̽ѡ

Jens Hjerling-Leffler

Jens Hjerling-Leffler

Senior Forskare | Docent
Telefon: +46852486974
ö: Solnavägen 9, 6C, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Leffler, 171 77 Stockholm
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Om mig

  • Docent och gruppledare
    Arbetar med mognad av neuronala nätverk, neuronal diversitet, musgenetik,  

  • singel-cell sekvensering, transkriptionell reglering, elektrofysiologi and 
  • virusbaserade verktyg.

    Postdoktorvistelser
    2007-2011 Fishell lab, NYU Langone Medical Center, New York, NY, US
    2006-2007 Koltzenburg lab, Queen Square Centre for Neuromuscular Disease, UCL, London, UK

    Doktorsutbildning
    2006 Patrik Ernfors, Medicinsk Biokemi and Biofysik, ̽ѡ, Sverige

    Forskningsvistelser under grundutbildningen
    1999 Frank Pfrieger lab, Max Delbrück Center for Molecular Medicine, Berlin, Germany

Forskningsbeskrivning

  • Vår forskargrupp studerar de genetiska och cellulära mekanismerna för mognaden och funktionen hos hjärnans inhibitoriska system. Vi använder oss
    av avancerad musgenetik i kombination med elektrofysiologi och moderna molekylära metoder för att undersöka rollen som individuella celltyper har och hur deras funktion är baserat på vilka neuronala nätverk de ingår i.

Artiklar

  • Article: NEURON. 2023;111(22):3590-3603.e5
    Munguba H; Nikouei K; Hochgerner H; Oberst P; Kouznetsova A; Ryge J; Munoz-Manchado AB; Close J; Batista-Brito R; Linnarsson S; Hjerling-Leffler J
  • Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2023;75:s85-s86
    Yao S; Harder A; Darki F; Li A; Zeng J; Nikouei K; Lundstrom J; Wray N; Lu Y; Sullivan P; Hjerling-Leffler J
  • Journal article: IBRO REPORTS. 2023;15:s222
    Salguero MD; Harder L; Llorca-Torralba M; Herr M; Reyes JMB; Berrocoso E; Hjerling-Leffler J; Manchado AM
  • Article: BIOLOGY DIRECT. 2023;18(1):22
    Adam AR; Martinez-Lopez JA; van der Spek SJF; Sullivan PF; Smit AB; Verhage M; Hjerling-Leffler J; Achsele T; Andres-Alonso M; Bagni C; Bayes A; Biederer T; Brose N; Chua JJE; Coba M; Cornelisse LN; de Juan-Sanz J; Goldschmidt HL; Gundelfinger ED; Huganir RL; Imig C; Jahn R; Jung H; Kaeser PS; Kim E; Koopmans F; Kreutz MR; Lipstein N; MacGillavry HD; McPherson PS; O'Connor V; Pielot R; Ryan TA; Sala C; Sheng M; Smalla K-H; Thomas PD; Toonen RF; van Weering JRT; Verhage M; Verpelli C
  • Article: STEM CELL REPORTS. 2023;18(1):337-353
    Nishimura K; Yang S; Lee KW; Asgrimsdottir ES; Nikouei K; Paslawski W; Gnodde S; Lyu G; Hu L; Salto C; Svenningsson P; Hjerling-Leffler J; Linnarsson S; Arenas E
  • Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2022;109(6):1077-1091
    Trpchevska N; Freidin MB; Broer L; Oosterloo BC; Yao S; Zhou Y; Vona B; Bishop C; Bizaki-Vallaskangas A; Canlon B; Castellana F; Chasman DI; Cherny S; Christensen K; Concas MP; Correa A; Elkon R; Mengel-From J; Gao Y; Giersch ABS; Girotto G; Gudjonsson A; Gudnason V; Heard-Costa NL; Hertzano R; v.B. Hjelmborg J; Hjerling-Leffler J; Hoffman HJ; Kaprio J; Kettunen J; Krebs K; Kahler AK; Lallemend F; Launer LJ; Lee I-M; Leonard H; Li C-M; Lowenheim H; Magnusson PKE; van Meurs J; Milani L; Morton CC; Makitie A; Nalls MA; Nardone GG; Nygaard M; Palviainen T; Pratt S; Quaranta N; Ramo J; Saarentaus E; Sardone R; Satizabal CL; Schweinfurth JM; Seshadri S; Shiroma E; Shulman E; Simonsick E; Spankovich C; Tropitzsch A; Lauschke VM; Sullivan PF; Goedegebure A; Cederroth CR; Williams FMK; Nagtegaal AP
  • Journal article: BIOLOGICAL PSYCHIATRY. 2022;91(9):s293-s294
    Giusti-Rodriguez P; Abrantes A; Memic F; Dijkstra A; Ancalade N; Sekle S; Hjerling-Leffler J; Smit A; Sullivan P
  • Article: JOURNAL OF NEUROSCIENCE. 2021;41(43):8876-8886
    Munguba H; Chattopadhyaya B; Nilsson S; Carrico JN; Memic F; Oberst P; Batista-Brito R; Munoz-Manchado AB; Wegner M; Fishell G; Di Cristo G; Hjerling-Leffler J
  • Article: MOLECULAR PSYCHIATRY. 2021;26(6):2070-2081
    Byrne EM; Zhu Z; Qi T; Skene NG; Bryois J; Pardinas AF; Stahl E; Smoller JW; Rietschel M; Owen MJ; Walters JTR; O'Donovan MC; McGrath JG; Hjerling-Leffler J; Sullivan PF; Goddard ME; Visscher PM; Yang J; Wray NR
  • Article: NATURE NEUROSCIENCE. 2020;23(12):1456-1468
    Yuste R; Hawrylycz M; Aalling N; Aguilar-Valles A; Arendt D; Arnedillo RA; Ascoli GA; Bielza C; Bokharaie V; Bergmann TB; Bystron I; Capogna M; Chang Y; Clemens A; de Kock CPJ; DeFelipe J; Dos Santos SE; Dunville K; Feldmeyer D; Fiath R; Fishell GJ; Foggetti A; Gao X; Ghaderi P; Goriounova NA; Guentuerkuen O; Hagihara K; Hall VJ; Helmstaedter M; Herculano S; Hilscher MM; Hirase H; Hjerling-Leffler J; Hodge R; Huang J; Huda R; Khodosevich K; Kiehn O; Koch H; Kuebler ES; Kuhnemund M; Larranaga P; Lelieveldt B; Louth EL; Lui JH; Mansvelder HD; Marin O; Martinez-Trujillo J; Moradi Chameh H; Nath A; Nedergaard M; Nemec P; Ofer N; Pfisterer UG; Pontes S; Redmond W; Rossier J; Sanes JR; Scheuermann R; Serrano-Saiz E; Steiger JF; Somogyi P; Tamas G; Tolias AS; Tosches MA; Garcia MT; Vieira HM; Wozny C; Wuttke TV; Yong L; Yuan J; Zeng H; Lein E
  • Article: SCIENTIFIC REPORTS. 2020;10(1):15680
    Gonzales CB; Hunt S; Munoz-Manchado AB; McBain CJ; Hjerling-Leffler J
  • Article: ELIFE. 2020;9:e59328
    Nagaeva E; Zubarev I; Gonzales CB; Forss M; Nikouei K; de Miguel E; Elsila L; Linden A-M; Hjerling-Leffler J; Augustine GJ; Korpi ER
  • Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2020;511:110835
    Lindqvist A; Shcherbina L; Prasad RB; Miskelly MG; Abels M; Martinez-Lopez JA; Fred RG; Nergard BJ; Hedenbro J; Groop L; Hjerling-Leffler J; Wierup N
  • Article: NATURE GENETICS. 2020;52(5):482-493
    Bryois J; Skene NG; Hansen TF; Kogelman LJA; Watson HJ; Liu Z; Brueggeman L; Breen G; Bulik CM; Arenas E; Hjerling-Leffler J; Sullivan PF
  • Article: BMC BIOLOGY. 2020;18(1):6
    Lundin E; Wu C; Widmark A; Behm M; Hjerling-Leffler J; Daniel C; Ohman M; Nilsson M
  • Article: JOURNAL OF CELL BIOLOGY. 2020;219(1):e201905002
    Gongrich C; Krapacher FA; Munguba H; Fernandez-Suarez D; Andersson A; Hjerling-Leffler J; Ibanez CF
  • Article: NATURE METHODS. 2020;17(1):101-106
    Qian X; Harris KD; Hauling T; Nicoloutsopoulos D; Munoz-Manchado AB; Skene N; Hjerling-Leffler J; Nilsson M
  • Article: SCIENCE. 2019;365(6454):695-699
    Abdo H; Calvo-Enrique L; Lopez JM; Song J; Zhang M-D; Usoskin D; El Manira A; Adameyko I; Hjerling-Leffler J; Ernfors P
  • Article: PLOS COMPUTATIONAL BIOLOGY. 2019;15(6):e1007113
    Bomkamp C; Tripathy SJ; Gonzales CB; Hjerling-Leffler J; Craig AM; Pavlidis P
  • Article: NATURE GENETICS. 2019;51(3):394-403
    Jansen PR; Watanabe K; Stringer S; Skene N; Bryois J; Hammerschlag AR; de Leeuw CA; Benjamins JS; Munoz-Manchado AB; Nagel M; Savage JE; Tiemeier H; White T; Tung JY; Hinds DA; Vacic V; Wang X; Sullivan PF; van der Sluis S; Polderman TJC; Smit AB; Hjerling-Leffler J; Van Someren EJW; Posthuma D; Agee M; Alipanahi B; Auton A; Bell RK; Bryc K; Elson SL; Fontanillas P; Furlotte NA; Huber KE; Kleinman A; Litterman NK; McCreight JC; McIntyre MH; Mountain JL; Noblin ES; Northover CAM; Pitts SJ; Sathirapongsasuti JF; Sazonova OV; Shelton JF; Shringarpure S; Tian C; Wilson CH
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Alla övriga publikationer

  • Preprint: MEDRXIV. 2024;MEDRXIV
    Bergstedt J; Pasman JA; Ma Z; Harder A; Yao S; Parker N; Treur JL; Smit DJA; Frei O; Shadrin A; Meijsen JJ; Shen Q; Hägg S; Tornvall P; Buil A; Werge T; Hjerling-Leffler J; Als TD; Børglum AD; Lewis CM; McIntosh AM; Valdimarsdóttir UA; Andreassen OA; Sullivan PF; Lu Y; Fang F
  • Preprint: MEDRXIV. 2024;MEDRXIV
    Yao S; Harder A; Darki F; Chang Y-W; Li A; Nikouei K; Volpe G; Lundström JN; Zeng J; Wray N; Lu Y; Sullivan PF; Leffler JH
  • Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2023;75:S85
    Yao S; Harder A; Darki F; Li A; Zeng J; Nikouei K; Lundstrom J; Wray N; Lu Y; Sullivan P; Hjerling-Leffler J
  • Preprint: BIORXIV. 2023
    Martínez-López JA; Lindqvist A; Lopez-Pascual A; Chen P; Shcherbina L; Chriett S; Skene NG; Prasad RB; Lancien M; Johnson PF; Eliasson P; Louvet C; Muñoz-Manchado AB; Sandberg R; Hjerling-Leffler J; Wierup N
  • Preprint: BIORXIV. 2022
    Adam AR; López JM; van der Spek S; The SYNGO consortium; Sullivan P; Smit A; Verhage M; Hjerling-Leffler J
  • Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:E156
    Abrantes A; Ancalade N; Sekle S; Memic F; Dijkstra A; Tseng E; Sheynkman G; Hjerling-Leffler J; Smit A; Sullivan P; Giusti-Rodriguez P
  • Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;63:E66-E67
    Yao S; Bast L; Martinez-Lopez J; Memic F; Wray N; Sullivan P; Hjerling-Leffler J
  • Preprint: BIORXIV. 2022
    Nishimura K; Yang S; Lee KW; Ásgrímsdóttir ES; Nikouei K; Paslawski W; Gnodde S; Lyu G; Hu L; Saltó C; Svenningsson P; Hjerling-Leffler J; Linnarsson S; Arenas E
  • Conference publication: BIOLOGICAL PSYCHIATRY. 2022;91(9):S293-S294
    Giusti-Rodriguez P; Abrantes A; Memic F; Dijkstra A; Ancalade N; Sekle S; Hjerling-Leffler J; Smit A; Sullivan P
  • Editorial comment: CURRENT OPINION IN GENETICS AND DEVELOPMENT. 2021;68:iii-ix
    Mulle JG; Sullivan PF; Hjerling-Leffler J
  • Corrigendum: NATURE NEUROSCIENCE. 2021;24(4):613
    Yuste R; Hawrylycz M; Aalling N; Aguilar-Valles A; Arendt D; Arnedillo RA; Ascoli GA; Bielza C; Bokharaie V; Bergmann TB; Bystron I; Capogna M; Chang Y; Clemens A; de Kock CPJ; DeFelipe J; Dos Santos SE; Dunville K; Feldmeyer D; Fiáth R; Fishell GJ; Foggetti A; Gao X; Ghaderi P; Goriounova NA; Güntürkün O; Hagihara K; Hall VJ; Helmstaedter M; Herculano S; Hilscher MM; Hirase H; Hjerling-Leffler J; Hodge R; Huang J; Huda R; Khodosevich K; Kiehn O; Koch H; Kuebler ES; Kühnemund M; Larrañaga P; Lelieveldt B; Louth EL; Lui JH; Mansvelder HD; Marin O; Martinez-Trujillo J; Moradi Chameh H; Nath A; Nedergaard M; Němec P; Ofer N; Pfisterer UG; Pontes S; Redmond W; Rossier J; Sanes JR; Scheuermann R; Serrano-Saiz E; Steiger JF; Somogyi P; Tamás G; Tolias AS; Tosches MA; García MT; Vieira HM; Wozny C; Wuttke TV; Yong L; Yuan J; Zeng H; Lein E
  • Corrigendum: NATURE NEUROSCIENCE. 2021;24(4):612
    Yuste R; Hawrylycz M; Aalling N; Aguilar-Valles A; Arendt D; Armañanzas R; Ascoli GA; Bielza C; Bokharaie V; Bergmann TB; Bystron I; Capogna M; Chang Y; Clemens A; de Kock CPJ; DeFelipe J; Dos Santos SE; Dunville K; Feldmeyer D; Fiáth R; Fishell GJ; Foggetti A; Gao X; Ghaderi P; Goriounova NA; Güntürkün O; Hagihara K; Hall VJ; Helmstaedter M; Herculano-Houzel S; Hilscher MM; Hirase H; Hjerling-Leffler J; Hodge R; Huang J; Huda R; Khodosevich K; Kiehn O; Koch H; Kuebler ES; Kühnemund M; Larrañaga P; Lelieveldt B; Louth EL; Lui JH; Mansvelder HD; Marin O; Martinez-Trujillo J; Chameh HM; Mohapatra AN; Munguba H; Nedergaard M; Němec P; Ofer N; Pfisterer UG; Pontes S; Redmond W; Rossier J; Sanes JR; Scheuermann RH; Serrano-Saiz E; Staiger JF; Somogyi P; Tamás G; Tolias AS; Tosches MA; García MT; Wozny C; Wuttke TV; Liu Y; Yuan J; Zeng H; Lein E
  • Conference publication: DIABETOLOGIA. 2021;64(SUPPL 1):8
    Lopez-Pascual A; Lindqvist A; Martinez-Lopez JA; Hjerling-Leffler J; Wierup N
  • Preprint: BIORXIV. 2020
    Nagaeva E; Zubarev I; Gonzales CB; Forss M; Nikouei K; de Miguel E; Elsilä L; Linden A-M; Hjerling-Leffler J; Augustine GJ; Korpi ER
  • Corrigendum: NATURE GENETICS. 2020;52(3):354
    Jansen IE; Savage JE; Watanabe K; Bryois J; Williams DM; Steinberg S; Sealock J; Karlsson IK; Haegg S; Athanasiu L; Voyle N; Proitsi P; Witoelar A; Stringer S; Aarsland D; Almdahl IS; Andersen F; Bergh S; Bettella F; Bjornsson S; Braekhus A; Brathen G; de Leeuw C; Desikan RS; Djurovic S; Dumitrescu L; Fladby T; Hohman TJ; Jonsson PV; Kiddle SJ; Rongve A; Saltvedt I; Sando SB; Selbaek G; Shoai M; Skene NG; Snaedal J; Stordal E; Ulstein ID; Wang Y; White LR; Hardy J; Hjerling-Leffler J; Sullivan PF; van der Flier WM; Dobson R; Davis LK; Stefansson H; Stefansson K; Pedersen NL; Ripke S; Andreassen OA; Posthuma D
  • Preprint: BIORXIV. 2019
    Göngrich C; Krapacher FA; Munguba H; Fernández-Suárez D; Andersson A; Hjerling-Leffler J; Ibáñez CF
  • Preprint: ARXIV. 2019
    Yuste R; Hawrylycz M; Aalling N; Arendt D; Armananzas R; Ascoli G; Bielza C; Bokharaie V; Bergmann T; Bystron I; Capogna M; Chang Y; Clemens A; de Kock C; DeFelipe J; Santos SD; Dunville K; Feldmeyer D; Fiath R; Fishell G; Foggetti A; Gao X; Ghaderi P; Gunturkun O; Hall VJ; Helmstaedter M; Herculano-Houzel S; Hilscher M; Hirase H; Hjerling-Leffler J; Hodge R; Huang ZJ; Huda R; Juan Y; Khodosevich K; Kiehn O; Koch H; Kuebler E; Kuhnemund M; Larranaga P; Lelieveldt B; Louth EL; Lui J; Mansvelder H; Marin O; Martínez-Trujillo J; Moradi H; Goriounova N; Mohapatra A; Nedergaard M; Němec P; Ofer N; Pfisterer U; Pontes S; Redmond W; Rossier J; Sanes J; Scheuermann R; Saiz ES; Somogyi P; Tamás G; Tolias A; Tosches M; Garcia MT; Aguilar-Valles A; Munguba H; Wozny C; Wuttke T; Yong L; Zeng H; Lein ES
  • Preprint: BIORXIV. 2019
    Munguba H; Nikouei K; Hochgerner H; Oberst P; Kouznetsova A; Ryge J; Batista-Brito R; Munoz-Manchado AB; Close J; Linnarsson S; Hjerling-Leffler J
  • Preprint: BIORXIV. 2019
    Byrne EM; Zhu Z; Qi T; Skene NG; Bryois J; Pardinas AF; Stahl E; Smoller JW; Rietschel M; Consortium BWGOTPG; Consortium MDDWGOT; Owen MJ; Walters JTR; O’Donovan MC; McGrath JG; Hjerling-Leffler J; Sullivan PF; Goddard ME; Visscher PM; Yang J; Wray NR
  • Preprint: BIORXIV. 2019
    Bryois J; Skene NG; Hansen TF; Kogelman L; Watson HJ; Liu Z; Consortium EDWGOTP; Consortium IHG; Team AR; Brueggeman L; Breen G; Bulik CM; Arenas E; Hjerling-Leffler J; Sullivan PF
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Forskningsbidrag

  • European Research Council
    1 April 2019 - 31 March 2024

ԲäԾԲ

  • Senior Forskare, Medicinsk biokemi och biofysik, ̽ѡ, 2022-

Examina och utbildning

  • Docent, Neurovetenskap, ̽ѡ, 2023
  • MEDICINE DOKTORSEXAMEN, Institutionen för medicinsk biokemi och biofysik, ̽ѡ, 2006

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