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Ahmed Osman

Ahmed Osman

Assistant Professor
Visiting address: BioMedicum A4, Solnavägen 9, 17165 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnonkologi och Barnkirurgi Blomgren, 171 77 Stockholm

About me

  • I received my undergraduate degree in Veterinary Medicine from the University of Khartoum, Sudan, and specialized in pathology. I was performing histopathological analyses, and necropsies, along with teaching and research. 

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  • In my master's years, my research focused on infectious diseases, developing molecular assays for characterization of the genotypes of the parasitic disease Hydatidosis caused by tapeworm Echinococcus granulosus.

     

  • For my PhD, I was enrolled in a Regenerative Neuroscience Program at the ̽»¨¾«Ñ¡ in Sweden, investigating the role of neural stem cells in brain repair after injuries caused by ischemia or cranial irradiation. Since brain injury is often accompanied by inflammation, my research then focused on how the immune response influences neural stem cell behavior, with a particular focus on microglia as the resident immune cell in the brain.

     

  • Over time, I developed an interest in investigating central nervous system cancers, especially cancer dissemination, known as cancer metastasis. Therefore, I joined the Adrienne Boire Laboratory at Memorial Sloan Kettering Cancer Center in New York City, USA, for postdoctoral training, investigating the molecular underpinnings of leptomeningeal metastasis response to craniospinal irradiation.

     

Research

  • Our research focuses on two lines:

     

  • 1- Investigation of the molecular determinants of the central nervous metastasis growth in pediatric patients, from both the brain or systemic origins. We aim to precisely dissect the molecular programs and cellular interactions within the metastatic ecosystem based on the cancer type using animal models and ex vivo 
  • systems. We also investigate metastatic microenvironments after cancer therapies, such as radiotherapy and chemotherapy to understand the molecular basis of the metastatic relapse and resistance to the current available therapies, with the overall goal to identify novel molecular targets and actionably exploit them to halt the disease progression.

     

  • 2- Understanding the molecular basis of the neurotoxicity and neurocognitive impairments induced by brain cancers and cancer therapies. Cancer therapy-induced neurotoxicity is a major clinical challenge in neuro-oncology as it can occur in up to 95% of cancer survivors treated with cranial irradiation or chemotherapy, especially in children, with no available treatment.

Articles

  • Journal article: NEURO-ONCOLOGY. 2024;26(9):1617-1627
    Romero AL; Seitz T; Zisiadis GA; Jeffery H; Osman AM
  • Article: HELIYON. 2024;10(16):e35838
    Preka E; Romero AL; Sun Y; Vilalta YO; Seitz T; Fragkopoulou A; Betsholtz C; Osman AM; Blomgren K
  • Journal article: NOA. 2024;6(Supplement_1):i37-i38
    Osman A; Romero AL; Preka E; Pizzirusso G; Arroyo-Garcia LE; Zisiadis GA; Oliva-Vilarnau N; Seitz T; Zhou K; Isla AG; Sun Y; Zhu C; Rodrigues C; Fisahn A; Fragkopoulou A; Lauschke V; Betsholtz C; Blomgren K
  • Article: AUTOPHAGY. 2023;19(7):1952-1981
    Beccari S; Sierra-Torre V; Valero J; Pereira-Iglesias M; Garcia-Zaballa M; Soria FN; De Las Heras-garcia L; Carretero-Guillen A; Capetillo-Zarate E; Domercq M; Huguet PR; Ramonet D; Osman A; Han W; Dominguez C; Faust TE; Touzani O; Pampliega O; Boya P; Schafer D; Marino G; Canet-Soulas E; Blomgren K; Plaza-Zabala A; Sierra A
  • Article: NATURE NEUROSCIENCE. 2023;26(6):1008-1020
    Stratoulias V; Ruiz R; Kanatani S; Osman AM; Keane L; Armengol JA; Rodriguez-Moreno A; Murgoci A-N; Garcia-Dominguez I; Alonso-Bellido I; Ibanez FG; Picard K; Vazquez-Cabrera G; Posada-Perez M; Vernoux N; Tejera D; Grabert K; Cheray M; Gonzalez-Rodriguez P; Perez-Villegas EM; Martinez-Gallego I; Lastra-Romero A; Brodin D; Avila-Carino J; Cao Y; Airavaara M; Uhlen P; Heneka MT; Tremblay M-E; Blomgren K; Venero JL; Joseph B
  • Article: CLINICAL CANCER RESEARCH. 2023;29(4):775-783
    Wijetunga NA; Goglia AG; Weinhold N; Berger MF; Cislo M; Higginson DS; Chabot K; Osman AM; Schaff L; Pentsova E; Miller AM; Powell SN; Boire A; Yang JT
  • Article: FRONTIERS IN ONCOLOGY. 2023;13:1202200
    Zisiadis GA; Alevyzaki A; Nicola E; Rodrigues CFD; Blomgren K; Osman AM
  • Journal article: NEURO-ONCOLOGY. 2022;24(Supplement_7):vii248-vii249
    Zisiadis GA; Rodrigues C; Pizzirusso G; Arroyo-García L; Osman A; Blomgren K
  • Journal article: NEURO-ONCOLOGY. 2022;24(Supplement_1):i192
    Zisiadis G; Rodrigues C; Pizzirusso G; Arroyo-García L; Osman A; Blomgren K
  • Article: STEM CELL REPORTS. 2022;17(5):1089-1104
    Muhl L; He L; Sun Y; Mae MA; Pietila R; Liu J; Genove G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Rasanen M; Hansson EM; Bjorkegren J; Vanlandewijck M; Blomgren K; Makinen T; Peng X-R; Hu Y; Ernfors P; Arnold TD; Alitalo K; Lendahl U; Betsholtz C
  • Article: JOURNAL OF NEUROINFLAMMATION. 2022;19(1):20
    Zhou K; Han J; Lund H; Boggavarapu NR; Lauschke VM; Goto S; Cheng H; Wang Y; Tachi A; Xie C; Zhu K; Sun Y; Osman AM; Liang D; Han W; Gemzell-Danielsson K; Betsholtz C; Zhang X-M; Zhu C; Enge M; Joseph B; Harris RA; Blomgren K
  • Article: SCIENTIFIC REPORTS. 2020;10(1):12369
    Neumann S; Porritt MJ; Osman AM; Kuhn HG
  • Article: CELL REPORTS. 2020;31(9):107699
    Osman AM; Sun Y; Burns TC; He L; Kee N; Oliva-Vilarnau N; Alevyzaki A; Zhou K; Louhivuori L; Uhlen P; Hedlund E; Betsholtz C; Lauschke VM; Kele J; Blomgren K
  • Article: NEUROSCIENCE. 2019;405:92-102
    Osman AM; Rodhe J; Shen X; Dominguez CA; Joseph B; Blomgren K
  • Article: NEUROSCIENCE. 2018;384:314-328
    Karlsson L; Gonzalez-Alvarado MN; Larrosa-Flor M; Osman A; Borjesson M; Blomgren K; Kuhn HG
  • Article: ONCOIMMUNOLOGY. 2018;7(2):e1382790
    Saidi D; Cheray M; Osman AM; Stratoulias V; Lindberg OR; Shen X; Blomgren K; Joseph B
  • Article: NATURE IMMUNOLOGY. 2016;17(11):1282-1290
    Shen X; Burguillos MA; Osman AM; Frijhoff J; Carrillo-Jimenez A; Kanatani S; Augsten M; Saidi D; Rodhe J; Kavanagh E; Rongvaux A; Rraklli V; Nyman U; Holmberg J; Ostman A; Flavell RA; Barragan A; Venero JL; Blomgren K; Joseph B
  • Article: ONCOTARGET. 2016;7(3):2239-2248
    Osman AM; Neumann S; Kuhn HG; Blomgren K
  • Article: GLIA. 2015;63(12):2220-2230
    Umekawa T; Osman AM; Han W; Ikeda T; Blomgren K
  • Article: CELL REPORTS. 2015;10(9):1626-1638
    Burguillos MA; Svensson M; Schulte T; Boza-Serrano A; Garcia-Quintanilla A; Kavanagh E; Santiago M; Viceconte N; Jose Oliva-Martin M; Osman AM; Salomonsson E; Amar L; Persson A; Blomgren K; Achour A; Englund E; Leffler H; Venero JL; Joseph B; Deierborg T
  • Article: CELL TRANSPLANTATION. 2014;23(12):1657-1671
    Osman AM; Zhou K; Zhu C; Blomgren K
  • Article: GLIA. 2013;61(5):790-799
    Persson A; Osman A; Bolouri H; Mallard C; Kuhn HG
  • Article: BRAIN RESEARCH. 2013;1503:62-77
    Lindwall C; Olsson M; Osman AM; Kuhn HG; Curtis MA
  • Article: STROKE. 2011;42(12):3559-3565
    Osman AM; Porritt MJ; Nilsson M; Kuhn HG
  • Show more

All other publications

  • Preprint: BIORXIV. 2023;BIORXIV
    Remsik J; Tong X; Kunes RZ; Li MJ; Osman A; Chabot K; Sener UT; Wilcox JA; Isakov D; Snyder J; Bale TA; Chaligné R; Pe'er D; Boire A
  • Conference publication: GLIA. 2023;71:E512
    Venero JL; Ruiz R; Kanatani S; Osman AM; Keane L; Armengol JA; Rodriguez-Moreno A; Murgoci A-N; Garcia-Dominguez I; Alonso-Bellido I; Ibanez FG; Picard K; Vazquez-Cabrera G; Posada-Perez M; Vernoux N; Tejera D; Grabert K; Cheray M; Gonzalez-Rodriguez P; Perez-Villegas EM; Martinez-Gallego I; Lastra-Romero A; Brodin D; Avila-Carino J; Cao Y; Airavaara M; Uhlen P; Heneka MT; Tremblay M-E; Blomgren K; Stratoulias V; Joseph B
  • Conference publication: BRAIN TUMOR RESEARCH AND TREATMENT. 2022;10(Suppl):s397-s391
    Romero AL; Osman A; Blomgren K
  • Conference publication: NEURO-ONCOLOGY. 2022;24:248-249
    Zisiadis GA; Rodrigues C; Pizzirusso G; Arroyo-Garcia L; Osman A; Blomgren K
  • Conference publication: NEURO-ONCOLOGY. 2022;24:192
    Zisiadis G; Rodrigues C; Pizzirusso G; Arroyo-Garcia L; Osman A; Blomgren K
  • Preprint: BIORXIV. 2021
    Beccari S; Sierra-Torre V; Valero J; García-Zaballa M; Carretero-Guillen A; Capetillo-Zarate E; Domercq M; Huguet P; Ramonet D; Osman A; Han W; Dominguez C; Faust T; Touzani O; Boya P; Schafer D; Mariño G; Canet-Soulas E; Blomgren K; Plaza-Zabala A; Sierra A
  • Preprint: BIORXIV. 2021
    Stratoulias V; Ruiz R; Kanatani S; Osman A; Armengol J; Rodríguez-Moreno A; Murgoci A-N; García-Domínguez I; Keane L; Vázquez-Cabrera G; Alonso-Bellido I; Vernoux N; Tejera D; Grabert K; Cheray M; González-Rodríguez P; Pérez-Villegas E; Martinez-Gallego I; Brodin D; Avila-Cariño J; Airavaara M; Uhlén P; Heneka M; Tremblay M-È; Blomgren K; Venero J; Joseph B
  • Preprint: BIORXIV. 2020
    He L; Mäe MA; Muhl L; Sun Y; Pietilä R; Nahar K; Liébanas EV; Fagerlund MJ; Oldner A; Oldner A; Liu J; Genové G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Räsänen M; Mirabeau O; Hansson E; Björkegren J; Vanlandewijck M; Blomgren K; Mäkinen T; Peng X-R; Arnold T; Alitalo K; Eriksson L; Lendahl U; Betsholtz C
  • Conference publication: GLIA. 2017;65:E330
    Galeano MSB; Umekawa T; Osman A; Han W; Dominguez C; Blomgren K; Sierra A
  • Conference publication: JOURNAL OF NEUROCHEMISTRY. 2017;142:38-39
    Kuhn G; Motalleb R; Osman A; Berns E; Stupp S
  • Thesis / dissertation: 2015
    Osman, Ahmed

Employments

  • Assistant Professor, Department of Women's and Children's Health, ̽»¨¾«Ñ¡, 2020-2026

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of Women's and Children's Health, ̽»¨¾«Ñ¡, 2015

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