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Gonçalo Castelo-Branco

Gonçalo Castelo-Branco

Professor | Docent
Telefon: +46852487936
µþ±ð²õö°ì²õ²¹»å°ù±ð²õ²õ: Solnavägen 9, 6C, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, C2 Molekylär neurobiologi Castelo-Branco, 171 77 Stockholm
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Om mig

  • Professor i gliacellsbiologi vid institutionen för medicinsk biokemi och biofysik

    Gonçalo Castelo Branco är född i Cantanhede, Portugal, 1976. Han är utbildad i biokemi vid University of Coimbra med examen 1999 och disputerade vid KI 2005. Han gjorde postdocs vid KI 2005-2008 och vid Gurdon Institute, Storbritannien, 2009-2012.

    Castelo Branco Ã¥tervände till KI och började bygga upp en forskargrupp 2012. Han blev docent 2016. 2019 belönades han med Svenska Sällskapet för Medicinsk Forskning Jubileumspriset och 2021 med bÃ¥de Göran Gustafssonpriset i medicin och Eric K Fernströms pris för unga, särskilt lovande och framgÃ¥ngsrika forskare. Gonçalo Castelo Branco har anställts som professor i gliacellsbiologi vid ̽»¨¾«Ñ¡ frÃ¥n 1 november 2021.

Forskningsbeskrivning

  • VÃ¥r forskargrupp är intresserad av de molekylära mekanismer som definierar den epigenetiska tillstÃ¥nd av stam/progenitorceller, sÃ¥som pluripotenta celler och oligodendrocytprekursorceller. Vi är särskilt fokuserade pÃ¥ hur samspelet mellan transkriptionsfaktorer , icke -kodande RNA och kromatin modifierande enzymer bidrar till övergÃ¥ngen mellan epigenetiska tillstÃ¥nd i oligodendrocytprekursorceller, och kunde pÃ¥ sÃ¥ sätt leda till terapier för sjukdomar som multipel skleros .

Utvalda publikationer

  • Article: CELL. 2024;187(8):1990-2009.e19
    Kukanja P; Langseth CM; Rodriguez-Kirby LAR; Agirre E; Zheng C; Raman A; Yokota C; Avenel C; Tiklova K; Guerreiro-Cacais AO; Olsson T; Hilscher MM; Nilsson M; Castelo-Branco G
  • Article: NATURE BIOTECHNOLOGY. 2023;41(6):794-805
    Bartosovic M; Castelo-Branco G
  • Article: NATURE. 2022;609(7926):375-383
    Deng Y; Bartosovic M; Ma S; Zhang D; Kukanja P; Xiao Y; Su G; Liu Y; Qin X; Rosoklija GB; Dwork AJ; Mann JJ; Xu ML; Halene S; Craft JE; Leong KW; Boldrini M; Castelo-Branco G; Fan R
  • Article: NEURON. 2022;110(7):1193-1210.e13
    Meijer M; Agirre E; Kabbe M; van Tuijn CA; Heskol A; Zheng C; Falcao AM; Bartosovic M; Kirby L; Calini D; Johnson MR; Corces MR; Montine TJ; Chen X; Chang HY; Malhotra D; Castelo-Branco G
  • Article: SCIENCE. 2022;375(6581):681-686
    Deng Y; Bartosovic M; Kukanja P; Zhang D; Liu Y; Su G; Enninful A; Bai Z; Castelo-Branco G; Fan R
  • Article: NATURE BIOTECHNOLOGY. 2021;39(7):825-835
    Bartosovic M; Kabbe M; Castelo-Branco G
  • Article: NATURE. 2019;566(7745):543-547
    Jakel S; Agirre E; Falcao AM; Van Bruggen D; Lee KW; Knuesel I; Malhotra D; Ffrench-Constant C; Williams A; Castelo-Branco G
  • Article: NATURE MEDICINE. 2018;24(12):1837-1844
    Falcao AM; van Bruggen D; Marques S; Meijer M; Jakel S; Agirre E; Samudyata; Floriddia EM; Vanichkina DP; Ffrench-Constant C; Williams A; Guerreiro-Cacais AO; Castelo-Branco G
  • Article: DEVELOPMENTAL CELL. 2018;46(4):504-517.e7
    Marques S; van Bruggen D; Vanichkina DP; Floriddia EM; Munguba H; Varemo L; Giacomello S; Falcao AM; Meijer M; Bjorklund AK; Hjerling-Leffler J; Taft RJ; Castelo-Branco G
  • Article: SCIENCE. 2016;352(6291):1326-1329
    Marques S; Zeisel A; Codeluppi S; van Bruggen D; Falcao AM; Xiao L; Li H; Haring M; Hochgerner H; Romanov RA; Gyllborg D; Munoz-Manchado AB; La Manno G; Lonnerberg P; Floriddia EM; Rezayee F; Ernfors P; Arenas E; Hjerling-Leffler J; Harkany T; Richardson WD; Linnarsson S; Castelo-Branco G

Artiklar

  • Article: NATURE NEUROSCIENCE. 2024;27(12):2267-2268
    Ernfors P; Castelo-Branco G; Uhlen P; Linnarsson S; Marklund U; Hjerling-Leffler J; Dagliyan O
  • Article: SCIENCE. 2024;386(6724):907-915
    Kanatani S; Kreutzmann JC; Li Y; West Z; Larsen LL; Nikou DV; Eidhof I; Walton A; Zhang S; Rodriguez-Kirby LR; Skytte JL; Salinas CG; Takamatsu K; Li X; Tanaka DH; Kaczynska D; Fukumoto K; Karamzadeh R; Xiang Y; Uesaka N; Tanabe T; Adner M; Hartman J; Miyakawa A; Sundstrom E; Castelo-Branco G; Roostalu U; Hecksher-Sorensen J; Uhlen P
  • Article: NATURE NEUROSCIENCE. 2024;27(9):1668-1674
    Sasmita AO; Depp C; Nazarenko T; Sun T; Siems SB; Ong EC; Nkeh YB; Boehler C; Yu X; Bues B; Evangelista L; Mao S; Morgado B; Wu Z; Ruhwedel T; Subramanian S; Boerensen F; Overhoff K; Spieth L; Berghoff SA; Sadleir KR; Vassar R; Eggert S; Goebbels S; Saito T; Saido T; Saher G; Moebius W; Castelo-Branco G; Klafki H-W; Wirths O; Wiltfang J; Jaekel S; Yan R; Nave K-A
  • Article: NATURE NEUROSCIENCE. 2024;27(8):1545-1554
    Foerster S; Floriddia EM; van Bruggen D; Kukanja P; Herve B; Cheng S; Kim E; Phillips BU; Heath CJ; Tripathi RB; Call C; Bartels T; Ridley K; Neumann B; Lopez-Cruz L; Crawford AH; Lynch CJ; Serrano M; Saksida L; Rowitch DH; Moebius W; Nave K-A; Rasband MN; Bergles DE; Kessaris N; Richardson WD; Bussey TJ; Zhao C; Castelo-Branco G; Franklin RJM
  • Article: NATURE PROTOCOLS. 2024;19(3):791-830
    Barcenas-Walls JR; Ansaloni F; Herve B; Strandback E; Nyman T; Castelo-Branco G; Bartosovic M
  • Article: PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON. BIOLOGICAL SCIENCES. 2023;378(1890):20220451
    Patil KV; Meijer M; Mak KH-M; Yang W; Falcao AM; Castelo-Branco G; Genander M
  • Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2023;11(1):84
    Seeker LA; Bestard-Cuche N; Jaekel S; Kazakou N-L; Bostrand SMK; Wagstaff LJ; Cholewa-Waclaw J; Kilpatrick AM; Van Bruggen D; Kabbe M; Baldivia Pohl F; Moslehi Z; Henderson NC; Vallejos CA; La Manno G; Castelo-Branco G; Williams A
  • Article: NATURE. 2023;616(7955):113-122
    Zhang D; Deng Y; Kukanja P; Agirre E; Bartosovic M; Dong M; Ma C; Ma S; Su G; Bao S; Liu Y; Xiao Y; Rosoklija GB; Dwork AJ; Mann JJ; Leong KW; Boldrini M; Wang L; Haeussler M; Raphael BJ; Kluger Y; Castelo-Branco G; Fan R
  • Article: NATURE NEUROSCIENCE. 2022;25(8):1104-1112
    Bryois J; Calini D; Macnair W; Foo L; Urich E; Ortmann W; Iglesias VA; Selvaraj S; Nutma E; Marzin M; Amor S; Williams A; Castelo-Branco G; Menon V; De Jager P; Malhotra D
  • Article: DEVELOPMENTAL CELL. 2022;57(11):1421-1436.e5
    van Bruggen D; Pohl F; Langseth CM; Kukanja P; Lee H; Albiach AM; Kabbe M; Meijer M; Linnarsson S; Hilscher MM; Nilsson M; Sundstrom E; Castelo-Branco G
  • Article: BMC BIOLOGY. 2022;20(1):122
    Hilscher MM; Langseth CM; Kukanja P; Yokota C; Nilsson M; Castelo-Branco G
  • Article: NATURE. 2021;599(7886):684-691
    Winick-Ng W; Kukalev A; Harabula I; Zea-Redondo L; Szabo D; Meijer M; Serebreni L; Zhang Y; Bianco S; Chiariello AM; Irastorza-Azcarate I; Thieme CJ; Sparks TM; Carvalho S; Fiorillo L; Musella F; Irani E; Triglia ET; Kolodziejczyk AA; Abentung A; Apostolova G; Paul EJ; Franke V; Kempfer R; Akalin A; Teichmann SA; Dechant G; Ungless MA; Nicodemi M; Welch L; Castelo-Branco G; Pombo A
  • Article: NATURE COMMUNICATIONS. 2020;11(1):5860
    Floriddia EM; Lourenco T; Zhang S; van Bruggen D; Hilscher MM; Kukanja P; dos Santos JPG; Altinkok M; Yokota C; Llorens-Bobadilla E; Mulinyawe SB; Graos M; Sun LO; Frisen J; Nilsson M; Castelo-Branco G
  • Article: NATURE COMMUNICATIONS. 2020;11(1):4071
    Carlstrom KE; Zhu K; Ewing E; Krabbendam IE; Harris RA; Falcao AM; Jagodic M; Castelo-Branco G; Piehl F
  • Article: GLIA. 2020;68(8):1619-1630
    Samudyata; Castelo-Branco G; Liu J
  • Article: NATURE NEUROSCIENCE. 2020;23(3):363-374
    Marisca R; Hoche T; Agirre E; Hoodless LJ; Barkey W; Auer F; Castelo-Branco G; Czopka T
  • Article: NATURE COMMUNICATIONS. 2020;11(1):1018
    Bonetti A; Agostini F; Suzuki AM; Hashimoto K; Pascarella G; Gimenez J; Roos L; Nash AJ; Ghilotti M; Cameron CJF; Valentine M; Medvedeva YA; Noguchi S; Agirre E; Kashi K; Samudyata; Luginbuhl J; Cazzoli R; Agrawal S; Luscombe NM; Blanchette M; Kasukawa T; de Hoon M; Arner E; Lenhard B; Plessy C; Castelo-Branco G; Orlando V; Carninci P
  • Article: CELL REPORTS. 2019;29(4):904-919.e9
    Tripathi A; Volsko C; Garcia JP; Agirre E; Allan KC; Tesar PJ; Trapp BD; Castelo-Branco G; Sim FJ; Dutta R
  • Article: EXPERIMENTAL CELL RESEARCH. 2019;381(1):129-138
    Samudyata; Amaral PP; Engstrom PG; Robson SC; Nielsen ML; Kouzarides T; Castelo-Branco G
  • Article: CELL REPORTS. 2019;27(8):2508-2523.e4
    Kupari J; Haring M; Agirre E; Castelo-Branco G; Ernfors P
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Alla övriga publikationer

  • Review: TRENDS IN IMMUNOLOGY. 2024;45(10):750-759
    Castelo-Branco G; Kukanja P; Guerreiro-Cacais AO; Rubio Rodríguez-Kirby LA
  • Preprint: BIORXIV. 2024
    Rodríguez-López C; Hernández IH; Terrón-Bautista J; Agirre E; Lozano-Muñoz D; Pose-Utrilla J; García-Ortiz I; Lucas-Santamaría M; Ruiz-Blas I; González-Bermejo M; Ortega MC; Chara JC; Martínez Z; Pérez-Cerdá F; Fransen NL; Martínez-Jiménez M; Sancho-González B; Pérez-Samartín A; Kabbe M; Zheng C; Casado-Barbero M; Santos-Galindo M; Borroto A; Alarcón B; Clemente D; Toma C; Matute C; Cortés-Ledesma F; Castelo-Branco G; Lucas JJ
  • Preprint: BIORXIV. 2024;BIORXIV
    Zhang D; Rubio Rodríguez-Kirby LA; Lin Y; Song M; Wang L; Wang L; Kanatani S; Jimenez-Beristain T; Dang Y; Zhong M; Kukanja P; Wang S; Chen XL; Gao F; Wang D; Xu H; Lou X; Liu Y; Chen J; Sestan N; Uhlén P; Kriegstein A; Zhao H; Castelo-Branco G; Fan R
  • Book chapter: NEUROPSYCHIATRIC DISORDERS AND EPIGENETICS. 2024;p. 183-223
    Kular L; Castelo-Branco G; Jagodic M
  • Preprint: BIORXIV. 2023
    Zheng C; Hervé B; Meijer M; Rubio Rodríguez-Kirby LA; Guerreiro Cacais AO; Kukanja P; Kabbe M; Olsson T; Agirre E; Castelo-Branco G
  • Preprint: BIORXIV. 2023
    Sasmita AO; Depp C; Nazarenko T; Sun T; Siems S; Yu X; Boehler C; Ong EC; Bues B; Evangelista L; Morgado B; Wu Z; Ruhwedel T; Subramanian S; Börensen F; Overhoff K; Spieth L; Berghoff S; Sadleir KR; Vassar R; Eggert S; Goebbels S; Saito T; Saido T; Möbius W; Castelo-Branco G; Klafki H-W; Wirths O; Wiltfang J; Jäkel S; Yan R; Nave K-A
  • Preprint: BIORXIV. 2023
    Langseth CM; Kukanja P; Rubio Rodríguez-Kirby LA; Agirre E; Raman A; Yokota C; Avenel C; Tiklová K; Guerreiro-Cacais AO; Olsson T; Hilscher MM; Nilsson M; Castelo-Branco G
  • Editorial comment: NATURE BIOTECHNOLOGY. 2023;41(6):767-768
    Bartosovic M; Castelo-Branco G
  • Editorial comment: NATURE. 2022;611(7937):670-671
    Carlstrom K; Castelo-Branco G
  • Preprint: BIORXIV. 2022
    Macnair W; Calini D; Agirre E; Bryois J; Jäkel S; Kukanja P; Stokar N; Ott V; Foo L; Collin L; Schippling S; Urich E; Nutma E; Marzin M; Amor S; Magliozzi R; Heidari E; Robinson M; ffrench-Constant C; Castelo-Branco G; Williams A; Malhotra D
  • Editorial comment: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;116:1-2
    Chrast R; Castelo-Branco G
  • Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2021;116:45-52
    Kirby L; Castelo-Branco G
  • Corrigendum: NATURE COMMUNICATIONS. 2021;12(1):3128
    Bonetti A; Agostini F; Suzuki AM; Hashimoto K; Pascarella G; Gimenez J; Roos L; Nash AJ; Ghilotti M; Cameron CJF; Valentine M; Medvedeva YA; Noguchi S; Agirre E; Kashi K; Samudyata; Luginbuehl J; Cazzoli R; Agrawal S; Luscombe NM; Blanchette M; Kasukawa T; de Hoon M; Arner E; Lenhard B; Plessy C; Castelo-Branco G; Orlando V; Carninci P
  • Editorial comment: CELL STEM CELL. 2019;24(5):677-679
    Floriddia EM; Castelo-Branco G
  • Review: SEMINARS IN CELL AND DEVELOPMENTAL BIOLOGY. 2018;79:143-152
    Samudyata; Castelo-Branco G; Bonetti A
  • Review: CURRENT OPINION IN NEUROBIOLOGY. 2017;47:168-175
    van Bruggen D; Agirre E; Castelo-Branco G
  • Editorial comment: BRIEFINGS IN FUNCTIONAL GENOMICS. 2013;12(3):161-163
    Castelo-Branco G; Bannister AJ
  • Thesis / dissertation: 2004
    Castelo-Branco, Gonçalo de Sá e Sousa de
  • Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(46):16390
    Castelo-Branco G; Wagner J; Rodriguez FJ; Kele J; Sousa K; Rawal N; Pasolli HA; Fuchs E; Kitajewski J; Arenas E

Forskningsbidrag

  • KAW Scholar
    Knut and Alice Wallenberg stiftelse
    1 September 2024 - 31 August 2029
  • Swedish Research Council
    1 January 2024 - 31 December 2031
  • ERC Advanced Grant
    European Research Council
    1 January 2024 - 31 December 2028
  • Swedish Research Council
    1 January 2020 - 31 December 2024
  • Swedish Research Council
    1 January 2016 - 31 December 2019

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  • Professor, Medicinsk biokemi och biofysik, ̽»¨¾«Ñ¡, 2021-

Examina och utbildning

  • Docent, Neurobiologi, ̽»¨¾«Ñ¡, 2016
  • FILOSOFIE DOKTOR, Institutionen för medicinsk biokemi och biofysik, ̽»¨¾«Ñ¡, 2005

Uppdrag

  • Administrativ chef, Deputy Head of Department, Department of Medical Biochemistry and Biophysics, ̽»¨¾«Ñ¡, 2024-
  • Administrativ chef, Chair of Senate, Department of Medical Biochemistry and Biophysics, ̽»¨¾«Ñ¡, 2024-

Uppdrag i kommitté

  • Medlem, Nobelförsamlingen vid ̽»¨¾«Ñ¡, ̽»¨¾«Ñ¡, 2023-

Nyheter från KI

Kalenderhändelser från KI