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Towards personalized physiology in Intensive Care

Using a combination of high-resolution intensive care unit (ICU) data and health registry data, we study the impact of chronic illness, acute physiological and biochemical patterns, and intensive care therapies on short- and long-term outcomes after critical illness.

Profilporträtt Johan Mårtensson
Johan MÃ¥rtensson.

In Sweden, approximately 50 000 patients are admitted to ICU every year. ICU patients are closely monitored with respect to physiological and biochemical changes with the aim to diagnose and treat life threatening complications in a timely manner as well as to evaluate the response to therapeutic interventions. Despite these efforts, a significant proportion of ICU patients develop progressive organ dysfunction requiring pharmacological and mechanical organ support. In addition, the long-term burden of morbidity (i.e. a continuing decline in organ function status) and mortality after critical illness remain high.

We focus on how the interaction between pre-ICU morbidity, critical care physiology, and process of care relates to patient outcomes. The overall aim is to identify modifiable targets in order to improve patient care and outcomes.

Group members

Johan Mårtensson – Associate Professor, Senior Consultant, research group leader

Anca Balintescu – PhD student

Niklas Jonsson – Postdoc

Axel Martling – Researcher

Jacob Sejersen – Researcher

Ola Friman – Research nurse, researcher

Indir Becic – Business Intelligence Architect

Collaborators

Rinaldo Bellomo, Professor, Austin Health, Melbourne

Anders Larsson, Professor, Uppsala University

Marcus Lind, Professor, University of Gothenburg

Ragnar Thobaben, Associate Professor, Royal Institute of Technology

Per Venge, Professor, Uppsala University

Funding

Region Stockholm (ALF project)

Region Stockholm (clinical research appointment)

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The Australian and New Zealand Intensive Care Foundation

Selected publications


Kwan TN, Zwakman-Hessels L, Marhoon N, Robbins R, MÃ¥rtensson J, Ekinci E, et al
Crit Care Med 2020 03;48(3):e233-e240


Ravn B, Rimes-Stigare C, Bell M, Hansson M, Hansson LO, Martling CR, et al
J Crit Care 2019 08;52():136-140


Jonsson N, Gille-Johnson P, Martling CR, Xu S, Venge P, MÃ¥rtensson J
J Crit Care 2019 10;53():264-270


Luethi N, Cioccari L, Eastwood G, Biesenbach P, Morgan R, Sprogis S, et al
Acta Anaesthesiol Scand 2019 07;63(6):761-768


MÃ¥rtensson J, Bihari S, Bannard-Smith J, Glassford NJ, Lloyd-Donald P, Cioccari L, et al
Intensive Care Med 2018 Nov;44(11):1797-1806


Yong PH, Weinberg L, Torkamani N, Churilov L, Robbins RJ, Ma R, et al
Diabetes Care 2018 06;41(6):1172-1179


Luethi N, Cioccari L, Eastwood G, Biesenbach P, Morgan R, Sprogis S, et al
Acta Anaesthesiol Scand 2019 07;63(6):761-768


Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, et al
J Am Coll Cardiol 2011 Apr;57(17):1752-61

Contact

Johan MÃ¥rtensson

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Karin Wrangö
2023-07-12