探花精选

Adamantia Fragkopoulou

Adamantia Fragkopoulou

Assistant Professor
Telephone: +46852482348
Visiting address: Widerstr枚mska huset, hiss 1, plan 8 Tomtebodav盲gen 18A, 17177 Stockholm
Postal address: K6 Kvinnors och barns h盲lsa, K6 Barnonkologi och Barnkirurgi, 171 77 Stockholm

About me

  •  

    I am an Assistant Professor and Team Leader at the Department of Women's and Children's Health, at the Division of Pediatric Oncology and Pediatric Surgery.

     

    I am a Neuroscientist specializing in Brain Injury, Radiation Biology, and Behavioural Neuroscience. My research spans the impact of both ionizing and non-ionizing radiation on the developing brain, with a translational focus on mitigating cognitive and behavioural deficits following early-life brain insults.


    During my PhD, I investigated how non-ionizing electromagnetic radiation affects the mouse brain and behaviour. In 2015, I joined the Department of Neuroscience at 探花精选 to pursue postdoctoral research on neurodevelopmental disorders, particularly neonatal hypoxic-ischemic encephalopathy (HIE) and cerebral palsy. Since my appointment as Assistant Professor in 2019 at the Department of Women鈥檚 and Children鈥檚 Health (KBH) at 探花精选, my research has focused on understanding how ionizing radiation鈥攗sed in paediatric brain tumour treatment鈥攊mpacts the young brain. 

     

    My team is developing predictive models that integrate single-cell RNA sequencing (scRNA-seq) time-series data with machine learning and deep learning techniques to map biological responses in healthy, injured, or diseased brains. These models allow us to infer causal relationships and pinpoint key molecular drivers through in silico gene expression modulation. This approach informs the development of targeted therapies tailored to factors such as sex, age, cell type, brain region, and injury profile. One of our therapeutic strategies involves using antisense oligonucleotides to alleviate long-term complications of radiotherapy, including cognitive decline in childhood cancer survivors.
    Concurrently, I investigate chronic inflammation following hypoxic-ischemic injury in murine models, focusing on lymphocyte activation. I am also developing innovative therapeutic approaches鈥攕uch as intranasal mechanical stimulation (INMEST)鈥攖o limit brain tissue damage and improve behavioural outcomes.

     

    In addition to my research, I provide expert user support at the X-ray Irradiation Core Facility at 探花精选.

     

    COMMISSIONS OF TRUST

     

    2025鈥損resent: Member, Board of Doctoral Education, Department of Women's and Children's Health (KBH), 探花精选

    2024鈥2025: Chair, Junior Faculty at KBH (JF-KBH)

    2024鈥損resent: Member, Animal Behavioral Core Facility (ABCF) Board, 探花精选

    2024: Vice-Chair, 探花精选 Junior Faculty (JF-KI)

    2024: Chairperson, PhD Thesis Public Defense of Christina Neofytou, 探花精选

    2023鈥2024: Vice-Chair, Junior Faculty 鈥 Pediatric Oncology and Pediatric Surgery (JF-POPS), KBH, KI

    2022-2023: Secretary, JF-POPS, KI

    2022鈥2024: Organizer, KBH-POPS 鈥淏arncancerforskningsenheten鈥 Research Seminar Series

    2019鈥損resent: Member, X-ray Irradiation Core Facility, 探花精选

     

     

    EDUCATION
    鈥    PhD in Electromagnetic Biology and Neurobiology, Dept. of Cell Biology and Biophysics, Faculty of Biology, National & Kapodistrian University of Athens (2013)
    鈥    MSc in Applications of Biology in Medical Sciences, Faculty of Biology & Faculty of Medicine, National & Kapodistrian University of Athens (2008)
    鈥    BSc in Biology, Faculty of Biology, National & Kapodistrian University of Athens (2006)

     


    HONOURS & AWARDS
    鈥    PhD Scholarship, Greek State Scholarships Foundation (IKY)
    鈥    Seal of Excellence, European Commission, Marie Sk艂odowska-Curie Actions (H2020-MSCA-IF-2016)
    鈥    Awards from: FENS, IBRO, ERRS, FELASA, AGU, KI Fonder

Research

  • Brain tumours
    Radiotherapy
    Hypoxia-ischemia
    Neuroinflammation
    Anstisense oligonucleotides
    Lithium

    Single-cell RNA sequencing

    Machine Learning
    Microglia
    Behavior
    Sex differences
    Stereotaxic surgeries

Teaching

    • Main supervisor of the PhD student Efthalia Preka (2021-2025).
    • Co-supervisor of the PhD student Eleni Stergiou (2023-2027).
    • 20 years of teaching experience at pre- and postgraduate courses, and supervision of Bachelor's, Master's, and Erasmus+ students.
    • Coordinator, teacher and examiner at the FoTO doctoral course "Applications of ionizing radiation in therapy and bio探花精选 research".

Articles

  • Article: BRAIN BEHAVIOR AND IMMUNITY. 2025;123:57-63
    Zhou K; Zisiadis GA; Havermans M; Fragkopoulou A; Dominguez C; Ohshima M; Osman AM; Rodrigues CFD; Blomgren K
  • Article: HELIYON. 2024;10(16):e35838
    Preka E; Romero AL; Sun Y; Vilalta YO; Seitz T; Fragkopoulou A; Betsholtz C; Osman AM; Blomgren K
  • Journal article: NOA. 2024;6(Supplement_1):i37-i38
    Osman A; Romero AL; Preka E; Pizzirusso G; Arroyo-Garcia LE; Zisiadis GA; Oliva-Vilarnau N; Seitz T; Zhou K; Isla AG; Sun Y; Zhu C; Rodrigues C; Fisahn A; Fragkopoulou A; Lauschke V; Betsholtz C; Blomgren K
  • Article: BRAIN BEHAVIOR AND IMMUNITY. 2024;119:286-300
    Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez-Rodriguez P; Vazquez-Cabrera G; Laterza S; Latorre-Leal M; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garcia LE
  • Journal article: NEURO-ONCOLOGY. 2024;26:0
    Rodrigues CFD; Preka E; Lastra-Romero A; Zisiadis GA; Ruchiy Y; Fragkopoulou A; Blomgren K
  • Article: MOLECULAR PSYCHIATRY. 2021;26(1):322-340
    Zanni G; Goto S; Fragopoulou AF; Gaudenzi G; Naidoo V; Di Martino E; Levy G; Dominguez CA; Dethlefsen O; Cedazo-Minguez A; Merino-Serrais P; Stamatakis A; Hermanson O; Blomgren K
  • Article: MOLECULAR NEUROBIOLOGY. 2019;56(10):6883-6900
    Fragopoulou AF; Qian Y; Heijtz RD; Forssberg H
  • Article: BRAIN AND BEHAVIOR. 2018;8(6):e01001
    Fragopoulou AF; Polyzos A; Papadopoulou M-D; Sansone A; Manta AK; Balafas E; Kostomitsopoulos N; Skouroliakou A; Chatgilialoglu C; Georgakilas A; Stravopodis DJ; Ferreri C; Thanos D; Margaritis LH
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2017;18(4):E838-838
    Souli MP; Klonos P; Fragopoulou AF; Mavragani IV; Pateras IS; Kostomitsopoulos N; Margaritis LH; Zoumpoulis P; Kaklamanis L; Kletsas D; Gorgoulis VG; Kyritsis A; Pissis P; Georgakilas AG
  • Article: FLY. 2017;11(2):75-95
    Manta AK; Papadopoulou D; Polyzos AP; Fragopoulou AF; Skouroliakou AS; Thanos D; Stravopodis DJ; Margaritis LH
  • Article: REPRODUCTIVE TOXICOLOGY. 2016;65:248-262
    Stasinopoulou M; Fragopoulou AF; Stamatakis A; Mantziaras G; Skouroliakou K; Papassideri IS; Stylianopoulou F; Lai H; Kostomitsopoulos N; Margaritis LH
  • Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2016;92(3):162-168
    Mina D; Sagonas K; Fragopoulou AF; Pafilis P; Skouroliakou A; Margaritis LH; Tsitsilonis OE; Valakos ED
  • Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2015;91(3):286-293
    Fasseas MK; Fragopoulou AF; Manta AK; Skouroliakou A; Vekrellis K; Margaritis LH; Syntichaki P
  • Article: ELECTROMAGNETIC BIOLOGY AND MEDICINE. 2012;31(4):250-274
    Fragopoulou AF; Samara A; Antonelou MH; Xanthopoulou A; Papadopoulou A; Vougas K; Koutsogiannopoulou E; Anastasiadou E; Stravopodis DJ; Tsangaris GT; Margaritis LH
  • Article: REVIEWS ON ENVIRONMENTAL HEALTH. 2010;25(4):307-317
    Fragopoulou A; Grigoriev Y; Johansson O; Margaritis LH; Morgan L; Richter E; Sage C
  • Article: PATHOPHYSIOLOGY. 2010;17(3):179-187
    Fragopoulou AF; Miltiadous P; Stamatakis A; Stylianopoulou F; Koussoulakos SL; Margaritis LH
  • Article: PATHOPHYSIOLOGY. 2010;17(3):169-177
    Fragopoulou AF; Koussoulakos SL; Margaritis LH

All other publications

  • Preprint: BIORXIV. 2025
    Cheray M; Murgoci A-N; Fragkopoulou A; Rodrigues CFD; 艩kand铆k M; Osman AM; Hong C; Vazquez-Cabrera G; Friess L; Carlson L-M; Kanatani S; Li Y; Damdimopoulos A; Uhl茅n P; Kamme F; Blomgren K; Joseph B
  • Preprint: BIORXIV. 2025
    Romero AL; Preka E; Pizzirusso G; Arroyo-Garc铆a LE; Zisiadis GA; Oliva-Vilarnau N; Seitz T; Zhou K; Isla AG; Friess L; Sun Y; Shamikh A; Xu Y; Zhu C; Rodrigues CFD; Fisahn A; Joseph B; Carlson L-M; Fragkopoulou A; Lauschke VM; Betsholtz C; Osman AM; Blomgren K
  • Preprint: BIORXIV. 2024
    Pizzirusso G; Preka E; Goikolea J; Aguilar-Ruiz C; Rodriguez PR; Cabrera GV; Laterza S; Leal ML; Eroli F; Blomgren K; Maioli S; Nilsson P; Fragkopoulou A; Fisahn A; Arroyo-Garc铆a LE
  • Conference publication: NEURO-ONCOLOGY. 2023;25:i78
    Rodrigues C; Preka E; Lastra-Romero A; Zisiadis GA; Zisiadis C; Fragkopoulou A; Blomgren K
  • Conference publication: BRAIN TUMOR RESEARCH AND TREATMENT. 2022;10(Suppl):s398
    Preka E; Fragkopoulou A; Blomgren K
  • Corrigendum: MOLECULAR NEUROBIOLOGY. 2019;56(10):6901
    Fragopoulou AF; Qian Y; Heijtz RD; Forssberg H
  • Letter: PATHOPHYSIOLOGY. 2012;19(1):63
    Margaritis LH; Koussoulakos SL; Fragopoulou AF
  • Letter: PATHOPHYSIOLOGY. 2011;18(2):165
    Margaritis LH; Koussoulakos SL; Fragopoulou AF

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