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Laura Orellana

Laura Orellana

Biträdande Lektor
E-postadress: laura.orellana@ki.se
ö: BioClinicum - J6:06, Akademiska Stråket 1, 17164 Solna
Postadress: K7 Onkologi-Patologi, K7 Forskning Orellana, 171 77 Stockholm
Del av:

Om mig

  • Jag är en strukturbiofysiker med medicinsk bakgrund. Mitt mål är att
    förstå mänskliga sjukdomar i atomskala: hur mutationer förändrar
    proteinstruktur, rörelser och biologisk funktion.
    2021: Petrus och Augusta Hedlunds Foundation Grant
    2021: Cancerfonden Junior Investigator Award
    2020: Jeanssons Foundation Young Leaders Grant
    2020: Karolinska Institute Research Foundation Special Grant
    2019: Karolinska Institute Tenure-track Faculty Position with start-up grant
    Award (KI Allocation of faculty funded career positions 2019 [1])
    2019: O.E. och Edla Johanssons Research Grant
    2016-2018: Sven och Lily Lawski Foundation Fellow
    *Academic Honors*
    2006: Extraordinary Prize for Academic Excellence in Biochemistry, University
    of Barcelona
    *2010–2014: PhD in Physics /summa cum laude/*/, /Faculty of Physics,
    University of Barcelona
    /Thesis: /“Protein Dynamics and Function studied by coarse-grained and
    atomistic theoretical approaches” [2]
    *2008–2011: Clinical training* (M.D. degree, 2nd cycle: 345 out of 500
    ECTS), Hospital Clínic de Barcelona & Hospital Universitari Sagrat Cor
    *2008 –2010: MSc in Biophysics*, Faculty of Physics, University of
    Barcelona
    *2006 – 2007: MSc in Structure & Function of Proteins*, Barcelona
    Autonomous University
    *2003–2005: BSc in Biochemistry with Extraordinary Prize & minor in
    Physics*, Faculty of Biology, University of Barcelona
    *1999–2003: Medicine* (M.D. degree, 1st cycle), Faculty of Medicine,
    University of Barcelona
    *Academic appointments*
    *Nov. 2020: Tenure-track Assistant Professor in Medical Sciences*,
    Karolinska Institute
    *2019-2020: Researcher (Forskare) in Structural Biology*, Stockholm
    University
    *2014-2018: Postdoctoral Fellow in Computational Biophysics & Cryo-EM*,
    Royal Institute of Technology (KTH) & Stockholm University
    *2008-2014: Graduate Student in Protein Biophysics & Molecular
    Modelling*, Institute for Research in Biomedicine in Barcelona & Barcelona
    Supercomputing Center
    [1] /en/about/allocation-of-faculty-funded-career-positions-2019
    [2]

Forskningsbeskrivning

  • Min grupp utvecklar teoretiska metoder och algoritmer för att förutsäga
    konformationsförändringar i proteiner och tillämpa dem på den fördjupade
    integrativa studien av cancermutationer, i syfte att generera ny mekanistisk
    hypotes och testa dem in vitro och in vivo.
    För mer information, se vår officiella KI sidan: Protein Dynamics and
    Cancer Lab [1]
    En fullständig publikationslista finns på Google scholar
    [2] och ResearchGate [3].
    [1] /en/onkpat/research-team-laura-orellana-protein-dynamics-and-cancer-lab
    [2] ;amp;user=s9mwu04AAAAJ&view_op=list_works&authuser=1&sortby=pubdate
    [3] _Orellana2

Artiklar

  • Article: NPJ GENOMIC MEDICINE. 2023;8(1):39
    Jacob P; Lindelof H; Rustad CF; Sutton VR; Moosa S; Udupa P; Hammarsjo A; Bhavani GS; Batkovskyte D; Tveten K; Dalal A; Horemuzova E; Nordgren A; Tham E; Shah H; Merckoll E; Orellana L; Nishimura G; Girisha KM; Grigelioniene G
  • Journal article: APPLIED SCIENCES-BASEL. 2023;13(11):6756
    Orellana L
  • Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2022;29(2):108-120
    Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Robinson CV; Nomura N; Iwata S; Landreh M; Orellana L; Beckstein O; Drew D
  • Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:890851
    Mhashal AR; Yoluk O; Orellana L
  • Article: NATURE COMMUNICATIONS. 2021;12(1):1728
    Thulasingam M; Orellana L; Nji E; Ahmad S; Rinaldo-Matthis A; Haeggstrom JZ
  • Article: EMBO JOURNAL. 2020;39(24):e105908-4559
    Winklemann I; Matsuoka R; Meier PF; Shutin D; Zhang C; Orellana L; Sexton R; Landreh M; Robinson CV; Beckstein O; Drew D
  • Article: NATURE. 2020;578(7794):321-325
    Qureshi AA; Suades A; Matsuoka R; Brock J; McComas SE; Nji E; Orellana L; Claesson M; Delemotte L; Drew D
  • Journal article: CANCER CELL. 2019;36(6):690-691
    Ma J; Benitez JA; Li J; Miki S; de Albuquerque CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
  • Article: BIOINFORMATICS. 2019;35(18):3505-3507
    Orellana L; Gustaysson J; Bergh C; Yoluk O; Lindahl E
  • Article: MOLECULAR & CELLULAR ONCOLOGY. 2019;6(5):e1630798
    Orellana L
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(20):10009-10018
    Orellana L; Thorne AH; Lema R; Gustavsson J; Parisian AD; Hospital A; Cordeiro TN; Bernado P; Scott AM; Brun-Heath I; Lindahl E; Cavenee WK; Furnari FB; Orozco M
  • Journal article: CANCER CELL. 2019;35(5):816
    Ma J; Benitez JA; Li J; Miki S; de Albuquerque CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
  • Article: CANCER CELL. 2019;35(3):504-518.e7
    Ma J; Benite JA; Li J; Miki S; de Albuquerqu CP; Galatro T; Orellana L; Zanca C; Reed R; Boyer A; Koga T; Varki NM; Fenton TR; Marie SKN; Lindahl E; Gahman TC; Shiau AK; Zhou H; DeGroot J; Sulman EP; Cavenee WK; Kolodner RD; Chen CC; Furnari FB
  • Article: CANCER CELL. 2018;34(1):163-177.e7
    Binder ZA; Thorne AH; Bakas S; Wileyto EP; Bilello M; Akbari H; Rathore S; Ha SM; Zhang L; Ferguson CJ; Dahiya S; Bi WL; Reardon DA; Idbaih A; Felsberg J; Hentschel B; Weller M; Bagley SJ; Morrissette JJD; Nasrallah MP; Ma J; Zanca C; Scott AM; Orellana L; Davatzikos C; Furnari FB; O'Rourke DM
  • Article: NATURE COMMUNICATIONS. 2016;7:12575
    Orellana L; Yoluk O; Carrillo O; Orozco M; Lindahl E
  • Article: NATURE COMMUNICATIONS. 2014;5:4070
    Bryn Fenwick R; Orellana L; Esteban-Martin S; Orozco M; Salvatella X
  • Journal article: SCIENCE. 2013;342(6154):37
    Van der Ploeg MJ
  • Article: JOURNAL OF CHEMICAL THEORY AND COMPUTATION. 2012;8(11):4707-4718
    Sfriso P; Emperador A; Orellana L; Hospital A; Lluis Gelpi J; Orozco M
  • Journal article: SCIENCE. 2012;336(6077):32-34
  • Journal article: ADVANCES IN PROTEIN CHEMISTRY AND STRUCTURAL BIOLOGY, VOL 123: TRANSPORT PROTEINS. 2011;85:183-215
    Orozco M; Orellana L; Hospital A; Naganathan AN; Emperador A; Carrillo O; Gelpi JL
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Alla övriga publikationer

  • Corrigendum: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2023;30(4):565
    Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Robinson CV; Nomura N; Iwata S; Landreh M; Orellana L; Beckstein O; Drew D
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S206
    Scaramozzino D; Orellana L
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S193
    Lee BH; Orellana L
  • Book chapter: ADVANCES IN PROTEIN MOLECULAR AND STRUCTURAL BIOLOGY METHODS. 2022;p. 199-212
    Mhashal A; Emperador A; Orellana L
  • Preprint: BIORXIV. 2021
    Matsuoka R; Fudim R; Jung S; Zhang C; Bazzone A; Chatzikyriakidou Y; Nomura N; Iwata S; Orellana L; Beckstein O; Drew D
  • Conference publication: BIOPHYSICAL JOURNAL. 2021;120(3):105A
    Zhang C; Sexton R; Winkelmann I; Matsuoka R; Meier P; Shutin D; Orellana L; Landreh M; Robinson CV; Drew D; Beckstein O
  • Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):584A
    Howard RJ; Zhuang Y; Heusser SA; Bergh CC; Rovsnik U; Orellana L; Lindahl E
  • Conference publication: BIOPHYSICAL JOURNAL. 2020;118(3):191A
    Bergh C; Orellana L; Heusser SA; Howard RJ; Lindahl E
  • Conference publication: BIOPHYSICAL JOURNAL. 2019;116(3):395A-396A
    Bergh CC; Orellana L; Howard RJ; Lindahl E
  • Conference publication: BIOPHYSICAL JOURNAL. 2019;116(3):245A-246A
    Howard RJ; Zhuang Y; Nakamura S; Lycksell M; Kiik H; Rovsnik U; Bergh C; Heusser SA; Orellana L; Lindahl E
  • Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2019;6:117
    Orellana L
  • Conference publication: BIOPHYSICAL JOURNAL. 2017;112(3):485A
    Orellana L; Yoluk O; Carrillo O; Orozco M; Lindahl E
  • Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):454A
    Yoluk O; Orellana L; Bertaccini EJ; Trudell JR; Lindahl E
  • Conference publication: BIOPHYSICAL JOURNAL. 2016;110(3):54A
    Orellana L; Yoluk O; Orozco M; Lindahl E
  • Conference publication: NEURO-ONCOLOGY. 2016;18:45
    Thorne AH; Orellana L; Parisian A; Cavenee W; Furnari F
  • Preprint: BIORXIV. 2014
    ORELLANA LAURA; HOSPITAL ADAM; OROZCO MODESTO

Forskningsbidrag

  • Swedish Research Council
    1 January 2022 - 31 December 2025

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