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Per Uhlén

Per Uhlén

Professor | Docent
E-postadress: per.uhlen@ki.se
µþ±ð²õö°ì²õ²¹»å°ù±ð²õ²õ: Solnavägen 9, 6C, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Uhlén, 171 77 Stockholm
Del av:

Om mig

  • UTBILDNING
    Universitetsstudier
    Civilingenjör i Teknisk Fysik, Kungliga Tekniska Högskolan, Stockholm (1993-1998)
    Doktorandstudier
    Inst. för Kvinnors och Barns Hälsa (KBH), ̽»¨¾«Ñ¡, Stockholm (1998-2002)
    Postdoktorala studier
    Yale University School of Medicine, New Haven, CT, USA (2003-2005)
    Marine Biological Laboratory (MBL), Woods Hole, MA, USA (2004)
    Forskarassistent
    Inst. för Medicinsk Biokemi och Biofysik (MBB), ̽»¨¾«Ñ¡, Stockholm (2005-2008)
    Docent
    Inst. för Medicinsk Biokemi och Biofysik (MBB), ̽»¨¾«Ñ¡, Stockholm (2008-)

     

  • POSITIONER
    Forskarassistent
    Inst. för Medicinsk Biokemi och Biofysik (MBB), ̽»¨¾«Ñ¡, Stockholm (2005-2008)
    Docent
    Inst. för Medicinsk Biokemi och Biofysik (MBB), ̽»¨¾«Ñ¡, Stockholm (2008-)
    Professor
    Inst. för Medicinsk Biokemi och Biofysik (MBB), ̽»¨¾«Ñ¡, Stockholm (2014-)
    Adjunkt forskare
    RIKEN Brain Science Institute, Hirosawa, Wako, Saitama, Japan (2017-2018)
    ³Òä²õ³Ù±è°ù´Ç´Ú±ð²õ²õ´Ç°ù
    Keio University School of Medicine, Shinanomachi, Tokyo, Japan (2017-2020)

Forskningsbeskrivning

  • Min forskargrupp undersöker olika cellsignaleringfenomen och deras pÃ¥verkan pÃ¥ kritiska biologiska och medicinska processer, bÃ¥de pÃ¥ cellulär och organisk nivÃ¥, med ett primärt fokus pÃ¥ neurovetenskap och cancer. Vi utvecklar innovativa vävnadsberedningsmetoder och använder oss av toppmoderna avbildningstekniker, sÃ¥som 3D light-sheet mikroskopi och spatial transcriptomik, tillsammans med avancerade analysverktyg som Fourier-transform och djupinlärning. Dessutom tillämpar vi moderna cell- och genetiska teknologier, inklusive iPS-celler, organoider, transgena djur, single-cell RNA-sekvensering och CRISPR-Cas, för att pÃ¥ olika sätt studera och manipulera diverse biologiska och medicinska processer. VÃ¥rt primära intresse är att belysa mekanismerna bakom intracellulär signalering och deras roller i utveckling och sjukdom. Ett viktigt mÃ¥l för vÃ¥rt arbete är att förstÃ¥ hur celler reglerar och tolkar frekvensen och amplituden av intracellulära kalciumsvängningar för att samordna essentiella biologiska funktioner.

Utvalda publikationer

  • Article: SCIENCE. 2024;386(6724):907-915
    Kanatani S; Kreutzmann JC; Li Y; West Z; Larsen LL; Nikou DV; Eidhof I; Walton A; Zhang S; Rodriguez-Kirby LR; Skytte JL; Salinas CG; Takamatsu K; Li X; Tanaka DH; Kaczynska D; Fukumoto K; Karamzadeh R; Xiang Y; Uesaka N; Tanabe T; Adner M; Hartman J; Miyakawa A; Sundstrom E; Castelo-Branco G; Roostalu U; Hecksher-Sorensen J; Uhlen P
  • Article: NATURE NEUROSCIENCE. 2023;26(6):1008-1020
    Stratoulias V; Ruiz R; Kanatani S; Osman AM; Keane L; Armengol JA; Rodriguez-Moreno A; Murgoci A-N; Garcia-Dominguez I; Alonso-Bellido I; Ibanez FG; Picard K; Vazquez-Cabrera G; Posada-Perez M; Vernoux N; Tejera D; Grabert K; Cheray M; Gonzalez-Rodriguez P; Perez-Villegas EM; Martinez-Gallego I; Lastra-Romero A; Brodin D; Avila-Carino J; Cao Y; Airavaara M; Uhlen P; Heneka MT; Tremblay M-E; Blomgren K; Venero JL; Joseph B
  • Article: NATURE BIOTECHNOLOGY. 2023;41(2):222-231
    Borm LE; Albiach AM; Mannens CCA; Janusauskas J; Ozgun C; Fernandez-Garcia D; Hodge R; Castillo F; Hedin CRH; Villablanca EJ; Uhlen P; Lein ES; Codeluppi S; Linnarsson S
  • Preprint: BIORXIV. 2022
    Kanatani S; Kreutzmann J; Li Y; West Z; Vougesi Nikou D; Lercke Skytte J; Lydolph Larsen L; Tanaka D; Kaczynska D; Fukumoto K; Uesaka N; Tanabe T; Miyakawa A; Roostalu U; Hecksher-Sørensen J; Uhlén P
  • Editorial comment: NATURE METHODS. 2022;19(5):527-529
    Kanatani S; Uhlen P
  • Article: NATURE COMMUNICATIONS. 2022;13(1):1537
    Zhang S; Miyakawa A; Wickstrom M; Dyberg C; Louhivuori L; Varas-Godoy M; Kemppainen K; Kanatani S; Kaczynska D; Ellstrom ID; Elfman L; Kronqvist P; Repo H; Mikoshiba K; Sahlgren C; Johnsen JI; Uhlen P
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(7):e2108768119
    Smedler E; Louhivuori L; Romanov RA; Masini D; Ellstrom ID; Wang C; Caramia M; West Z; Zhang S; Rebellato P; Malmersjo S; Brusini I; Kanatani S; Fisone G; Harkany T; Uhlen P
  • Article: NATURE BIOMEDICAL ENGINEERING. 2020;4(9):875-888
    Tanaka N; Kanatani S; Kaczynska D; Fukumoto K; Louhivuori L; Mizutani T; Kopper O; Kronqvist P; Robertson S; Lindh C; Kis L; Pronk R; Niwa N; Matsumoto K; Oya M; Miyakawa A; Falk A; Hartman J; Sahlgren C; Clevers H; Uhlen P
  • Editorial comment: TRENDS IN CANCER. 2018;4(5):337-341
    Uhlen P; Tanaka N
  • Article: NATURE BIOMEDICAL ENGINEERING. 2017;1(10):796-806
    Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
  • Article: FRONTIERS IN NEURAL CIRCUITS. 2014;8:111
    Smedler E; Malmersjoe S; Uhlen P
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(16):E1524-E1532
    Malmersjo S; Rebellato P; Smedler E; Planert H; Kanatani S; Liste I; Nanou E; Sunner H; Abdelhady S; Zhang S; Andang M; El Manira A; Silberberg G; Arenas E; Uhlen P
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(7):2212-2217
    Desfrere L; Karlsson M; Hiyoshi H; Malmersjo S; Nanou E; Estrada M; Miyakawa A; Lagercrantz H; El Manira A; Lal M; Uhlen P
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(7):2160-2165
    Uhlén P; Burch PM; Zito CL; Estrada M; Ehrlich BE; Bennett AM
  • Article: NATURE. 2000;405(6787):694-697
    Uhlén P; Laestadius Å; Jahnukainen T; Söderblom T; Bäckhed F; Celsi G; Brismar H; Normark S; Aperia A; Richter-Dahlfors A

Artiklar

  • Article: NATURE NEUROSCIENCE. 2024;27(12):2267-2268
    Ernfors P; Castelo-Branco G; Uhlen P; Linnarsson S; Marklund U; Hjerling-Leffler J; Dagliyan O
  • Article: RES SQ. 2024
    Fan R; Zhang D; Rodríguez-Kirby L; Lin Y; Song M; Wang L; Wang L; Kanatani S; Jimenez-Beristain T; Dang Y; Zhong M; Kukanja P; Wang S; Chen X; Gao F; Wang D; Xu H; Lou X; Liu Y; Chen J; Sestan N; Uhlen P; Kriegstein AR; Zhao H; Castelo-Branco G
  • Article: JCI INSIGHT. 2024;9(14):e175751
    Fukumoto K; Kanatani S; Jaremko G; West Z; Li Y; Takamatsu K; Al Rayyes I; Mikami S; Niwa N; Axelsson TA; Tanaka N; Oya M; Miyakawa A; Brehmer M; Uhlen P
  • Article: WORLD JOURNAL OF UROLOGY. 2023;41(12):3405-3411
    Grahn A; Coleman JA; Eriksson Y; Gabrielsson S; Madsen JS; Tham E; Thomas K; Turney B; Uhlen P; Vollmer T; Zieger K; Osther PJS; Brehmer M
  • Article: EXPERIMENTAL EYE RESEARCH. 2023;237:109674
    Krimpenfort LT; Garcia-Collado M; van Leeuwen T; Locri F; Luik A-L; Queiro-Palou A; Kanatani S; Andre H; Uhlen P; Jakobsson L
  • Article: ACS APPLIED BIO MATERIALS. 2023;6(9):3790-3797
    Ilkhanizadeh S; Gracias A; Aslund AKO; Back M; Simon R; Kavanagh E; Migliori B; Neofytou C; Nelander S; Westermark B; Uhrbom L; Forsberg-Nilsson K; Konradsson P; Teixeira AI; Uhlen P; Joseph B; Hermanson O; Nilsson KPR
  • Journal article: NEURO-ONCOLOGY. 2022;24(Supplement_7):vii35
    Ilkhanizadeh S; Gracias A; Åslund AKO; Bäck M; Simon R; Neofytou C; Rraklli V; Migliori B; Kavanagh E; Nelander S; Westermark B; Uhrbom L; Forsberg-Nilsson K; Teixeira AI; Konradsson P; Uhlén P; Holmberg J; Joseph B; Nilsson KPR; Hermanson O
  • Article: ENVIRONMENTAL TOXICOLOGY. 2022;37(8):2044-2057
    Reis L; Raciti M; Rodriguez PG; Joseph B; Al Rayyes I; Uhlen P; Falk A; Lima STDC; Ceccatelli S
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(18):e2118927119
    Lee MD; Buckley C; Zhang X; Louhivuori L; Uhlen P; Wilson C; McCarron JG
  • Article: FRONTIERS IN MATERIALS. 2021;7:560372
    Lewicka M; Rebellato P; Lewicki J; Uhlen P; Rising A; Hermanson O
  • Article: EXPERIMENTAL CELL RESEARCH. 2020;395(1):112156
    Phoon YP; Chivukula IV; Tsoi YL; Kanatani S; Uhlen P; Kuiper R; Lendahl U
  • Article: STEM CELLS AND DEVELOPMENT. 2020;29(17):1160-1177
    Louhivuori LM; Turunen PM; Louhivuori V; Al Rayyes I; Nordstrom T; Uhlen P; Akerman KE
  • Article: STEM CELL RESEARCH AND THERAPY. 2020;11(1):320
    Lin C; Calzarossa C; Fernandez-Zafra T; Liu J; Li X; Ekblad-Nordberg A; Vazquez-Juarez E; Codeluppi S; Holmberg L; Lindskog M; Uhlen P; Akesson E
  • Article: CELL REPORTS. 2020;31(9):107699
    Osman AM; Sun Y; Burns TC; He L; Kee N; Oliva-Vilarnau N; Alevyzaki A; Zhou K; Louhivuori L; Uhlen P; Hedlund E; Betsholtz C; Lauschke VM; Kele J; Blomgren K
  • Article: CELL CALCIUM. 2020;88:102210
    Aperia A; Brismar H; Uhlen P
  • Article: WORLD JOURNAL OF UROLOGY. 2019;37(11):2297-2302
    Grahn A; Tanaka N; Uhlen P; Brehmer M
  • Article: EXPERIMENTAL CELL RESEARCH. 2019;383(1):111469
    Lam M; Moslem M; Bryois J; Pronk RJ; Uhlin E; Ellstrom ID; Laan L; Olive J; Morse R; Ronnholm H; Louhivuori L; Korol SV; Dahl N; Uhlen P; Anderlid B-M; Kele M; Sullivan PF; Falk A
  • Article: NEUROSCIENCE. 2019;402:78-89
    Rebellato P; Kaczynska A; Kanatani S; Al Rayyes I; Zhang S; Villaescusa C; Falk A; Arenas E; Hermanson O; Louhivuori L; Uhlen P
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(6):2328-2337
    Bernard-Marissal N; van Hameren G; Juneja M; Pellegrino C; Louhivuori L; Bartesaghi L; Rochat C; El Mansour O; Medard J-J; Croisier M; Maclachlan C; Poirot O; Uhlen P; Timmerman V; Tricaud N; Schneider BL; Chrast R
  • Article: MOLECULAR ONCOLOGY. 2019;13(2):202-211
    Ibarra C; Karlsson M; Codeluppi S; Varas-Godoy M; Zhang S; Louhivuori L; Mangsbo S; Hosseini A; Soltani N; Kaba R; Lundgren TK; Hosseini A; Tanaka N; Oya M; Wiklund P; Miyakawa A; Uhlen P
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Alla övriga publikationer

  • Preprint: BIORXIV. 2024;BIORXIV
    Zhang D; Rubio Rodríguez-Kirby LA; Lin Y; Song M; Wang L; Wang L; Kanatani S; Jimenez-Beristain T; Dang Y; Zhong M; Kukanja P; Wang S; Chen XL; Gao F; Wang D; Xu H; Lou X; Liu Y; Chen J; Sestan N; Uhlén P; Kriegstein A; Zhao H; Castelo-Branco G; Fan R
  • Preprint: BIORXIV. 2024
    Al Rayyes I; Louhivuori L; Ellström ID; Smedler E; Uhlén P
  • Preprint: BIORXIV. 2023
    Eidhof I; Kele M; Shasavani M; Ulfenborg B; Winn D; Uhlén P; Falk A
  • Preprint: BIORXIV. 2022
    Krimpenfort L; Garcia-Collado M; van Leeuwen T; Locri F; Luik A-L; Queiro-Palou A; Kanatani S; André H; Uhlén P; Jakobsson L
  • Preprint: BIORXIV. 2021
    Stratoulias V; Ruiz R; Kanatani S; Osman A; Armengol J; Rodríguez-Moreno A; Murgoci A-N; García-Domínguez I; Keane L; Vázquez-Cabrera G; Alonso-Bellido I; Vernoux N; Tejera D; Grabert K; Cheray M; González-Rodríguez P; Pérez-Villegas E; Martinez-Gallego I; Brodin D; Avila-Cariño J; Airavaara M; Uhlén P; Heneka M; Tremblay M-È; Blomgren K; Venero J; Joseph B
  • Corrigendum: STEM CELL RESEARCH AND THERAPY. 2020;11(1):369
    Lin C; Calzarossa C; Fernandez-Zafra T; Liu J; Li X; Ekblad-Nordberg A; Vazquez-Juarez E; Codeluppi S; Holmberg L; Lindskog M; Uhlen P; Akesson E
  • Editorial comment: NATURE BIOMEDICAL ENGINEERING. 2018;2(10):717-718
    Louhivuori L; Kanatani S; Uhlen P
  • Corrigendum: NATURE BIOMEDICAL ENGINEERING. 2018;2(1):48
    Tanaka N; Kanatani S; Tomer R; Sahlgren C; Kronqvist P; Kaczynska D; Louhivuori L; Kis L; Lindh C; Mitura P; Stepulak A; Corvigno S; Hartman J; Micke P; Mezheyeuski A; Strell C; Carlson JW; Moro CF; Dahlstrand H; Ostman A; Matsumoto K; Wiklund P; Oya M; Miyakawa A; Deisseroth K; Uhlen P
  • Review: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2014;75:40-48
    Ibarra C; Vicencio JM; Varas-Godoy M; Jaimovich E; Rothermel BA; Uhlen P; Hill JA; Lavandero S
  • Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1840(3):964-969
    Smedler E; Uhlen P
  • Letter: BRITISH JOURNAL OF CANCER. 2013;108(10):2191
    Hiyoshi H; Johnsen JI; Andang M; Uhlen P
  • Conference publication: ANGIOGENESIS. 2013;16(1):246-247
    Gaengel K; Niaudet C; Hagikura K; Siemsen LB; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
  • Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264
    Gaengel K; Niaudet C; Hagikura K; Lavina B; Muhl L; Hofmann JJ; Ebarasi L; Nystroem S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstroem M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
  • Review: CELL CALCIUM. 2011;49(5):350-356
    Baczyk D; Kingdom JCP; Uhlen P
  • Conference publication: THE FASEB JOURNAL. 2006;20(5):A1238
    Malmersjö S; Zhang SB; Uhlen P; Mikoshiba K; Aperia A
  • Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2003;986:514-518
    Uhlén P
  • Thesis / dissertation: 2002
    Uhlén, Per
  • Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. 2002;477(1-3):82-87
    Bäck T; Cederkäll J; Cederwall B; Johnson A; Kerek A; Klamra W; van der Marel J; Molnár J; Novák D; Sohler D; Steén M; Uhlén P
  • Published conference paper: NUCLEAR INSTRUMENTS AND METHODS IN PHYSICS RESEARCH, SECTION A: ACCELERATORS, SPECTROMETERS, DETECTORS AND ASSOCIATED EQUIPMENT. 2001;471(1-2):200-204
    Bäck T; Cederkäll J; Cederwall B; Johnson A; Kerek A; Klamra W; van der Marel J; Molnár J; Novák D; Sohler D; Steèn M; Uhlèn P

Forskningsbidrag

  • Three-Dimensional Mapping of Molecular Mechanisms After Spinal Cord Injury
    ±áÂáä°ù²Ô´Ú´Ç²Ô»å±ð²Ô
    1 July 2024 - 30 June 2027
  • Spatial Single-Cell Analysis of Proteins and RNAs in the Tumor Microenvironment by 3D Imaging
    Cancerfonden
    1 January 2023 - 31 December 2025
  • Exploration of Intratumoral Heterogeneity with Multimodal 3D Imaging at Single-Cell Resolution to Improve Precision Medicine for Cancer
    ³Õ±ð³Ù±ð²Ô²õ°ì²¹±è²õ°ùÃ¥»å±ð³Ù
    1 January 2022 - 31 December 2025

´¡²Ô²õ³Ùä±ô±ô²Ô¾±²Ô²µ²¹°ù

  • Professor, Medicinsk biokemi och biofysik, ̽»¨¾«Ñ¡, 2014-

Examina och utbildning

  • Docent, Cellbiologi, ̽»¨¾«Ñ¡, 2008
  • MEDICINE DOKTORSEXAMEN, Institutionen för kvinnors och barns hälsa, ̽»¨¾«Ñ¡, 2002

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