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Integrativ fysiologi – Juleen Zieraths forskargrupp

Det övergripande syftet med forskningen inom integrativ fysiologi är att upptäcka och definiera riktpunkter som är viktiga inom metabola sjukdomar, till exempel vid nedsatt glukos homeostas och typ 2-diabetes mellitus.

Research group leader

Excecutive Assistant, Research group leader

Jane Thomsen

Annan Grund

Deputy Research group leader

Profile image

Anna Krook

Professor
+46852487824

News from the group

News from the Integrative physiology group

Address

Integrative Physiology, ̽»¨¾«Ñ¡
Biomedicum, C4, Solnavägen 9, 171 77 Stockholm

Research Projects

Our central hypothesis is that alterations in insulin signal transduction to glucose transport contribute to the profound impairment in whole body glucose homeostasis and Type 2 diabetes pathogenesis and that identification of the defects can lead to the development of new therapeutic strategies to prevent and cure this disease. Research activities are divided into two main objectives:

1) Development of target identification platforms using microarray, proteomics and bioinformatics to identify dysregulated genes in healthy and diabetic patients or genetically modified model systems.

a) Gene expression profiling is performed in healthy and Type 2 diabetic subjects and defined genetic models to create a fingerprint of dysregulated genes associated.

b) Bioinformatics and predictive pathway analysis is performed to identify mechanism for insulin action and resistance.

c) Proteomics is being developed to validate the target genes identified in the gene expression profile.

2) Functional genomics is used to assign a physiological role to the identified targets using cellular (in vivo siRNA) and whole-body (genetically modified mice) models. We are developing:

a) high-through-puts screen in human skeletal muscle cells to silence or overexpress candidate genes to establish the functional impact on metabolism.

b) medium-through-put screens (electroporation) to determine the consequence of gene silencing or overexpression on the whole-body metabolic phenotype at tissue (organ) level.

c) tissue-specific gene knockout or transgenic models to provide proof-of concept that the identified gene(s) and the pathway(s) they regulate play a causative or preventive role in the development of type 2 diabetes.

More information about the ongoing research at Integrative Physiology, FYFA

Medarbetare och kontakt

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Nyckelord:
Cell- och molekylärbiologi Endokrinologi och diabetes Fysiologi och anatomi
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Lilian Pagrot
2025-03-25