Erik Norberg
Affiliated to Research | Docent
E-mail: erik.norberg@ki.se
Telephone: +46852487170
Visiting address: Solnavägen 9, Biomedicum C5, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Signalvägar för proteinnedbrytning, 171 77 Stockholm
About me
- *2019*-present: /Assoc. Professor/ of Metabolism (Docent), Karolinska Inst.
*2014*-*2018*: /Asst. Professor/, Karolinska Inst.
*2011*-*2013*: /PostDoc/ at Dana-Farber Cancer Institute, Harvard Medical
School, Boston, USA.
*2011*: /Ph.D./ Karolinska Institute, Stockholm, Sweden.
*2006*: /MSc/. Stockholm Research School in Molecular Life Science.
*2005*: /MSc./ Uppsala University, Uppsala, Sweden.
1) Dimitris N Chorafas Prize - for best Ph.D. thesis at the Karolinska
Institute 2011.
2) The Lennart Philipson Award 2015 - Awarded biannuallly to one researcher
at the Karolinska Institute.
Research
- We are mainly focusing on the following overarching topics:
*1.* Metabolic Adaptations to Oncogenes and Tumor Suppressors.
*2.* Metabolic Signal Transduction.
*3.* Molecular Regulators of Metabolic Heterogeneity
/*Research Group ' Cellular Metabolism: */
Vitaly Kaminsky, PhD, Senior Researcher.
Elena Kochetkova, PhD, PostDoc,
Boxi Zhang, PhD, PostDoc.
Lyudmila Krassikova, PhD, PostDoc.
Divya Nagarajan, PhD, PostDoc.
Vagelis Samakidis, MSc, Lab technician.
Anastasiia Krasko, MSc student.
Alumni:
Dawn E Comstock, MD-PhD student, Harvard Medical School.
Yiwei Ai, MD, research student
Dominique Smith, Masters student, Uppsala University.
Wirood Aldjezani, Masters Student, Uppsala University.
/*Select Original Publications:*/
*1.* The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.
Krassikova L, Zhang B, Nagarajan D, Queiroz AL, Kacal M, Samakidis E,
Vakifahmetoglu-Norberg H, * Norberg E.* /Cell Death Differ/. 2020 Oct 20. doi:
10.1038/s41418-020-00639-1. Online ahead of print.
/> - News:
_ga=2.70076304.168021435.1603384257-969318966.1587422954
/
*2.* Ambroise G, Yu TT, Zhang B, Kacal M, Hao Y, Queiroz AL, Ouchida AT,
Lindskog C, *Norberg E#, * Vakifahmetoglu-Norberg H#. Systematic analysis
reveals a functional role for STAMBPL1 in the epithelial-mesenchymal
transition process across multiple carcinomas. /British Journal of Cancer/.
2020 Sep - 123(7):1164-1177. *# co-corresponding author*
*3.* Zhang B, Zheng A, Hydbring P, Ambroise G, Ouchida AT, Goiny M,
Vakifahmetoglu-Norberg, H, *Norberg E*. PHGDH Defines a metabolic subtype in
lung adenocarcinomas with poor prognosis. /Cell Reports /2017 Jun
13 - 19(11):2289-2303.
/> - Selected as 'Issue Highlight' by Cell Reports./
*4.* Eriksson M, Ambroise G, Ouchida AT, Queiroz AL, Smith D, Gimenez-Cassina
A, Iwanicki MP, Muller PA, *Norberg E#*, Vakifahmetoglu-Norberg H#. The
effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism.
/Mol Cell Biol./ 2017 Nov 28 - 37(24) * # Co-corresponding author.*
/> - Selected for the Cover volume 37, issue 24./
*5.* Zhang B, Tornmalm J, Widengren J, Vakifahmetoglu-Norberg H, *Norberg E*.
Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell
Survival. /Journal of Cancer/ 2017 - 8(11):2088-2096.
/*Select Collaboration papers: */
*1. *Quantitative proteomic analysis of temporal lysosomal proteome and the
impact of the KFERQ-like motif and LAMP2A in lysosomal targeting. [1] Kacal
M, Zhang B, Hao Y, *Norberg E*, Vakifahmetoglu-Norberg H /Autophagy 2021 /Jan
14. doi: 10.1080/15548627.2021.1876343. [Online ahead of print.]
*2. *Targetome analysis of chaperone-mediated autophagy in cancer cells.
[2]Hao Y, Kacal M, Ouchida AT, Zhang B, *Norberg E*, Vakifahmetoglu-Norberg
H. /Autophagy 2019 09 - 15(9):1558-1571/
/*Select Reviews/Editorials: */
1. Queiroz AL, Vakifahmetoglu-Norberg H, *Norberg E*. Resistant to Targeted
Therapy - Aim for Metabolic Liabilities. /Theranostics/ 2018 - 8(7):
2061-2063.
2. Vakifahmetoglu-Norberg H, Ouchida A, *Norberg E*. The role of Mitochondria
in Metabolism and Cell Death. /Biochem Biophys Res Commun./ (2017) Jan
15 - 482(3):426-431
/> - As of July/August 2017, this Review received enough citations to place it
in the top 1% of the academic field of Biology & - Biochemistry (Web of
Science)./
3. Stanley I, Ribeiro S, Gimenez-Cassina A, * Norberg E*, Danial NN. Changing
appetites: The adaptive advantages of fuel choice./ Trends in Cell Biology./
2014 Feb - 24(2):118-27
/*Open Positions:*/
2 Master of Science Project (start 2021)
1 PhD student position available from end of 2021 or begining of 2022.
1 PostDoc positions available. start 2021
[1]
[2]
Articles
- Journal article: CELL DEATH DISCOVERY. 2024;10(1):502
- Article: AUTOPHAGY. 2023;19(9):2575-2577
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:329-335
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:289-302
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:275-288
- Article: AUTOPHAGY. 2021;17(11):3865-3874
- Article: CELL DEATH AND DIFFERENTIATION. 2021;28(3):1091-1109
- Article: BRITISH JOURNAL OF CANCER. 2020;123(7):1164-1177
- Article: AUTOPHAGY. 2019;15(9):1558-1571
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2019;511(2):260-265
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;502(4):429-434
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;499(2):314-320
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2017;37(24):e00328-e00317
- Article: CELL REPORTS. 2017;19(11):2289-2303
- Article: CELL DEATH AND DIFFERENTIATION. 2017;24(2):251-262
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;482(3):426-431
- Article: JOURNAL OF CANCER. 2017;8(11):2088-2096
- Article: JOURNAL OF CELL BIOLOGY. 2015;210(5):705-716
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2015;460(3):572-577
- Article: CELL DEATH AND DISEASE. 2013;4(12):e940
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2013;57:176-187
- Article: CANCER CELL. 2012;22(4):547-560
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(11):1546-1555
- Article: EMBO JOURNAL. 2010;29(22):3869-3878
- Article: INTERNATIONAL JOURNAL OF CANCER. 2010;127(8):1823-1832
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):95-100
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2010;48(6):791-797
- Article: CELL DEATH AND DIFFERENTIATION. 2008;15(12):1857-1864
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(38):27633-27639
- Show more
All other publications
- Preprint: BIORXIV. 2024;BIORXIV
- Preprint: BIORXIV. 2022
- Review: FRONTIERS IN ONCOLOGY. 2020;10:607149
- Editorial comment: THERANOSTICS. 2018;8(7):2061-2063
- Review: AUTOPHAGY. 2016;12(1):1-222
- Review: TRENDS IN CELL BIOLOGY. 2014;24(2):118-127
- Corrigendum: FREE RADICAL BIOLOGY AND MEDICINE. 2013;65:895-896
- Review: CELL DEATH AND DIFFERENTIATION. 2009;16(8):1075-1082
Employments
- Affiliated to Research, Department of Physiology and Pharmacology, ̽»¨¾«Ñ¡, 2024-2026
- Principal Researcher, Department of Physiology and Pharmacology, ̽»¨¾«Ñ¡, 2021-2024
Degrees and Education
- Docent, ̽»¨¾«Ñ¡, 2019
- Degree Of Doctor Of Philosophy, Institute of Environmental Medicine, ̽»¨¾«Ñ¡, 2011