̽ѡ

Anna Karlsson

Anna Karlsson

ʰǴڱǰ/𳦾ٱä첹 | Docent
E-postadress: anna.karlsson@ki.se
Telefon: +46852483914
ö: Nobels väg 7, 17165 Solna
Postadress: H5 Laboratoriemedicin, H5 Klin Mikrobiologi Anna Karlsson, 141 52 Huddinge
Del av:

Om mig

  • Jag har sedan många år en forskargrupp som har fokus på utveckling av bättre behandling av virussjukdomar och cancer. Vi studerar hur byggstenarna till DNA tillverkas och hur man i den syntesvägen kan stoppa DNA-syntesen för virus samt för cancerceller. Genom vårt smala fokus har vi genom åren varit framgångsrika och bidragit med flera upptäckter. Jag är också verksam som läkare inom virologisk diagnostik och har en kombinationstjänst vid mikrobiologiska kliniken på Karolinska Universitetssjukhuset. I min verksamhet vid ̽ѡ har jag haft många uppdrag. Jag har under många år varit aktiv i Disputationskommitté Syd och därefter i Docenturnämnden. Jag var under en period vice ordförande i Rekryteringsutskottet. Jag har tidigare varit lärarrepresentant i Styrelsen för Forskarutbildning och är under nuvarande mandatperiod lärarrepresentant i Forskningsstyrelsen samt i Forskningsstrategiska kommittén. Ett viktigt externt uppdrag som jag har sedan flera år är som Vetenskaplig sekreterare på Cancerfonden.

    Utbildning
    Läkarlinjen, ̽ѡ (1978-1985)
    Läkarexamen, ̽ѡ (January 18, 1985)
    1985-1990, Forskarutbildning, ̽ѡ (Thesis Adviser: Prof. Peter Reichard and Prof. Britta Wahren)
    April 27, 1990, Degree of Doctor in Medical Sciences (Ph.D)
    1994- 1995, Postdoc position, Pasteur Institute, Paris, France
    1996, Docent i Medicinsk Biokemi, ̽ѡ
    1998, Residence in Clinical Virology, Huddinge University Hospital, Stockholm
    2000- 2006, Senior Research Position, Swedish Cancer Society
    2008, Specialist in Clinical Virology, Karolinska Hospital
    2008, Professor in Clinical Virology, Karolinska Institute

    Akademiska priser och utmärkelser
    1994, European Molecular Biology Organization (EMBO), fellowship
    1994, Wennergren foundation, fellowship
    1995, Institut National de la Santé et de la Recherche Médicale (INSERM), fellowship
    1996, Citation Impact in AIDS Research, 1993-1995
  • 11.64 Cites per paper, Rank 21, (among authors publishing 20 papers or more). Source: ISI’s Science Indicators Database
    2001, Descartes Prize “Outstanding research results from transnational collaboration”

Forskningsbeskrivning

  • My research focus is nucleotide metabolism/ chemotherapy with special focus on anti-viral and anti-cancer therapy. During the 1990s I was greatly involved in the international network developing the combination treatment strategies for HIV infection that today is established in clinical use. My focus was to determine the RT mutations occurring and to elucidate treatment strategies to circumvent resistance development. During these years I was ranked among the most cited scientists in HIV research. In recent years I have initiated a project with a novel concept for antiviral treatment that is based on a different strategy focusing on viral entry.

    During the years my research group has identified and characterized several nucleoside and nucleotide kinases. We were the first to clone and characterize the mitochondrial thymidine kinase 2 and deoxyguanosine kinase as well as the multisubstrate nucleoside kinase from Drosophila melanogaster that we also demonstrated to be an excellent gene candidate for suicide gene therapy. Some of the enzymes we have identified have mitochondrial translocation signal whereas other have nuclear or cytosolic expression. We have studied the importance of the intracellular location of nucleoside kinases for the cytotoxicity of nucleoside analogs and also how intracellular compartment can be used in suicide gene constructs. We have established the first model to study deficiency of mitochondrial thymidine kinase 2 (TK2) by creating a strain of TK2 knock-out mice. The phenotype clearly demonstrates the importance of mitochondrial TK2 for cell growth and survival and thus consequently reveals this enzyme as a possible target to arrest tumor growth. We are presently developing treatment strategies to compensate for the mitochondrial deficiency that may be of clinical relevance in mitochondrial disease and related disorders.

Artiklar

  • Article: PLOS ONE. 2022;17(6):e0270418
    Zhao Q; Zhou X; Kuiper R; Curbo S; Karlsson A
  • Article: HUMAN MOLECULAR GENETICS. 2021;30(21):2012-2026
    Zhou X; Mikaeloff F; Curbo S; Zhao Q; Kuiper R; Vegvari A; Neogi U; Karlsson A
  • Article: FRONTIERS IN GENETICS. 2021;12:658446
    Aleshin VA; Zhou X; Krishnan S; Karlsson A; Bunik VI
  • Article: BIOCHEMISTRY (MOSCOW). 2020;85(7):801-807
    Bunik VI; Aleshin VA; Zhou X; Krishnan S; Karlsson A
  • Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(11):E3759-3759
    Bunik VI; Aleshin VA; Zhou X; Tabakov VY; Karlsson A
  • Article: HUMAN MOLECULAR GENETICS. 2019;28(17):2874-2884
    Zhou X; Curbo S; Zhao Q; Krishnan S; Kuiper R; Karlsson A
  • Article: EBIOMEDICINE. 2019;46:342-355
    Blazquez-Bermejo C; Molina-Granada D; Vila-Julia F; Jimenez-Heis D; Zhou X; Torres-Torronteras J; Karlsson A; Marti R; Camara Y
  • Article: BIOCHEMICAL PHARMACOLOGY. 2018;156:444-450
    Zhao Q; Zhou X; Curbo S; Karlsson A
  • Article: BMC CANCER. 2018;18(1):559
    Zhou X; Curbo S; Li F; Krishnan S; Karlsson A
  • Article: PLOS ONE. 2016;11(1):e0147773
    Reiser K; Mathys L; Curbo S; Pannecouque C; Noppen S; Liekens S; Engman L; Lundberg M; Balzarini J; Karlsson A
  • Article: ONCOLOGY REPORTS. 2015;34(3):1487-1493
    Jiang H; Zhao L; Dong X; He A; Zheng C; Johansson M; Karlsson A; Zheng X
  • Article: ONCOTARGET. 2015;6(11):9271-9283
    Zhou X; Paredes JA; Krishnan S; Curbo S; Karlsson A
  • Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(4):1059-1064
    Bartesaghi S; Graziano V; Galavotti S; Henriquez NV; Betts J; Saxena J; Deli A; Karlsson A; Martins LM; Capasso M; Nicotera P; Brandner S; De Laurenzi V; Salomoni P
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(47):32835-32844
    Krishnan S; Paredes JA; Zhou X; Kuiper RV; Hultenby K; Curbo S; Karlsson A
  • Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2013;45(5):925-931
    Amiri M; Conserva F; Panayiotou C; Karlsson A; Solaroli N
  • Article: ANTIOXIDANTS AND REDOX SIGNALING. 2013;18(7):795-799
    Curbo S; Reiser K; Rundlof A-K; Karlsson A; Lundberg M
  • Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(7):5072-5079
    Krishnan S; Zhou X; Paredes JA; Kuiper RV; Curbo S; Karlsson A
  • Article: PLOS ONE. 2013;8(3):e58843
    Zhou X; Kannisto K; Curbo S; von Dobeln U; Hultenby K; Isetun S; Gafvels M; Karlsson A
  • Article: CANCER LETTERS. 2013;328(1):95-103
    Dong X; Qu W; Ma S; Zhu Z; Zheng C; He A; Karlsson A; Xu K; Zheng X
  • Article: PLOS ONE. 2013;8(1):e53698
    Paredes JA; Zhou X; Hoglund S; Karlsson A
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Alla övriga publikationer

  • Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(11):E1401
    Bartesaghi S; Graziano V; Galavotti S; Henriquez NV; Betts J; Saxena J; Minieri V; A D; Karlsson A; Martin LM; Capasso M; Nicotera P; Brandner S; De laurenzi V; Salomoni P
  • Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND CELL BIOLOGY. 2014;49:75-83
    Panayiotou C; Solaroli N; Karlsson A
  • Editorial comment: NEUROLOGY. 2013;81(23):2051-2053
    Alston CL; Schaefer AM; Raman P; Solaroli N; Krishnan KJ; Blakely EL; He L; Craig K; Roberts M; Vyas A; Nixon J; Horvath R; Turnbull DM; Karlsson A; Gorman GS; Taylor RW
  • Review: CURRENT PHARMACEUTICAL DESIGN. 2012;18(20):2981-2994
    Priego E-M; Karlsson A; Gago F; Camarasa M-J; Balzarini J; Perez-Perez M-J
  • Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2008;27(6-7):746-749
    Bjerke M; Balzarini J; Karlsson A
  • Review: REVIEWS ON RECENT CLINICAL TRIALS. 2006;1(3):185-192
    Curbo S; Karlsson A
  • Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2006;25(9-11):1189-1192
    Solaroli N; Johansson M; Balzarini J; Karlsson A
  • Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2006;25(9-11):987-990
    Bjerke M; Franco M; Johansson M; Balzarini J; Karlsson A
  • Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2004;23(8-9):1527-1529
    Solaroli N; Bjerke M; Johansson M; Karlsson A
  • Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2004;23(8-9):1495-1498
    Curbo S; Johansson M; Karlsson A
  • Review: PHARMACOLOGY AND THERAPEUTICS. 2003;100(2):119-139
    Van Rompay AR; Johansson M; Karlsson A
  • Published conference paper: PHARMACOLOGY AND THERAPEUTICS. 2000;87(2-3):189-198
    Van Rompay AR; Johansson M; Karlsson A
  • Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 1999;18(4-5):1007-1008
    Manfredini S; Baraldi PG; Durini E; Balzarini J; De Clercq E; Karlsson A; Buzzoni V; Thelander L
  • Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 1995;14(3-5):585-594
    CAMARASA MJ; PEREZPEREZ MJ; VELAZQUEZ S; SANFELIX A; ALVAREZ R; INGATE S; JIMENO ML; KARLSSON A; DECLERCQ E; BALZARINI J

ԲäԾԲ

  • ʰǴڱǰ/𳦾ٱä첹, Laboratoriemedicin, ̽ѡ, 2008-

Examina och utbildning

  • Docent, Biokemi, ̽ѡ, 1996

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