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Axel Abelein

Axel Abelein

Biträdande Lektor | Docent
E-postadress: axel.abelein@ki.se
µþ±ð²õö°ì²õ²¹»å°ù±ð²õ²õ: BlickagÃ¥ngen 16, Neo, Flemingsberg, 14152 Hudding
Postadress: H7 Medicin, Huddinge, H7 BioNut Abelein, 171 77 Stockholm
Del av:

Forskningsbeskrivning

  • My research concerns protein self-assembly related to neurodegenerative
    diseases with the focus on characterization of protein structure and
    molecular mechanisms of self-assembly. The studies in our lab include a
    broad range of different techniques within biophysics, protein
    biochemistry and biomedicine. My current research focuses on the
    aggregation mechanisms of amyloid-β peptide (Aβ) fibril formation,
    associated to Alzheimer’s disease and inhibition mechanisms by the
    BRICHOS domain, a chaperone-like protein that is potential candidate to be
    implemented in Alzheimer’s disease treatment. Furthermore, another research
    line is the development of new expression and purification protocols for
    aggregation-prone proteins using a spider silk-derived solubility tag, where
    one possible application is the generation of new biomaterials.
    Please visit our group homepage for more information:
    /en/bionut/laboratory-for-protein-misfolding-and-assembly

Utvalda publikationer

  • Article: PROTEIN SCIENCE. 2024;33(8):e5091
    Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstal H; Otzen DE; Johansson J; Abelein A
  • Journal article: NATURE COMMUNICATIONS. 2024;15(1):965
    Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstål H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
  • Article: NATURE COMMUNICATIONS. 2024;15(1):965
    Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
  • Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511
    Kumar R; Arroyo-Garcia LE; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
  • Article: MOLECULAR THERAPY. 2023;31(2):487-502
    Manchanda S; Galan-Acosta L; Abelein A; Tambaro S; Chen G; Nilsson P; Johansson J
  • Article: JACS AU. 2022;2(11):2571-2584
    Abelein A; Ciofi-Baffoni S; Morman C; Kumar R; Giachetti A; Piccioli M; Biverstal H
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(21):7224-7234
    Wallin C; Jarvet J; Biverstal H; Warmlander S; Danielsson J; Graslund A; Abelein A
  • Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
    Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
  • Article: NATURE COMMUNICATIONS. 2017;8(1):2081
    Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
  • Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2016;138(21):6893-6902
    Abelein A; Jarvet J; Barth A; Graslund A; Danielsson J
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(17):5407-5412
    Abelein A; Graslund A; Danielsson J

Artiklar

  • Article: PROTEIN SCIENCE. 2024;33(7):e5063
    Chen G; Wang Y; Zheng Z; Jiang W; Leppert A; Zhong X; Belorusova A; Siegal G; Jegerschold C; Koeck PJB; Abelein A; Hebert H; Knight SD; Johansson J
  • Journal article: BIOPHYSICAL JOURNAL. 2024;123(3):413a-414a
    Morman C; Leppert A; Johansson J; Luo J; Abelein A
  • Article: COMMUNICATIONS BIOLOGY. 2023;6(1):497
    Chen G; Leppert A; Poska H; Nilsson HE; Alvira CP; Zhong X; Koeck P; Jegerschold C; Abelein A; Hebert H; Johansson J
  • Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358
    Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
  • Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211
    Zhong X; Kumar R; Wang Y; Biverstal H; Jegerschoeld CI; Koeck PJB; Johansson J; Abelein A; Chen G
  • Article: NATURE COMMUNICATIONS. 2022;13(1):4695
    Arndt T; Jaudzems K; Shilkova O; Francis J; Johansson M; Laity PR; Sahin C; Chatterjee U; Kronqvist N; Barajas-Ledesma E; Kumar R; Chen G; Stromberg R; Abelein A; Langton M; Landreh M; Barth A; Holland C; Johansson J; Rising A
  • Article: EMBO REPORTS. 2022;23(7):e54405
    Brackhan M; Calza G; Lundgren K; Bascunana P; Bruning T; Soliymani R; Kumar R; Abelein A; Baumann M; Lalowski M; Pahnke J
  • Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2022;10(1):96
    Jiang R; Smailovic U; Haytural H; Tijms BM; Li H; Haret RM; Shevchenko G; Chen G; Abelein A; Gobom J; Frykman S; Sekiguchi M; Fujioka R; Watamura N; Sasaguri H; Nystrom S; Hammarstrom P; Saido TC; Jelic V; Syvanen S; Zetterberg H; Winblad B; Bergquist J; Visser PJ; Nilsson P
  • Article: STRUCTURE. 2022;30(5):733-742.e7
    Kaldmae M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Osterlund N; Ilag LL; Vaananen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
  • Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303
    Jiang R; Shimozawa M; Mayer J; Tambaro S; Kumar R; Abelein A; Winblad B; Bogdanovic N; Nilsson P
  • Article: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 2021;198:113996
    Tigro H; Kronqvist N; Abelein A; Galan-Acosta L; Chen G; Landreh M; Lyashkov A; Aon MA; Ferrucci L; Shimmo R; Johansson J; Moaddel R
  • Article: BIOCHEMISTRY. 2021;60(9):678-688
    Leppert A; Tiiman A; Kronqvist N; Landreh M; Abelein A; Vukojevic V; Johansson J
  • Article: SCIENTIFIC REPORTS. 2020;10(1):21765
    Biverstal H; Kumar R; Schellhaus AK; Sarr M; Dantuma NP; Abelein A; Johansson J
  • Article: FEBS JOURNAL. 2020;287(13):2823-2833
    Kaldmae M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Lain S; Biverstal H; Jornvall H; Lane DP; Rising A; Johansson J; Landreh M
  • Article: SCIENTIFIC REPORTS. 2020;10(1):235
    Abelein A; Chen G; Kitoka K; Aleksis R; Oleskovs F; Sarr M; Landreh M; Pahnke J; Nordling K; Kronqvist N; Jaudzems K; Rising A; Johansson J; Biverstal H
  • Article: JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY. 2016;38:183-193
    Wallin C; Kulkarni YS; Abelein A; Jarvet J; Liao Q; Strodel B; Olsson L; Luo J; Abrahams JP; Sholts SB; Roos PM; Kamerlin SCL; Graslund A; Warmlander SKTS
  • Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704
    Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstal H; Crux S; Fisahn A; Presto J; Johansson J
  • Journal article: BIOPHYSICAL JOURNAL. 2015;108(2):64a
    Graslund A; Abelein A; Danielsson J
  • Article: CHEMBIOCHEM. 2013;14(14):1692-1704
    Warmlander S; Tiiman A; Abelein A; Luo J; Jarvet J; Soderberg KL; Danielsson J; Graslund A
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(32):23518-23528
    Abelein A; Kaspersen JD; Nielsen SB; Jensen GV; Christiansen G; Pedersen JS; Danielsson J; Otzen DE; Graslund A
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Alla övriga publikationer

  • Preprint: BIORXIV. 2023
    Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstål H; Otzen DE; Johansson J; Abelein A
  • Review: ACCOUNTS OF CHEMICAL RESEARCH. 2023;56(19):2653-2663
    Abelein A
  • Review: PROTEIN SCIENCE. 2023;32(6):e4645
    Leppert A; Poska H; Landreh M; Abelein A; Chen G; Johansson J
  • Review: RSC MEDICINAL CHEMISTRY. 2023;14(5):848-857
    Abelein A; Johansson J
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S96
    Molenkamp W; Kronqvist N; Johansson J; Abelein A
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S89
    Kumar R; Garcia LEA; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S97
    Morman C; Leppert A; Johansson J; Luo J; Abelein A
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S189
    Klute H; Adam L; Molenkamp W; Kumar R; Johansson J; Abelein A
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S54
    Abelein A; Kumar R; Le Marchand T; Adam L; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G
  • Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S168
    Adam L; Kumar R; Molenkamp W; Alkenayeh R; Biverstal H; Johansson J; Abelein A
  • Review: FRONTIERS IN MOLECULAR BIOSCIENCES. 2023;10:1193458
    Pena-Bautista C; Kumar R; Baquero M; Johansson J; Chafer-Pericas C; Abelein A; Ferreira D
  • Conference publication: ALZHEIMERS & DEMENTIA. 2021;17(S5)
    Jiang R; Smailovic U; Haytural H; Haret RM; Shevchenko G; Tijms B; Gobom J; Abelein A; Johansson J; Zetterberg H; Winblad B; Frykman S; Jelic V; Bergquist J; Visser PJ; Nilsson P
  • Conference publication: PROTEIN SCIENCE. 2017;26:31-32
    Chen G; Abelein A; Leppert A; Tambaro S; Biverstal H; Presto J; Johansson J
  • Review: JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 2014;19(4-5):623-634
    Abelein A; Abrahams JP; Danielsson J; Graslund A; Jarvet J; Luo J; Tiiman A; Warmlander SKTS
  • Corrigendum: FEBS LETTERS. 2013;587(9):1452
    Abelein A; Lang L; Lendel C; Graslund A; Danielsson J

Forskningsbidrag

  • Swedish Research Council
    1 January 2024 - 31 December 2027
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2021 - 31 December 2024

´¡²Ô²õ³Ùä±ô±ô²Ô¾±²Ô²µ²¹°ù

  • Biträdande Lektor, Medicin, Huddinge, ̽»¨¾«Ñ¡, 2024-2026

Examina och utbildning

  • Docent, Biofysik, ̽»¨¾«Ñ¡, 2024

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