N; Massagué J; Melnick AM; Cantley LC; Tyler JK; Blenis J
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(39):19523-19529
    He L; Fei DL; Nagiec MJ; Mutvei AP; Lamprakis A; Kim BY; Blenis J
  • Article: ONCOGENE. 2018;37(46):6083-6095
    Mutvei AP; Landor SK-J; Fox R; Braune E-B; Tsoi YL; Phoon YP; Sahlgren C; Hartman J; Bergh J; Jin S; Lendahl U
  • Article: BLOOD. 2018;131(15):1712-1719
    Duarte S; Woll PS; Buza-Vidas N; Chin DWL; Boukarabila H; Luis TC; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Jin S; Clark S-A; Wu B; Repapi E; Gray N; Taylor S; Mutvei AP; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW
  • Article: NATURE CELL BIOLOGY. 2018;20(3):332-343
    Zhang H; Freitas D; Kim HS; Fabijanic K; Li Z; Chen H; Mark MT; Molina H; Martin AB; Bojmar L; Fang J; Rampersaud S; Hoshino A; Matei I; Kenific CM; Nakajima M; Mutvei AP; Sansone P; Buehring W; Wang H; Jimenez JP; Cohen-Gould L; Paknejad N; Brendel M; Manova-Todorova K; Magalhães A; Ferreira JA; Osório H; Silva AM; Massey A; Cubillos-Ruiz JR; Galletti G; Giannakakou P; Cuervo AM; Blenis J; Schwartz R; Brady MS; Peinado H; Bromberg J; Matsui H; Reis CA; Lyden D
  • Article: BMC CANCER. 2015;15:311
    Mutvei AP; Fredlund E; Lendahl U
  • Article: CELL RESEARCH. 2014;24(4):433-450
    Sjoqvist M; Antfolk D; Ferraris S; Rraklli V; Haga C; Antila C; Mutvei A; Imanishi SY; Holmberg J; Jin S; Eriksson JE; Lendahl U; Sahlgren C
  • Article: ONCOGENE. 2013;32(41):4892-4902
    Jin S; Mutvei AP; Chivukula IV; Andersson ER; Ramskold D; Sandberg R; Lee KL; Kronqvist P; Mamaeva V; Ostling P; Mpindi J-P; Kallioniemi O; Screpanti I; Poellinger L; Sahlgren C; Lendahl U
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(46):18814-18819
    Landor SK-J; Mutvei AP; Mamaeva V; Jin S; Busk M; Borra R; Gronroos TJ; Kronqvist P; Lendahl U; Sahlgren CM
  • Article: JOURNAL OF CELL SCIENCE. 2010;123(17):2931-2942
    Hansson EM; Lanner F; Das D; Mutvei A; Marklund U; Ericson J; Farnebo F; Stumm G; Stenmark H; Andersson ER; Lendahl U

All other publications

  • Review: NATURE CELL BIOLOGY. 2023;25(9):1254-1264
    Mutvei APP; Nagiec MJJ; Blenis J
  • Conference publication: HAEMATOLOGICA. 2017;102:456
    Duarte S; Woll PS; Natalija B-V; Boukarabila H; Stenson L; Bouriez-Jones T; Ferry H; Mead AJ; Atkinson D; Thongjuea S; Jin S; Clark S-A; Chin D; Lu-S T; Repapi E; Gray N; Taylor S; Mutvei A; Tsoi YL; Nerlov C; Lendahl U; Jacobsen SEW

Employments

  • Principal Researcher, Department of Laboratory Medicine, ̽ѡ, 2023-

Degrees and Education

  • Docent, KI, 2024
  • Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, ̽ѡ, 2014

Visiting research fellowships

  • Postdoctoral research Weill Cornell Medicine / Harvard Medical School, Weill Cornell Medicine, 2014-2019

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