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Alexander Espinosa

Alexander Espinosa

Senior Research Specialist | Docent
Visiting address: CMM, L8:04, Karolinska universitetssjukhuset, 17176 Stockholm
Postal address: K2 Medicin, Solna, K2 Reuma Wahren-Herlenius M, 171 77 Stockholm
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About me

  • After undergraduate studies in molecular biology and mathematics at Stockholm University I obtained a PhD in Experimental Medicine from ̽»¨¾«Ñ¡ in 2008. After postdoctoral training in USA I returned to Karolinska to start my own laboratory.

Research

  • My research interest is to develop new methods and mouse models to improve the understanding of immune cells in autoimmune disease and cancer. We have developed an optogenetic CRISPR method for more precise spatiotemporal control of gene activity in vivo, as well as genetically engineered mouse models to improve the understanding of human disease.

Teaching

  • I arrange and teach at the postgraduate course 2186 "How to generate genetically modified mice for immunological research" as a part of the Aii (Allergy, immunology and inflammation) doctoral program. The course curriculum includes construct design for the generation of transgenic and gene targeted mice, including traditional methods and newer CRISPR based methods, as well as genotyping and breeding schemes. 

Articles

  • Article: EMBO REPORTS. 2023;24(1):e54944
    Nyberg WA; Velasquez-Pulgarin DA; He T; Sjostrand M; Pelle L; Covacu R; Espinosa A
  • Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(8):1151-1161
    Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Ottosson V; Forsberg D; Thorlacius GE; Biavati L; Strandberg L; Mofors J; Ramskold D; Ruhrmann S; Meneghel L; Nyberg W; Espinosa A; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
  • Article: BIOMOLECULES. 2022;12(6):779
    Qu H; Heinback R; Salo H; Ewing E; Espinosa A; Aulin C; Erlandsson Harris H
  • Article: FRONTIERS IN IMMUNOLOGY. 2021;12:642173
    Gao Y; Liu R; He C; Basile J; Vesterlund M; Wahren-Herlenius M; Espinoza A; Hokka-Zakrisson C; Zadjali F; Yoshimura A; Karlsson M; Carow B; Rottenberg ME
  • Article: IMMUNOLOGY. 2020;159(3):335-343
    Sjoestrand M; Carow B; Nyberg WA; Covacu R; Rottenberg ME; Espinosa A
  • Article: RMD OPEN. 2020;6(1):e000989
    Hedlund M; Thorlacius GE; Ivanchenko M; Ottosson V; Kyriakidis N; Lagnefeldt L; Tingstrom J; Sirsjo A; Bengtsson AA; Aronsson E; Gemzell-Danielsson K; Ronnblom L; Bergman G; Espinosa A; Sonesson S-E; Eloranta M-L; Wahren-Herlenius M
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(30):11404-11419
    Anandapadamanaban M; Kyriakidis NC; Csizmok V; Wallenhammar A; Espinosa AC; Ahlner A; Round AR; Trewhella J; Moche M; Wahren-Herlenius M; Sunnerhagen M
  • Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(2):313-322
    Johansson A; Nyberg WA; Sjostrand M; Moruzzi N; Bergman P; Khademi M; Andersson M; Piehl F; Berggren P-O; Covacu R; Jagodic M; Espinosa A
  • Article: NATURE COMMUNICATIONS. 2018;9(1):4845
    Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
  • Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;193(2):167-177
    Mentlein L; Thorlacius GE; Meneghel L; Aqrawi LA; Sepulveda JIR; Grunewald J; Espinosa A; Wahren-Herlenius M
  • Article: EXPERIMENTAL DERMATOLOGY. 2017;26(8):713-720
    Vinter H; Langkilde A; Ottosson V; Espinosa A; Wahren-Herlenius M; Raaby L; Johansen C; Iversen L
  • Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2016;473(4):789-794
    Nyberg WA; Espinosa A
  • Article: JOURNAL OF IMMUNOLOGY. 2016;196(1):91-96
    Sjostrand M; Johansson A; Aqrawi L; Olsson T; Wahren-Herlenius M; Espinosa A
  • Article: JOURNAL OF IMMUNOLOGY. 2013;191(7):3753-3763
    Sjostrand M; Ambrosi A; Brauner S; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
  • Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(5):1601-1609
    Smith S; Gabhann JN; Higgs R; Stacey K; Wahren-Herlenius M; Espinosa A; Totaro MG; Sica A; Ball E; Bell A; Johnston J; Browne P; O'Neill L; Kearns G; Jefferies CA
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(42):36478-36491
    Espinosa A; Hennig J; Ambrosi A; Anandapadmanaban M; Abelius MS; Sheng Y; Nyberg F; Arrowsmith CH; Sunnerhagen M; Wahren-Herlenius M
  • Article: MULTIPLE SCLEROSIS JOURNAL. 2010;16(9):1056-1065
    Gillett A; Hedreul MT; Khademi M; Espinosa A; Beyeen AD; Jagodic M; Kockum I; Harris RA; Olsson T
  • Article: PLOS ONE. 2010;5(7):e11776
    Higgs R; Lazzari E; Wynne C; Gabhann JN; Espinosa A; Wahren-Herlenius M; Jefferies CA
  • Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2009;206(8):1661-1671
    Espinosa A; Dardalhon V; Brauner S; Ambrosi A; Higgs R; Quintana FJ; Sjostrand M; Eloranta M-L; Gabhann JN; Winqvist O; Sundelin B; Jefferies CA; Rozell B; Kuchroo VK; Wahren-Herlenius M
  • Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129(8):2000-2010
    Oke V; Vassilaki I; Espinosa A; Strandberg L; Kuchroo VK; Nyberg F; Wahren-Herlenius M
  • Show more

All other publications

  • Preprint: BIORXIV. 2023;BIORXIV
    Pulgarin DV; Pelo N; Ferrandiz L; Trselic T; Nyberg WA; Bowlin G; Espinosa A
  • Letter: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(12):1840-1842
    Aqrawi LA; Mentlein L; Meneghel L; Bjork A; Thorlacius GE; Ivanchenko M; Sepulveda JIR; Skarstein K; Kvarnstrom M; Brauner S; Espinosa A; Wahren-Herlenius M
  • Review: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(9):2274-2284
    Ambrosi A; Espinosa A; Wahren-Herlenius M
  • Review: IMMUNOLOGY LETTERS. 2011;141(1):1-9
    Jonsson R; Vogelsang P; Volchenkov R; Espinosa A; Wahren-Herlenius M; Appel S
  • Letter: JOURNAL OF IMMUNOLOGY. 2009;183(12):7620-7621
    Espinosa A; Brauner S; Ambrosi A; Kuchroo V; Wahren-Herlenius M
  • Doctoral thesis: 2008
    Espinosa A
  • Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S24
    Espinosa A; Hennig J; Ambrosi A; Nyberg F; Sunnerhaqen M; Wahren-Herlenius M
  • Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S25
    Espinosa A; Zhou W; Oukka M; Kuchroo V; Wahren-Herlenius M

Employments

  • Senior Research Specialist, Department of Medicine, ̽»¨¾«Ñ¡, 2022-

Degrees and Education

  • Docent, ̽»¨¾«Ñ¡, 2020
  • Doctor Of Philosophy, Department of Medicine, Solna, ̽»¨¾«Ñ¡, 2008

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